Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Mitochondrial assembly of ribosomal large subunit protein 1

Gene

MALSU1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May function as a ribosomal silencing factor. Addition to isolated mitochondrial ribosomal subunits partially inhibits translation. Interacts with mitochondrial ribosomal protein L14 (MRPL14), probably blocking formation of intersubunit bridge B8, preventing association of the 28S and 39S ribosomal subunits and the formation of functional ribosomes, thus repressing translation. May also participate in the assembly and/or regulation of the stability of the large subunit of the mitochondrial ribosome.1 Publication

GO - Molecular functioni

GO - Biological processi

  • negative regulation of mitochondrial translation Source: UniProtKB
  • negative regulation of ribosome biogenesis Source: GO_Central
  • ribosomal large subunit biogenesis Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Enzyme and pathway databases

BioCyciZFISH:ENSG00000156928-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial assembly of ribosomal large subunit protein 1
Gene namesi
Name:MALSU1
Synonyms:C7orf30
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:21721. MALSU1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: HPA
  • mitochondrial matrix Source: UniProtKB-SubCell
  • mitochondrion Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000156928.
PharmGKBiPA134866345.

Polymorphism and mutation databases

BioMutaiMALSU1.
DMDMi74731563.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002281081 – 234Mitochondrial assembly of ribosomal large subunit protein 1Add BLAST234

Proteomic databases

EPDiQ96EH3.
MaxQBiQ96EH3.
PaxDbiQ96EH3.
PeptideAtlasiQ96EH3.
PRIDEiQ96EH3.

PTM databases

iPTMnetiQ96EH3.
PhosphoSitePlusiQ96EH3.

Expressioni

Gene expression databases

BgeeiENSG00000156928.
CleanExiHS_C7orf30.
GenevisibleiQ96EH3. HS.

Organism-specific databases

HPAiHPA020487.
HPA052210.

Interactioni

Subunit structurei

Associates with the mitochondrial ribosome large subunit (39S). Interacts with MRPL12 and MRPL14.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
DCTDP323213EBI-2339737,EBI-739870

Protein-protein interaction databases

BioGridi125433. 32 interactors.
IntActiQ96EH3. 7 interactors.
MINTiMINT-8051854.
STRINGi9606.ENSP00000419370.

Structurei

3D structure databases

ProteinModelPortaliQ96EH3.
SMRiQ96EH3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Iojap/RsfS family.Curated

Phylogenomic databases

eggNOGiKOG3212. Eukaryota.
COG0799. LUCA.
GeneTreeiENSGT00390000015035.
HOGENOMiHOG000252940.
HOVERGENiHBG081123.
InParanoidiQ96EH3.
OMAiDHTGPKF.
OrthoDBiEOG091G0TZ9.
PhylomeDBiQ96EH3.
TreeFamiTF326763.

Family and domain databases

HAMAPiMF_01477. Iojap_RsfS. 1 hit.
InterProiIPR004394. Iojap/RsfS/C7orf30.
[Graphical view]
PANTHERiPTHR21043. PTHR21043. 1 hit.
TIGRFAMsiTIGR00090. rsfS_iojap_ybeB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q96EH3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGPGGRVARL LAPLMWRRAV SSVAGSAVGA EPGLRLLAVQ RLPVGAAFCR
60 70 80 90 100
ACQTPNFVRG LHSEPGLEER AEGTVNEGRP ESDAADHTGP KFDIDMMVSL
110 120 130 140 150
LRQENARDIC VIQVPPEMRY TDYFVIVSGT STRHLHAMAF YVVKMYKHLK
160 170 180 190 200
CKRDPHVKIE GKDTDDWLCV DFGSMVIHLM LPETREIYEL EKLWTLRSYD
210 220 230
DQLAQIAPET VPEDFILGIE DDTSSVTPVE LKCE
Length:234
Mass (Da):26,170
Last modified:December 1, 2001 - v1
Checksum:iD0B1CD0C9562FF2A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK316559 mRNA. Translation: BAG38148.1.
AK127742 mRNA. Translation: BAG54562.1.
AC005082 Genomic DNA. No translation available.
CH236948 Genomic DNA. Translation: EAL24258.1.
CH471073 Genomic DNA. Translation: EAW93785.1.
BC012331 mRNA. Translation: AAH12331.1.
CCDSiCCDS5381.1.
RefSeqiNP_612455.1. NM_138446.1.
UniGeneiHs.87385.

Genome annotation databases

EnsembliENST00000466681; ENSP00000419370; ENSG00000156928.
GeneIDi115416.
KEGGihsa:115416.
UCSCiuc003swd.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK316559 mRNA. Translation: BAG38148.1.
AK127742 mRNA. Translation: BAG54562.1.
AC005082 Genomic DNA. No translation available.
CH236948 Genomic DNA. Translation: EAL24258.1.
CH471073 Genomic DNA. Translation: EAW93785.1.
BC012331 mRNA. Translation: AAH12331.1.
CCDSiCCDS5381.1.
RefSeqiNP_612455.1. NM_138446.1.
UniGeneiHs.87385.

3D structure databases

ProteinModelPortaliQ96EH3.
SMRiQ96EH3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125433. 32 interactors.
IntActiQ96EH3. 7 interactors.
MINTiMINT-8051854.
STRINGi9606.ENSP00000419370.

PTM databases

iPTMnetiQ96EH3.
PhosphoSitePlusiQ96EH3.

Polymorphism and mutation databases

BioMutaiMALSU1.
DMDMi74731563.

Proteomic databases

EPDiQ96EH3.
MaxQBiQ96EH3.
PaxDbiQ96EH3.
PeptideAtlasiQ96EH3.
PRIDEiQ96EH3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000466681; ENSP00000419370; ENSG00000156928.
GeneIDi115416.
KEGGihsa:115416.
UCSCiuc003swd.2. human.

Organism-specific databases

CTDi115416.
GeneCardsiMALSU1.
H-InvDBHIX0201159.
HGNCiHGNC:21721. MALSU1.
HPAiHPA020487.
HPA052210.
MIMi614624. gene.
neXtProtiNX_Q96EH3.
OpenTargetsiENSG00000156928.
PharmGKBiPA134866345.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3212. Eukaryota.
COG0799. LUCA.
GeneTreeiENSGT00390000015035.
HOGENOMiHOG000252940.
HOVERGENiHBG081123.
InParanoidiQ96EH3.
OMAiDHTGPKF.
OrthoDBiEOG091G0TZ9.
PhylomeDBiQ96EH3.
TreeFamiTF326763.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000156928-MONOMER.

Miscellaneous databases

ChiTaRSiMALSU1. human.
GeneWikiiC7orf30.
GenomeRNAii115416.
PROiQ96EH3.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000156928.
CleanExiHS_C7orf30.
GenevisibleiQ96EH3. HS.

Family and domain databases

HAMAPiMF_01477. Iojap_RsfS. 1 hit.
InterProiIPR004394. Iojap/RsfS/C7orf30.
[Graphical view]
PANTHERiPTHR21043. PTHR21043. 1 hit.
TIGRFAMsiTIGR00090. rsfS_iojap_ybeB. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMASU1_HUMAN
AccessioniPrimary (citable) accession number: Q96EH3
Secondary accession number(s): A4D154
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: December 1, 2001
Last modified: November 30, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.