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Protein

28S ribosomal protein S24, mitochondrial

Gene

MRPS24

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • poly(A) RNA binding Source: UniProtKB
  • structural constituent of ribosome Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-5368286. Mitochondrial translation initiation.
R-HSA-5389840. Mitochondrial translation elongation.
R-HSA-5419276. Mitochondrial translation termination.

Names & Taxonomyi

Protein namesi
Recommended name:
28S ribosomal protein S24, mitochondrial
Short name:
MRP-S24
Short name:
S24mt
Alternative name(s):
bMRP-47
Short name:
bMRP47
Gene namesi
Name:MRPS24
ORF Names:HSPC335
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:14510. MRPS24.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000062582.
PharmGKBiPA31012.

Polymorphism and mutation databases

BioMutaiMRPS24.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 35MitochondrionBy similarityAdd BLAST35
ChainiPRO_000027306636 – 16728S ribosomal protein S24, mitochondrialAdd BLAST132

Proteomic databases

EPDiQ96EL2.
MaxQBiQ96EL2.
PaxDbiQ96EL2.
PeptideAtlasiQ96EL2.
PRIDEiQ96EL2.
TopDownProteomicsiQ96EL2.

PTM databases

iPTMnetiQ96EL2.
PhosphoSitePlusiQ96EL2.

Expressioni

Gene expression databases

BgeeiENSG00000062582.
CleanExiHS_MRPS24.
ExpressionAtlasiQ96EL2. baseline and differential.
GenevisibleiQ96EL2. HS.

Organism-specific databases

HPAiHPA020983.

Interactioni

Subunit structurei

Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.By similarity

Protein-protein interaction databases

BioGridi122357. 37 interactors.
IntActiQ96EL2. 1 interactor.
STRINGi9606.ENSP00000318158.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J9Melectron microscopy3.50AC1-167[»]
ProteinModelPortaliQ96EL2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiENOG410IY06. Eukaryota.
ENOG4111JJW. LUCA.
GeneTreeiENSGT00390000011179.
HOGENOMiHOG000252979.
HOVERGENiHBG093920.
InParanoidiQ96EL2.
KOiK17403.
OMAiYKCPVKL.
OrthoDBiEOG091G0TCJ.
PhylomeDBiQ96EL2.
TreeFamiTF324311.

Family and domain databases

InterProiIPR026146. MRPS24.
[Graphical view]
PANTHERiPTHR21244. PTHR21244. 1 hit.
PfamiPF14955. MRP-S24. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q96EL2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAASVCSGLL GPRVLSWSRE LPCAWRALHT SPVCAKNRAA RVRVSKGDKP
60 70 80 90 100
VTYEEAHAPH YIAHRKGWLS LHTGNLDGED HAAERTVEDV FLRKFMWGTF
110 120 130 140 150
PGCLADQLVL KRRGNQLEIC AVVLRQLSPH KYYFLVGYSE TLLSYFYKCP
160
VRLHLQTVPS KVVYKYL
Length:167
Mass (Da):19,015
Last modified:December 1, 2001 - v1
Checksum:iD48DCB3803CFB37E
GO

Sequence cautioni

The sequence AAF29013 differs from that shown. Reason: Frameshift at positions 27 and 45.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03007797W → R.Corresponds to variant rs670573dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF161453 mRNA. Translation: AAF29013.1. Frameshift.
CH236951 Genomic DNA. Translation: EAL24009.1.
CH471073 Genomic DNA. Translation: EAW94173.1.
BC012167 mRNA. Translation: AAH12167.1.
BC054865 mRNA. Translation: AAH54865.1.
AB061207 Genomic DNA. Translation: BAB54957.1.
CCDSiCCDS5473.1.
RefSeqiNP_114403.1. NM_032014.2.
UniGeneiHs.284286.

Genome annotation databases

EnsembliENST00000317534; ENSP00000318158; ENSG00000062582.
GeneIDi64951.
KEGGihsa:64951.
UCSCiuc003tit.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF161453 mRNA. Translation: AAF29013.1. Frameshift.
CH236951 Genomic DNA. Translation: EAL24009.1.
CH471073 Genomic DNA. Translation: EAW94173.1.
BC012167 mRNA. Translation: AAH12167.1.
BC054865 mRNA. Translation: AAH54865.1.
AB061207 Genomic DNA. Translation: BAB54957.1.
CCDSiCCDS5473.1.
RefSeqiNP_114403.1. NM_032014.2.
UniGeneiHs.284286.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J9Melectron microscopy3.50AC1-167[»]
ProteinModelPortaliQ96EL2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122357. 37 interactors.
IntActiQ96EL2. 1 interactor.
STRINGi9606.ENSP00000318158.

PTM databases

iPTMnetiQ96EL2.
PhosphoSitePlusiQ96EL2.

Polymorphism and mutation databases

BioMutaiMRPS24.

Proteomic databases

EPDiQ96EL2.
MaxQBiQ96EL2.
PaxDbiQ96EL2.
PeptideAtlasiQ96EL2.
PRIDEiQ96EL2.
TopDownProteomicsiQ96EL2.

Protocols and materials databases

DNASUi64951.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000317534; ENSP00000318158; ENSG00000062582.
GeneIDi64951.
KEGGihsa:64951.
UCSCiuc003tit.2. human.

Organism-specific databases

CTDi64951.
GeneCardsiMRPS24.
HGNCiHGNC:14510. MRPS24.
HPAiHPA020983.
MIMi611986. gene.
neXtProtiNX_Q96EL2.
OpenTargetsiENSG00000062582.
PharmGKBiPA31012.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IY06. Eukaryota.
ENOG4111JJW. LUCA.
GeneTreeiENSGT00390000011179.
HOGENOMiHOG000252979.
HOVERGENiHBG093920.
InParanoidiQ96EL2.
KOiK17403.
OMAiYKCPVKL.
OrthoDBiEOG091G0TCJ.
PhylomeDBiQ96EL2.
TreeFamiTF324311.

Enzyme and pathway databases

ReactomeiR-HSA-5368286. Mitochondrial translation initiation.
R-HSA-5389840. Mitochondrial translation elongation.
R-HSA-5419276. Mitochondrial translation termination.

Miscellaneous databases

ChiTaRSiMRPS24. human.
GeneWikiiMRPS24.
GenomeRNAii64951.
PROiQ96EL2.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000062582.
CleanExiHS_MRPS24.
ExpressionAtlasiQ96EL2. baseline and differential.
GenevisibleiQ96EL2. HS.

Family and domain databases

InterProiIPR026146. MRPS24.
[Graphical view]
PANTHERiPTHR21244. PTHR21244. 1 hit.
PfamiPF14955. MRP-S24. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRT24_HUMAN
AccessioniPrimary (citable) accession number: Q96EL2
Secondary accession number(s): A4D1U9
, P82668, Q96Q23, Q9P047
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: December 1, 2001
Last modified: November 2, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.