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Protein

Transcription elongation factor A protein-like 4

Gene

TCEAL4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription elongation factor A protein-like 4
Short name:
TCEA-like protein 4
Alternative name(s):
Transcription elongation factor S-II protein-like 4
Gene namesi
Name:TCEAL4
ORF Names:NPD017
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome X

Organism-specific databases

HGNCiHGNC:26121. TCEAL4.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA128394724.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 215215Transcription elongation factor A protein-like 4PRO_0000239209Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ96EI5.
PaxDbiQ96EI5.
PRIDEiQ96EI5.

PTM databases

PhosphoSiteiQ96EI5.

Expressioni

Gene expression databases

BgeeiQ96EI5.
CleanExiHS_TCEAL4.
ExpressionAtlasiQ96EI5. baseline and differential.
GenevestigatoriQ96EI5.

Interactioni

Protein-protein interaction databases

BioGridi122998. 14 interactions.
IntActiQ96EI5. 4 interactions.
STRINGi9606.ENSP00000378477.

Structurei

3D structure databases

ProteinModelPortaliQ96EI5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi2 – 109108Glu-richAdd
BLAST

Sequence similaritiesi

Belongs to the TFS-II family. TFA subfamily.Curated

Phylogenomic databases

eggNOGiNOG79939.
GeneTreeiENSGT00510000046867.
HOGENOMiHOG000231342.
HOVERGENiHBG055896.
InParanoidiQ96EI5.
OMAiGGLRVCC.
OrthoDBiEOG79KPGM.
PhylomeDBiQ96EI5.
TreeFamiTF336871.

Family and domain databases

InterProiIPR021156. TF_A-like/BEX-like.
IPR010370. TFA.
[Graphical view]
PANTHERiPTHR14754. PTHR14754. 1 hit.
PfamiPF04538. BEX. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q96EI5-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEKLYSENEG MASNQGKMEN EEQPQDERKP EVTCTLEDKK LENEGKTENK
60 70 80 90 100
GKTGDEEMLK DKGKPESEGE AKEGKSEREG ESEMEGGSER EGKPEIEGKP
110 120 130 140 150
ESEGEPGSET RAAGKRPAED DVPRKAKRKT NKGLAHYLKE YKEAIHDMNF
160 170 180 190 200
SNEDMIREFD NMAKVQDEKR KSKQKLGAFL WMQRNLQDPF YPRGPREFRG
210
GCRAPRRDIE DIPYV
Length:215
Mass (Da):24,647
Last modified:May 30, 2006 - v2
Checksum:i53420116CD9A7A0B
GO
Isoform 2 (identifier: Q96EI5-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MPAGGQAPQL...DRKRRGNLDM

Note: No experimental confirmation available.

Show »
Length:358
Mass (Da):40,578
Checksum:i0440D280DE089040
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti132 – 1321K → T in AAH12296. (PubMed:15489334)Curated
Sequence conflicti157 – 1571R → G in BAB15023. (PubMed:14702039)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 11M → MPAGGQAPQLTPVIPAFWEA RGLPNSKGRDKVHICQCEEW KGHISYVERDITTSEIKSLP QVSVRAFHAASGTLEWRKGN GYGRGKGWGWGRVESREAGP SVDRDGGLRVCCSQRSAKPE KEEQPVQNPRRSVKDRKRRG NLDM in isoform 2. 1 PublicationVSP_019109

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF314542 mRNA. Translation: AAL40909.1.
AF271783 mRNA. Translation: AAG44794.1.
AK024827 mRNA. Translation: BAB15023.1.
Z73965 Genomic DNA. Translation: CAI42031.1.
BC012296 mRNA. Translation: AAH12296.1.
CCDSiCCDS14510.2. [Q96EI5-1]
CCDS76004.1. [Q96EI5-2]
RefSeqiNP_001006936.1. NM_001006935.1. [Q96EI5-1]
NP_001006938.1. NM_001006937.1. [Q96EI5-1]
NP_001287830.1. NM_001300901.1. [Q96EI5-2]
NP_079139.4. NM_024863.4. [Q96EI5-1]
XP_005262250.1. XM_005262193.2. [Q96EI5-1]
XP_005262251.1. XM_005262194.2. [Q96EI5-1]
UniGeneiHs.194329.

Genome annotation databases

EnsembliENST00000372629; ENSP00000361712; ENSG00000133142. [Q96EI5-2]
ENST00000415568; ENSP00000415564; ENSG00000133142. [Q96EI5-1]
ENST00000468024; ENSP00000421857; ENSG00000133142. [Q96EI5-1]
ENST00000472484; ENSP00000421156; ENSG00000133142. [Q96EI5-1]
ENST00000472745; ENSP00000424314; ENSG00000133142. [Q96EI5-1]
ENST00000494801; ENSP00000427494; ENSG00000133142. [Q96EI5-1]
GeneIDi79921.
KEGGihsa:79921.
UCSCiuc004ekl.3. human. [Q96EI5-1]

Polymorphism databases

DMDMi108935938.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF314542 mRNA. Translation: AAL40909.1.
AF271783 mRNA. Translation: AAG44794.1.
AK024827 mRNA. Translation: BAB15023.1.
Z73965 Genomic DNA. Translation: CAI42031.1.
BC012296 mRNA. Translation: AAH12296.1.
CCDSiCCDS14510.2. [Q96EI5-1]
CCDS76004.1. [Q96EI5-2]
RefSeqiNP_001006936.1. NM_001006935.1. [Q96EI5-1]
NP_001006938.1. NM_001006937.1. [Q96EI5-1]
NP_001287830.1. NM_001300901.1. [Q96EI5-2]
NP_079139.4. NM_024863.4. [Q96EI5-1]
XP_005262250.1. XM_005262193.2. [Q96EI5-1]
XP_005262251.1. XM_005262194.2. [Q96EI5-1]
UniGeneiHs.194329.

3D structure databases

ProteinModelPortaliQ96EI5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122998. 14 interactions.
IntActiQ96EI5. 4 interactions.
STRINGi9606.ENSP00000378477.

PTM databases

PhosphoSiteiQ96EI5.

Polymorphism databases

DMDMi108935938.

Proteomic databases

MaxQBiQ96EI5.
PaxDbiQ96EI5.
PRIDEiQ96EI5.

Protocols and materials databases

DNASUi79921.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000372629; ENSP00000361712; ENSG00000133142. [Q96EI5-2]
ENST00000415568; ENSP00000415564; ENSG00000133142. [Q96EI5-1]
ENST00000468024; ENSP00000421857; ENSG00000133142. [Q96EI5-1]
ENST00000472484; ENSP00000421156; ENSG00000133142. [Q96EI5-1]
ENST00000472745; ENSP00000424314; ENSG00000133142. [Q96EI5-1]
ENST00000494801; ENSP00000427494; ENSG00000133142. [Q96EI5-1]
GeneIDi79921.
KEGGihsa:79921.
UCSCiuc004ekl.3. human. [Q96EI5-1]

Organism-specific databases

CTDi79921.
GeneCardsiGC0XP102831.
HGNCiHGNC:26121. TCEAL4.
neXtProtiNX_Q96EI5.
PharmGKBiPA128394724.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG79939.
GeneTreeiENSGT00510000046867.
HOGENOMiHOG000231342.
HOVERGENiHBG055896.
InParanoidiQ96EI5.
OMAiGGLRVCC.
OrthoDBiEOG79KPGM.
PhylomeDBiQ96EI5.
TreeFamiTF336871.

Miscellaneous databases

ChiTaRSiTCEAL4. human.
GeneWikiiTCEAL4.
GenomeRNAii79921.
NextBioi69816.
PROiQ96EI5.

Gene expression databases

BgeeiQ96EI5.
CleanExiHS_TCEAL4.
ExpressionAtlasiQ96EI5. baseline and differential.
GenevestigatoriQ96EI5.

Family and domain databases

InterProiIPR021156. TF_A-like/BEX-like.
IPR010370. TFA.
[Graphical view]
PANTHERiPTHR14754. PTHR14754. 1 hit.
PfamiPF04538. BEX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of human B lymphocyte activation-related novel gene."
    Lu X.W., Yin J.Y., Cui L.X.
    Zhongguo Yi Xue Ke Xue Yuan Xue Bao 23:27-31(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  2. Xu X., Yang Y., Gao G., Xiao H., Chen Z., Han Z.
    Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Pituitary.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Smooth muscle.
  4. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Placenta.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiTCAL4_HUMAN
AccessioniPrimary (citable) accession number: Q96EI5
Secondary accession number(s): Q8WY12, Q9H2H1, Q9H775
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: May 30, 2006
Last modified: January 7, 2015
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.