Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

39S ribosomal protein L53, mitochondrial

Gene

MRPL53

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-5368286. Mitochondrial translation initiation.
R-HSA-5389840. Mitochondrial translation elongation.
R-HSA-5419276. Mitochondrial translation termination.

Names & Taxonomyi

Protein namesi
Recommended name:
39S ribosomal protein L53, mitochondrial
Short name:
L53mt
Short name:
MRP-L53
Alternative name(s):
Mitochondrial large ribosomal subunit protein mL531 Publication
Gene namesi
Name:MRPL53
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000204822.6.
HGNCiHGNC:16684. MRPL53.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30986.

Polymorphism and mutation databases

BioMutaiMRPL53.
DMDMi74731579.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000261664? – 11239S ribosomal protein L53, mitochondrial
Transit peptidei1 – ?MitochondrionSequence analysis

Proteomic databases

EPDiQ96EL3.
MaxQBiQ96EL3.
PaxDbiQ96EL3.
PeptideAtlasiQ96EL3.
PRIDEiQ96EL3.
TopDownProteomicsiQ96EL3.

PTM databases

iPTMnetiQ96EL3.
PhosphoSitePlusiQ96EL3.
SwissPalmiQ96EL3.

Expressioni

Gene expression databases

BgeeiENSG00000204822.
CleanExiHS_MRPL53.
ExpressionAtlasiQ96EL3. baseline and differential.
GenevisibleiQ96EL3. HS.

Organism-specific databases

HPAiHPA056185.

Interactioni

Subunit structurei

Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins. mL53 is located at the L7/L12 stalk.2 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi125521. 61 interactors.
CORUMiQ96EL3.
IntActiQ96EL3. 19 interactors.
STRINGi9606.ENSP00000258105.

Structurei

Secondary structure

1112
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi22 – 24Combined sources3
Helixi28 – 35Combined sources8
Turni36 – 38Combined sources3
Helixi42 – 45Combined sources4
Beta strandi59 – 61Combined sources3
Beta strandi74 – 76Combined sources3
Beta strandi79 – 81Combined sources3
Helixi83 – 95Combined sources13

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J7Yelectron microscopy3.40k1-112[»]
3J9Melectron microscopy3.50k1-112[»]
ProteinModelPortaliQ96EL3.
SMRiQ96EL3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiENOG410J0VJ. Eukaryota.
ENOG4111ZNN. LUCA.
GeneTreeiENSGT00390000001440.
HOGENOMiHOG000230705.
HOVERGENiHBG057368.
InParanoidiQ96EL3.
KOiK17434.
OMAiRATNLNC.
OrthoDBiEOG091G16T7.
PhylomeDBiQ96EL3.
TreeFamiTF300292.

Family and domain databases

InterProiView protein in InterPro
IPR019716. Ribosomal_L53_mit.
PfamiView protein in Pfam
PF10780. MRP_L53. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q96EL3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAALARLGL RPVKQVRVQF CPFEKNVEST RTFLQTVSSE KVRSTNLNCS
60 70 80 90 100
VIADVRHDGS EPCVDVLFGD GHRLIMRGAH LTALEMLTAF ASHIRARDAA
110
GSGDKPGADT GR
Length:112
Mass (Da):12,107
Last modified:December 1, 2001 - v1
Checksum:iBFC43FF93A148C36
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0294754A → S. Corresponds to variant dbSNP:rs1047911Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC012163 mRNA. Translation: AAH12163.1.
CCDSiCCDS1944.1.
RefSeqiNP_444278.1. NM_053050.4.
UniGeneiHs.534527.

Genome annotation databases

EnsembliENST00000258105; ENSP00000258105; ENSG00000204822.
GeneIDi116540.
KEGGihsa:116540.
UCSCiuc002sln.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiRM53_HUMAN
AccessioniPrimary (citable) accession number: Q96EL3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: December 1, 2001
Last modified: September 27, 2017
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Ribosomal proteins
    Ribosomal proteins families and list of entries
  7. SIMILARITY comments
    Index of protein domains and families