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Q96EN9 (CS060_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Uncharacterized protein C19orf60
Gene names
Name:C19orf60
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length201 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Sequence caution

The sequence BAA91400.1 differs from that shown. Reason: Frameshift at position 107.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Binary interactions

With

Entry

#Exp.

IntAct

Notes

MDFIQ997503EBI-745810,EBI-724076

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q96EN9-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q96EN9-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-61: MITETAAEPT...RAQGFRRLEE → MGRGFRGTGS...SGDTSWGPFR
     179-201: Missing.
Note: No experimental confirmation available.
Isoform 3 (identifier: Q96EN9-3)

The sequence of this isoform differs from the canonical sequence as follows:
     62-83: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 201201Uncharacterized protein C19orf60
PRO_0000305285

Natural variations

Alternative sequence1 – 6161MITET…RRLEE → MGRGFRGTGSSPSRERPHST SPLPDDSLFVASLSSPRAGV GLSRVPLRESGSVLPTYQSS PLVSGDTSWGPFR in isoform 2.
VSP_028325
Alternative sequence62 – 8322Missing in isoform 3.
VSP_047493
Alternative sequence179 – 20123Missing in isoform 2.
VSP_028326

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: AFB04D5FABDA5571

FASTA20122,599
        10         20         30         40         50         60 
MITETAAEPT VPAVPAAEEA TEARGREEPA WPWKDAPIRT LVQRIHQLQA ERAQGFRRLE 

        70         80         90        100        110        120 
EWLAPVQGLR AWGRGLRVPT CRRGHRQYLR SGPDYDFARY RSTVHGVTQA FAAASREVLA 

       130        140        150        160        170        180 
VEAELGGPRR QPLLAGHVRS LQELEQTRLG TVALLQLMET PELAGQEDAV RMQQLKMKVI 

       190        200 
KTMEAISEVL QDLRFDAESA E 

« Hide

Isoform 2 [UniParc].

Checksum: 3DCCEE15027A4084
Show »

FASTA19020,789
Isoform 3 [UniParc].

Checksum: E162B578BA3DCAAA
Show »

FASTA17920,068

References

[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Tissue: Adipose tissue and Kidney.
[2]"The DNA sequence and biology of human chromosome 19."
Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. expand/collapse author list , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 7-179 (ISOFORM 3).
Tissue: Colon and Glioblastoma.
[5]"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK000857 mRNA. Translation: BAA91400.1. Frameshift.
AK091925 mRNA. Translation: BAC03773.1.
AC003112 Genomic DNA. No translation available.
CH471106 Genomic DNA. Translation: EAW84723.1.
BC012078 mRNA. Translation: AAH12078.1.
BF344503 mRNA. No translation available.
RefSeqNP_001093888.1. NM_001100418.1.
NP_001093889.1. NM_001100419.1.
UniGeneHs.655317.

3D structure databases

ProteinModelPortalQ96EN9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid120372. 6 interactions.
IntActQ96EN9. 8 interactions.
MINTMINT-1453391.
STRING9606.ENSP00000351422.

PTM databases

PhosphoSiteQ96EN9.

Polymorphism databases

DMDM74731590.

Proteomic databases

PaxDbQ96EN9.
PRIDEQ96EN9.

Protocols and materials databases

DNASU55049.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000358607; ENSP00000351422; ENSG00000006015. [Q96EN9-1]
ENST00000450195; ENSP00000398467; ENSG00000006015. [Q96EN9-3]
GeneID55049.
KEGGhsa:55049.
UCSCuc002nju.2. human. [Q96EN9-2]
uc002njv.4. human. [Q96EN9-1]

Organism-specific databases

CTD55049.
GeneCardsGC19P018699.
HGNCHGNC:26098. C19orf60.
HPAHPA043414.
neXtProtNX_Q96EN9.
PharmGKBPA162378719.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG289799.
HOGENOMHOG000007586.
HOVERGENHBG098316.
OMAPIRTLVQ.
OrthoDBEOG7673CB.
PhylomeDBQ96EN9.
TreeFamTF332536.

Gene expression databases

ArrayExpressQ96EN9.
BgeeQ96EN9.
CleanExHS_C19orf60.
GenevestigatorQ96EN9.

Family and domain databases

ProtoNetSearch...

Other

ChiTaRSC19orf60. human.
GenomeRNAi55049.
NextBio58509.

Entry information

Entry nameCS060_HUMAN
AccessionPrimary (citable) accession number: Q96EN9
Secondary accession number(s): E9PAS0, Q8NAX4, Q9NWI0
Entry history
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: December 1, 2001
Last modified: April 16, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM