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Protein

Protein KTI12 homolog

Gene

KTI12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi8 – 15ATPSequence analysis8

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:G66-31454-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein KTI12 homolog
Gene namesi
Name:KTI12
ORF Names:SBBI81
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:25160. KTI12.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000198841.
PharmGKBiPA142671571.

Polymorphism and mutation databases

BioMutaiKTI12.
DMDMi74751844.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002856861 – 354Protein KTI12 homologAdd BLAST354

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei184PhosphoserineCombined sources1
Modified residuei200PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ96EK9.
MaxQBiQ96EK9.
PaxDbiQ96EK9.
PeptideAtlasiQ96EK9.
PRIDEiQ96EK9.

PTM databases

iPTMnetiQ96EK9.
PhosphoSitePlusiQ96EK9.

Expressioni

Gene expression databases

BgeeiENSG00000198841.
CleanExiHS_KTI12.
GenevisibleiQ96EK9. HS.

Organism-specific databases

HPAiHPA031204.
HPA031205.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
FHL3Q136433EBI-7951092,EBI-741101

Protein-protein interaction databases

BioGridi125220. 4 interactors.
IntActiQ96EK9. 2 interactors.
MINTiMINT-2813929.
STRINGi9606.ENSP00000360676.

Structurei

3D structure databases

ProteinModelPortaliQ96EK9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the KTI12 family.Curated

Phylogenomic databases

eggNOGiKOG3062. Eukaryota.
COG4088. LUCA.
GeneTreeiENSGT00390000002443.
HOGENOMiHOG000247843.
HOVERGENiHBG056053.
InParanoidiQ96EK9.
KOiK15456.
OMAiEKGEPTY.
OrthoDBiEOG091G0CCR.
PhylomeDBiQ96EK9.
TreeFamiTF312974.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR013641. KTI12/PSTK.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF08433. KTI12. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

Q96EK9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPLVVFCGLP YSGKSRRAEE LRVALAAEGR AVYVVDDAAV LGAEDPAVYG
60 70 80 90 100
DSAREKALRG ALRASVERRL SRHDVVILDS LNYIKGFRYE LYCLARAART
110 120 130 140 150
PLCLVYCVRP GGPIAGPQVA GANENPGRNV SVSWRPRAEE DGRAQAAGSS
160 170 180 190 200
VLRELHTADS VVNGSAQADV PKELEREESG AAESPALVTP DSEKSAKHGS
210 220 230 240 250
GAFYSPELLE ALTLRFEAPD SRNRWDRPLF TLVGLEEPLP LAGIRSALFE
260 270 280 290 300
NRAPPPHQST QSQPLASGSF LHQLDQVTSQ VLAGLMEAQK SAVPGDLLTL
310 320 330 340 350
PGTTEHLRFT RPLTMAELSR LRRQFISYTK MHPNNENLPQ LANMFLQYLS

QSLH
Length:354
Mass (Da):38,616
Last modified:December 1, 2001 - v1
Checksum:i877F297D28AF1E24
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_032046191D → E.Corresponds to variant rs2783175dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF327348 mRNA. Translation: AAL56009.1.
AL445685 Genomic DNA. Translation: CAI17029.1.
BC012173 mRNA. Translation: AAH12173.1.
CCDSiCCDS562.1.
RefSeqiNP_612426.1. NM_138417.2.
UniGeneiHs.476033.

Genome annotation databases

EnsembliENST00000371614; ENSP00000360676; ENSG00000198841.
GeneIDi112970.
KEGGihsa:112970.
UCSCiuc001ctj.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF327348 mRNA. Translation: AAL56009.1.
AL445685 Genomic DNA. Translation: CAI17029.1.
BC012173 mRNA. Translation: AAH12173.1.
CCDSiCCDS562.1.
RefSeqiNP_612426.1. NM_138417.2.
UniGeneiHs.476033.

3D structure databases

ProteinModelPortaliQ96EK9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125220. 4 interactors.
IntActiQ96EK9. 2 interactors.
MINTiMINT-2813929.
STRINGi9606.ENSP00000360676.

PTM databases

iPTMnetiQ96EK9.
PhosphoSitePlusiQ96EK9.

Polymorphism and mutation databases

BioMutaiKTI12.
DMDMi74751844.

Proteomic databases

EPDiQ96EK9.
MaxQBiQ96EK9.
PaxDbiQ96EK9.
PeptideAtlasiQ96EK9.
PRIDEiQ96EK9.

Protocols and materials databases

DNASUi112970.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000371614; ENSP00000360676; ENSG00000198841.
GeneIDi112970.
KEGGihsa:112970.
UCSCiuc001ctj.2. human.

Organism-specific databases

CTDi112970.
GeneCardsiKTI12.
HGNCiHGNC:25160. KTI12.
HPAiHPA031204.
HPA031205.
neXtProtiNX_Q96EK9.
OpenTargetsiENSG00000198841.
PharmGKBiPA142671571.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3062. Eukaryota.
COG4088. LUCA.
GeneTreeiENSGT00390000002443.
HOGENOMiHOG000247843.
HOVERGENiHBG056053.
InParanoidiQ96EK9.
KOiK15456.
OMAiEKGEPTY.
OrthoDBiEOG091G0CCR.
PhylomeDBiQ96EK9.
TreeFamiTF312974.

Enzyme and pathway databases

BioCyciZFISH:G66-31454-MONOMER.

Miscellaneous databases

GenomeRNAii112970.
PROiQ96EK9.

Gene expression databases

BgeeiENSG00000198841.
CleanExiHS_KTI12.
GenevisibleiQ96EK9. HS.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR013641. KTI12/PSTK.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF08433. KTI12. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiKTI12_HUMAN
AccessioniPrimary (citable) accession number: Q96EK9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: December 1, 2001
Last modified: November 2, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.