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Protein

Sodium/bile acid cotransporter 4

Gene

SLC10A4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Transporter for bile acids.1 Publication

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Ion transport, Sodium transport, Symport, Transport

Keywords - Ligandi

Sodium

Enzyme and pathway databases

BioCyciZFISH:ENSG00000145248-MONOMER.

Protein family/group databases

TCDBi2.A.28.1.7. the bile acid:na(+) symporter (bass) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/bile acid cotransporter 4
Alternative name(s):
Na(+)/bile acid cotransporter 4
Solute carrier family 10 member 4
Gene namesi
Name:SLC10A4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:22980. SLC10A4.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 103ExtracellularSequence analysisAdd BLAST103
Transmembranei104 – 124HelicalSequence analysisAdd BLAST21
Topological domaini125 – 140CytoplasmicSequence analysisAdd BLAST16
Transmembranei141 – 161HelicalSequence analysisAdd BLAST21
Topological domaini162 – 197ExtracellularSequence analysisAdd BLAST36
Transmembranei198 – 218HelicalSequence analysisAdd BLAST21
Topological domaini219 – 233CytoplasmicSequence analysisAdd BLAST15
Transmembranei234 – 254HelicalSequence analysisAdd BLAST21
Topological domaini255 – 267ExtracellularSequence analysisAdd BLAST13
Transmembranei268 – 288HelicalSequence analysisAdd BLAST21
Topological domaini289 – 291CytoplasmicSequence analysis3
Transmembranei292 – 312HelicalSequence analysisAdd BLAST21
Topological domaini313 – 360ExtracellularSequence analysisAdd BLAST48
Transmembranei361 – 381HelicalSequence analysisAdd BLAST21
Topological domaini382 – 437CytoplasmicSequence analysisAdd BLAST56

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000145248.
PharmGKBiPA134941471.

Polymorphism and mutation databases

BioMutaiSLC10A4.
DMDMi74731592.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002637421 – 437Sodium/bile acid cotransporter 4Add BLAST437

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi6N-linked (GlcNAc...)Sequence analysis1
Glycosylationi18N-linked (GlcNAc...)Sequence analysis1
Glycosylationi24N-linked (GlcNAc...)Sequence analysis1
Glycosylationi181N-linked (GlcNAc...)Sequence analysis1
Glycosylationi195N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

Activated following N-terminal proteolytic cleavage by thrombin and/or proteases.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei87 – 88Cleavage; by thrombin2

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ96EP9.
PaxDbiQ96EP9.
PeptideAtlasiQ96EP9.
PRIDEiQ96EP9.

PTM databases

iPTMnetiQ96EP9.
PhosphoSitePlusiQ96EP9.

Expressioni

Tissue specificityi

Highly expressed in brain and small intestine, and moderately expressed in colon, heart, prostate, and testis. Very low levels were detected in kidney, liver, ovary, placenta, spleen, and thymus.1 Publication

Gene expression databases

BgeeiENSG00000145248.
CleanExiHS_SLC10A4.
GenevisibleiQ96EP9. HS.

Organism-specific databases

HPAiHPA028835.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000273861.

Structurei

3D structure databases

ProteinModelPortaliQ96EP9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2718. Eukaryota.
COG0385. LUCA.
GeneTreeiENSGT00550000074505.
HOGENOMiHOG000234524.
HOVERGENiHBG096155.
InParanoidiQ96EP9.
KOiK14344.
OMAiPHALPFW.
OrthoDBiEOG091G0GT5.
PhylomeDBiQ96EP9.
TreeFamiTF315811.

Family and domain databases

InterProiIPR002657. BilAc:Na_symport/Acr3.
[Graphical view]
PANTHERiPTHR10361. PTHR10361. 1 hit.
PfamiPF01758. SBF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96EP9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDGNDNVTLL FAPLLRDNYT LAPNASSLGP GTDLALAPAS SAGPGPGLSL
60 70 80 90 100
GPGPSFGFSP GPTPTPEPTT SGLAGGAASH GPSPFPRPWA PHALPFWDTP
110 120 130 140 150
LNHGLNVFVG AALCITMLGL GCTVDVNHFG AHVRRPVGAL LAALCQFGLL
160 170 180 190 200
PLLAFLLALA FKLDEVAAVA VLLCGCCPGG NLSNLMSLLV DGDMNLSIIM
210 220 230 240 250
TISSTLLALV LMPLCLWIYS WAWINTPIVQ LLPLGTVTLT LCSTLIPIGL
260 270 280 290 300
GVFIRYKYSR VADYIVKVSL WSLLVTLVVL FIMTGTMLGP ELLASIPAAV
310 320 330 340 350
YVIAIFMPLA GYASGYGLAT LFHLPPNCKR TVCLETGSQN VQLCTAILKL
360 370 380 390 400
AFPPQFIGSM YMFPLLYALF QSAEAGIFVL IYKMYGSEML HKRDPLDEDE
410 420 430
DTDISYKKLK EEEMADTSYG TVKAENIIMM ETAQTSL
Length:437
Mass (Da):46,504
Last modified:March 1, 2004 - v2
Checksum:i055E989629CC13D1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY704414 mRNA. Translation: AAW30130.1.
BC012048 mRNA. Translation: AAH12048.2.
BC019066 mRNA. Translation: AAH19066.1.
CCDSiCCDS3482.1.
RefSeqiNP_689892.1. NM_152679.3.
UniGeneiHs.132591.

Genome annotation databases

EnsembliENST00000273861; ENSP00000273861; ENSG00000145248.
GeneIDi201780.
KEGGihsa:201780.
UCSCiuc003gyc.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY704414 mRNA. Translation: AAW30130.1.
BC012048 mRNA. Translation: AAH12048.2.
BC019066 mRNA. Translation: AAH19066.1.
CCDSiCCDS3482.1.
RefSeqiNP_689892.1. NM_152679.3.
UniGeneiHs.132591.

3D structure databases

ProteinModelPortaliQ96EP9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000273861.

Protein family/group databases

TCDBi2.A.28.1.7. the bile acid:na(+) symporter (bass) family.

PTM databases

iPTMnetiQ96EP9.
PhosphoSitePlusiQ96EP9.

Polymorphism and mutation databases

BioMutaiSLC10A4.
DMDMi74731592.

Proteomic databases

MaxQBiQ96EP9.
PaxDbiQ96EP9.
PeptideAtlasiQ96EP9.
PRIDEiQ96EP9.

Protocols and materials databases

DNASUi201780.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000273861; ENSP00000273861; ENSG00000145248.
GeneIDi201780.
KEGGihsa:201780.
UCSCiuc003gyc.3. human.

Organism-specific databases

CTDi201780.
GeneCardsiSLC10A4.
HGNCiHGNC:22980. SLC10A4.
HPAiHPA028835.
neXtProtiNX_Q96EP9.
OpenTargetsiENSG00000145248.
PharmGKBiPA134941471.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2718. Eukaryota.
COG0385. LUCA.
GeneTreeiENSGT00550000074505.
HOGENOMiHOG000234524.
HOVERGENiHBG096155.
InParanoidiQ96EP9.
KOiK14344.
OMAiPHALPFW.
OrthoDBiEOG091G0GT5.
PhylomeDBiQ96EP9.
TreeFamiTF315811.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000145248-MONOMER.

Miscellaneous databases

GenomeRNAii201780.
PROiQ96EP9.

Gene expression databases

BgeeiENSG00000145248.
CleanExiHS_SLC10A4.
GenevisibleiQ96EP9. HS.

Family and domain databases

InterProiIPR002657. BilAc:Na_symport/Acr3.
[Graphical view]
PANTHERiPTHR10361. PTHR10361. 1 hit.
PfamiPF01758. SBF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNTCP4_HUMAN
AccessioniPrimary (citable) accession number: Q96EP9
Secondary accession number(s): Q8WUZ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: March 1, 2004
Last modified: November 2, 2016
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.