Q96ER3 (SAAL1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein SAAL1

Gene names

Name:

SAAL1

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	474 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Post-translational modification	Phosphorylated upon DNA damage, probably by ATM or ATR. Ref.4
Sequence similarities	Belongs to the SAAL1 family.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	acute-phase response Inferred from electronic annotation. Source: InterPro
Cellular component	extracellular region Inferred from electronic annotation. Source: InterPro
Molecular function	binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 474	474	Protein SAAL1		PRO_0000279540
Amino acid modifications
	Modified residue	6	1	Phosphoserine By similarity
	Modified residue	378	1	Phosphothreonine By similarity
	Modified residue	387	1	Phosphothreonine Ref.4
Natural variations
	Natural variant	315	1	I → V. Corresponds to variant rs35525096 [ dbSNP | Ensembl ].		VAR_053846
	Natural variant	426	1	S → G. Corresponds to variant rs28930681 [ dbSNP | Ensembl ].		VAR_053847
Experimental info
	Sequence conflict	10	1	P → PP in AAH12010. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Q96ER3 [UniParc]. Last modified October 14, 2008. Version 2. Checksum: C206C80827F49681	FASTA	474	53,558
	10 20 30 40 50 60 MDRNPSPPPP GRDKEEEEEV AGGDCIGSTV YSKHWLFGVL SGLIQIVSPE NTKSSSDDEE 70 80 90 100 110 120 QLTELDEEME NEICRVWDMS MDEDVALFLQ EFNAPDIFMG VLAKSKCPRL REICVGILGN 130 140 150 160 170 180 MACFQEICVS ISSDKNLGQV LLHCLYDSDP PTLLETSRLL LTCLSQAEVA SVWVERIQEH 190 200 210 220 230 240 PAIYDSICFI MSSSTNVDLL VKVGEVVDKL FDLDEKLMLE WVRNGAAQPL DQPQEESEEQ 250 260 270 280 290 300 PVFRLVPCIL EAAKQVRSEN PEWLDVYMHI LQLLTTVDDG IQAIVHCPDT GKDIWNLLFD 310 320 330 340 350 360 LVCHEFCQSD DPPIILQEQK TVLASVFSVL SAIYASQTEQ EYLKIEKVDL PLIDSLIRVL 370 380 390 400 410 420 QNMEQCQKKP ENSAESNTEE TKRTDLTQDD FHLKILKDIL CEFLSNIFQA LTKETVAQGV 430 440 450 460 470 KEGQLSKQKC SSAFQNLLPF YSPVVEDFIK ILREVDKALA DDLEKNFPSL KVQT

References

[1]	"Human chromosome 11 DNA sequence and analysis including novel gene identification." Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y. Nature 440:497-500(2006) [PubMed: 16554811] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Liver.
[4]	"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage." Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J. Science 316:1160-1166(2007) [PubMed: 17525332] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-387, MASS SPECTROMETRY. Tissue: Embryonic kidney.
[5]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed: 21269460] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC090099 Genomic DNA. No translation available. CH471064 Genomic DNA. Translation: EAW68419.1. BC012010 mRNA. Translation: AAH12010.1.
IPI	IPI00304935.
RefSeq	NP_612430.2. NM_138421.2.
UniGene	Hs.591998.
3D structure databases
ProteinModelPortal	Q96ER3.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q96ER3. 4 interactions.
MINT	MINT-1430177.
PTM databases
PhosphoSite	Q96ER3.
Polymorphism databases
DMDM	209572677.
Proteomic databases
PRIDE	Q96ER3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000300013; ENSP00000300013; ENSG00000166788.
GeneID	113174.
KEGG	hsa:113174.
Organism-specific databases
CTD	113174.
GeneCards	GC11M018059.
H-InvDB	HIX0009481.
HGNC	HGNC:25158. SAAL1.
HPA	HPA039004.
neXtProt	NX_Q96ER3.
PharmGKB	PA142670959.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG08793.
GeneTree	ENSGT00510000048056.
HOGENOM	HBG713555.
HOVERGEN	HBG061166.
InParanoid	Q96ER3.
OMA	SAIYASQ.
OrthoDB	EOG4NKBVF.
PhylomeDB	Q96ER3.
Gene expression databases
ArrayExpress	Q96ER3.
Bgee	Q96ER3.
CleanEx	HS_SAAL1.
Genevestigator	Q96ER3.
Family and domain databases
InterPro	IPR011989. ARM-like. IPR016024. ARM-type_fold. IPR000096. Serum_amyloid_A. [Graphical view]
Gene3D	G3DSA:1.25.10.10. ARM-like. 1 hit.
PANTHER	PTHR23424. Serum_amyloid_A. 1 hit.
SUPFAM	SSF48371. ARM-type_fold. 1 hit.
ProtoNet	Search...
Other
NextBio	78763.

Entry information

Entry name

SAAL1_HUMAN

Accession

Primary (citable) accession number: Q96ER3
Secondary accession number(s): A6NH05

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 6, 2007
Last sequence update:	October 14, 2008
Last modified:	January 25, 2012
This is version 70 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.