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Protein

PHD finger protein 21B

Gene

PHF21B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri352 – 39948PHD-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
PHD finger protein 21B
Gene namesi
Name:PHF21B
Synonyms:KIAA1661
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:25161. PHF21B.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134872136.

Polymorphism and mutation databases

BioMutaiPHF21B.
DMDMi74731574.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 531531PHD finger protein 21BPRO_0000226769Add
BLAST

Proteomic databases

PaxDbiQ96EK2.
PeptideAtlasiQ96EK2.
PRIDEiQ96EK2.

PTM databases

iPTMnetiQ96EK2.
PhosphoSiteiQ96EK2.

Expressioni

Gene expression databases

BgeeiENSG00000056487.
CleanExiHS_PHF21B.
ExpressionAtlasiQ96EK2. baseline and differential.
GenevisibleiQ96EK2. HS.

Organism-specific databases

HPAiHPA053834.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi125214. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ96EK2.
SMRiQ96EK2. Positions 351-402.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili423 – 46543Sequence analysisAdd
BLAST

Sequence similaritiesi

Contains 1 PHD-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri352 – 39948PHD-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IRE8. Eukaryota.
ENOG4111F4Y. LUCA.
GeneTreeiENSGT00530000063984.
HOGENOMiHOG000231466.
HOVERGENiHBG080293.
InParanoidiQ96EK2.
OMAiRHQNGDL.
OrthoDBiEOG091G03CB.
PhylomeDBiQ96EK2.
TreeFamiTF331518.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF00628. PHD. 1 hit.
[Graphical view]
SMARTiSM00249. PHD. 1 hit.
[Graphical view]
SUPFAMiSSF57903. SSF57903. 1 hit.
PROSITEiPS50016. ZF_PHD_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96EK2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MELQSRPEAL AVELARHQNG DLKKQLHERQ PRIAALSDKQ ALGTITAVPV
60 70 80 90 100
TGPQVSSLQR LAGQGAAVLP QVRPKTLIPD SLPVAPGRDR PPKQPPTFQK
110 120 130 140 150
ATVVSVKNPS PALPTANNTV SHVPAPGSQP QALAEPAALA SPLSSAGVAY
160 170 180 190 200
AIISTSPSNA AAMAPSTAVS VVSDSIKVQP LLISADNKPP PRLLSSPHPA
210 220 230 240 250
THHCPLHPSS LPLTPPSPSL SPSPLHGIFQ VIIIQPQVQT QPESTAESRP
260 270 280 290 300
PTEEPSQGAQ ATKKKKEDRP PTQENPEKIA FMVALGLVTT EHLEEIQSKR
310 320 330 340 350
QERKRRSTAN PAYSGLLETE RKRLASNYLN NPLFLTARAN EDPCWKNEIT
360 370 380 390 400
HDEHCAACKR GANLQPCGTC PGAYHLSCLE PPLKTAPKGV WVCPRCQQKA
410 420 430 440 450
LKKDEGVPWT GMLAIVHSYV THKTVKEEEK QKLLQRGSEL QNEHQQLEER
460 470 480 490 500
DRRLASAVQK CLELKTSLLA RQRGTQSSLD RLRALLRLIQ GEQLLQVTMT
510 520 530
TTSPAPLLAG PWTKPSVAAT HPTVQHPQGH N
Length:531
Mass (Da):57,455
Last modified:December 1, 2001 - v1
Checksum:i5EFBAAEC1D952941
GO
Isoform 2 (identifier: Q96EK2-3) [UniParc]FASTAAdd to basket
Also known as: 3

The sequence of this isoform differs from the canonical sequence as follows:
     189-230: Missing.

Show »
Length:489
Mass (Da):53,040
Checksum:i71AF064E6C2CA34A
GO
Isoform 3 (identifier: Q96EK2-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-17: MELQSRPEALAVELARH → MRRQP
     189-230: Missing.

Note: No experimental confirmation available.
Show »
Length:477
Mass (Da):51,776
Checksum:i69B5D050360F14D6
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti127 – 1271G → S.
Corresponds to variant rs8135982 [ dbSNP | Ensembl ].
VAR_051601

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 1717MELQS…ELARH → MRRQP in isoform 3. 1 PublicationVSP_043149Add
BLAST
Alternative sequencei189 – 23042Missing in isoform 2 and isoform 3. 2 PublicationsVSP_017456Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR456448 mRNA. Translation: CAG30334.1.
AK092243 mRNA. Translation: BAG52506.1.
AK297317 mRNA. Translation: BAH12544.1.
AL049760, Z83838 Genomic DNA. Translation: CAQ06723.1.
AL049760, Z83838 Genomic DNA. Translation: CAQ06724.1.
Z83838, AL049760 Genomic DNA. Translation: CAQ07744.1.
Z83838, AL049760 Genomic DNA. Translation: CAQ07745.1.
CH471138 Genomic DNA. Translation: EAW73366.1.
BC012187 mRNA. Translation: AAH12187.1.
CCDSiCCDS14061.1. [Q96EK2-1]
CCDS46727.1. [Q96EK2-3]
CCDS56234.1. [Q96EK2-4]
RefSeqiNP_001129334.1. NM_001135862.2. [Q96EK2-3]
NP_001229379.1. NM_001242450.1. [Q96EK2-4]
NP_001271225.1. NM_001284296.1.
NP_612424.1. NM_138415.4. [Q96EK2-1]
XP_006724185.1. XM_006724122.1. [Q96EK2-3]
UniGeneiHs.254097.

Genome annotation databases

EnsembliENST00000313237; ENSP00000324403; ENSG00000056487. [Q96EK2-1]
ENST00000396103; ENSP00000379410; ENSG00000056487. [Q96EK2-4]
ENST00000629843; ENSP00000487086; ENSG00000056487. [Q96EK2-3]
GeneIDi112885.
KEGGihsa:112885.
UCSCiuc003bfn.4. human. [Q96EK2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR456448 mRNA. Translation: CAG30334.1.
AK092243 mRNA. Translation: BAG52506.1.
AK297317 mRNA. Translation: BAH12544.1.
AL049760, Z83838 Genomic DNA. Translation: CAQ06723.1.
AL049760, Z83838 Genomic DNA. Translation: CAQ06724.1.
Z83838, AL049760 Genomic DNA. Translation: CAQ07744.1.
Z83838, AL049760 Genomic DNA. Translation: CAQ07745.1.
CH471138 Genomic DNA. Translation: EAW73366.1.
BC012187 mRNA. Translation: AAH12187.1.
CCDSiCCDS14061.1. [Q96EK2-1]
CCDS46727.1. [Q96EK2-3]
CCDS56234.1. [Q96EK2-4]
RefSeqiNP_001129334.1. NM_001135862.2. [Q96EK2-3]
NP_001229379.1. NM_001242450.1. [Q96EK2-4]
NP_001271225.1. NM_001284296.1.
NP_612424.1. NM_138415.4. [Q96EK2-1]
XP_006724185.1. XM_006724122.1. [Q96EK2-3]
UniGeneiHs.254097.

3D structure databases

ProteinModelPortaliQ96EK2.
SMRiQ96EK2. Positions 351-402.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125214. 1 interaction.

PTM databases

iPTMnetiQ96EK2.
PhosphoSiteiQ96EK2.

Polymorphism and mutation databases

BioMutaiPHF21B.
DMDMi74731574.

Proteomic databases

PaxDbiQ96EK2.
PeptideAtlasiQ96EK2.
PRIDEiQ96EK2.

Protocols and materials databases

DNASUi112885.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000313237; ENSP00000324403; ENSG00000056487. [Q96EK2-1]
ENST00000396103; ENSP00000379410; ENSG00000056487. [Q96EK2-4]
ENST00000629843; ENSP00000487086; ENSG00000056487. [Q96EK2-3]
GeneIDi112885.
KEGGihsa:112885.
UCSCiuc003bfn.4. human. [Q96EK2-1]

Organism-specific databases

CTDi112885.
GeneCardsiPHF21B.
HGNCiHGNC:25161. PHF21B.
HPAiHPA053834.
MIMi616727. gene.
neXtProtiNX_Q96EK2.
PharmGKBiPA134872136.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IRE8. Eukaryota.
ENOG4111F4Y. LUCA.
GeneTreeiENSGT00530000063984.
HOGENOMiHOG000231466.
HOVERGENiHBG080293.
InParanoidiQ96EK2.
OMAiRHQNGDL.
OrthoDBiEOG091G03CB.
PhylomeDBiQ96EK2.
TreeFamiTF331518.

Miscellaneous databases

ChiTaRSiPHF21B. human.
GenomeRNAii112885.
PROiQ96EK2.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000056487.
CleanExiHS_PHF21B.
ExpressionAtlasiQ96EK2. baseline and differential.
GenevisibleiQ96EK2. HS.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF00628. PHD. 1 hit.
[Graphical view]
SMARTiSM00249. PHD. 1 hit.
[Graphical view]
SUPFAMiSSF57903. SSF57903. 1 hit.
PROSITEiPS50016. ZF_PHD_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPF21B_HUMAN
AccessioniPrimary (citable) accession number: Q96EK2
Secondary accession number(s): B0QYW3
, B0QYW4, B3KRU4, B7Z4F8, Q5TFL2, Q6ICC0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: December 1, 2001
Last modified: September 7, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.