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Protein

Small glutamine-rich tetratricopeptide repeat-containing protein beta

Gene

SGTB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Co-chaperone that binds directly to HSC70 and HSP70 and regulates their ATPase activity.By similarity

Keywordsi

Molecular functionChaperone

Names & Taxonomyi

Protein namesi
Recommended name:
Small glutamine-rich tetratricopeptide repeat-containing protein beta
Alternative name(s):
Beta-SGT
Small glutamine-rich protein with tetratricopeptide repeats 2
Gene namesi
Name:SGTB
Synonyms:SGT2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000197860.9
HGNCiHGNC:23567 SGTB
neXtProtiNX_Q96EQ0

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000197860
PharmGKBiPA134957805

Polymorphism and mutation databases

BioMutaiSGTB
DMDMi41018109

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001063681 – 304Small glutamine-rich tetratricopeptide repeat-containing protein betaAdd BLAST304

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei131N6-acetyllysineBy similarity1
Modified residuei293PhosphoserineBy similarity1
Modified residuei295PhosphoserineCombined sources1
Modified residuei297PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ96EQ0
MaxQBiQ96EQ0
PaxDbiQ96EQ0
PeptideAtlasiQ96EQ0
PRIDEiQ96EQ0

PTM databases

iPTMnetiQ96EQ0
PhosphoSitePlusiQ96EQ0

Expressioni

Gene expression databases

BgeeiENSG00000197860
CleanExiHS_SGTB
ExpressionAtlasiQ96EQ0 baseline and differential
GenevisibleiQ96EQ0 HS

Organism-specific databases

HPAiHPA044689
HPA063674

Interactioni

Subunit structurei

Homooligomerize.By similarity

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi12004286 interactors.
IntActiQ96EQ0 183 interactors.
MINTiQ96EQ0
STRINGi9606.ENSP00000370395

Structurei

3D structure databases

ProteinModelPortaliQ96EQ0
SMRiQ96EQ0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati15 – 49TPR 1Add BLAST35
Repeati85 – 118TPR 2Add BLAST34
Repeati119 – 152TPR 3Add BLAST34
Repeati153 – 186TPR 4Add BLAST34

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi267 – 279Gln-richAdd BLAST13

Sequence similaritiesi

Belongs to the SGT family.Curated

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG0553 Eukaryota
COG0457 LUCA
GeneTreeiENSGT00730000110724
HOGENOMiHOG000208193
HOVERGENiHBG000885
InParanoidiQ96EQ0
OMAiPAMMNMA
OrthoDBiEOG091G0C0Q
PhylomeDBiQ96EQ0
TreeFamiTF313092

Family and domain databases

Gene3Di1.25.40.101 hit
InterProiView protein in InterPro
IPR032374 SGTA_dimer
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR001440 TPR_1
IPR019734 TPR_repeat
PfamiView protein in Pfam
PF16546 SGTA_dimer, 1 hit
PF00515 TPR_1, 1 hit
SMARTiView protein in SMART
SM00028 TPR, 3 hits
SUPFAMiSSF48452 SSF48452, 1 hit
PROSITEiView protein in PROSITE
PS50005 TPR, 3 hits
PS50293 TPR_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

Q96EQ0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSIKHLVYA VIRFLREQSQ MDTYTSDEQE SLEVAIQCLE TVFKISPEDT
60 70 80 90 100
HLAVSQPLTE MFTSSFCKND VLPLSNSVPE DVGKADQLKD EGNNHMKEEN
110 120 130 140 150
YAAAVDCYTQ AIELDPNNAV YYCNRAAAQS KLGHYTDAIK DCEKAIAIDS
160 170 180 190 200
KYSKAYGRMG LALTALNKFE EAVTSYQKAL DLDPENDSYK SNLKIAEQKL
210 220 230 240 250
REVSSPTGTG LSFDMASLIN NPAFISMAAS LMQNPQVQQL MSGMMTNAIG
260 270 280 290 300
GPAAGVGGLT DLSSLIQAGQ QFAQQIQQQN PELIEQLRNH IRSRSFSSSA

EEHS
Length:304
Mass (Da):33,429
Last modified:December 1, 2001 - v1
Checksum:i10819155C4E150FB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF368281 mRNA Translation: AAP29459.1
AK096321 mRNA Translation: BAC04761.1
BC012044 mRNA Translation: AAH12044.1
CCDSiCCDS3988.1
RefSeqiNP_061945.1, NM_019072.2
XP_005248605.1, XM_005248548.3
UniGeneiHs.482301
Hs.707786

Genome annotation databases

EnsembliENST00000381007; ENSP00000370395; ENSG00000197860
GeneIDi54557
KEGGihsa:54557
UCSCiuc003jud.4 human

Similar proteinsi

Entry informationi

Entry nameiSGTB_HUMAN
AccessioniPrimary (citable) accession number: Q96EQ0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: December 1, 2001
Last modified: March 28, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome