Q96EN9 (CS060_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Uncharacterized protein C19orf60

Gene names

Name:

C19orf60

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	201 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence caution

The sequence BAA91400.1 differs from that shown. Reason: Frameshift at position 107.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Binary interactions

With	Entry	#Exp.	IntAct	Notes
MDFI	Q99750	3	EBI-745810,EBI-724076

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q96EN9-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q96EN9-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-61: MITETAAEPT...RAQGFRRLEE → MGRGFRGTGS...SGDTSWGPFR
     179-201: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 201	201	Uncharacterized protein C19orf60		PRO_0000305285
Natural variations
	Alternative sequence	1 – 61	61	MITET…RRLEE → MGRGFRGTGSSPSRERPHST SPLPDDSLFVASLSSPRAGV GLSRVPLRESGSVLPTYQSS PLVSGDTSWGPFR in isoform 2.		VSP_028325
	Alternative sequence	179 – 201	23	Missing in isoform 2.		VSP_028326

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: AFB04D5FABDA5571	FASTA	201	22,599
	10 20 30 40 50 60 MITETAAEPT VPAVPAAEEA TEARGREEPA WPWKDAPIRT LVQRIHQLQA ERAQGFRRLE 70 80 90 100 110 120 EWLAPVQGLR AWGRGLRVPT CRRGHRQYLR SGPDYDFARY RSTVHGVTQA FAAASREVLA 130 140 150 160 170 180 VEAELGGPRR QPLLAGHVRS LQELEQTRLG TVALLQLMET PELAGQEDAV RMQQLKMKVI 190 200 KTMEAISEVL QDLRFDAESA E
	Isoform 2 [UniParc]. Checksum: 3DCCEE15027A4084	FASTA	190	20,789
	10 20 30 40 50 60 MGRGFRGTGS SPSRERPHST SPLPDDSLFV ASLSSPRAGV GLSRVPLRES GSVLPTYQSS 70 80 90 100 110 120 PLVSGDTSWG PFRWLAPVQG LRAWGRGLRV PTCRRGHRQY LRSGPDYDFA RYRSTVHGVT 130 140 150 160 170 180 QAFAAASREV LAVEAELGGP RRQPLLAGHV RSLQELEQTR LGTVALLQLM ETPELAGQED 190 AVRMQQLKMK

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Adipose tissue and Kidney.
[2]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Colon.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK000857 mRNA. Translation: BAA91400.1. Frameshift. AK091925 mRNA. Translation: BAC03773.1. CH471106 Genomic DNA. Translation: EAW84723.1. BC012078 mRNA. Translation: AAH12078.1.
IPI	IPI00101267. IPI00953361.
RefSeq	NP_001093888.1. NM_001100418.1. NP_001093889.1. NM_001100419.1.
UniGene	Hs.655317.
3D structure databases
ProteinModelPortal	Q96EN9.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q96EN9. 4 interactions.
MINT	MINT-1453391.
STRING	9606.ENSP00000351422.
PTM databases
PhosphoSite	Q96EN9.
Polymorphism databases
DMDM	74731590.
Proteomic databases
PaxDb	Q96EN9.
PRIDE	Q96EN9.
Protocols and materials databases
DNASU	55049.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000358607; ENSP00000351422; ENSG00000006015.
GeneID	55049.
KEGG	hsa:55049.
UCSC	uc002nju.2. human. uc002njv.4. human.
Organism-specific databases
CTD	55049.
GeneCards	GC19P018699.
HGNC	HGNC:26098. C19orf60.
HPA	HPA043414.
neXtProt	NX_Q96EN9.
PharmGKB	PA162378719.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG289799.
HOGENOM	HOG000007586.
HOVERGEN	HBG098316.
OMA	RAQGFRR.
Gene expression databases
ArrayExpress	Q96EN9.
Bgee	Q96EN9.
CleanEx	HS_C19orf60.
Genevestigator	Q96EN9.
Family and domain databases
ProtoNet	Search...
Other
ChiTaRS	C19orf60. human.
GenomeRNAi	55049.
NextBio	58509.

Entry information

Entry name

CS060_HUMAN

Accession

Primary (citable) accession number: Q96EN9
Secondary accession number(s): Q8NAX4, Q9NWI0

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 2, 2007
Last sequence update:	December 1, 2001
Last modified:	April 3, 2013
This is version 74 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.