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Protein

Sodium/bile acid cotransporter 4

Gene

SLC10A4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Transporter for bile acids.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei87 – 882Cleavage; by thrombin

GO - Molecular functioni

  1. bile acid:sodium symporter activity Source: GO_Central

GO - Biological processi

  1. bile acid and bile salt transport Source: GO_Central
Complete GO annotation...

Keywords - Biological processi

Ion transport, Sodium transport, Symport, Transport

Keywords - Ligandi

Sodium

Protein family/group databases

TCDBi2.A.28.1.7. the bile acid:na(+) symporter (bass) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/bile acid cotransporter 4
Alternative name(s):
Na(+)/bile acid cotransporter 4
Solute carrier family 10 member 4
Gene namesi
Name:SLC10A4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:22980. SLC10A4.

Subcellular locationi

Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 103103ExtracellularSequence AnalysisAdd
BLAST
Transmembranei104 – 12421HelicalSequence AnalysisAdd
BLAST
Topological domaini125 – 14016CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei141 – 16121HelicalSequence AnalysisAdd
BLAST
Topological domaini162 – 19736ExtracellularSequence AnalysisAdd
BLAST
Transmembranei198 – 21821HelicalSequence AnalysisAdd
BLAST
Topological domaini219 – 23315CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei234 – 25421HelicalSequence AnalysisAdd
BLAST
Topological domaini255 – 26713ExtracellularSequence AnalysisAdd
BLAST
Transmembranei268 – 28821HelicalSequence AnalysisAdd
BLAST
Topological domaini289 – 2913CytoplasmicSequence Analysis
Transmembranei292 – 31221HelicalSequence AnalysisAdd
BLAST
Topological domaini313 – 36048ExtracellularSequence AnalysisAdd
BLAST
Transmembranei361 – 38121HelicalSequence AnalysisAdd
BLAST
Topological domaini382 – 43756CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134941471.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 437437Sodium/bile acid cotransporter 4PRO_0000263742Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi6 – 61N-linked (GlcNAc...)Sequence Analysis
Glycosylationi18 – 181N-linked (GlcNAc...)Sequence Analysis
Glycosylationi24 – 241N-linked (GlcNAc...)Sequence Analysis
Glycosylationi181 – 1811N-linked (GlcNAc...)Sequence Analysis
Glycosylationi195 – 1951N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

Activated following N-terminal proteolytic cleavage by thrombin and/or proteases.1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ96EP9.
PaxDbiQ96EP9.
PRIDEiQ96EP9.

PTM databases

PhosphoSiteiQ96EP9.

Expressioni

Tissue specificityi

Highly expressed in brain and small intestine, and moderately expressed in colon, heart, prostate, and testis. Very low levels were detected in kidney, liver, ovary, placenta, spleen, and thymus.1 Publication

Gene expression databases

BgeeiQ96EP9.
CleanExiHS_SLC10A4.
GenevestigatoriQ96EP9.

Organism-specific databases

HPAiHPA028835.

Interactioni

Protein-protein interaction databases

BioGridi128402. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ96EP9.
SMRiQ96EP9. Positions 104-376.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0385.
GeneTreeiENSGT00550000074505.
HOGENOMiHOG000234524.
HOVERGENiHBG096155.
InParanoidiQ96EP9.
KOiK14344.
OMAiVDVNHFG.
OrthoDBiEOG7XWPNW.
PhylomeDBiQ96EP9.
TreeFamiTF315811.

Family and domain databases

InterProiIPR002657. BilAc:Na_symport/Acr3.
IPR030204. SLC10A4.
[Graphical view]
PANTHERiPTHR10361. PTHR10361. 1 hit.
PTHR10361:SF20. PTHR10361:SF20. 1 hit.
PfamiPF01758. SBF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96EP9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDGNDNVTLL FAPLLRDNYT LAPNASSLGP GTDLALAPAS SAGPGPGLSL
60 70 80 90 100
GPGPSFGFSP GPTPTPEPTT SGLAGGAASH GPSPFPRPWA PHALPFWDTP
110 120 130 140 150
LNHGLNVFVG AALCITMLGL GCTVDVNHFG AHVRRPVGAL LAALCQFGLL
160 170 180 190 200
PLLAFLLALA FKLDEVAAVA VLLCGCCPGG NLSNLMSLLV DGDMNLSIIM
210 220 230 240 250
TISSTLLALV LMPLCLWIYS WAWINTPIVQ LLPLGTVTLT LCSTLIPIGL
260 270 280 290 300
GVFIRYKYSR VADYIVKVSL WSLLVTLVVL FIMTGTMLGP ELLASIPAAV
310 320 330 340 350
YVIAIFMPLA GYASGYGLAT LFHLPPNCKR TVCLETGSQN VQLCTAILKL
360 370 380 390 400
AFPPQFIGSM YMFPLLYALF QSAEAGIFVL IYKMYGSEML HKRDPLDEDE
410 420 430
DTDISYKKLK EEEMADTSYG TVKAENIIMM ETAQTSL
Length:437
Mass (Da):46,504
Last modified:February 29, 2004 - v2
Checksum:i055E989629CC13D1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY704414 mRNA. Translation: AAW30130.1.
BC012048 mRNA. Translation: AAH12048.2.
BC019066 mRNA. Translation: AAH19066.1.
CCDSiCCDS3482.1.
RefSeqiNP_689892.1. NM_152679.3.
UniGeneiHs.132591.

Genome annotation databases

EnsembliENST00000273861; ENSP00000273861; ENSG00000145248.
GeneIDi201780.
KEGGihsa:201780.
UCSCiuc003gyc.2. human.

Polymorphism databases

DMDMi74731592.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY704414 mRNA. Translation: AAW30130.1.
BC012048 mRNA. Translation: AAH12048.2.
BC019066 mRNA. Translation: AAH19066.1.
CCDSiCCDS3482.1.
RefSeqiNP_689892.1. NM_152679.3.
UniGeneiHs.132591.

3D structure databases

ProteinModelPortaliQ96EP9.
SMRiQ96EP9. Positions 104-376.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128402. 1 interaction.

Protein family/group databases

TCDBi2.A.28.1.7. the bile acid:na(+) symporter (bass) family.

PTM databases

PhosphoSiteiQ96EP9.

Polymorphism databases

DMDMi74731592.

Proteomic databases

MaxQBiQ96EP9.
PaxDbiQ96EP9.
PRIDEiQ96EP9.

Protocols and materials databases

DNASUi201780.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000273861; ENSP00000273861; ENSG00000145248.
GeneIDi201780.
KEGGihsa:201780.
UCSCiuc003gyc.2. human.

Organism-specific databases

CTDi201780.
GeneCardsiGC04P048485.
HGNCiHGNC:22980. SLC10A4.
HPAiHPA028835.
neXtProtiNX_Q96EP9.
PharmGKBiPA134941471.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG0385.
GeneTreeiENSGT00550000074505.
HOGENOMiHOG000234524.
HOVERGENiHBG096155.
InParanoidiQ96EP9.
KOiK14344.
OMAiVDVNHFG.
OrthoDBiEOG7XWPNW.
PhylomeDBiQ96EP9.
TreeFamiTF315811.

Miscellaneous databases

GenomeRNAii201780.
NextBioi90198.
PROiQ96EP9.

Gene expression databases

BgeeiQ96EP9.
CleanExiHS_SLC10A4.
GenevestigatoriQ96EP9.

Family and domain databases

InterProiIPR002657. BilAc:Na_symport/Acr3.
IPR030204. SLC10A4.
[Graphical view]
PANTHERiPTHR10361. PTHR10361. 1 hit.
PTHR10361:SF20. PTHR10361:SF20. 1 hit.
PfamiPF01758. SBF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a novel bile acid transporter in human, SLC10A4."
    Mikkaichi T., Natori M., Abe T., Hishinuma T., Goto J.
    Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. "Cloning and molecular characterization of the orphan carrier protein Slc10a4: expression in cholinergic neurons of the rat central nervous system."
    Geyer J., Fernandes C.F., Doring B., Burger S., Godoy J.R., Rafalzik S., Hubschle T., Gerstberger R., Petzinger E.
    Neuroscience 152:990-1005(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  4. Cited for: FUNCTION, PROTEOLYTIC CLEAVAGE, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiNTCP4_HUMAN
AccessioniPrimary (citable) accession number: Q96EP9
Secondary accession number(s): Q8WUZ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 11, 2006
Last sequence update: February 29, 2004
Last modified: February 3, 2015
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.