Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q96EH3

- MASU1_HUMAN

UniProt

Q96EH3 - MASU1_HUMAN

Protein

Mitochondrial assembly of ribosomal large subunit protein 1

Gene

MALSU1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    May function as a ribosomal silencing factor. Addition to isolated mitochondrial ribosomal subunits partially inhibits translation. Interacts with mitochondrial ribosomal protein L14 (MRPL14), probably blocking formation of intersubunit bridge B8, preventing association of the 28S and 39S ribosomal subunits and the formation of functional ribosomes, thus repressing translation. May also participate in the assembly and/or regulation of the stability of the large subunit of the mitochondrial ribosome.1 Publication

    GO - Biological processi

    1. negative regulation of mitochondrial translation Source: UniProtKB
    2. ribosomal large subunit biogenesis Source: UniProtKB

    Keywords - Molecular functioni

    Repressor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mitochondrial assembly of ribosomal large subunit protein 1
    Gene namesi
    Name:MALSU1
    Synonyms:C7orf30
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:21721. MALSU1.

    Subcellular locationi

    Mitochondrion matrix 4 Publications
    Note: Colocalizes with MRPL12 (PubMed:22238375) and/or MRPL14 (PubMed:22829778).2 Publications

    GO - Cellular componenti

    1. mitochondrial matrix Source: UniProtKB-SubCell
    2. mitochondrion Source: UniProtKB

    Keywords - Cellular componenti

    Mitochondrion

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134866345.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 234234Mitochondrial assembly of ribosomal large subunit protein 1PRO_0000228108Add
    BLAST

    Proteomic databases

    MaxQBiQ96EH3.
    PaxDbiQ96EH3.
    PRIDEiQ96EH3.

    PTM databases

    PhosphoSiteiQ96EH3.

    Expressioni

    Gene expression databases

    BgeeiQ96EH3.
    CleanExiHS_C7orf30.
    GenevestigatoriQ96EH3.

    Organism-specific databases

    HPAiHPA020487.
    HPA052210.

    Interactioni

    Subunit structurei

    Associates with the mitochondrial ribosome large subunit (39S). Interacts with MRPL12 and MRPL14.2 Publications

    Protein-protein interaction databases

    BioGridi125433. 4 interactions.
    IntActiQ96EH3. 2 interactions.
    MINTiMINT-8051854.
    STRINGi9606.ENSP00000419370.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96EH3.
    SMRiQ96EH3. Positions 96-194.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the Iojap/RsfS family.Curated

    Phylogenomic databases

    eggNOGiCOG0799.
    HOGENOMiHOG000252940.
    HOVERGENiHBG081123.
    InParanoidiQ96EH3.
    OMAiDHTGPKF.
    OrthoDBiEOG70W3FR.
    PhylomeDBiQ96EH3.
    TreeFamiTF326763.

    Family and domain databases

    HAMAPiMF_01477. Iojap_RsfS.
    InterProiIPR004394. Iojap/RsfS.
    IPR025656. Oligomer_dom.
    [Graphical view]
    PANTHERiPTHR21043. PTHR21043. 1 hit.
    PfamiPF02410. Oligomerisation. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00090. iojap_ybeB. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q96EH3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGPGGRVARL LAPLMWRRAV SSVAGSAVGA EPGLRLLAVQ RLPVGAAFCR    50
    ACQTPNFVRG LHSEPGLEER AEGTVNEGRP ESDAADHTGP KFDIDMMVSL 100
    LRQENARDIC VIQVPPEMRY TDYFVIVSGT STRHLHAMAF YVVKMYKHLK 150
    CKRDPHVKIE GKDTDDWLCV DFGSMVIHLM LPETREIYEL EKLWTLRSYD 200
    DQLAQIAPET VPEDFILGIE DDTSSVTPVE LKCE 234
    Length:234
    Mass (Da):26,170
    Last modified:December 1, 2001 - v1
    Checksum:iD0B1CD0C9562FF2A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK316559 mRNA. Translation: BAG38148.1.
    AK127742 mRNA. Translation: BAG54562.1.
    AC005082 Genomic DNA. No translation available.
    CH236948 Genomic DNA. Translation: EAL24258.1.
    CH471073 Genomic DNA. Translation: EAW93785.1.
    BC012331 mRNA. Translation: AAH12331.1.
    CCDSiCCDS5381.1.
    RefSeqiNP_612455.1. NM_138446.1.
    UniGeneiHs.87385.

    Genome annotation databases

    EnsembliENST00000466681; ENSP00000419370; ENSG00000156928.
    GeneIDi115416.
    KEGGihsa:115416.
    UCSCiuc003swd.1. human.

    Polymorphism databases

    DMDMi74731563.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK316559 mRNA. Translation: BAG38148.1 .
    AK127742 mRNA. Translation: BAG54562.1 .
    AC005082 Genomic DNA. No translation available.
    CH236948 Genomic DNA. Translation: EAL24258.1 .
    CH471073 Genomic DNA. Translation: EAW93785.1 .
    BC012331 mRNA. Translation: AAH12331.1 .
    CCDSi CCDS5381.1.
    RefSeqi NP_612455.1. NM_138446.1.
    UniGenei Hs.87385.

    3D structure databases

    ProteinModelPortali Q96EH3.
    SMRi Q96EH3. Positions 96-194.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 125433. 4 interactions.
    IntActi Q96EH3. 2 interactions.
    MINTi MINT-8051854.
    STRINGi 9606.ENSP00000419370.

    PTM databases

    PhosphoSitei Q96EH3.

    Polymorphism databases

    DMDMi 74731563.

    Proteomic databases

    MaxQBi Q96EH3.
    PaxDbi Q96EH3.
    PRIDEi Q96EH3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000466681 ; ENSP00000419370 ; ENSG00000156928 .
    GeneIDi 115416.
    KEGGi hsa:115416.
    UCSCi uc003swd.1. human.

    Organism-specific databases

    CTDi 115416.
    GeneCardsi GC07P023338.
    H-InvDB HIX0201159.
    HGNCi HGNC:21721. MALSU1.
    HPAi HPA020487.
    HPA052210.
    MIMi 614624. gene.
    neXtProti NX_Q96EH3.
    PharmGKBi PA134866345.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0799.
    HOGENOMi HOG000252940.
    HOVERGENi HBG081123.
    InParanoidi Q96EH3.
    OMAi DHTGPKF.
    OrthoDBi EOG70W3FR.
    PhylomeDBi Q96EH3.
    TreeFami TF326763.

    Miscellaneous databases

    GeneWikii C7orf30.
    GenomeRNAii 115416.
    NextBioi 79594.
    PROi Q96EH3.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q96EH3.
    CleanExi HS_C7orf30.
    Genevestigatori Q96EH3.

    Family and domain databases

    HAMAPi MF_01477. Iojap_RsfS.
    InterProi IPR004394. Iojap/RsfS.
    IPR025656. Oligomer_dom.
    [Graphical view ]
    PANTHERi PTHR21043. PTHR21043. 1 hit.
    Pfami PF02410. Oligomerisation. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00090. iojap_ybeB. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Cerebellum and Tongue.
    2. "The DNA sequence of human chromosome 7."
      Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
      , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
      Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "Human chromosome 7: DNA sequence and biology."
      Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
      , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
      Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Eye.
    6. "Alterations of the mitochondrial proteome caused by the absence of mitochondrial DNA: A proteomic view."
      Chevallet M., Lescuyer P., Diemer H., van Dorsselaer A., Leize-Wagner E., Rabilloud T.
      Electrophoresis 27:1574-1583(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.
    7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    8. "C7orf30 is necessary for biogenesis of the large subunit of the mitochondrial ribosome."
      Rorbach J., Gammage P.A., Minczuk M.
      Nucleic Acids Res. 40:4097-4109(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, FUNCTION, ASSOCIATION WITH MITOCHONDRIAL RIBOSOME LARGE SUBUNIT.
    9. "C7orf30 specifically associates with the large subunit of the mitochondrial ribosome and is involved in translation."
      Wanschers B.F., Szklarczyk R., Pajak A., van den Brand M.A., Gloerich J., Rodenburg R.J., Lightowlers R.N., Nijtmans L.G., Huynen M.A.
      Nucleic Acids Res. 40:4040-4051(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, INTERACTION WITH MRPL12.
    10. Cited for: POSSIBLE FUNCTION IN RIBOSOMAL SILENCING, SUBCELLULAR LOCATION, INTERACTION WITH MRPL14.

    Entry informationi

    Entry nameiMASU1_HUMAN
    AccessioniPrimary (citable) accession number: Q96EH3
    Secondary accession number(s): A4D154
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 21, 2006
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 90 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3