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Q96EP9

- NTCP4_HUMAN

UniProt

Q96EP9 - NTCP4_HUMAN

Protein

Sodium/bile acid cotransporter 4

Gene

SLC10A4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 2 (01 Mar 2004)
      Previous versions | rss
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    Functioni

    Transporter for bile acids.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei87 – 882Cleavage; by thrombin

    GO - Molecular functioni

    1. bile acid:sodium symporter activity Source: InterPro

    Keywords - Biological processi

    Ion transport, Sodium transport, Symport, Transport

    Keywords - Ligandi

    Sodium

    Protein family/group databases

    TCDBi2.A.28.1.7. the bile acid:na(+) symporter (bass) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sodium/bile acid cotransporter 4
    Alternative name(s):
    Na(+)/bile acid cotransporter 4
    Solute carrier family 10 member 4
    Gene namesi
    Name:SLC10A4
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:22980. SLC10A4.

    Subcellular locationi

    Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134941471.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 437437Sodium/bile acid cotransporter 4PRO_0000263742Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi6 – 61N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi18 – 181N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi24 – 241N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi181 – 1811N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi195 – 1951N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    Activated following N-terminal proteolytic cleavage by thrombin and/or proteases.1 Publication

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiQ96EP9.
    PaxDbiQ96EP9.
    PRIDEiQ96EP9.

    PTM databases

    PhosphoSiteiQ96EP9.

    Expressioni

    Tissue specificityi

    Highly expressed in brain and small intestine, and moderately expressed in colon, heart, prostate, and testis. Very low levels were detected in kidney, liver, ovary, placenta, spleen, and thymus.1 Publication

    Gene expression databases

    BgeeiQ96EP9.
    CleanExiHS_SLC10A4.
    GenevestigatoriQ96EP9.

    Organism-specific databases

    HPAiHPA028835.

    Interactioni

    Protein-protein interaction databases

    BioGridi128402. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96EP9.
    SMRiQ96EP9. Positions 104-376.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 103103ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini125 – 14016CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini162 – 19736ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini219 – 23315CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini255 – 26713ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini289 – 2913CytoplasmicSequence Analysis
    Topological domaini313 – 36048ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini382 – 43756CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei104 – 12421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei141 – 16121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei198 – 21821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei234 – 25421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei268 – 28821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei292 – 31221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei361 – 38121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0385.
    HOGENOMiHOG000234524.
    HOVERGENiHBG096155.
    InParanoidiQ96EP9.
    KOiK14344.
    OMAiVDVNHFG.
    OrthoDBiEOG7XWPNW.
    PhylomeDBiQ96EP9.
    TreeFamiTF315811.

    Family and domain databases

    InterProiIPR002657. BilAc/Na_symport.
    [Graphical view]
    PANTHERiPTHR10361. PTHR10361. 1 hit.
    PfamiPF01758. SBF. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q96EP9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDGNDNVTLL FAPLLRDNYT LAPNASSLGP GTDLALAPAS SAGPGPGLSL    50
    GPGPSFGFSP GPTPTPEPTT SGLAGGAASH GPSPFPRPWA PHALPFWDTP 100
    LNHGLNVFVG AALCITMLGL GCTVDVNHFG AHVRRPVGAL LAALCQFGLL 150
    PLLAFLLALA FKLDEVAAVA VLLCGCCPGG NLSNLMSLLV DGDMNLSIIM 200
    TISSTLLALV LMPLCLWIYS WAWINTPIVQ LLPLGTVTLT LCSTLIPIGL 250
    GVFIRYKYSR VADYIVKVSL WSLLVTLVVL FIMTGTMLGP ELLASIPAAV 300
    YVIAIFMPLA GYASGYGLAT LFHLPPNCKR TVCLETGSQN VQLCTAILKL 350
    AFPPQFIGSM YMFPLLYALF QSAEAGIFVL IYKMYGSEML HKRDPLDEDE 400
    DTDISYKKLK EEEMADTSYG TVKAENIIMM ETAQTSL 437
    Length:437
    Mass (Da):46,504
    Last modified:March 1, 2004 - v2
    Checksum:i055E989629CC13D1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY704414 mRNA. Translation: AAW30130.1.
    BC012048 mRNA. Translation: AAH12048.2.
    BC019066 mRNA. Translation: AAH19066.1.
    CCDSiCCDS3482.1.
    RefSeqiNP_689892.1. NM_152679.3.
    UniGeneiHs.132591.

    Genome annotation databases

    EnsembliENST00000273861; ENSP00000273861; ENSG00000145248.
    GeneIDi201780.
    KEGGihsa:201780.
    UCSCiuc003gyc.2. human.

    Polymorphism databases

    DMDMi74731592.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY704414 mRNA. Translation: AAW30130.1 .
    BC012048 mRNA. Translation: AAH12048.2 .
    BC019066 mRNA. Translation: AAH19066.1 .
    CCDSi CCDS3482.1.
    RefSeqi NP_689892.1. NM_152679.3.
    UniGenei Hs.132591.

    3D structure databases

    ProteinModelPortali Q96EP9.
    SMRi Q96EP9. Positions 104-376.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 128402. 1 interaction.

    Protein family/group databases

    TCDBi 2.A.28.1.7. the bile acid:na(+) symporter (bass) family.

    PTM databases

    PhosphoSitei Q96EP9.

    Polymorphism databases

    DMDMi 74731592.

    Proteomic databases

    MaxQBi Q96EP9.
    PaxDbi Q96EP9.
    PRIDEi Q96EP9.

    Protocols and materials databases

    DNASUi 201780.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000273861 ; ENSP00000273861 ; ENSG00000145248 .
    GeneIDi 201780.
    KEGGi hsa:201780.
    UCSCi uc003gyc.2. human.

    Organism-specific databases

    CTDi 201780.
    GeneCardsi GC04P048485.
    HGNCi HGNC:22980. SLC10A4.
    HPAi HPA028835.
    neXtProti NX_Q96EP9.
    PharmGKBi PA134941471.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0385.
    HOGENOMi HOG000234524.
    HOVERGENi HBG096155.
    InParanoidi Q96EP9.
    KOi K14344.
    OMAi VDVNHFG.
    OrthoDBi EOG7XWPNW.
    PhylomeDBi Q96EP9.
    TreeFami TF315811.

    Miscellaneous databases

    GenomeRNAii 201780.
    NextBioi 90198.
    PROi Q96EP9.

    Gene expression databases

    Bgeei Q96EP9.
    CleanExi HS_SLC10A4.
    Genevestigatori Q96EP9.

    Family and domain databases

    InterProi IPR002657. BilAc/Na_symport.
    [Graphical view ]
    PANTHERi PTHR10361. PTHR10361. 1 hit.
    Pfami PF01758. SBF. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of a novel bile acid transporter in human, SLC10A4."
      Mikkaichi T., Natori M., Abe T., Hishinuma T., Goto J.
      Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    3. "Cloning and molecular characterization of the orphan carrier protein Slc10a4: expression in cholinergic neurons of the rat central nervous system."
      Geyer J., Fernandes C.F., Doring B., Burger S., Godoy J.R., Rafalzik S., Hubschle T., Gerstberger R., Petzinger E.
      Neuroscience 152:990-1005(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    4. Cited for: FUNCTION, PROTEOLYTIC CLEAVAGE, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiNTCP4_HUMAN
    AccessioniPrimary (citable) accession number: Q96EP9
    Secondary accession number(s): Q8WUZ2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 12, 2006
    Last sequence update: March 1, 2004
    Last modified: October 1, 2014
    This is version 93 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3