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Protein

Small glutamine-rich tetratricopeptide repeat-containing protein beta

Gene

SGTB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Co-chaperone that binds directly to HSC70 and HSP70 and regulates their ATPase activity.By similarity

Keywords - Molecular functioni

Chaperone

Enzyme and pathway databases

BioCyciZFISH:G66-31823-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Small glutamine-rich tetratricopeptide repeat-containing protein beta
Alternative name(s):
Beta-SGT
Small glutamine-rich protein with tetratricopeptide repeats 2
Gene namesi
Name:SGTB
Synonyms:SGT2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:23567. SGTB.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000197860.
PharmGKBiPA134957805.

Polymorphism and mutation databases

BioMutaiSGTB.
DMDMi41018109.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001063681 – 304Small glutamine-rich tetratricopeptide repeat-containing protein betaAdd BLAST304

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei131N6-acetyllysineBy similarity1
Modified residuei293PhosphoserineBy similarity1
Modified residuei295PhosphoserineCombined sources1
Modified residuei297PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ96EQ0.
MaxQBiQ96EQ0.
PaxDbiQ96EQ0.
PeptideAtlasiQ96EQ0.
PRIDEiQ96EQ0.

PTM databases

iPTMnetiQ96EQ0.
PhosphoSitePlusiQ96EQ0.

Expressioni

Gene expression databases

BgeeiENSG00000197860.
CleanExiHS_SGTB.
ExpressionAtlasiQ96EQ0. baseline and differential.
GenevisibleiQ96EQ0. HS.

Organism-specific databases

HPAiHPA044689.
HPA063674.

Interactioni

Subunit structurei

Homooligomerize.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
EFEMP2O959676EBI-744081,EBI-743414
IL6STQ17RA03EBI-744081,EBI-10238517
RAI2Q9Y5P34EBI-744081,EBI-746228
SERPINE1P051215EBI-744081,EBI-953978
TXNDC12O958813EBI-744081,EBI-2564581

Protein-protein interaction databases

BioGridi120042. 86 interactors.
IntActiQ96EQ0. 95 interactors.
MINTiMINT-1471872.
STRINGi9606.ENSP00000370395.

Structurei

3D structure databases

ProteinModelPortaliQ96EQ0.
SMRiQ96EQ0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati15 – 49TPR 1Add BLAST35
Repeati85 – 118TPR 2Add BLAST34
Repeati119 – 152TPR 3Add BLAST34
Repeati153 – 186TPR 4Add BLAST34

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi267 – 279Gln-richAdd BLAST13

Sequence similaritiesi

Belongs to the SGT family.Curated
Contains 4 TPR repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG0553. Eukaryota.
COG0457. LUCA.
GeneTreeiENSGT00730000110724.
HOGENOMiHOG000208193.
HOVERGENiHBG000885.
InParanoidiQ96EQ0.
OMAiGMMSNAI.
OrthoDBiEOG091G0C0Q.
PhylomeDBiQ96EQ0.
TreeFamiTF313092.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR032374. SGTA_dimer.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR001440. TPR_1.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF16546. SGTA_dimer. 1 hit.
PF00515. TPR_1. 1 hit.
PF13414. TPR_11. 1 hit.
[Graphical view]
SMARTiSM00028. TPR. 3 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
PROSITEiPS50005. TPR. 3 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96EQ0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSIKHLVYA VIRFLREQSQ MDTYTSDEQE SLEVAIQCLE TVFKISPEDT
60 70 80 90 100
HLAVSQPLTE MFTSSFCKND VLPLSNSVPE DVGKADQLKD EGNNHMKEEN
110 120 130 140 150
YAAAVDCYTQ AIELDPNNAV YYCNRAAAQS KLGHYTDAIK DCEKAIAIDS
160 170 180 190 200
KYSKAYGRMG LALTALNKFE EAVTSYQKAL DLDPENDSYK SNLKIAEQKL
210 220 230 240 250
REVSSPTGTG LSFDMASLIN NPAFISMAAS LMQNPQVQQL MSGMMTNAIG
260 270 280 290 300
GPAAGVGGLT DLSSLIQAGQ QFAQQIQQQN PELIEQLRNH IRSRSFSSSA

EEHS
Length:304
Mass (Da):33,429
Last modified:December 1, 2001 - v1
Checksum:i10819155C4E150FB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF368281 mRNA. Translation: AAP29459.1.
AK096321 mRNA. Translation: BAC04761.1.
BC012044 mRNA. Translation: AAH12044.1.
CCDSiCCDS3988.1.
RefSeqiNP_061945.1. NM_019072.2.
XP_005248605.1. XM_005248548.3.
UniGeneiHs.482301.
Hs.707786.

Genome annotation databases

EnsembliENST00000381007; ENSP00000370395; ENSG00000197860.
GeneIDi54557.
KEGGihsa:54557.
UCSCiuc003jud.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF368281 mRNA. Translation: AAP29459.1.
AK096321 mRNA. Translation: BAC04761.1.
BC012044 mRNA. Translation: AAH12044.1.
CCDSiCCDS3988.1.
RefSeqiNP_061945.1. NM_019072.2.
XP_005248605.1. XM_005248548.3.
UniGeneiHs.482301.
Hs.707786.

3D structure databases

ProteinModelPortaliQ96EQ0.
SMRiQ96EQ0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120042. 86 interactors.
IntActiQ96EQ0. 95 interactors.
MINTiMINT-1471872.
STRINGi9606.ENSP00000370395.

PTM databases

iPTMnetiQ96EQ0.
PhosphoSitePlusiQ96EQ0.

Polymorphism and mutation databases

BioMutaiSGTB.
DMDMi41018109.

Proteomic databases

EPDiQ96EQ0.
MaxQBiQ96EQ0.
PaxDbiQ96EQ0.
PeptideAtlasiQ96EQ0.
PRIDEiQ96EQ0.

Protocols and materials databases

DNASUi54557.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000381007; ENSP00000370395; ENSG00000197860.
GeneIDi54557.
KEGGihsa:54557.
UCSCiuc003jud.4. human.

Organism-specific databases

CTDi54557.
GeneCardsiSGTB.
HGNCiHGNC:23567. SGTB.
HPAiHPA044689.
HPA063674.
neXtProtiNX_Q96EQ0.
OpenTargetsiENSG00000197860.
PharmGKBiPA134957805.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0553. Eukaryota.
COG0457. LUCA.
GeneTreeiENSGT00730000110724.
HOGENOMiHOG000208193.
HOVERGENiHBG000885.
InParanoidiQ96EQ0.
OMAiGMMSNAI.
OrthoDBiEOG091G0C0Q.
PhylomeDBiQ96EQ0.
TreeFamiTF313092.

Enzyme and pathway databases

BioCyciZFISH:G66-31823-MONOMER.

Miscellaneous databases

GenomeRNAii54557.
PROiQ96EQ0.

Gene expression databases

BgeeiENSG00000197860.
CleanExiHS_SGTB.
ExpressionAtlasiQ96EQ0. baseline and differential.
GenevisibleiQ96EQ0. HS.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR032374. SGTA_dimer.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR001440. TPR_1.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF16546. SGTA_dimer. 1 hit.
PF00515. TPR_1. 1 hit.
PF13414. TPR_11. 1 hit.
[Graphical view]
SMARTiSM00028. TPR. 3 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
PROSITEiPS50005. TPR. 3 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSGTB_HUMAN
AccessioniPrimary (citable) accession number: Q96EQ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: December 1, 2001
Last modified: November 30, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.