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Protein

Required for excision 1-B domain-containing protein

Gene

REX1BD

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Required for excision 1-B domain-containing proteinCurated
Gene namesi
Name:REX1BDImported
Synonyms:C19orf60Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000006015.17
HGNCiHGNC:26098 REX1BD
neXtProtiNX_Q96EN9

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000006015
PharmGKBiPA162378719

Polymorphism and mutation databases

BioMutaiC19orf60
DMDMi74731590

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003052851 – 201Required for excision 1-B domain-containing proteinAdd BLAST201

Proteomic databases

EPDiQ96EN9
MaxQBiQ96EN9
PaxDbiQ96EN9
PeptideAtlasiQ96EN9
PRIDEiQ96EN9
ProteomicsDBi76427
76428 [Q96EN9-2]

PTM databases

iPTMnetiQ96EN9
PhosphoSitePlusiQ96EN9

Expressioni

Gene expression databases

BgeeiENSG00000006015
CleanExiHS_C19orf60
ExpressionAtlasiQ96EN9 baseline and differential
GenevisibleiQ96EN9 HS

Organism-specific databases

HPAiHPA043414

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
MDFIQ997505EBI-745810,EBI-724076

Protein-protein interaction databases

BioGridi120372, 8 interactors
IntActiQ96EN9, 12 interactors
MINTiQ96EN9
STRINGi9606.ENSP00000351422

Structurei

3D structure databases

ProteinModelPortaliQ96EN9
SMRiQ96EN9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IXEZ Eukaryota
ENOG4111IFY LUCA
GeneTreeiENSGT00390000011631
HOGENOMiHOG000007586
HOVERGENiHBG098316
InParanoidiQ96EN9
OMAiVWPWKDA
OrthoDBiEOG091G0VNX
PhylomeDBiQ96EN9
TreeFamiTF332536

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96EN9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MITETAAEPT VPAVPAAEEA TEARGREEPA WPWKDAPIRT LVQRIHQLQA
60 70 80 90 100
ERAQGFRRLE EWLAPVQGLR AWGRGLRVPT CRRGHRQYLR SGPDYDFARY
110 120 130 140 150
RSTVHGVTQA FAAASREVLA VEAELGGPRR QPLLAGHVRS LQELEQTRLG
160 170 180 190 200
TVALLQLMET PELAGQEDAV RMQQLKMKVI KTMEAISEVL QDLRFDAESA

E
Length:201
Mass (Da):22,599
Last modified:December 1, 2001 - v1
Checksum:iAFB04D5FABDA5571
GO
Isoform 2 (identifier: Q96EN9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-61: MITETAAEPT...RAQGFRRLEE → MGRGFRGTGS...SGDTSWGPFR
     179-201: Missing.

Note: No experimental confirmation available.
Show »
Length:190
Mass (Da):20,789
Checksum:i3DCCEE15027A4084
GO
Isoform 3 (identifier: Q96EN9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     62-83: Missing.

Note: No experimental confirmation available.
Show »
Length:179
Mass (Da):20,068
Checksum:iE162B578BA3DCAAA
GO

Sequence cautioni

The sequence BAA91400 differs from that shown. Reason: Frameshift at position 107.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0283251 – 61MITET…RRLEE → MGRGFRGTGSSPSRERPHST SPLPDDSLFVASLSSPRAGV GLSRVPLRESGSVLPTYQSS PLVSGDTSWGPFR in isoform 2. 1 PublicationAdd BLAST61
Alternative sequenceiVSP_04749362 – 83Missing in isoform 3. 1 PublicationAdd BLAST22
Alternative sequenceiVSP_028326179 – 201Missing in isoform 2. 1 PublicationAdd BLAST23

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000857 mRNA Translation: BAA91400.1 Frameshift.
AK091925 mRNA Translation: BAC03773.1
AC003112 Genomic DNA No translation available.
CH471106 Genomic DNA Translation: EAW84723.1
BC012078 mRNA Translation: AAH12078.1
BF344503 mRNA No translation available.
CCDSiCCDS42524.1 [Q96EN9-1]
CCDS46019.1 [Q96EN9-3]
RefSeqiNP_001093888.1, NM_001100418.1 [Q96EN9-1]
NP_001093889.1, NM_001100419.1 [Q96EN9-3]
UniGeneiHs.655317

Genome annotation databases

EnsembliENST00000358607; ENSP00000351422; ENSG00000006015 [Q96EN9-1]
ENST00000450195; ENSP00000398467; ENSG00000006015 [Q96EN9-3]
GeneIDi55049
KEGGihsa:55049
UCSCiuc002njv.5 human [Q96EN9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiREX1B_HUMAN
AccessioniPrimary (citable) accession number: Q96EN9
Secondary accession number(s): E9PAS0, Q8NAX4, Q9NWI0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: December 1, 2001
Last modified: June 20, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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