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Q96EP9

- NTCP4_HUMAN

UniProt

Q96EP9 - NTCP4_HUMAN

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Protein

Sodium/bile acid cotransporter 4

Gene

SLC10A4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Transporter for bile acids.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei87 – 882Cleavage; by thrombin

GO - Molecular functioni

  1. bile acid:sodium symporter activity Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Ion transport, Sodium transport, Symport, Transport

Keywords - Ligandi

Sodium

Protein family/group databases

TCDBi2.A.28.1.7. the bile acid:na(+) symporter (bass) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/bile acid cotransporter 4
Alternative name(s):
Na(+)/bile acid cotransporter 4
Solute carrier family 10 member 4
Gene namesi
Name:SLC10A4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:22980. SLC10A4.

Subcellular locationi

Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 103103ExtracellularSequence AnalysisAdd
BLAST
Transmembranei104 – 12421HelicalSequence AnalysisAdd
BLAST
Topological domaini125 – 14016CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei141 – 16121HelicalSequence AnalysisAdd
BLAST
Topological domaini162 – 19736ExtracellularSequence AnalysisAdd
BLAST
Transmembranei198 – 21821HelicalSequence AnalysisAdd
BLAST
Topological domaini219 – 23315CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei234 – 25421HelicalSequence AnalysisAdd
BLAST
Topological domaini255 – 26713ExtracellularSequence AnalysisAdd
BLAST
Transmembranei268 – 28821HelicalSequence AnalysisAdd
BLAST
Topological domaini289 – 2913CytoplasmicSequence Analysis
Transmembranei292 – 31221HelicalSequence AnalysisAdd
BLAST
Topological domaini313 – 36048ExtracellularSequence AnalysisAdd
BLAST
Transmembranei361 – 38121HelicalSequence AnalysisAdd
BLAST
Topological domaini382 – 43756CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134941471.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 437437Sodium/bile acid cotransporter 4PRO_0000263742Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi6 – 61N-linked (GlcNAc...)Sequence Analysis
Glycosylationi18 – 181N-linked (GlcNAc...)Sequence Analysis
Glycosylationi24 – 241N-linked (GlcNAc...)Sequence Analysis
Glycosylationi181 – 1811N-linked (GlcNAc...)Sequence Analysis
Glycosylationi195 – 1951N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

Activated following N-terminal proteolytic cleavage by thrombin and/or proteases.1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ96EP9.
PaxDbiQ96EP9.
PRIDEiQ96EP9.

PTM databases

PhosphoSiteiQ96EP9.

Expressioni

Tissue specificityi

Highly expressed in brain and small intestine, and moderately expressed in colon, heart, prostate, and testis. Very low levels were detected in kidney, liver, ovary, placenta, spleen, and thymus.1 Publication

Gene expression databases

BgeeiQ96EP9.
CleanExiHS_SLC10A4.
GenevestigatoriQ96EP9.

Organism-specific databases

HPAiHPA028835.

Interactioni

Protein-protein interaction databases

BioGridi128402. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ96EP9.
SMRiQ96EP9. Positions 104-376.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0385.
GeneTreeiENSGT00550000074505.
HOGENOMiHOG000234524.
HOVERGENiHBG096155.
InParanoidiQ96EP9.
KOiK14344.
OMAiVDVNHFG.
OrthoDBiEOG7XWPNW.
PhylomeDBiQ96EP9.
TreeFamiTF315811.

Family and domain databases

InterProiIPR002657. BilAc/Na_symport.
[Graphical view]
PANTHERiPTHR10361. PTHR10361. 1 hit.
PfamiPF01758. SBF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96EP9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDGNDNVTLL FAPLLRDNYT LAPNASSLGP GTDLALAPAS SAGPGPGLSL
60 70 80 90 100
GPGPSFGFSP GPTPTPEPTT SGLAGGAASH GPSPFPRPWA PHALPFWDTP
110 120 130 140 150
LNHGLNVFVG AALCITMLGL GCTVDVNHFG AHVRRPVGAL LAALCQFGLL
160 170 180 190 200
PLLAFLLALA FKLDEVAAVA VLLCGCCPGG NLSNLMSLLV DGDMNLSIIM
210 220 230 240 250
TISSTLLALV LMPLCLWIYS WAWINTPIVQ LLPLGTVTLT LCSTLIPIGL
260 270 280 290 300
GVFIRYKYSR VADYIVKVSL WSLLVTLVVL FIMTGTMLGP ELLASIPAAV
310 320 330 340 350
YVIAIFMPLA GYASGYGLAT LFHLPPNCKR TVCLETGSQN VQLCTAILKL
360 370 380 390 400
AFPPQFIGSM YMFPLLYALF QSAEAGIFVL IYKMYGSEML HKRDPLDEDE
410 420 430
DTDISYKKLK EEEMADTSYG TVKAENIIMM ETAQTSL
Length:437
Mass (Da):46,504
Last modified:March 1, 2004 - v2
Checksum:i055E989629CC13D1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY704414 mRNA. Translation: AAW30130.1.
BC012048 mRNA. Translation: AAH12048.2.
BC019066 mRNA. Translation: AAH19066.1.
CCDSiCCDS3482.1.
RefSeqiNP_689892.1. NM_152679.3.
UniGeneiHs.132591.

Genome annotation databases

EnsembliENST00000273861; ENSP00000273861; ENSG00000145248.
GeneIDi201780.
KEGGihsa:201780.
UCSCiuc003gyc.2. human.

Polymorphism databases

DMDMi74731592.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY704414 mRNA. Translation: AAW30130.1 .
BC012048 mRNA. Translation: AAH12048.2 .
BC019066 mRNA. Translation: AAH19066.1 .
CCDSi CCDS3482.1.
RefSeqi NP_689892.1. NM_152679.3.
UniGenei Hs.132591.

3D structure databases

ProteinModelPortali Q96EP9.
SMRi Q96EP9. Positions 104-376.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 128402. 1 interaction.

Protein family/group databases

TCDBi 2.A.28.1.7. the bile acid:na(+) symporter (bass) family.

PTM databases

PhosphoSitei Q96EP9.

Polymorphism databases

DMDMi 74731592.

Proteomic databases

MaxQBi Q96EP9.
PaxDbi Q96EP9.
PRIDEi Q96EP9.

Protocols and materials databases

DNASUi 201780.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000273861 ; ENSP00000273861 ; ENSG00000145248 .
GeneIDi 201780.
KEGGi hsa:201780.
UCSCi uc003gyc.2. human.

Organism-specific databases

CTDi 201780.
GeneCardsi GC04P048485.
HGNCi HGNC:22980. SLC10A4.
HPAi HPA028835.
neXtProti NX_Q96EP9.
PharmGKBi PA134941471.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0385.
GeneTreei ENSGT00550000074505.
HOGENOMi HOG000234524.
HOVERGENi HBG096155.
InParanoidi Q96EP9.
KOi K14344.
OMAi VDVNHFG.
OrthoDBi EOG7XWPNW.
PhylomeDBi Q96EP9.
TreeFami TF315811.

Miscellaneous databases

GenomeRNAii 201780.
NextBioi 90198.
PROi Q96EP9.

Gene expression databases

Bgeei Q96EP9.
CleanExi HS_SLC10A4.
Genevestigatori Q96EP9.

Family and domain databases

InterProi IPR002657. BilAc/Na_symport.
[Graphical view ]
PANTHERi PTHR10361. PTHR10361. 1 hit.
Pfami PF01758. SBF. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a novel bile acid transporter in human, SLC10A4."
    Mikkaichi T., Natori M., Abe T., Hishinuma T., Goto J.
    Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. "Cloning and molecular characterization of the orphan carrier protein Slc10a4: expression in cholinergic neurons of the rat central nervous system."
    Geyer J., Fernandes C.F., Doring B., Burger S., Godoy J.R., Rafalzik S., Hubschle T., Gerstberger R., Petzinger E.
    Neuroscience 152:990-1005(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  4. Cited for: FUNCTION, PROTEOLYTIC CLEAVAGE, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiNTCP4_HUMAN
AccessioniPrimary (citable) accession number: Q96EP9
Secondary accession number(s): Q8WUZ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: March 1, 2004
Last modified: October 29, 2014
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3