Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q96EP9 (NTCP4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Sodium/bile acid cotransporter 4
Alternative name(s):
Na(+)/bile acid cotransporter 4
Solute carrier family 10 member 4
Gene names
Name:SLC10A4
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length437 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Transporter for bile acids. Ref.4

Subcellular location

Cell membrane; Multi-pass membrane protein Ref.4.

Tissue specificity

Highly expressed in brain and small intestine, and moderately expressed in colon, heart, prostate, and testis. Very low levels were detected in kidney, liver, ovary, placenta, spleen, and thymus. Ref.3

Post-translational modification

Activated following N-terminal proteolytic cleavage by thrombin and/or proteases.

Sequence similarities

Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family. [View classification]

Ontologies

Keywords
   Biological processIon transport
Sodium transport
Symport
Transport
   Cellular componentCell membrane
Membrane
   DomainTransmembrane
Transmembrane helix
   LigandSodium
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionbile acid:sodium symporter activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 437437Sodium/bile acid cotransporter 4
PRO_0000263742

Regions

Topological domain1 – 103103Extracellular Potential
Transmembrane104 – 12421Helical; Potential
Topological domain125 – 14016Cytoplasmic Potential
Transmembrane141 – 16121Helical; Potential
Topological domain162 – 19736Extracellular Potential
Transmembrane198 – 21821Helical; Potential
Topological domain219 – 23315Cytoplasmic Potential
Transmembrane234 – 25421Helical; Potential
Topological domain255 – 26713Extracellular Potential
Transmembrane268 – 28821Helical; Potential
Topological domain289 – 2913Cytoplasmic Potential
Transmembrane292 – 31221Helical; Potential
Topological domain313 – 36048Extracellular Potential
Transmembrane361 – 38121Helical; Potential
Topological domain382 – 43756Cytoplasmic Potential

Sites

Site87 – 882Cleavage; by thrombin

Amino acid modifications

Glycosylation61N-linked (GlcNAc...) Potential
Glycosylation181N-linked (GlcNAc...) Potential
Glycosylation241N-linked (GlcNAc...) Potential
Glycosylation1811N-linked (GlcNAc...) Potential
Glycosylation1951N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q96EP9 [UniParc].

Last modified March 1, 2004. Version 2.
Checksum: 055E989629CC13D1

FASTA43746,504
        10         20         30         40         50         60 
MDGNDNVTLL FAPLLRDNYT LAPNASSLGP GTDLALAPAS SAGPGPGLSL GPGPSFGFSP 

        70         80         90        100        110        120 
GPTPTPEPTT SGLAGGAASH GPSPFPRPWA PHALPFWDTP LNHGLNVFVG AALCITMLGL 

       130        140        150        160        170        180 
GCTVDVNHFG AHVRRPVGAL LAALCQFGLL PLLAFLLALA FKLDEVAAVA VLLCGCCPGG 

       190        200        210        220        230        240 
NLSNLMSLLV DGDMNLSIIM TISSTLLALV LMPLCLWIYS WAWINTPIVQ LLPLGTVTLT 

       250        260        270        280        290        300 
LCSTLIPIGL GVFIRYKYSR VADYIVKVSL WSLLVTLVVL FIMTGTMLGP ELLASIPAAV 

       310        320        330        340        350        360 
YVIAIFMPLA GYASGYGLAT LFHLPPNCKR TVCLETGSQN VQLCTAILKL AFPPQFIGSM 

       370        380        390        400        410        420 
YMFPLLYALF QSAEAGIFVL IYKMYGSEML HKRDPLDEDE DTDISYKKLK EEEMADTSYG 

       430 
TVKAENIIMM ETAQTSL 

« Hide

References

« Hide 'large scale' references
[1]"Identification of a novel bile acid transporter in human, SLC10A4."
Mikkaichi T., Natori M., Abe T., Hishinuma T., Goto J.
Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[3]"Cloning and molecular characterization of the orphan carrier protein Slc10a4: expression in cholinergic neurons of the rat central nervous system."
Geyer J., Fernandes C.F., Doring B., Burger S., Godoy J.R., Rafalzik S., Hubschle T., Gerstberger R., Petzinger E.
Neuroscience 152:990-1005(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
[4]"SLC10A4 is a protease-activated transporter that transports bile acids."
Abe T., Kanemitu Y., Nakasone M., Kawahata I., Yamakuni T., Nakajima A., Suzuki N., Nishikawa M., Hishinuma T., Tomioka Y.
J. Biochem. 154:93-101(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, PROTEOLYTIC CLEAVAGE, SUBCELLULAR LOCATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY704414 mRNA. Translation: AAW30130.1.
BC012048 mRNA. Translation: AAH12048.2.
BC019066 mRNA. Translation: AAH19066.1.
CCDSCCDS3482.1.
RefSeqNP_689892.1. NM_152679.3.
UniGeneHs.132591.

3D structure databases

ProteinModelPortalQ96EP9.
SMRQ96EP9. Positions 104-376.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid128402. 1 interaction.

Protein family/group databases

TCDB2.A.28.1.7. the bile acid:na(+) symporter (bass) family.

PTM databases

PhosphoSiteQ96EP9.

Polymorphism databases

DMDM74731592.

Proteomic databases

MaxQBQ96EP9.
PaxDbQ96EP9.
PRIDEQ96EP9.

Protocols and materials databases

DNASU201780.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000273861; ENSP00000273861; ENSG00000145248.
GeneID201780.
KEGGhsa:201780.
UCSCuc003gyc.2. human.

Organism-specific databases

CTD201780.
GeneCardsGC04P048485.
HGNCHGNC:22980. SLC10A4.
HPAHPA028835.
neXtProtNX_Q96EP9.
PharmGKBPA134941471.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0385.
HOGENOMHOG000234524.
HOVERGENHBG096155.
InParanoidQ96EP9.
KOK14344.
OMAVDVNHFG.
OrthoDBEOG7XWPNW.
PhylomeDBQ96EP9.
TreeFamTF315811.

Gene expression databases

BgeeQ96EP9.
CleanExHS_SLC10A4.
GenevestigatorQ96EP9.

Family and domain databases

InterProIPR002657. BilAc/Na_symport.
[Graphical view]
PANTHERPTHR10361. PTHR10361. 1 hit.
PfamPF01758. SBF. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi201780.
NextBio90198.
PROQ96EP9.

Entry information

Entry nameNTCP4_HUMAN
AccessionPrimary (citable) accession number: Q96EP9
Secondary accession number(s): Q8WUZ2
Entry history
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: March 1, 2004
Last modified: July 9, 2014
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 4

Human chromosome 4: entries, gene names and cross-references to MIM