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Protein

PAK4-inhibitor INKA1

Gene

FAM212A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Inhibitor of the serine/threonine-protein kinase PAK4 (PubMed:26607847). Acts by binding PAK4 in a substrate-like manner, inhibiting the protein kinase activity (PubMed:26607847).1 Publication

GO - Molecular functioni

  • protein kinase binding Source: UniProtKB
  • protein serine/threonine kinase inhibitor activity Source: UniProtKB

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
PAK4-inhibitor INKA1Curated
Alternative name(s):
Induced in neural crest by AP2-alpha protein homolog1 Publication
Short name:
HInca1 Publication
Gene namesi
Name:FAM212AImported
Synonyms:C3orf54Imported, INKA11 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:32480. FAM212A.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • nucleus Source: UniProtKB

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA143485330.

Polymorphism and mutation databases

BioMutaiFAM212A.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002397171 – 285PAK4-inhibitor INKA1Add BLAST285

Proteomic databases

PaxDbiQ96EL1.
PeptideAtlasiQ96EL1.
PRIDEiQ96EL1.

PTM databases

iPTMnetiQ96EL1.
PhosphoSitePlusiQ96EL1.

Expressioni

Gene expression databases

BgeeiENSG00000185614.
CleanExiHS_C3orf54.
GenevisibleiQ96EL1. HS.

Organism-specific databases

HPAiHPA041879.

Interactioni

Subunit structurei

Interacts with PAK4 (PubMed:26607847).1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
PAK7Q8TB934EBI-10285157,EBI-741896

GO - Molecular functioni

  • protein kinase binding Source: UniProtKB

Protein-protein interaction databases

BioGridi132984. 2 interactors.
IntActiQ96EL1. 3 interactors.
STRINGi9606.ENSP00000329735.

Structurei

Secondary structure

1285
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi188 – 190Combined sources3
Helixi191 – 194Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4XBRX-ray2.94A166-203[»]
4XBUX-ray2.06B167-190[»]
SMRiQ96EL1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni166 – 203Inka box 11 PublicationAdd BLAST38
Regioni259 – 285Inka box 21 PublicationAdd BLAST27

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi63 – 71Poly-Glu9

Domaini

Contains 2 Inka boxes (also named iBox or inca box) (PubMed:26607847). The Inka boxes bind and inhibit PAK4 by binding a substrate-like manner (PubMed:26607847).1 Publication

Sequence similaritiesi

Belongs to the INKA family.Curated

Phylogenomic databases

eggNOGiENOG410IWR5. Eukaryota.
ENOG4111TCQ. LUCA.
HOGENOMiHOG000294066.
HOVERGENiHBG066206.
InParanoidiQ96EL1.
OrthoDBiEOG091G0PTP.
PhylomeDBiQ96EL1.
TreeFamiTF332839.

Family and domain databases

InterProiView protein in InterPro
IPR029267. FAM212.
PfamiView protein in Pfam
PF15342. FAM212. 1 hit.

Sequencei

Sequence statusi: Complete.

Q96EL1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHSARLDSFL SQLRWELLCG RDTGSPSMPG PLQPTSQTGP DVQPSHQLRA
60 70 80 90 100
SGALEEDSVC CVEEEEEEEE EAVVTEDRDA ALGGPREHAL DWDSGFSEVS
110 120 130 140 150
GSTWREEELP VSQRPAPSAQ PLRRQCLSVS GLPMPSRAPV ASVPPVHHPR
160 170 180 190 200
PKSTPDACLE HWQGLEAEDW TAALLNRGRS RQPLVLGDNC FADLVHNWME
210 220 230 240 250
LPETGSEGGD GGGHRARARP PQFLLGLSEQ LRRRLARARR TAMAGKRLSC
260 270 280
PPRPEPELPA DVSRFAALMS CRSRQPIICN DVSYL
Length:285
Mass (Da):31,328
Last modified:December 1, 2001 - v1
Checksum:i230722F958009C12
GO

Sequence cautioni

The sequence AAH12170 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC139451 Genomic DNA. No translation available.
BC012170 mRNA. Translation: AAH12170.2. Different initiation.
RefSeqiNP_976248.1. NM_203370.1.
UniGeneiHs.86674.

Genome annotation databases

EnsembliENST00000333323; ENSP00000329735; ENSG00000185614.
GeneIDi389119.
KEGGihsa:389119.
UCSCiuc003cxq.1. human.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiINKA1_HUMAN
AccessioniPrimary (citable) accession number: Q96EL1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: December 1, 2001
Last modified: April 12, 2017
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families