SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q96EI5

- TCAL4_HUMAN

UniProt

Q96EI5 - TCAL4_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Transcription elongation factor A protein-like 4

Gene
TCEAL4, NPD017
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription elongation factor A protein-like 4
Short name:
TCEA-like protein 4
Alternative name(s):
Transcription elongation factor S-II protein-like 4
Gene namesi
Name:TCEAL4
ORF Names:NPD017
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome X

Organism-specific databases

HGNCiHGNC:26121. TCEAL4.

Subcellular locationi

Nucleus Inferred

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA128394724.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 215215Transcription elongation factor A protein-like 4PRO_0000239209Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ96EI5.
PaxDbiQ96EI5.
PRIDEiQ96EI5.

PTM databases

PhosphoSiteiQ96EI5.

Expressioni

Gene expression databases

ArrayExpressiQ96EI5.
BgeeiQ96EI5.
CleanExiHS_TCEAL4.
GenevestigatoriQ96EI5.

Interactioni

Protein-protein interaction databases

BioGridi122998. 9 interactions.
IntActiQ96EI5. 4 interactions.
STRINGi9606.ENSP00000378477.

Structurei

3D structure databases

ProteinModelPortaliQ96EI5.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi2 – 109108Glu-richAdd
BLAST

Sequence similaritiesi

Belongs to the TFS-II family. TFA subfamily.

Phylogenomic databases

eggNOGiNOG79939.
HOGENOMiHOG000231342.
HOVERGENiHBG055896.
InParanoidiQ96EI5.
OMAiGGLRVCC.
OrthoDBiEOG79KPGM.
PhylomeDBiQ96EI5.
TreeFamiTF336871.

Family and domain databases

InterProiIPR021156. TF_A-like/BEX-like.
IPR010370. TFA.
[Graphical view]
PANTHERiPTHR14754. PTHR14754. 1 hit.
PfamiPF04538. BEX. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q96EI5-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MEKLYSENEG MASNQGKMEN EEQPQDERKP EVTCTLEDKK LENEGKTENK    50
GKTGDEEMLK DKGKPESEGE AKEGKSEREG ESEMEGGSER EGKPEIEGKP 100
ESEGEPGSET RAAGKRPAED DVPRKAKRKT NKGLAHYLKE YKEAIHDMNF 150
SNEDMIREFD NMAKVQDEKR KSKQKLGAFL WMQRNLQDPF YPRGPREFRG 200
GCRAPRRDIE DIPYV 215
Length:215
Mass (Da):24,647
Last modified:May 30, 2006 - v2
Checksum:i53420116CD9A7A0B
GO
Isoform 2 (identifier: Q96EI5-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MPAGGQAPQL...DRKRRGNLDM

Note: No experimental confirmation available.

Show »
Length:358
Mass (Da):40,578
Checksum:i0440D280DE089040
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 11M → MPAGGQAPQLTPVIPAFWEA RGLPNSKGRDKVHICQCEEW KGHISYVERDITTSEIKSLP QVSVRAFHAASGTLEWRKGN GYGRGKGWGWGRVESREAGP SVDRDGGLRVCCSQRSAKPE KEEQPVQNPRRSVKDRKRRG NLDM in isoform 2. VSP_019109

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti132 – 1321K → T in AAH12296. 1 Publication
Sequence conflicti157 – 1571R → G in BAB15023. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF314542 mRNA. Translation: AAL40909.1.
AF271783 mRNA. Translation: AAG44794.1.
AK024827 mRNA. Translation: BAB15023.1.
Z73965 Genomic DNA. Translation: CAI42031.1.
BC012296 mRNA. Translation: AAH12296.1.
CCDSiCCDS14510.2. [Q96EI5-1]
RefSeqiNP_001006936.1. NM_001006935.1. [Q96EI5-1]
NP_001006938.1. NM_001006937.1. [Q96EI5-1]
NP_079139.4. NM_024863.4. [Q96EI5-1]
XP_005262249.1. XM_005262192.1. [Q96EI5-2]
XP_005262250.1. XM_005262193.2. [Q96EI5-1]
XP_005262251.1. XM_005262194.2. [Q96EI5-1]
UniGeneiHs.194329.

Genome annotation databases

EnsembliENST00000372629; ENSP00000361712; ENSG00000133142. [Q96EI5-2]
ENST00000415568; ENSP00000415564; ENSG00000133142. [Q96EI5-1]
ENST00000468024; ENSP00000421857; ENSG00000133142. [Q96EI5-1]
ENST00000472484; ENSP00000421156; ENSG00000133142. [Q96EI5-1]
ENST00000472745; ENSP00000424314; ENSG00000133142. [Q96EI5-1]
ENST00000494801; ENSP00000427494; ENSG00000133142. [Q96EI5-1]
GeneIDi79921.
KEGGihsa:79921.
UCSCiuc004ekl.3. human. [Q96EI5-1]

Polymorphism databases

DMDMi108935938.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF314542 mRNA. Translation: AAL40909.1 .
AF271783 mRNA. Translation: AAG44794.1 .
AK024827 mRNA. Translation: BAB15023.1 .
Z73965 Genomic DNA. Translation: CAI42031.1 .
BC012296 mRNA. Translation: AAH12296.1 .
CCDSi CCDS14510.2. [Q96EI5-1 ]
RefSeqi NP_001006936.1. NM_001006935.1. [Q96EI5-1 ]
NP_001006938.1. NM_001006937.1. [Q96EI5-1 ]
NP_079139.4. NM_024863.4. [Q96EI5-1 ]
XP_005262249.1. XM_005262192.1. [Q96EI5-2 ]
XP_005262250.1. XM_005262193.2. [Q96EI5-1 ]
XP_005262251.1. XM_005262194.2. [Q96EI5-1 ]
UniGenei Hs.194329.

3D structure databases

ProteinModelPortali Q96EI5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 122998. 9 interactions.
IntActi Q96EI5. 4 interactions.
STRINGi 9606.ENSP00000378477.

PTM databases

PhosphoSitei Q96EI5.

Polymorphism databases

DMDMi 108935938.

Proteomic databases

MaxQBi Q96EI5.
PaxDbi Q96EI5.
PRIDEi Q96EI5.

Protocols and materials databases

DNASUi 79921.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000372629 ; ENSP00000361712 ; ENSG00000133142 . [Q96EI5-2 ]
ENST00000415568 ; ENSP00000415564 ; ENSG00000133142 . [Q96EI5-1 ]
ENST00000468024 ; ENSP00000421857 ; ENSG00000133142 . [Q96EI5-1 ]
ENST00000472484 ; ENSP00000421156 ; ENSG00000133142 . [Q96EI5-1 ]
ENST00000472745 ; ENSP00000424314 ; ENSG00000133142 . [Q96EI5-1 ]
ENST00000494801 ; ENSP00000427494 ; ENSG00000133142 . [Q96EI5-1 ]
GeneIDi 79921.
KEGGi hsa:79921.
UCSCi uc004ekl.3. human. [Q96EI5-1 ]

Organism-specific databases

CTDi 79921.
GeneCardsi GC0XP102831.
HGNCi HGNC:26121. TCEAL4.
neXtProti NX_Q96EI5.
PharmGKBi PA128394724.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG79939.
HOGENOMi HOG000231342.
HOVERGENi HBG055896.
InParanoidi Q96EI5.
OMAi GGLRVCC.
OrthoDBi EOG79KPGM.
PhylomeDBi Q96EI5.
TreeFami TF336871.

Miscellaneous databases

ChiTaRSi TCEAL4. human.
GeneWikii TCEAL4.
GenomeRNAii 79921.
NextBioi 69816.
PROi Q96EI5.

Gene expression databases

ArrayExpressi Q96EI5.
Bgeei Q96EI5.
CleanExi HS_TCEAL4.
Genevestigatori Q96EI5.

Family and domain databases

InterProi IPR021156. TF_A-like/BEX-like.
IPR010370. TFA.
[Graphical view ]
PANTHERi PTHR14754. PTHR14754. 1 hit.
Pfami PF04538. BEX. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of human B lymphocyte activation-related novel gene."
    Lu X.W., Yin J.Y., Cui L.X.
    Zhongguo Yi Xue Ke Xue Yuan Xue Bao 23:27-31(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  2. Xu X., Yang Y., Gao G., Xiao H., Chen Z., Han Z.
    Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Pituitary.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Smooth muscle.
  4. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Placenta.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiTCAL4_HUMAN
AccessioniPrimary (citable) accession number: Q96EI5
Secondary accession number(s): Q8WY12, Q9H2H1, Q9H775
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: May 30, 2006
Last modified: July 9, 2014
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi