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Q96EN9

- CS060_HUMAN

UniProt

Q96EN9 - CS060_HUMAN

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Protein
Uncharacterized protein C19orf60
Gene
C19orf60
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. protein binding Source: IntAct
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized protein C19orf60
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:26098. C19orf60.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162378719.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 201201Uncharacterized protein C19orf60
PRO_0000305285Add
BLAST

Proteomic databases

MaxQBiQ96EN9.
PaxDbiQ96EN9.
PRIDEiQ96EN9.

PTM databases

PhosphoSiteiQ96EN9.

Expressioni

Gene expression databases

ArrayExpressiQ96EN9.
BgeeiQ96EN9.
CleanExiHS_C19orf60.
GenevestigatoriQ96EN9.

Organism-specific databases

HPAiHPA043414.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
MDFIQ997503EBI-745810,EBI-724076

Protein-protein interaction databases

BioGridi120372. 6 interactions.
IntActiQ96EN9. 8 interactions.
MINTiMINT-1453391.
STRINGi9606.ENSP00000351422.

Structurei

3D structure databases

ProteinModelPortaliQ96EN9.

Family & Domainsi

Phylogenomic databases

eggNOGiNOG289799.
HOGENOMiHOG000007586.
HOVERGENiHBG098316.
OMAiTGPHYDF.
OrthoDBiEOG7673CB.
PhylomeDBiQ96EN9.
TreeFamiTF332536.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q96EN9-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MITETAAEPT VPAVPAAEEA TEARGREEPA WPWKDAPIRT LVQRIHQLQA    50
ERAQGFRRLE EWLAPVQGLR AWGRGLRVPT CRRGHRQYLR SGPDYDFARY 100
RSTVHGVTQA FAAASREVLA VEAELGGPRR QPLLAGHVRS LQELEQTRLG 150
TVALLQLMET PELAGQEDAV RMQQLKMKVI KTMEAISEVL QDLRFDAESA 200
E 201
Length:201
Mass (Da):22,599
Last modified:December 1, 2001 - v1
Checksum:iAFB04D5FABDA5571
GO
Isoform 2 (identifier: Q96EN9-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-61: MITETAAEPT...RAQGFRRLEE → MGRGFRGTGS...SGDTSWGPFR
     179-201: Missing.

Note: No experimental confirmation available.

Show »
Length:190
Mass (Da):20,789
Checksum:i3DCCEE15027A4084
GO
Isoform 3 (identifier: Q96EN9-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     62-83: Missing.

Note: No experimental confirmation available.

Show »
Length:179
Mass (Da):20,068
Checksum:iE162B578BA3DCAAA
GO

Sequence cautioni

The sequence BAA91400.1 differs from that shown. Reason: Frameshift at position 107.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 6161MITET…RRLEE → MGRGFRGTGSSPSRERPHST SPLPDDSLFVASLSSPRAGV GLSRVPLRESGSVLPTYQSS PLVSGDTSWGPFR in isoform 2.
VSP_028325Add
BLAST
Alternative sequencei62 – 8322Missing in isoform 3.
VSP_047493Add
BLAST
Alternative sequencei179 – 20123Missing in isoform 2.
VSP_028326Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK000857 mRNA. Translation: BAA91400.1. Frameshift.
AK091925 mRNA. Translation: BAC03773.1.
AC003112 Genomic DNA. No translation available.
CH471106 Genomic DNA. Translation: EAW84723.1.
BC012078 mRNA. Translation: AAH12078.1.
BF344503 mRNA. No translation available.
CCDSiCCDS42524.1. [Q96EN9-1]
CCDS46019.1. [Q96EN9-3]
RefSeqiNP_001093888.1. NM_001100418.1. [Q96EN9-1]
NP_001093889.1. NM_001100419.1. [Q96EN9-3]
UniGeneiHs.655317.

Genome annotation databases

EnsembliENST00000358607; ENSP00000351422; ENSG00000006015. [Q96EN9-1]
ENST00000450195; ENSP00000398467; ENSG00000006015. [Q96EN9-3]
GeneIDi55049.
KEGGihsa:55049.
UCSCiuc002nju.2. human. [Q96EN9-2]
uc002njv.4. human. [Q96EN9-1]

Polymorphism databases

DMDMi74731590.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK000857 mRNA. Translation: BAA91400.1 . Frameshift.
AK091925 mRNA. Translation: BAC03773.1 .
AC003112 Genomic DNA. No translation available.
CH471106 Genomic DNA. Translation: EAW84723.1 .
BC012078 mRNA. Translation: AAH12078.1 .
BF344503 mRNA. No translation available.
CCDSi CCDS42524.1. [Q96EN9-1 ]
CCDS46019.1. [Q96EN9-3 ]
RefSeqi NP_001093888.1. NM_001100418.1. [Q96EN9-1 ]
NP_001093889.1. NM_001100419.1. [Q96EN9-3 ]
UniGenei Hs.655317.

3D structure databases

ProteinModelPortali Q96EN9.
ModBasei Search...

Protein-protein interaction databases

BioGridi 120372. 6 interactions.
IntActi Q96EN9. 8 interactions.
MINTi MINT-1453391.
STRINGi 9606.ENSP00000351422.

PTM databases

PhosphoSitei Q96EN9.

Polymorphism databases

DMDMi 74731590.

Proteomic databases

MaxQBi Q96EN9.
PaxDbi Q96EN9.
PRIDEi Q96EN9.

Protocols and materials databases

DNASUi 55049.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000358607 ; ENSP00000351422 ; ENSG00000006015 . [Q96EN9-1 ]
ENST00000450195 ; ENSP00000398467 ; ENSG00000006015 . [Q96EN9-3 ]
GeneIDi 55049.
KEGGi hsa:55049.
UCSCi uc002nju.2. human. [Q96EN9-2 ]
uc002njv.4. human. [Q96EN9-1 ]

Organism-specific databases

CTDi 55049.
GeneCardsi GC19P018699.
HGNCi HGNC:26098. C19orf60.
HPAi HPA043414.
neXtProti NX_Q96EN9.
PharmGKBi PA162378719.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG289799.
HOGENOMi HOG000007586.
HOVERGENi HBG098316.
OMAi TGPHYDF.
OrthoDBi EOG7673CB.
PhylomeDBi Q96EN9.
TreeFami TF332536.

Miscellaneous databases

ChiTaRSi C19orf60. human.
GenomeRNAii 55049.
NextBioi 58509.

Gene expression databases

ArrayExpressi Q96EN9.
Bgeei Q96EN9.
CleanExi HS_C19orf60.
Genevestigatori Q96EN9.

Family and domain databases

ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Adipose tissue and Kidney.
  2. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 7-179 (ISOFORM 3).
    Tissue: Colon and Glioblastoma.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCS060_HUMAN
AccessioniPrimary (citable) accession number: Q96EN9
Secondary accession number(s): E9PAS0, Q8NAX4, Q9NWI0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: December 1, 2001
Last modified: July 9, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM

External Data

Dasty 3

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