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Protein

Transcription elongation factor A protein-like 4

Gene

TCEAL4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription elongation factor A protein-like 4
Short name:
TCEA-like protein 4
Alternative name(s):
Transcription elongation factor S-II protein-like 4
Gene namesi
Name:TCEAL4
ORF Names:NPD017
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000133142.17
HGNCiHGNC:26121 TCEAL4
neXtProtiNX_Q96EI5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi79921
OpenTargetsiENSG00000133142
PharmGKBiPA128394724

Polymorphism and mutation databases

BioMutaiTCEAL4
DMDMi108935938

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002392091 – 215Transcription elongation factor A protein-like 4Add BLAST215

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei6PhosphoserineCombined sources1
Modified residuei88PhosphoserineCombined sources1
Modified residuei102PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ96EI5
MaxQBiQ96EI5
PaxDbiQ96EI5
PeptideAtlasiQ96EI5
PRIDEiQ96EI5

PTM databases

iPTMnetiQ96EI5
PhosphoSitePlusiQ96EI5

Expressioni

Gene expression databases

BgeeiENSG00000133142
CleanExiHS_TCEAL4
ExpressionAtlasiQ96EI5 baseline and differential
GenevisibleiQ96EI5 HS

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi122998, 24 interactors
IntActiQ96EI5, 16 interactors
STRINGi9606.ENSP00000415564

Structurei

3D structure databases

ProteinModelPortaliQ96EI5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi2 – 109Glu-richAdd BLAST108

Sequence similaritiesi

Belongs to the TFS-II family. TFA subfamily.Curated

Phylogenomic databases

eggNOGiENOG410KDY0 Eukaryota
ENOG4111ECD LUCA
GeneTreeiENSGT00510000046867
HOGENOMiHOG000231342
HOVERGENiHBG055896
InParanoidiQ96EI5
OMAiDNMAKVQ
OrthoDBiEOG091G0OCO
PhylomeDBiQ96EI5
TreeFamiTF336871

Family and domain databases

InterProiView protein in InterPro
IPR021156 TF_A-like/BEX
PfamiView protein in Pfam
PF04538 BEX, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96EI5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEKLYSENEG MASNQGKMEN EEQPQDERKP EVTCTLEDKK LENEGKTENK
60 70 80 90 100
GKTGDEEMLK DKGKPESEGE AKEGKSEREG ESEMEGGSER EGKPEIEGKP
110 120 130 140 150
ESEGEPGSET RAAGKRPAED DVPRKAKRKT NKGLAHYLKE YKEAIHDMNF
160 170 180 190 200
SNEDMIREFD NMAKVQDEKR KSKQKLGAFL WMQRNLQDPF YPRGPREFRG
210
GCRAPRRDIE DIPYV
Length:215
Mass (Da):24,647
Last modified:May 30, 2006 - v2
Checksum:i53420116CD9A7A0B
GO
Isoform 2 (identifier: Q96EI5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MPAGGQAPQL...DRKRRGNLDM

Note: No experimental confirmation available.
Show »
Length:358
Mass (Da):40,578
Checksum:i0440D280DE089040
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti132K → T in AAH12296 (PubMed:15489334).Curated1
Sequence conflicti157R → G in BAB15023 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0191091M → MPAGGQAPQLTPVIPAFWEA RGLPNSKGRDKVHICQCEEW KGHISYVERDITTSEIKSLP QVSVRAFHAASGTLEWRKGN GYGRGKGWGWGRVESREAGP SVDRDGGLRVCCSQRSAKPE KEEQPVQNPRRSVKDRKRRG NLDM in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF314542 mRNA Translation: AAL40909.1
AF271783 mRNA Translation: AAG44794.1
AK024827 mRNA Translation: BAB15023.1
Z73965 Genomic DNA No translation available.
BC012296 mRNA Translation: AAH12296.1
CCDSiCCDS14510.2 [Q96EI5-1]
CCDS76004.1 [Q96EI5-2]
RefSeqiNP_001006936.1, NM_001006935.2 [Q96EI5-1]
NP_001006938.1, NM_001006937.2 [Q96EI5-1]
NP_001287830.1, NM_001300901.1 [Q96EI5-2]
NP_001292769.1, NM_001305840.1 [Q96EI5-1]
NP_001292770.1, NM_001305841.1 [Q96EI5-1]
NP_001292771.1, NM_001305842.1 [Q96EI5-1]
NP_079139.4, NM_024863.5 [Q96EI5-1]
XP_016885346.1, XM_017029857.1 [Q96EI5-1]
UniGeneiHs.194329

Genome annotation databases

EnsembliENST00000372629; ENSP00000361712; ENSG00000133142 [Q96EI5-2]
ENST00000415568; ENSP00000415564; ENSG00000133142 [Q96EI5-1]
ENST00000468024; ENSP00000421857; ENSG00000133142 [Q96EI5-1]
ENST00000472484; ENSP00000421156; ENSG00000133142 [Q96EI5-1]
ENST00000472745; ENSP00000424314; ENSG00000133142 [Q96EI5-1]
ENST00000494801; ENSP00000427494; ENSG00000133142 [Q96EI5-1]
GeneIDi79921
KEGGihsa:79921
UCSCiuc004ekl.4 human [Q96EI5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiTCAL4_HUMAN
AccessioniPrimary (citable) accession number: Q96EI5
Secondary accession number(s): Q8WY12, Q9H2H1, Q9H775
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: May 30, 2006
Last modified: March 28, 2018
This is version 124 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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