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Protein

Protein SAAL1

Gene

SAAL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein SAAL1
Gene namesi
Name:SAAL1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:25158. SAAL1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670959.

Polymorphism and mutation databases

BioMutaiSAAL1.
DMDMi209572677.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 474474Protein SAAL1PRO_0000279540Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei6 – 61PhosphoserineBy similarity
Modified residuei387 – 3871PhosphothreonineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ96ER3.
MaxQBiQ96ER3.
PaxDbiQ96ER3.
PeptideAtlasiQ96ER3.
PRIDEiQ96ER3.

PTM databases

iPTMnetiQ96ER3.
PhosphoSiteiQ96ER3.

Expressioni

Gene expression databases

BgeeiENSG00000166788.
CleanExiHS_SAAL1.
ExpressionAtlasiQ96ER3. baseline and differential.
GenevisibleiQ96ER3. HS.

Organism-specific databases

HPAiHPA039003.
HPA039004.

Interactioni

Protein-protein interaction databases

BioGridi125228. 38 interactions.
IntActiQ96ER3. 4 interactions.
MINTiMINT-1430177.
STRINGi9606.ENSP00000432487.

Structurei

3D structure databases

ProteinModelPortaliQ96ER3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SAAL1 family.Curated

Phylogenomic databases

eggNOGiENOG410IMST. Eukaryota.
ENOG4110KPS. LUCA.
GeneTreeiENSGT00510000048056.
HOGENOMiHOG000154242.
HOVERGENiHBG061166.
InParanoidiQ96ER3.
PhylomeDBiQ96ER3.
TreeFamiTF323873.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.

Sequencei

Sequence statusi: Complete.

Q96ER3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDRNPSPPPP GRDKEEEEEV AGGDCIGSTV YSKHWLFGVL SGLIQIVSPE
60 70 80 90 100
NTKSSSDDEE QLTELDEEME NEICRVWDMS MDEDVALFLQ EFNAPDIFMG
110 120 130 140 150
VLAKSKCPRL REICVGILGN MACFQEICVS ISSDKNLGQV LLHCLYDSDP
160 170 180 190 200
PTLLETSRLL LTCLSQAEVA SVWVERIQEH PAIYDSICFI MSSSTNVDLL
210 220 230 240 250
VKVGEVVDKL FDLDEKLMLE WVRNGAAQPL DQPQEESEEQ PVFRLVPCIL
260 270 280 290 300
EAAKQVRSEN PEWLDVYMHI LQLLTTVDDG IQAIVHCPDT GKDIWNLLFD
310 320 330 340 350
LVCHEFCQSD DPPIILQEQK TVLASVFSVL SAIYASQTEQ EYLKIEKVDL
360 370 380 390 400
PLIDSLIRVL QNMEQCQKKP ENSAESNTEE TKRTDLTQDD FHLKILKDIL
410 420 430 440 450
CEFLSNIFQA LTKETVAQGV KEGQLSKQKC SSAFQNLLPF YSPVVEDFIK
460 470
ILREVDKALA DDLEKNFPSL KVQT
Length:474
Mass (Da):53,558
Last modified:October 14, 2008 - v2
Checksum:iC206C80827F49681
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti10 – 101P → PP in AAH12010 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti315 – 3151I → V.
Corresponds to variant rs35525096 [ dbSNP | Ensembl ].
VAR_053846
Natural varianti426 – 4261S → G.
Corresponds to variant rs28930681 [ dbSNP | Ensembl ].
VAR_053847

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC090099 Genomic DNA. No translation available.
CH471064 Genomic DNA. Translation: EAW68419.1.
BC012010 mRNA. Translation: AAH12010.1.
CCDSiCCDS31439.1.
RefSeqiNP_612430.2. NM_138421.2.
UniGeneiHs.591998.

Genome annotation databases

EnsembliENST00000524803; ENSP00000432487; ENSG00000166788.
GeneIDi113174.
KEGGihsa:113174.
UCSCiuc001mnq.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC090099 Genomic DNA. No translation available.
CH471064 Genomic DNA. Translation: EAW68419.1.
BC012010 mRNA. Translation: AAH12010.1.
CCDSiCCDS31439.1.
RefSeqiNP_612430.2. NM_138421.2.
UniGeneiHs.591998.

3D structure databases

ProteinModelPortaliQ96ER3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125228. 38 interactions.
IntActiQ96ER3. 4 interactions.
MINTiMINT-1430177.
STRINGi9606.ENSP00000432487.

PTM databases

iPTMnetiQ96ER3.
PhosphoSiteiQ96ER3.

Polymorphism and mutation databases

BioMutaiSAAL1.
DMDMi209572677.

Proteomic databases

EPDiQ96ER3.
MaxQBiQ96ER3.
PaxDbiQ96ER3.
PeptideAtlasiQ96ER3.
PRIDEiQ96ER3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000524803; ENSP00000432487; ENSG00000166788.
GeneIDi113174.
KEGGihsa:113174.
UCSCiuc001mnq.4. human.

Organism-specific databases

CTDi113174.
GeneCardsiSAAL1.
H-InvDBHIX0009481.
HGNCiHGNC:25158. SAAL1.
HPAiHPA039003.
HPA039004.
neXtProtiNX_Q96ER3.
PharmGKBiPA142670959.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IMST. Eukaryota.
ENOG4110KPS. LUCA.
GeneTreeiENSGT00510000048056.
HOGENOMiHOG000154242.
HOVERGENiHBG061166.
InParanoidiQ96ER3.
PhylomeDBiQ96ER3.
TreeFamiTF323873.

Miscellaneous databases

ChiTaRSiSAAL1. human.
GenomeRNAii113174.
PROiQ96ER3.

Gene expression databases

BgeeiENSG00000166788.
CleanExiHS_SAAL1.
ExpressionAtlasiQ96ER3. baseline and differential.
GenevisibleiQ96ER3. HS.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiSAAL1_HUMAN
AccessioniPrimary (citable) accession number: Q96ER3
Secondary accession number(s): A6NH05
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: October 14, 2008
Last modified: September 7, 2016
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.