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Q96EI5

- TCAL4_HUMAN

UniProt

Q96EI5 - TCAL4_HUMAN

Protein

Transcription elongation factor A protein-like 4

Gene

TCEAL4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 2 (30 May 2006)
      Previous versions | rss
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    Functioni

    May be involved in transcriptional regulation.

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transcription elongation factor A protein-like 4
    Short name:
    TCEA-like protein 4
    Alternative name(s):
    Transcription elongation factor S-II protein-like 4
    Gene namesi
    Name:TCEAL4
    ORF Names:NPD017
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:26121. TCEAL4.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA128394724.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 215215Transcription elongation factor A protein-like 4PRO_0000239209Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionine1 Publication

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ96EI5.
    PaxDbiQ96EI5.
    PRIDEiQ96EI5.

    PTM databases

    PhosphoSiteiQ96EI5.

    Expressioni

    Gene expression databases

    ArrayExpressiQ96EI5.
    BgeeiQ96EI5.
    CleanExiHS_TCEAL4.
    GenevestigatoriQ96EI5.

    Interactioni

    Protein-protein interaction databases

    BioGridi122998. 9 interactions.
    IntActiQ96EI5. 4 interactions.
    STRINGi9606.ENSP00000378477.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96EI5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi2 – 109108Glu-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the TFS-II family. TFA subfamily.Curated

    Phylogenomic databases

    eggNOGiNOG79939.
    HOGENOMiHOG000231342.
    HOVERGENiHBG055896.
    InParanoidiQ96EI5.
    OMAiGGLRVCC.
    OrthoDBiEOG79KPGM.
    PhylomeDBiQ96EI5.
    TreeFamiTF336871.

    Family and domain databases

    InterProiIPR021156. TF_A-like/BEX-like.
    IPR010370. TFA.
    [Graphical view]
    PANTHERiPTHR14754. PTHR14754. 1 hit.
    PfamiPF04538. BEX. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q96EI5-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEKLYSENEG MASNQGKMEN EEQPQDERKP EVTCTLEDKK LENEGKTENK    50
    GKTGDEEMLK DKGKPESEGE AKEGKSEREG ESEMEGGSER EGKPEIEGKP 100
    ESEGEPGSET RAAGKRPAED DVPRKAKRKT NKGLAHYLKE YKEAIHDMNF 150
    SNEDMIREFD NMAKVQDEKR KSKQKLGAFL WMQRNLQDPF YPRGPREFRG 200
    GCRAPRRDIE DIPYV 215
    Length:215
    Mass (Da):24,647
    Last modified:May 30, 2006 - v2
    Checksum:i53420116CD9A7A0B
    GO
    Isoform 2 (identifier: Q96EI5-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1: M → MPAGGQAPQL...DRKRRGNLDM

    Note: No experimental confirmation available.

    Show »
    Length:358
    Mass (Da):40,578
    Checksum:i0440D280DE089040
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti132 – 1321K → T in AAH12296. (PubMed:15489334)Curated
    Sequence conflicti157 – 1571R → G in BAB15023. (PubMed:14702039)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 11M → MPAGGQAPQLTPVIPAFWEA RGLPNSKGRDKVHICQCEEW KGHISYVERDITTSEIKSLP QVSVRAFHAASGTLEWRKGN GYGRGKGWGWGRVESREAGP SVDRDGGLRVCCSQRSAKPE KEEQPVQNPRRSVKDRKRRG NLDM in isoform 2. 1 PublicationVSP_019109

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF314542 mRNA. Translation: AAL40909.1.
    AF271783 mRNA. Translation: AAG44794.1.
    AK024827 mRNA. Translation: BAB15023.1.
    Z73965 Genomic DNA. Translation: CAI42031.1.
    BC012296 mRNA. Translation: AAH12296.1.
    CCDSiCCDS14510.2. [Q96EI5-1]
    RefSeqiNP_001006936.1. NM_001006935.1. [Q96EI5-1]
    NP_001006938.1. NM_001006937.1. [Q96EI5-1]
    NP_079139.4. NM_024863.4. [Q96EI5-1]
    XP_005262249.1. XM_005262192.1. [Q96EI5-2]
    XP_005262250.1. XM_005262193.2. [Q96EI5-1]
    XP_005262251.1. XM_005262194.2. [Q96EI5-1]
    UniGeneiHs.194329.

    Genome annotation databases

    EnsembliENST00000372629; ENSP00000361712; ENSG00000133142. [Q96EI5-2]
    ENST00000415568; ENSP00000415564; ENSG00000133142. [Q96EI5-1]
    ENST00000468024; ENSP00000421857; ENSG00000133142. [Q96EI5-1]
    ENST00000472484; ENSP00000421156; ENSG00000133142. [Q96EI5-1]
    ENST00000472745; ENSP00000424314; ENSG00000133142. [Q96EI5-1]
    ENST00000494801; ENSP00000427494; ENSG00000133142. [Q96EI5-1]
    GeneIDi79921.
    KEGGihsa:79921.
    UCSCiuc004ekl.3. human. [Q96EI5-1]

    Polymorphism databases

    DMDMi108935938.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF314542 mRNA. Translation: AAL40909.1 .
    AF271783 mRNA. Translation: AAG44794.1 .
    AK024827 mRNA. Translation: BAB15023.1 .
    Z73965 Genomic DNA. Translation: CAI42031.1 .
    BC012296 mRNA. Translation: AAH12296.1 .
    CCDSi CCDS14510.2. [Q96EI5-1 ]
    RefSeqi NP_001006936.1. NM_001006935.1. [Q96EI5-1 ]
    NP_001006938.1. NM_001006937.1. [Q96EI5-1 ]
    NP_079139.4. NM_024863.4. [Q96EI5-1 ]
    XP_005262249.1. XM_005262192.1. [Q96EI5-2 ]
    XP_005262250.1. XM_005262193.2. [Q96EI5-1 ]
    XP_005262251.1. XM_005262194.2. [Q96EI5-1 ]
    UniGenei Hs.194329.

    3D structure databases

    ProteinModelPortali Q96EI5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 122998. 9 interactions.
    IntActi Q96EI5. 4 interactions.
    STRINGi 9606.ENSP00000378477.

    PTM databases

    PhosphoSitei Q96EI5.

    Polymorphism databases

    DMDMi 108935938.

    Proteomic databases

    MaxQBi Q96EI5.
    PaxDbi Q96EI5.
    PRIDEi Q96EI5.

    Protocols and materials databases

    DNASUi 79921.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000372629 ; ENSP00000361712 ; ENSG00000133142 . [Q96EI5-2 ]
    ENST00000415568 ; ENSP00000415564 ; ENSG00000133142 . [Q96EI5-1 ]
    ENST00000468024 ; ENSP00000421857 ; ENSG00000133142 . [Q96EI5-1 ]
    ENST00000472484 ; ENSP00000421156 ; ENSG00000133142 . [Q96EI5-1 ]
    ENST00000472745 ; ENSP00000424314 ; ENSG00000133142 . [Q96EI5-1 ]
    ENST00000494801 ; ENSP00000427494 ; ENSG00000133142 . [Q96EI5-1 ]
    GeneIDi 79921.
    KEGGi hsa:79921.
    UCSCi uc004ekl.3. human. [Q96EI5-1 ]

    Organism-specific databases

    CTDi 79921.
    GeneCardsi GC0XP102831.
    HGNCi HGNC:26121. TCEAL4.
    neXtProti NX_Q96EI5.
    PharmGKBi PA128394724.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG79939.
    HOGENOMi HOG000231342.
    HOVERGENi HBG055896.
    InParanoidi Q96EI5.
    OMAi GGLRVCC.
    OrthoDBi EOG79KPGM.
    PhylomeDBi Q96EI5.
    TreeFami TF336871.

    Miscellaneous databases

    ChiTaRSi TCEAL4. human.
    GeneWikii TCEAL4.
    GenomeRNAii 79921.
    NextBioi 69816.
    PROi Q96EI5.

    Gene expression databases

    ArrayExpressi Q96EI5.
    Bgeei Q96EI5.
    CleanExi HS_TCEAL4.
    Genevestigatori Q96EI5.

    Family and domain databases

    InterProi IPR021156. TF_A-like/BEX-like.
    IPR010370. TFA.
    [Graphical view ]
    PANTHERi PTHR14754. PTHR14754. 1 hit.
    Pfami PF04538. BEX. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of human B lymphocyte activation-related novel gene."
      Lu X.W., Yin J.Y., Cui L.X.
      Zhongguo Yi Xue Ke Xue Yuan Xue Bao 23:27-31(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    2. Xu X., Yang Y., Gao G., Xiao H., Chen Z., Han Z.
      Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Pituitary.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Smooth muscle.
    4. "The DNA sequence of the human X chromosome."
      Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
      , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
      Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Placenta.
    6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    7. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiTCAL4_HUMAN
    AccessioniPrimary (citable) accession number: Q96EI5
    Secondary accession number(s): Q8WY12, Q9H2H1, Q9H775
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2006
    Last sequence update: May 30, 2006
    Last modified: October 1, 2014
    This is version 96 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3