Q96EP9 (NTCP4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Sodium/bile acid cotransporter 4

Alternative name(s):
Na(+)/bile acid cotransporter 4
Solute carrier family 10 member 4

Gene names

Name:

SLC10A4

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	437 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family. [View classification]

Ontologies

Keywords
Biological process	Ion transport Sodium transport Symport Transport
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
Ligand	Sodium
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	bile acid:sodium symporter activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 437	437	Sodium/bile acid cotransporter 4		PRO_0000263742
Regions
	Topological domain	1 – 103	103	Extracellular Potential
	Transmembrane	104 – 124	21	Helical; Potential
	Topological domain	125 – 140	16	Cytoplasmic Potential
	Transmembrane	141 – 161	21	Helical; Potential
	Topological domain	162 – 165	4	Extracellular Potential
	Transmembrane	166 – 186	21	Helical; Potential
	Topological domain	187 – 197	11	Cytoplasmic Potential
	Transmembrane	198 – 218	21	Helical; Potential
	Topological domain	219 – 233	15	Extracellular Potential
	Transmembrane	234 – 254	21	Helical; Potential
	Topological domain	255 – 267	13	Cytoplasmic Potential
	Transmembrane	268 – 288	21	Helical; Potential
	Topological domain	289 – 291	3	Extracellular Potential
	Transmembrane	292 – 312	21	Helical; Potential
	Topological domain	313 – 360	48	Cytoplasmic Potential
	Transmembrane	361 – 381	21	Helical; Potential
	Topological domain	382 – 437	56	Extracellular Potential
Amino acid modifications
	Glycosylation	6	1	N-linked (GlcNAc...) Potential
	Glycosylation	18	1	N-linked (GlcNAc...) Potential
	Glycosylation	24	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q96EP9 [UniParc]. Last modified March 1, 2004. Version 2. Checksum: 055E989629CC13D1	FASTA	437	46,504
	10 20 30 40 50 60 MDGNDNVTLL FAPLLRDNYT LAPNASSLGP GTDLALAPAS SAGPGPGLSL GPGPSFGFSP 70 80 90 100 110 120 GPTPTPEPTT SGLAGGAASH GPSPFPRPWA PHALPFWDTP LNHGLNVFVG AALCITMLGL 130 140 150 160 170 180 GCTVDVNHFG AHVRRPVGAL LAALCQFGLL PLLAFLLALA FKLDEVAAVA VLLCGCCPGG 190 200 210 220 230 240 NLSNLMSLLV DGDMNLSIIM TISSTLLALV LMPLCLWIYS WAWINTPIVQ LLPLGTVTLT 250 260 270 280 290 300 LCSTLIPIGL GVFIRYKYSR VADYIVKVSL WSLLVTLVVL FIMTGTMLGP ELLASIPAAV 310 320 330 340 350 360 YVIAIFMPLA GYASGYGLAT LFHLPPNCKR TVCLETGSQN VQLCTAILKL AFPPQFIGSM 370 380 390 400 410 420 YMFPLLYALF QSAEAGIFVL IYKMYGSEML HKRDPLDEDE DTDISYKKLK EEEMADTSYG 430 TVKAENIIMM ETAQTSL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of a novel bile acid transporter in human, SLC10A4." Mikkaichi T., Natori M., Abe T., Hishinuma T., Goto J. Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY704414 mRNA. Translation: AAW30130.1. BC012048 mRNA. Translation: AAH12048.2. BC019066 mRNA. Translation: AAH19066.1.
IPI	IPI00157034.
RefSeq	NP_689892.1. NM_152679.3.
UniGene	Hs.132591.
3D structure databases
ProteinModelPortal	Q96EP9.
ModBase	Search...
PTM databases
PhosphoSite	Q96EP9.
Polymorphism databases
DMDM	74731592.
Proteomic databases
PaxDb	Q96EP9.
PRIDE	Q96EP9.
Protocols and materials databases
DNASU	201780.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000273861; ENSP00000273861; ENSG00000145248.
GeneID	201780.
KEGG	hsa:201780.
UCSC	uc003gyc.2. human.
Organism-specific databases
CTD	201780.
GeneCards	GC04P048485.
HGNC	HGNC:22980. SLC10A4.
HPA	HPA028835.
neXtProt	NX_Q96EP9.
PharmGKB	PA134941471.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0385.
HOGENOM	HOG000234524.
HOVERGEN	HBG096155.
InParanoid	Q96EP9.
KO	K14344.
OMA	TVDVNHF.
OrthoDB	EOG4H72C2.
PhylomeDB	Q96EP9.
Gene expression databases
Bgee	Q96EP9.
CleanEx	HS_SLC10A4.
Genevestigator	Q96EP9.
GermOnline	ENSG00000145248. Homo sapiens.
Family and domain databases
InterPro	IPR002657. BilAc/Na_symport. [Graphical view]
PANTHER	PTHR10361. PTHR10361. 1 hit.
Pfam	PF01758. SBF. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	201780.
NextBio	90198.

Entry information

Entry name

NTCP4_HUMAN

Accession

Primary (citable) accession number: Q96EP9
Secondary accession number(s): Q8WUZ2

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 12, 2006
Last sequence update:	March 1, 2004
Last modified:	May 1, 2013
This is version 81 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.