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Protein

Uncharacterized protein C19orf60

Gene

C19orf60

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized protein C19orf60
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:26098. C19orf60.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162378719.

Polymorphism and mutation databases

BioMutaiC19orf60.
DMDMi74731590.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 201201Uncharacterized protein C19orf60PRO_0000305285Add
BLAST

Proteomic databases

MaxQBiQ96EN9.
PaxDbiQ96EN9.
PRIDEiQ96EN9.

PTM databases

PhosphoSiteiQ96EN9.

Expressioni

Gene expression databases

BgeeiQ96EN9.
CleanExiHS_C19orf60.
ExpressionAtlasiQ96EN9. baseline and differential.
GenevisibleiQ96EN9. HS.

Organism-specific databases

HPAiHPA043414.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
MDFIQ997503EBI-745810,EBI-724076

Protein-protein interaction databases

BioGridi120372. 7 interactions.
IntActiQ96EN9. 8 interactions.
MINTiMINT-1453391.
STRINGi9606.ENSP00000351422.

Structurei

3D structure databases

ProteinModelPortaliQ96EN9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiNOG289799.
GeneTreeiENSGT00390000011631.
HOGENOMiHOG000007586.
HOVERGENiHBG098316.
InParanoidiQ96EN9.
OMAiSEIMQDF.
OrthoDBiEOG7673CB.
PhylomeDBiQ96EN9.
TreeFamiTF332536.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96EN9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MITETAAEPT VPAVPAAEEA TEARGREEPA WPWKDAPIRT LVQRIHQLQA
60 70 80 90 100
ERAQGFRRLE EWLAPVQGLR AWGRGLRVPT CRRGHRQYLR SGPDYDFARY
110 120 130 140 150
RSTVHGVTQA FAAASREVLA VEAELGGPRR QPLLAGHVRS LQELEQTRLG
160 170 180 190 200
TVALLQLMET PELAGQEDAV RMQQLKMKVI KTMEAISEVL QDLRFDAESA

E
Length:201
Mass (Da):22,599
Last modified:December 1, 2001 - v1
Checksum:iAFB04D5FABDA5571
GO
Isoform 2 (identifier: Q96EN9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-61: MITETAAEPT...RAQGFRRLEE → MGRGFRGTGS...SGDTSWGPFR
     179-201: Missing.

Note: No experimental confirmation available.
Show »
Length:190
Mass (Da):20,789
Checksum:i3DCCEE15027A4084
GO
Isoform 3 (identifier: Q96EN9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     62-83: Missing.

Note: No experimental confirmation available.
Show »
Length:179
Mass (Da):20,068
Checksum:iE162B578BA3DCAAA
GO

Sequence cautioni

The sequence BAA91400.1 differs from that shown. Reason: Frameshift at position 107. Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 6161MITET…RRLEE → MGRGFRGTGSSPSRERPHST SPLPDDSLFVASLSSPRAGV GLSRVPLRESGSVLPTYQSS PLVSGDTSWGPFR in isoform 2. 1 PublicationVSP_028325Add
BLAST
Alternative sequencei62 – 8322Missing in isoform 3. 1 PublicationVSP_047493Add
BLAST
Alternative sequencei179 – 20123Missing in isoform 2. 1 PublicationVSP_028326Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000857 mRNA. Translation: BAA91400.1. Frameshift.
AK091925 mRNA. Translation: BAC03773.1.
AC003112 Genomic DNA. No translation available.
CH471106 Genomic DNA. Translation: EAW84723.1.
BC012078 mRNA. Translation: AAH12078.1.
BF344503 mRNA. No translation available.
CCDSiCCDS42524.1. [Q96EN9-1]
CCDS46019.1. [Q96EN9-3]
RefSeqiNP_001093888.1. NM_001100418.1. [Q96EN9-1]
NP_001093889.1. NM_001100419.1. [Q96EN9-3]
UniGeneiHs.655317.

Genome annotation databases

EnsembliENST00000358607; ENSP00000351422; ENSG00000006015.
ENST00000450195; ENSP00000398467; ENSG00000006015. [Q96EN9-3]
GeneIDi55049.
KEGGihsa:55049.
UCSCiuc002nju.2. human. [Q96EN9-2]
uc002njv.4. human. [Q96EN9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000857 mRNA. Translation: BAA91400.1. Frameshift.
AK091925 mRNA. Translation: BAC03773.1.
AC003112 Genomic DNA. No translation available.
CH471106 Genomic DNA. Translation: EAW84723.1.
BC012078 mRNA. Translation: AAH12078.1.
BF344503 mRNA. No translation available.
CCDSiCCDS42524.1. [Q96EN9-1]
CCDS46019.1. [Q96EN9-3]
RefSeqiNP_001093888.1. NM_001100418.1. [Q96EN9-1]
NP_001093889.1. NM_001100419.1. [Q96EN9-3]
UniGeneiHs.655317.

3D structure databases

ProteinModelPortaliQ96EN9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120372. 7 interactions.
IntActiQ96EN9. 8 interactions.
MINTiMINT-1453391.
STRINGi9606.ENSP00000351422.

PTM databases

PhosphoSiteiQ96EN9.

Polymorphism and mutation databases

BioMutaiC19orf60.
DMDMi74731590.

Proteomic databases

MaxQBiQ96EN9.
PaxDbiQ96EN9.
PRIDEiQ96EN9.

Protocols and materials databases

DNASUi55049.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000358607; ENSP00000351422; ENSG00000006015.
ENST00000450195; ENSP00000398467; ENSG00000006015. [Q96EN9-3]
GeneIDi55049.
KEGGihsa:55049.
UCSCiuc002nju.2. human. [Q96EN9-2]
uc002njv.4. human. [Q96EN9-1]

Organism-specific databases

CTDi55049.
GeneCardsiGC19P018699.
HGNCiHGNC:26098. C19orf60.
HPAiHPA043414.
neXtProtiNX_Q96EN9.
PharmGKBiPA162378719.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG289799.
GeneTreeiENSGT00390000011631.
HOGENOMiHOG000007586.
HOVERGENiHBG098316.
InParanoidiQ96EN9.
OMAiSEIMQDF.
OrthoDBiEOG7673CB.
PhylomeDBiQ96EN9.
TreeFamiTF332536.

Miscellaneous databases

ChiTaRSiC19orf60. human.
GenomeRNAii55049.
NextBioi58509.
PROiQ96EN9.

Gene expression databases

BgeeiQ96EN9.
CleanExiHS_C19orf60.
ExpressionAtlasiQ96EN9. baseline and differential.
GenevisibleiQ96EN9. HS.

Family and domain databases

ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Adipose tissue and Kidney.
  2. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 7-179 (ISOFORM 3).
    Tissue: Colon and Glioblastoma.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCS060_HUMAN
AccessioniPrimary (citable) accession number: Q96EN9
Secondary accession number(s): E9PAS0, Q8NAX4, Q9NWI0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: December 1, 2001
Last modified: July 22, 2015
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.