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Protein

39S ribosomal protein L53, mitochondrial

Gene

MRPL53

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-5368286. Mitochondrial translation initiation.
R-HSA-5389840. Mitochondrial translation elongation.
R-HSA-5419276. Mitochondrial translation termination.

Names & Taxonomyi

Protein namesi
Recommended name:
39S ribosomal protein L53, mitochondrial
Short name:
L53mt
Short name:
MRP-L53
Gene namesi
Name:MRPL53
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:16684. MRPL53.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30986.

Polymorphism and mutation databases

BioMutaiMRPL53.
DMDMi74731579.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 11239S ribosomal protein L53, mitochondrialPRO_0000261664
Transit peptidei1 – ?MitochondrionSequence analysis

Proteomic databases

EPDiQ96EL3.
MaxQBiQ96EL3.
PaxDbiQ96EL3.
PeptideAtlasiQ96EL3.
PRIDEiQ96EL3.
TopDownProteomicsiQ96EL3.

PTM databases

iPTMnetiQ96EL3.
PhosphoSiteiQ96EL3.
SwissPalmiQ96EL3.

Expressioni

Gene expression databases

BgeeiENSG00000204822.
CleanExiHS_MRPL53.
ExpressionAtlasiQ96EL3. baseline and differential.
GenevisibleiQ96EL3. HS.

Organism-specific databases

HPAiHPA056185.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
IKZF3Q9UKT93EBI-2513715,EBI-747204
KIF2AO001393EBI-2513715,EBI-2692369
SSX2IPQ9Y2D83EBI-2513715,EBI-2212028
TAX1BP1Q86VP13EBI-2513715,EBI-529518

Protein-protein interaction databases

BioGridi125521. 56 interactions.
IntActiQ96EL3. 15 interactions.
STRINGi9606.ENSP00000258105.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3J7Yelectron microscopy3.40k1-112[»]
3J9Melectron microscopy3.50k1-112[»]
ProteinModelPortaliQ96EL3.
SMRiQ96EL3. Positions 13-96.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiENOG410J0VJ. Eukaryota.
ENOG4111ZNN. LUCA.
GeneTreeiENSGT00390000001440.
HOGENOMiHOG000230705.
HOVERGENiHBG057368.
InParanoidiQ96EL3.
KOiK17434.
OMAiAFASHIQ.
OrthoDBiEOG091G16T7.
PhylomeDBiQ96EL3.
TreeFamiTF300292.

Family and domain databases

InterProiIPR019716. Ribosomal_L53_mit.
[Graphical view]
PfamiPF10780. MRP_L53. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q96EL3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAALARLGL RPVKQVRVQF CPFEKNVEST RTFLQTVSSE KVRSTNLNCS
60 70 80 90 100
VIADVRHDGS EPCVDVLFGD GHRLIMRGAH LTALEMLTAF ASHIRARDAA
110
GSGDKPGADT GR
Length:112
Mass (Da):12,107
Last modified:December 1, 2001 - v1
Checksum:iBFC43FF93A148C36
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti4 – 41A → S.
Corresponds to variant rs1047911 [ dbSNP | Ensembl ].
VAR_029475

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC012163 mRNA. Translation: AAH12163.1.
CCDSiCCDS1944.1.
RefSeqiNP_444278.1. NM_053050.4.
UniGeneiHs.534527.

Genome annotation databases

EnsembliENST00000258105; ENSP00000258105; ENSG00000204822.
GeneIDi116540.
KEGGihsa:116540.
UCSCiuc002sln.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC012163 mRNA. Translation: AAH12163.1.
CCDSiCCDS1944.1.
RefSeqiNP_444278.1. NM_053050.4.
UniGeneiHs.534527.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3J7Yelectron microscopy3.40k1-112[»]
3J9Melectron microscopy3.50k1-112[»]
ProteinModelPortaliQ96EL3.
SMRiQ96EL3. Positions 13-96.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125521. 56 interactions.
IntActiQ96EL3. 15 interactions.
STRINGi9606.ENSP00000258105.

PTM databases

iPTMnetiQ96EL3.
PhosphoSiteiQ96EL3.
SwissPalmiQ96EL3.

Polymorphism and mutation databases

BioMutaiMRPL53.
DMDMi74731579.

Proteomic databases

EPDiQ96EL3.
MaxQBiQ96EL3.
PaxDbiQ96EL3.
PeptideAtlasiQ96EL3.
PRIDEiQ96EL3.
TopDownProteomicsiQ96EL3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000258105; ENSP00000258105; ENSG00000204822.
GeneIDi116540.
KEGGihsa:116540.
UCSCiuc002sln.4. human.

Organism-specific databases

CTDi116540.
GeneCardsiMRPL53.
H-InvDBHIX0022694.
HIX0077799.
HGNCiHGNC:16684. MRPL53.
HPAiHPA056185.
MIMi611857. gene.
neXtProtiNX_Q96EL3.
PharmGKBiPA30986.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J0VJ. Eukaryota.
ENOG4111ZNN. LUCA.
GeneTreeiENSGT00390000001440.
HOGENOMiHOG000230705.
HOVERGENiHBG057368.
InParanoidiQ96EL3.
KOiK17434.
OMAiAFASHIQ.
OrthoDBiEOG091G16T7.
PhylomeDBiQ96EL3.
TreeFamiTF300292.

Enzyme and pathway databases

ReactomeiR-HSA-5368286. Mitochondrial translation initiation.
R-HSA-5389840. Mitochondrial translation elongation.
R-HSA-5419276. Mitochondrial translation termination.

Miscellaneous databases

GenomeRNAii116540.
PROiQ96EL3.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000204822.
CleanExiHS_MRPL53.
ExpressionAtlasiQ96EL3. baseline and differential.
GenevisibleiQ96EL3. HS.

Family and domain databases

InterProiIPR019716. Ribosomal_L53_mit.
[Graphical view]
PfamiPF10780. MRP_L53. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRM53_HUMAN
AccessioniPrimary (citable) accession number: Q96EL3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: December 1, 2001
Last modified: September 7, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.