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Protein

Constitutive coactivator of peroxisome proliferator-activated receptor gamma

Gene

FAM120B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Functions as a transactivator of PPARG and ESR1. Functions in adipogenesis through PPARG activation (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Differentiation, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Constitutive coactivator of peroxisome proliferator-activated receptor gamma
Short name:
Constitutive coactivator of PPAR-gamma
Short name:
Constitutive coactivator of PPARG
Alternative name(s):
PPARG constitutive coactivator 1
Short name:
PGCC1
Protein FAM120B
Gene namesi
Name:FAM120B
Synonyms:CCPG, KIAA1838
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:21109. FAM120B.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134920525.

Polymorphism and mutation databases

BioMutaiFAM120B.
DMDMi74751843.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 910910Constitutive coactivator of peroxisome proliferator-activated receptor gammaPRO_0000332990Add
BLAST

Proteomic databases

EPDiQ96EK7.
MaxQBiQ96EK7.
PaxDbiQ96EK7.
PeptideAtlasiQ96EK7.
PRIDEiQ96EK7.

PTM databases

iPTMnetiQ96EK7.
PhosphoSiteiQ96EK7.

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

BgeeiQ96EK7.
CleanExiHS_FAM120B.
ExpressionAtlasiQ96EK7. baseline and differential.
GenevisibleiQ96EK7. HS.

Organism-specific databases

HPAiHPA037518.
HPA037519.

Interactioni

Subunit structurei

Interacts with ESR1 and RXRA. Interacts with PPARG; in a ligand-independent manner (By similarity).By similarity

Protein-protein interaction databases

BioGridi124101. 10 interactions.
IntActiQ96EK7. 3 interactions.
MINTiMINT-7034505.
STRINGi9606.ENSP00000417970.

Structurei

3D structure databases

ProteinModelPortaliQ96EK7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410IGHB. Eukaryota.
ENOG410ZBE9. LUCA.
GeneTreeiENSGT00530000063168.
HOVERGENiHBG107861.
InParanoidiQ96EK7.
PhylomeDBiQ96EK7.
TreeFamiTF331093.

Family and domain databases

Gene3Di3.40.50.1010. 1 hit.
InterProiIPR026784. Coact_PPARg.
IPR029060. PIN_domain-like.
[Graphical view]
PANTHERiPTHR15976. PTHR15976. 3 hits.
SUPFAMiSSF88723. SSF88723. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96EK7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGVRGLQGFV GSTCPHICTV VNFKELAEHH RSKYPGCTPT IVVDAMCCLR
60 70 80 90 100
YWYTPESWIC GGQWREYFSA LRDFVKTFTA AGIKLIFFFD GMVEQDKRDE
110 120 130 140 150
WVKRRLKNNR EISRIFHYIK SHKEQPGRNM FFIPSGLAVF TRFALKTLGQ
160 170 180 190 200
ETLCSLQEAD YEVASYGLQH NCLGILGEDT DYLIYDTCPY FSISELCLES
210 220 230 240 250
LDTVMLCREK LCESLGLCVA DLPLLACLLG NDIIPEGMFE SFRYKCLSSY
260 270 280 290 300
TSVKENFDKK GNIILAVSDH ISKVLYLYQG EKKLEEILPL GPNKALFYKG
310 320 330 340 350
MASYLLPGQK SPWFFQKPKG VITLDKQVIS TSSDAESREE VPMCSDAESR
360 370 380 390 400
QEVPMCTGPE SRREVPVYTD SEPRQEVPMC SDPEPRQEVP TCTGPESRRE
410 420 430 440 450
VPMCSDPEPR QEVPMCTGPE ARQEVPMYTD SEPRQEVPMY TDSEPRQEVP
460 470 480 490 500
MYTGSEPRQE VPMYTGPESR QEVPMYTGPE SRQEVLIRTD PESRQEIMCT
510 520 530 540 550
GHESKQEVPI CTDPISKQED SMCTHAEINQ KLPVATDFEF KLEALMCTNP
560 570 580 590 600
EIKQEDPTNV GPEVKQQVTM VSDTEILKVA RTHHVQAESY LVYNIMSSGE
610 620 630 640 650
IECSNTLEDE LDQALPSQAF IYRPIRQRVY SLLLEDCQDV TSTCLAVKEW
660 670 680 690 700
FVYPGNPLRH PDLVRPLQMT IPGGTPSLKI LWLNQEPEIQ VRRLDTLLAC
710 720 730 740 750
FNLSSSREEL QAVESPFQAL CCLLIYLFVQ VDTLCLEDLH AFIAQALCLQ
760 770 780 790 800
GKSTSQLVNL QPDYINPRAV QLGSLLVRGL TTLVLVNSAC GFPWKTSDFM
810 820 830 840 850
PWNVFDGKLF HQKYLQSEKG YAVEVLLEQN RSRLTKFHNL KAVVCKACMK
860 870 880 890 900
ENRRITGRAH WGSHHAGRWG RQGSSYHRTG SGYSRSSQGQ PWRDQGPGSR
910
QYEHDQWRRY
Length:910
Mass (Da):103,783
Last modified:December 1, 2001 - v1
Checksum:i079F9385733B5FAC
GO
Isoform 2 (identifier: Q96EK7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     762-764: PDY → VQT
     765-910: Missing.

Show »
Length:764
Mass (Da):86,878
Checksum:i3C059F20148DC432
GO
Isoform 3 (identifier: Q96EK7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-668: Missing.

Note: No experimental confirmation available.
Show »
Length:242
Mass (Da):27,627
Checksum:i81DA1455D369ADCB
GO

Sequence cautioni

The sequence BAB47467.1 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti370 – 3701D → Y.
Corresponds to variant rs6917485 [ dbSNP | Ensembl ].
VAR_043021
Natural varianti379 – 3791M → T.
Corresponds to variant rs6905356 [ dbSNP | Ensembl ].
VAR_043022
Natural varianti428 – 4281Y → C.
Corresponds to variant rs6900199 [ dbSNP | Ensembl ].
VAR_043023
Natural varianti430 – 4301D → G.
Corresponds to variant rs6900202 [ dbSNP | Ensembl ].
VAR_043024
Natural varianti431 – 4311S → P.
Corresponds to variant rs6905610 [ dbSNP | Ensembl ].
VAR_043025
Natural varianti433 – 4331P → A.
Corresponds to variant rs6934830 [ dbSNP | Ensembl ].
VAR_043026
Natural varianti440 – 4401Y → C.
Corresponds to variant rs9366138 [ dbSNP | Ensembl ].
VAR_043027
Natural varianti511 – 5111C → G.
Corresponds to variant rs9348266 [ dbSNP | Ensembl ].
VAR_043028

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 668668Missing in isoform 3. 1 PublicationVSP_055267Add
BLAST
Alternative sequencei762 – 7643PDY → VQT in isoform 2. 1 PublicationVSP_033415
Alternative sequencei765 – 910146Missing in isoform 2. 1 PublicationVSP_033416Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ873695 mRNA. Translation: ABH09086.1.
AB058741 mRNA. Translation: BAB47467.1. Different initiation.
AK296825 mRNA. Translation: BAG59396.1.
AL008628, AL078605 Genomic DNA. Translation: CAI19554.1.
AL078605, AL008628 Genomic DNA. Translation: CAI23205.1.
CH471051 Genomic DNA. Translation: EAW47424.1.
BC012177 mRNA. Translation: AAH12177.1.
AY266458 mRNA. Translation: AAP31032.1.
CCDSiCCDS5314.1. [Q96EK7-1]
CCDS69243.1. [Q96EK7-3]
RefSeqiNP_001273310.1. NM_001286381.1. [Q96EK7-3]
NP_115824.1. NM_032448.2. [Q96EK7-1]
UniGeneiHs.369522.

Genome annotation databases

EnsembliENST00000476287; ENSP00000417970; ENSG00000112584. [Q96EK7-1]
ENST00000616072; ENSP00000482544; ENSG00000275333. [Q96EK7-3]
ENST00000617082; ENSP00000481344; ENSG00000275333. [Q96EK7-1]
ENST00000625626; ENSP00000485793; ENSG00000112584. [Q96EK7-3]
GeneIDi84498.
KEGGihsa:84498.
UCSCiuc003qxp.5. human. [Q96EK7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ873695 mRNA. Translation: ABH09086.1.
AB058741 mRNA. Translation: BAB47467.1. Different initiation.
AK296825 mRNA. Translation: BAG59396.1.
AL008628, AL078605 Genomic DNA. Translation: CAI19554.1.
AL078605, AL008628 Genomic DNA. Translation: CAI23205.1.
CH471051 Genomic DNA. Translation: EAW47424.1.
BC012177 mRNA. Translation: AAH12177.1.
AY266458 mRNA. Translation: AAP31032.1.
CCDSiCCDS5314.1. [Q96EK7-1]
CCDS69243.1. [Q96EK7-3]
RefSeqiNP_001273310.1. NM_001286381.1. [Q96EK7-3]
NP_115824.1. NM_032448.2. [Q96EK7-1]
UniGeneiHs.369522.

3D structure databases

ProteinModelPortaliQ96EK7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124101. 10 interactions.
IntActiQ96EK7. 3 interactions.
MINTiMINT-7034505.
STRINGi9606.ENSP00000417970.

PTM databases

iPTMnetiQ96EK7.
PhosphoSiteiQ96EK7.

Polymorphism and mutation databases

BioMutaiFAM120B.
DMDMi74751843.

Proteomic databases

EPDiQ96EK7.
MaxQBiQ96EK7.
PaxDbiQ96EK7.
PeptideAtlasiQ96EK7.
PRIDEiQ96EK7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000476287; ENSP00000417970; ENSG00000112584. [Q96EK7-1]
ENST00000616072; ENSP00000482544; ENSG00000275333. [Q96EK7-3]
ENST00000617082; ENSP00000481344; ENSG00000275333. [Q96EK7-1]
ENST00000625626; ENSP00000485793; ENSG00000112584. [Q96EK7-3]
GeneIDi84498.
KEGGihsa:84498.
UCSCiuc003qxp.5. human. [Q96EK7-1]

Organism-specific databases

CTDi84498.
GeneCardsiFAM120B.
HGNCiHGNC:21109. FAM120B.
HPAiHPA037518.
HPA037519.
MIMi612266. gene.
neXtProtiNX_Q96EK7.
PharmGKBiPA134920525.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGHB. Eukaryota.
ENOG410ZBE9. LUCA.
GeneTreeiENSGT00530000063168.
HOVERGENiHBG107861.
InParanoidiQ96EK7.
PhylomeDBiQ96EK7.
TreeFamiTF331093.

Miscellaneous databases

ChiTaRSiFAM120B. human.
GenomeRNAii84498.
PROiQ96EK7.
SOURCEiSearch...

Gene expression databases

BgeeiQ96EK7.
CleanExiHS_FAM120B.
ExpressionAtlasiQ96EK7. baseline and differential.
GenevisibleiQ96EK7. HS.

Family and domain databases

Gene3Di3.40.50.1010. 1 hit.
InterProiIPR026784. Coact_PPARg.
IPR029060. PIN_domain-like.
[Graphical view]
PANTHERiPTHR15976. PTHR15976. 3 hits.
SUPFAMiSSF88723. SSF88723. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Constitutive coactivator of peroxisome proliferator-activated receptor (PPARgamma), a novel coactivator of PPARgamma that promotes adipogenesis."
    Li D., Kang Q., Wang D.-M.
    Mol. Endocrinol. 21:2320-2333(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Nakayama M., Nakajima D., Kikuno R., Ohara O.
    DNA Res. 8:85-95(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Tongue.
  4. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Placenta.
  7. "The human gene CXorf17 encodes a member of a novel family of putative transmembrane proteins: cDNA cloning and characterization of CXorf17 and its mouse ortholog orf34."
    Holden S., Raymond F.L.
    Gene 318:149-161(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 705-910 (ISOFORM 2), TISSUE SPECIFICITY.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiF120B_HUMAN
AccessioniPrimary (citable) accession number: Q96EK7
Secondary accession number(s): B4DL34, Q86V68, Q96JI9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: December 1, 2001
Last modified: July 6, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.