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Q96EN9

- CS060_HUMAN

UniProt

Q96EN9 - CS060_HUMAN

Protein

Uncharacterized protein C19orf60

Gene

C19orf60

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 86 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. protein binding Source: IntAct

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Uncharacterized protein C19orf60
    Gene namesi
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:26098. C19orf60.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162378719.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 201201Uncharacterized protein C19orf60PRO_0000305285Add
    BLAST

    Proteomic databases

    MaxQBiQ96EN9.
    PaxDbiQ96EN9.
    PRIDEiQ96EN9.

    PTM databases

    PhosphoSiteiQ96EN9.

    Expressioni

    Gene expression databases

    ArrayExpressiQ96EN9.
    BgeeiQ96EN9.
    CleanExiHS_C19orf60.
    GenevestigatoriQ96EN9.

    Organism-specific databases

    HPAiHPA043414.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    MDFIQ997503EBI-745810,EBI-724076

    Protein-protein interaction databases

    BioGridi120372. 6 interactions.
    IntActiQ96EN9. 8 interactions.
    MINTiMINT-1453391.
    STRINGi9606.ENSP00000351422.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96EN9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    eggNOGiNOG289799.
    HOGENOMiHOG000007586.
    HOVERGENiHBG098316.
    OMAiTGPHYDF.
    OrthoDBiEOG7673CB.
    PhylomeDBiQ96EN9.
    TreeFamiTF332536.

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q96EN9-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MITETAAEPT VPAVPAAEEA TEARGREEPA WPWKDAPIRT LVQRIHQLQA    50
    ERAQGFRRLE EWLAPVQGLR AWGRGLRVPT CRRGHRQYLR SGPDYDFARY 100
    RSTVHGVTQA FAAASREVLA VEAELGGPRR QPLLAGHVRS LQELEQTRLG 150
    TVALLQLMET PELAGQEDAV RMQQLKMKVI KTMEAISEVL QDLRFDAESA 200
    E 201
    Length:201
    Mass (Da):22,599
    Last modified:December 1, 2001 - v1
    Checksum:iAFB04D5FABDA5571
    GO
    Isoform 2 (identifier: Q96EN9-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-61: MITETAAEPT...RAQGFRRLEE → MGRGFRGTGS...SGDTSWGPFR
         179-201: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:190
    Mass (Da):20,789
    Checksum:i3DCCEE15027A4084
    GO
    Isoform 3 (identifier: Q96EN9-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         62-83: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:179
    Mass (Da):20,068
    Checksum:iE162B578BA3DCAAA
    GO

    Sequence cautioni

    The sequence BAA91400.1 differs from that shown. Reason: Frameshift at position 107.

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 6161MITET…RRLEE → MGRGFRGTGSSPSRERPHST SPLPDDSLFVASLSSPRAGV GLSRVPLRESGSVLPTYQSS PLVSGDTSWGPFR in isoform 2. 1 PublicationVSP_028325Add
    BLAST
    Alternative sequencei62 – 8322Missing in isoform 3. 1 PublicationVSP_047493Add
    BLAST
    Alternative sequencei179 – 20123Missing in isoform 2. 1 PublicationVSP_028326Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK000857 mRNA. Translation: BAA91400.1. Frameshift.
    AK091925 mRNA. Translation: BAC03773.1.
    AC003112 Genomic DNA. No translation available.
    CH471106 Genomic DNA. Translation: EAW84723.1.
    BC012078 mRNA. Translation: AAH12078.1.
    BF344503 mRNA. No translation available.
    CCDSiCCDS42524.1. [Q96EN9-1]
    CCDS46019.1. [Q96EN9-3]
    RefSeqiNP_001093888.1. NM_001100418.1. [Q96EN9-1]
    NP_001093889.1. NM_001100419.1. [Q96EN9-3]
    UniGeneiHs.655317.

    Genome annotation databases

    EnsembliENST00000358607; ENSP00000351422; ENSG00000006015. [Q96EN9-1]
    ENST00000450195; ENSP00000398467; ENSG00000006015. [Q96EN9-3]
    GeneIDi55049.
    KEGGihsa:55049.
    UCSCiuc002nju.2. human. [Q96EN9-2]
    uc002njv.4. human. [Q96EN9-1]

    Polymorphism databases

    DMDMi74731590.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK000857 mRNA. Translation: BAA91400.1 . Frameshift.
    AK091925 mRNA. Translation: BAC03773.1 .
    AC003112 Genomic DNA. No translation available.
    CH471106 Genomic DNA. Translation: EAW84723.1 .
    BC012078 mRNA. Translation: AAH12078.1 .
    BF344503 mRNA. No translation available.
    CCDSi CCDS42524.1. [Q96EN9-1 ]
    CCDS46019.1. [Q96EN9-3 ]
    RefSeqi NP_001093888.1. NM_001100418.1. [Q96EN9-1 ]
    NP_001093889.1. NM_001100419.1. [Q96EN9-3 ]
    UniGenei Hs.655317.

    3D structure databases

    ProteinModelPortali Q96EN9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120372. 6 interactions.
    IntActi Q96EN9. 8 interactions.
    MINTi MINT-1453391.
    STRINGi 9606.ENSP00000351422.

    PTM databases

    PhosphoSitei Q96EN9.

    Polymorphism databases

    DMDMi 74731590.

    Proteomic databases

    MaxQBi Q96EN9.
    PaxDbi Q96EN9.
    PRIDEi Q96EN9.

    Protocols and materials databases

    DNASUi 55049.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000358607 ; ENSP00000351422 ; ENSG00000006015 . [Q96EN9-1 ]
    ENST00000450195 ; ENSP00000398467 ; ENSG00000006015 . [Q96EN9-3 ]
    GeneIDi 55049.
    KEGGi hsa:55049.
    UCSCi uc002nju.2. human. [Q96EN9-2 ]
    uc002njv.4. human. [Q96EN9-1 ]

    Organism-specific databases

    CTDi 55049.
    GeneCardsi GC19P018699.
    HGNCi HGNC:26098. C19orf60.
    HPAi HPA043414.
    neXtProti NX_Q96EN9.
    PharmGKBi PA162378719.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG289799.
    HOGENOMi HOG000007586.
    HOVERGENi HBG098316.
    OMAi TGPHYDF.
    OrthoDBi EOG7673CB.
    PhylomeDBi Q96EN9.
    TreeFami TF332536.

    Miscellaneous databases

    ChiTaRSi C19orf60. human.
    GenomeRNAii 55049.
    NextBioi 58509.

    Gene expression databases

    ArrayExpressi Q96EN9.
    Bgeei Q96EN9.
    CleanExi HS_C19orf60.
    Genevestigatori Q96EN9.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Adipose tissue and Kidney.
    2. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 7-179 (ISOFORM 3).
      Tissue: Colon and Glioblastoma.
    5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiCS060_HUMAN
    AccessioniPrimary (citable) accession number: Q96EN9
    Secondary accession number(s): E9PAS0, Q8NAX4, Q9NWI0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 2, 2007
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 86 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM

    External Data

    Dasty 3