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Protein

PHD finger protein 21B

Gene

PHF21B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Caution

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri352 – 399PHD-typePROSITE-ProRule annotationAdd BLAST48

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
PHD finger protein 21B
Gene namesi
Name:PHF21B
Synonyms:KIAA1661
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000056487.15
HGNCiHGNC:25161 PHF21B
MIMi616727 gene
neXtProtiNX_Q96EK2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi112885
OpenTargetsiENSG00000056487
PharmGKBiPA134872136

Polymorphism and mutation databases

BioMutaiPHF21B
DMDMi74731574

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002267691 – 531PHD finger protein 21BAdd BLAST531

Proteomic databases

MaxQBiQ96EK2
PaxDbiQ96EK2
PeptideAtlasiQ96EK2
PRIDEiQ96EK2

PTM databases

iPTMnetiQ96EK2
PhosphoSitePlusiQ96EK2

Expressioni

Gene expression databases

BgeeiENSG00000056487
CleanExiHS_PHF21B
ExpressionAtlasiQ96EK2 baseline and differential
GenevisibleiQ96EK2 HS

Organism-specific databases

HPAiHPA053834

Interactioni

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi1252141 interactor.
CORUMiQ96EK2
IntActiQ96EK2 2 interactors.
STRINGi9606.ENSP00000324403

Structurei

3D structure databases

ProteinModelPortaliQ96EK2
SMRiQ96EK2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili423 – 465Sequence analysisAdd BLAST43

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri352 – 399PHD-typePROSITE-ProRule annotationAdd BLAST48

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IRE8 Eukaryota
ENOG4111F4Y LUCA
GeneTreeiENSGT00530000063984
HOGENOMiHOG000231466
HOVERGENiHBG080293
InParanoidiQ96EK2
OMAiNEDPCWK
OrthoDBiEOG091G03CB
PhylomeDBiQ96EK2
TreeFamiTF331518

Family and domain databases

Gene3Di3.30.40.101 hit
InterProiView protein in InterPro
IPR011011 Znf_FYVE_PHD
IPR001965 Znf_PHD
IPR019787 Znf_PHD-finger
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF00628 PHD, 1 hit
SMARTiView protein in SMART
SM00249 PHD, 1 hit
SUPFAMiSSF57903 SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS50016 ZF_PHD_2, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96EK2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MELQSRPEAL AVELARHQNG DLKKQLHERQ PRIAALSDKQ ALGTITAVPV
60 70 80 90 100
TGPQVSSLQR LAGQGAAVLP QVRPKTLIPD SLPVAPGRDR PPKQPPTFQK
110 120 130 140 150
ATVVSVKNPS PALPTANNTV SHVPAPGSQP QALAEPAALA SPLSSAGVAY
160 170 180 190 200
AIISTSPSNA AAMAPSTAVS VVSDSIKVQP LLISADNKPP PRLLSSPHPA
210 220 230 240 250
THHCPLHPSS LPLTPPSPSL SPSPLHGIFQ VIIIQPQVQT QPESTAESRP
260 270 280 290 300
PTEEPSQGAQ ATKKKKEDRP PTQENPEKIA FMVALGLVTT EHLEEIQSKR
310 320 330 340 350
QERKRRSTAN PAYSGLLETE RKRLASNYLN NPLFLTARAN EDPCWKNEIT
360 370 380 390 400
HDEHCAACKR GANLQPCGTC PGAYHLSCLE PPLKTAPKGV WVCPRCQQKA
410 420 430 440 450
LKKDEGVPWT GMLAIVHSYV THKTVKEEEK QKLLQRGSEL QNEHQQLEER
460 470 480 490 500
DRRLASAVQK CLELKTSLLA RQRGTQSSLD RLRALLRLIQ GEQLLQVTMT
510 520 530
TTSPAPLLAG PWTKPSVAAT HPTVQHPQGH N
Length:531
Mass (Da):57,455
Last modified:December 1, 2001 - v1
Checksum:i5EFBAAEC1D952941
GO
Isoform 2 (identifier: Q96EK2-3) [UniParc]FASTAAdd to basket
Also known as: 3

The sequence of this isoform differs from the canonical sequence as follows:
     189-230: Missing.

Show »
Length:489
Mass (Da):53,040
Checksum:i71AF064E6C2CA34A
GO
Isoform 3 (identifier: Q96EK2-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-17: MELQSRPEALAVELARH → MRRQP
     189-230: Missing.

Note: No experimental confirmation available.
Show »
Length:477
Mass (Da):51,776
Checksum:i69B5D050360F14D6
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_051601127G → S. Corresponds to variant dbSNP:rs8135982Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0431491 – 17MELQS…ELARH → MRRQP in isoform 3. 1 PublicationAdd BLAST17
Alternative sequenceiVSP_017456189 – 230Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST42

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR456448 mRNA Translation: CAG30334.1
AK092243 mRNA Translation: BAG52506.1
AK297317 mRNA Translation: BAH12544.1
AL049760 Genomic DNA No translation available.
Z83838 Genomic DNA No translation available.
CH471138 Genomic DNA Translation: EAW73366.1
BC012187 mRNA Translation: AAH12187.1
CCDSiCCDS14061.1 [Q96EK2-1]
CCDS46727.1 [Q96EK2-3]
CCDS56234.1 [Q96EK2-4]
RefSeqiNP_001129334.1, NM_001135862.2 [Q96EK2-3]
NP_001229379.1, NM_001242450.1 [Q96EK2-4]
NP_001271225.1, NM_001284296.1
NP_612424.1, NM_138415.4 [Q96EK2-1]
XP_006724185.1, XM_006724122.1 [Q96EK2-3]
UniGeneiHs.254097

Genome annotation databases

EnsembliENST00000313237; ENSP00000324403; ENSG00000056487 [Q96EK2-1]
ENST00000396103; ENSP00000379410; ENSG00000056487 [Q96EK2-4]
ENST00000629843; ENSP00000487086; ENSG00000056487 [Q96EK2-3]
GeneIDi112885
KEGGihsa:112885
UCSCiuc003bfn.4 human [Q96EK2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiPF21B_HUMAN
AccessioniPrimary (citable) accession number: Q96EK2
Secondary accession number(s): B0QYW3
, B0QYW4, B3KRU4, B7Z4F8, Q5TFL2, Q6ICC0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: December 1, 2001
Last modified: January 31, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome