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Protein

THAP domain-containing protein 11

Gene

THAP11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional repressor that plays a central role for embryogenesis and the pluripotency of embryonic stem (ES) cells. Sequence-specific DNA-binding factor that represses gene expression in pluripotent ES cells by directly binding to key genetic loci and recruiting epigenetic modifiers (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri1 – 8080THAP-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • DNA binding Source: UniProtKB
  • zinc ion binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
THAP domain-containing protein 11
Gene namesi
Name:THAP11
ORF Names:HRIHFB2206
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:23194. THAP11.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134979842.

Polymorphism and mutation databases

BioMutaiTHAP11.
DMDMi209572685.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 314314THAP domain-containing protein 11PRO_0000068653Add
BLAST

Proteomic databases

EPDiQ96EK4.
MaxQBiQ96EK4.
PaxDbiQ96EK4.
PeptideAtlasiQ96EK4.
PRIDEiQ96EK4.

PTM databases

iPTMnetiQ96EK4.
PhosphoSiteiQ96EK4.

Expressioni

Gene expression databases

BgeeiQ96EK4.
CleanExiHS_THAP11.
GenevisibleiQ96EK4. HS.

Organism-specific databases

HPAiHPA041434.
HPA042189.

Interactioni

Subunit structurei

Interacts (via coiled coil domain) with HCFC1.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Casp3P706772EBI-1790529,EBI-1790419From a different organism.
CTBP1Q133632EBI-1790529,EBI-908846
HCFC1P516102EBI-1790529,EBI-396176
PCBP1Q153654EBI-1790529,EBI-946095
VPS52Q8N1B43EBI-1790529,EBI-2799833

Protein-protein interaction databases

BioGridi121453. 41 interactions.
IntActiQ96EK4. 22 interactions.
MINTiMINT-8362103.
STRINGi9606.ENSP00000304689.

Structurei

Secondary structure

1
314
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi9 – 135Combined sources
Beta strandi15 – 173Combined sources
Helixi30 – 4011Combined sources
Helixi62 – 643Combined sources
Beta strandi65 – 717Combined sources
Helixi254 – 31259Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2LAUNMR-A2-80[»]
5AJSX-ray2.30A/B/C/D247-314[»]
ProteinModelPortaliQ96EK4.
SMRiQ96EK4. Positions 2-80.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili255 – 30551Sequence analysisAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi243 – 2464HCFC1-binding motif (HBM)By similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi95 – 1006Poly-Ala
Compositional biasi104 – 14643Gln-richAdd
BLAST
Compositional biasi197 – 22125Ala-richAdd
BLAST

Sequence similaritiesi

Belongs to the THAP11 family.Curated
Contains 1 THAP-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri1 – 8080THAP-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IFX3. Eukaryota.
ENOG4111FSQ. LUCA.
GeneTreeiENSGT00390000006585.
HOGENOMiHOG000154562.
HOVERGENiHBG062269.
InParanoidiQ96EK4.
OMAiTGHRVCS.
OrthoDBiEOG7WQ7TG.
PhylomeDBiQ96EK4.
TreeFamiTF331359.

Family and domain databases

InterProiIPR006612. Znf_C2CH.
[Graphical view]
PfamiPF05485. THAP. 1 hit.
[Graphical view]
SMARTiSM00692. DM3. 1 hit.
SM00980. THAP. 1 hit.
[Graphical view]
PROSITEiPS50950. ZF_THAP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96EK4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGFTCCVPG CYNNSHRDKA LHFYTFPKDA ELRRLWLKNV SRAGVSGCFS
60 70 80 90 100
TFQPTTGHRL CSVHFQGGRK TYTVRVPTIF PLRGVNERKV ARRPAGAAAA
110 120 130 140 150
RRRQQQQQQQ QQQQQQQQQQ QQQQQQQQQQ QQSSPSASTA QTAQLQPNLV
160 170 180 190 200
SASAAVLLTL QATVDSSQAP GSVQPAPITP TGEDVKPIDL TVQVEFAAAE
210 220 230 240 250
GAAAAAAASE LQAATAGLEA AECPMGPQLV VVGEEGFPDT GSDHSYSLSS
260 270 280 290 300
GTTEEELLRK LNEQRDILAL MEVKMKEMKG SIRHLRLTEA KLREELREKD
310
RLLAMAVIRK KHGM
Length:314
Mass (Da):34,455
Last modified:October 14, 2008 - v2
Checksum:i25235D20CB54D8C2
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti132 – 1321Missing in AAH12182 (PubMed:15489334).Curated

Polymorphismi

The length of the poly-Gln region is variable in the population.1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK289367 mRNA. Translation: BAF82056.1.
BC012182 mRNA. Translation: AAH12182.1.
EF036502 mRNA. Translation: ABO65088.1.
AB015338 mRNA. Translation: BAA34796.1.
CCDSiCCDS10847.1.
RefSeqiNP_065190.2. NM_020457.2.
UniGeneiHs.632200.

Genome annotation databases

EnsembliENST00000303596; ENSP00000304689; ENSG00000168286.
GeneIDi57215.
KEGGihsa:57215.
UCSCiuc002euo.4. human.

Keywords - Coding sequence diversityi

Triplet repeat expansion

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK289367 mRNA. Translation: BAF82056.1.
BC012182 mRNA. Translation: AAH12182.1.
EF036502 mRNA. Translation: ABO65088.1.
AB015338 mRNA. Translation: BAA34796.1.
CCDSiCCDS10847.1.
RefSeqiNP_065190.2. NM_020457.2.
UniGeneiHs.632200.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2LAUNMR-A2-80[»]
5AJSX-ray2.30A/B/C/D247-314[»]
ProteinModelPortaliQ96EK4.
SMRiQ96EK4. Positions 2-80.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121453. 41 interactions.
IntActiQ96EK4. 22 interactions.
MINTiMINT-8362103.
STRINGi9606.ENSP00000304689.

PTM databases

iPTMnetiQ96EK4.
PhosphoSiteiQ96EK4.

Polymorphism and mutation databases

BioMutaiTHAP11.
DMDMi209572685.

Proteomic databases

EPDiQ96EK4.
MaxQBiQ96EK4.
PaxDbiQ96EK4.
PeptideAtlasiQ96EK4.
PRIDEiQ96EK4.

Protocols and materials databases

DNASUi57215.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000303596; ENSP00000304689; ENSG00000168286.
GeneIDi57215.
KEGGihsa:57215.
UCSCiuc002euo.4. human.

Organism-specific databases

CTDi57215.
GeneCardsiTHAP11.
HGNCiHGNC:23194. THAP11.
HPAiHPA041434.
HPA042189.
MIMi609119. gene.
neXtProtiNX_Q96EK4.
PharmGKBiPA134979842.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFX3. Eukaryota.
ENOG4111FSQ. LUCA.
GeneTreeiENSGT00390000006585.
HOGENOMiHOG000154562.
HOVERGENiHBG062269.
InParanoidiQ96EK4.
OMAiTGHRVCS.
OrthoDBiEOG7WQ7TG.
PhylomeDBiQ96EK4.
TreeFamiTF331359.

Miscellaneous databases

GenomeRNAii57215.
PROiQ96EK4.
SOURCEiSearch...

Gene expression databases

BgeeiQ96EK4.
CleanExiHS_THAP11.
GenevisibleiQ96EK4. HS.

Family and domain databases

InterProiIPR006612. Znf_C2CH.
[Graphical view]
PfamiPF05485. THAP. 1 hit.
[Graphical view]
SMARTiSM00692. DM3. 1 hit.
SM00980. THAP. 1 hit.
[Graphical view]
PROSITEiPS50950. ZF_THAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Neuroblastoma.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Uterus.
  3. "Searching for interaction partners of the transcription factor REST/NRSF by two-hybrid screening."
    Santana-Roman H., Curiel-Quesada E., Tapia-Ramirez J.
    Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 44-197.
  4. "Selection system for genes encoding nuclear-targeted proteins."
    Ueki N., Oda T., Kondo M., Yano K., Noguchi T., Muramatsu M.-A.
    Nat. Biotechnol. 16:1338-1342(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 226-313, SUBCELLULAR LOCATION.
    Tissue: Brain.
  5. "SMARCA2 and THAP11: potential candidates for polyglutamine disorders as evidenced from polymorphism and protein-folding simulation studies."
    Pandey N., Mittal U., Srivastava A.K., Mukerji M.
    J. Hum. Genet. 49:596-602(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: TRIPLET REPEAT EXPANSION.
  6. "NMR studies of a new family of DNA binding proteins: the THAP proteins."
    Gervais V., Campagne S., Durand J., Muller I., Milon A.
    J. Biomol. NMR 56:3-15(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 1-81 IN COMPLEX WITH ZINC ION, DNA-BINDING.

Entry informationi

Entry nameiTHA11_HUMAN
AccessioniPrimary (citable) accession number: Q96EK4
Secondary accession number(s): A4UCT5, A8K002, O94795
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: October 14, 2008
Last modified: July 6, 2016
This is version 131 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.