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Protein

Sodium/bile acid cotransporter 4

Gene

SLC10A4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transporter for bile acids.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processIon transport, Sodium transport, Symport, Transport
LigandSodium

Protein family/group databases

TCDBi2.A.28.1.7 the bile acid:na(+) symporter (bass) family

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/bile acid cotransporter 4
Alternative name(s):
Na(+)/bile acid cotransporter 4
Solute carrier family 10 member 4
Gene namesi
Name:SLC10A4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000145248.6
HGNCiHGNC:22980 SLC10A4
neXtProtiNX_Q96EP9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 103ExtracellularSequence analysisAdd BLAST103
Transmembranei104 – 124HelicalSequence analysisAdd BLAST21
Topological domaini125 – 140CytoplasmicSequence analysisAdd BLAST16
Transmembranei141 – 161HelicalSequence analysisAdd BLAST21
Topological domaini162 – 197ExtracellularSequence analysisAdd BLAST36
Transmembranei198 – 218HelicalSequence analysisAdd BLAST21
Topological domaini219 – 233CytoplasmicSequence analysisAdd BLAST15
Transmembranei234 – 254HelicalSequence analysisAdd BLAST21
Topological domaini255 – 267ExtracellularSequence analysisAdd BLAST13
Transmembranei268 – 288HelicalSequence analysisAdd BLAST21
Topological domaini289 – 291CytoplasmicSequence analysis3
Transmembranei292 – 312HelicalSequence analysisAdd BLAST21
Topological domaini313 – 360ExtracellularSequence analysisAdd BLAST48
Transmembranei361 – 381HelicalSequence analysisAdd BLAST21
Topological domaini382 – 437CytoplasmicSequence analysisAdd BLAST56

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000145248
PharmGKBiPA134941471

Polymorphism and mutation databases

BioMutaiSLC10A4
DMDMi74731592

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002637421 – 437Sodium/bile acid cotransporter 4Add BLAST437

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi6N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi18N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi24N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi181N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi195N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Activated following N-terminal proteolytic cleavage by thrombin and/or proteases.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei87 – 88Cleavage; by thrombin2

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ96EP9
PaxDbiQ96EP9
PeptideAtlasiQ96EP9
PRIDEiQ96EP9

PTM databases

iPTMnetiQ96EP9
PhosphoSitePlusiQ96EP9

Expressioni

Tissue specificityi

Highly expressed in brain and small intestine, and moderately expressed in colon, heart, prostate, and testis. Very low levels were detected in kidney, liver, ovary, placenta, spleen, and thymus.1 Publication

Gene expression databases

BgeeiENSG00000145248
CleanExiHS_SLC10A4
GenevisibleiQ96EP9 HS

Organism-specific databases

HPAiHPA028835

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000273861

Structurei

3D structure databases

ProteinModelPortaliQ96EP9
SMRiQ96EP9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2718 Eukaryota
COG0385 LUCA
GeneTreeiENSGT00550000074505
HOGENOMiHOG000234524
HOVERGENiHBG096155
InParanoidiQ96EP9
KOiK14344
OMAiVDVNHFG
OrthoDBiEOG091G0GT5
PhylomeDBiQ96EP9
TreeFamiTF315811

Family and domain databases

InterProiView protein in InterPro
IPR002657 BilAc:Na_symport/Acr3
IPR004710 Bilac:Na_transpt
IPR030204 SLC10A4
PANTHERiPTHR10361 PTHR10361, 1 hit
PTHR10361:SF41 PTHR10361:SF41, 1 hit
PfamiView protein in Pfam
PF01758 SBF, 1 hit

Sequencei

Sequence statusi: Complete.

Q96EP9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDGNDNVTLL FAPLLRDNYT LAPNASSLGP GTDLALAPAS SAGPGPGLSL
60 70 80 90 100
GPGPSFGFSP GPTPTPEPTT SGLAGGAASH GPSPFPRPWA PHALPFWDTP
110 120 130 140 150
LNHGLNVFVG AALCITMLGL GCTVDVNHFG AHVRRPVGAL LAALCQFGLL
160 170 180 190 200
PLLAFLLALA FKLDEVAAVA VLLCGCCPGG NLSNLMSLLV DGDMNLSIIM
210 220 230 240 250
TISSTLLALV LMPLCLWIYS WAWINTPIVQ LLPLGTVTLT LCSTLIPIGL
260 270 280 290 300
GVFIRYKYSR VADYIVKVSL WSLLVTLVVL FIMTGTMLGP ELLASIPAAV
310 320 330 340 350
YVIAIFMPLA GYASGYGLAT LFHLPPNCKR TVCLETGSQN VQLCTAILKL
360 370 380 390 400
AFPPQFIGSM YMFPLLYALF QSAEAGIFVL IYKMYGSEML HKRDPLDEDE
410 420 430
DTDISYKKLK EEEMADTSYG TVKAENIIMM ETAQTSL
Length:437
Mass (Da):46,504
Last modified:March 1, 2004 - v2
Checksum:i055E989629CC13D1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY704414 mRNA Translation: AAW30130.1
BC012048 mRNA Translation: AAH12048.2
BC019066 mRNA Translation: AAH19066.1
CCDSiCCDS3482.1
RefSeqiNP_689892.1, NM_152679.3
UniGeneiHs.132591

Genome annotation databases

EnsembliENST00000273861; ENSP00000273861; ENSG00000145248
GeneIDi201780
KEGGihsa:201780
UCSCiuc003gyc.3 human

Similar proteinsi

Entry informationi

Entry nameiNTCP4_HUMAN
AccessioniPrimary (citable) accession number: Q96EP9
Secondary accession number(s): Q8WUZ2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: March 1, 2004
Last modified: April 25, 2018
This is version 119 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health