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Protein

Mitochondrial assembly of ribosomal large subunit protein 1

Gene

MALSU1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May function as a ribosomal silencing factor. Addition to isolated mitochondrial ribosomal subunits partially inhibits translation. Interacts with mitochondrial ribosomal protein L14 (MRPL14), probably blocking formation of intersubunit bridge B8, preventing association of the 28S and 39S ribosomal subunits and the formation of functional ribosomes, thus repressing translation. May also participate in the assembly and/or regulation of the stability of the large subunit of the mitochondrial ribosome.1 Publication

GO - Molecular functioni

GO - Biological processi

  • negative regulation of mitochondrial translation Source: UniProtKB
  • negative regulation of ribosome biogenesis Source: GO_Central
  • ribosomal large subunit biogenesis Source: UniProtKB

Keywordsi

Molecular functionRepressor

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial assembly of ribosomal large subunit protein 1
Gene namesi
Name:MALSU1
Synonyms:C7orf30
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000156928.4.
HGNCiHGNC:21721. MALSU1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000156928.
PharmGKBiPA134866345.

Polymorphism and mutation databases

BioMutaiMALSU1.
DMDMi74731563.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002281081 – 234Mitochondrial assembly of ribosomal large subunit protein 1Add BLAST234

Proteomic databases

EPDiQ96EH3.
MaxQBiQ96EH3.
PaxDbiQ96EH3.
PeptideAtlasiQ96EH3.
PRIDEiQ96EH3.

PTM databases

iPTMnetiQ96EH3.
PhosphoSitePlusiQ96EH3.

Expressioni

Gene expression databases

BgeeiENSG00000156928.
CleanExiHS_C7orf30.
GenevisibleiQ96EH3. HS.

Organism-specific databases

HPAiHPA020487.
HPA052210.

Interactioni

Subunit structurei

Associates with the mitochondrial ribosome large subunit (39S). Interacts with MRPL12 and MRPL14.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
DCTDP323215EBI-2339737,EBI-739870

Protein-protein interaction databases

BioGridi125433. 39 interactors.
IntActiQ96EH3. 9 interactors.
MINTiMINT-8051854.
STRINGi9606.ENSP00000419370.

Structurei

Secondary structure

1234
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi94 – 104Combined sources11
Beta strandi107 – 113Combined sources7
Beta strandi122 – 128Combined sources7
Helixi132 – 149Combined sources18
Beta strandi152 – 154Combined sources3
Beta strandi168 – 171Combined sources4
Beta strandi173 – 180Combined sources8
Helixi182 – 188Combined sources7
Helixi190 – 193Combined sources4
Beta strandi197 – 199Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5OOLelectron microscopy3.06u1-234[»]
5OOMelectron microscopy3.03u1-234[»]
ProteinModelPortaliQ96EH3.
SMRiQ96EH3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Iojap/RsfS family.Curated

Phylogenomic databases

eggNOGiKOG3212. Eukaryota.
COG0799. LUCA.
GeneTreeiENSGT00390000015035.
HOGENOMiHOG000252940.
HOVERGENiHBG081123.
InParanoidiQ96EH3.
OMAiDHTGPKF.
OrthoDBiEOG091G0TZ9.
PhylomeDBiQ96EH3.
TreeFamiTF326763.

Family and domain databases

HAMAPiMF_01477. Iojap_RsfS. 1 hit.
InterProiView protein in InterPro
IPR004394. Iojap/RsfS/C7orf30.
PANTHERiPTHR21043. PTHR21043. 1 hit.
TIGRFAMsiTIGR00090. rsfS_iojap_ybeB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q96EH3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGPGGRVARL LAPLMWRRAV SSVAGSAVGA EPGLRLLAVQ RLPVGAAFCR
60 70 80 90 100
ACQTPNFVRG LHSEPGLEER AEGTVNEGRP ESDAADHTGP KFDIDMMVSL
110 120 130 140 150
LRQENARDIC VIQVPPEMRY TDYFVIVSGT STRHLHAMAF YVVKMYKHLK
160 170 180 190 200
CKRDPHVKIE GKDTDDWLCV DFGSMVIHLM LPETREIYEL EKLWTLRSYD
210 220 230
DQLAQIAPET VPEDFILGIE DDTSSVTPVE LKCE
Length:234
Mass (Da):26,170
Last modified:December 1, 2001 - v1
Checksum:iD0B1CD0C9562FF2A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK316559 mRNA. Translation: BAG38148.1.
AK127742 mRNA. Translation: BAG54562.1.
AC005082 Genomic DNA. No translation available.
CH236948 Genomic DNA. Translation: EAL24258.1.
CH471073 Genomic DNA. Translation: EAW93785.1.
BC012331 mRNA. Translation: AAH12331.1.
CCDSiCCDS5381.1.
RefSeqiNP_612455.1. NM_138446.1.
UniGeneiHs.87385.

Genome annotation databases

EnsembliENST00000466681; ENSP00000419370; ENSG00000156928.
GeneIDi115416.
KEGGihsa:115416.
UCSCiuc003swd.2. human.

Similar proteinsi

Entry informationi

Entry nameiMASU1_HUMAN
AccessioniPrimary (citable) accession number: Q96EH3
Secondary accession number(s): A4D154
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: December 1, 2001
Last modified: November 22, 2017
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families