ID   ZN837_HUMAN             Reviewed;         531 AA.
AC   Q96EG3;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   19-SEP-2006, sequence version 2.
DT   27-MAR-2024, entry version 163.
DE   RecName: Full=Zinc finger protein 837;
GN   Name=ZNF837;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=B-cell;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: May be involved in transcriptional regulation. {ECO:0000250}.
CC   -!- INTERACTION:
CC       Q96EG3; Q8TBE0: BAHD1; NbExp=3; IntAct=EBI-11962574, EBI-742750;
CC       Q96EG3; Q9BUH8: BEGAIN; NbExp=3; IntAct=EBI-11962574, EBI-742722;
CC       Q96EG3; Q9BWT7: CARD10; NbExp=3; IntAct=EBI-11962574, EBI-3866279;
CC       Q96EG3; Q8NEC5: CATSPER1; NbExp=3; IntAct=EBI-11962574, EBI-744545;
CC       Q96EG3; Q86Z20: CCDC125; NbExp=3; IntAct=EBI-11962574, EBI-11977221;
CC       Q96EG3; O95273: CCNDBP1; NbExp=3; IntAct=EBI-11962574, EBI-748961;
CC       Q96EG3; Q16543: CDC37; NbExp=3; IntAct=EBI-11962574, EBI-295634;
CC       Q96EG3; Q9UKJ5: CHIC2; NbExp=3; IntAct=EBI-11962574, EBI-741528;
CC       Q96EG3; P49760: CLK2; NbExp=3; IntAct=EBI-11962574, EBI-750020;
CC       Q96EG3; A8MQ03: CYSRT1; NbExp=3; IntAct=EBI-11962574, EBI-3867333;
CC       Q96EG3; Q6P158: DHX57; NbExp=3; IntAct=EBI-11962574, EBI-1051531;
CC       Q96EG3; Q92997: DVL3; NbExp=3; IntAct=EBI-11962574, EBI-739789;
CC       Q96EG3; O95967: EFEMP2; NbExp=3; IntAct=EBI-11962574, EBI-743414;
CC       Q96EG3; Q96KQ7: EHMT2; NbExp=3; IntAct=EBI-11962574, EBI-744366;
CC       Q96EG3; A1L4K1: FSD2; NbExp=3; IntAct=EBI-11962574, EBI-5661036;
CC       Q96EG3; A6NEM1: GOLGA6L9; NbExp=3; IntAct=EBI-11962574, EBI-5916454;
CC       Q96EG3; Q9NWQ4-1: GPATCH2L; NbExp=3; IntAct=EBI-11962574, EBI-11959863;
CC       Q96EG3; A0A024R8L2: hCG_1987119; NbExp=3; IntAct=EBI-11962574, EBI-14103818;
CC       Q96EG3; P49639: HOXA1; NbExp=5; IntAct=EBI-11962574, EBI-740785;
CC       Q96EG3; Q5VWX1: KHDRBS2; NbExp=3; IntAct=EBI-11962574, EBI-742808;
CC       Q96EG3; Q07627: KRTAP1-1; NbExp=3; IntAct=EBI-11962574, EBI-11959885;
CC       Q96EG3; Q8IUG1: KRTAP1-3; NbExp=3; IntAct=EBI-11962574, EBI-11749135;
CC       Q96EG3; P60409: KRTAP10-7; NbExp=3; IntAct=EBI-11962574, EBI-10172290;
CC       Q96EG3; P60410: KRTAP10-8; NbExp=3; IntAct=EBI-11962574, EBI-10171774;
CC       Q96EG3; P60411: KRTAP10-9; NbExp=3; IntAct=EBI-11962574, EBI-10172052;
CC       Q96EG3; P60328: KRTAP12-3; NbExp=3; IntAct=EBI-11962574, EBI-11953334;
CC       Q96EG3; Q9BYQ6: KRTAP4-11; NbExp=3; IntAct=EBI-11962574, EBI-10302392;
CC       Q96EG3; Q9BQ66: KRTAP4-12; NbExp=3; IntAct=EBI-11962574, EBI-739863;
CC       Q96EG3; Q9BYR2: KRTAP4-5; NbExp=3; IntAct=EBI-11962574, EBI-11993254;
CC       Q96EG3; P26371: KRTAP5-9; NbExp=3; IntAct=EBI-11962574, EBI-3958099;
CC       Q96EG3; Q99750: MDFI; NbExp=3; IntAct=EBI-11962574, EBI-724076;
CC       Q96EG3; Q5JR59-3: MTUS2; NbExp=3; IntAct=EBI-11962574, EBI-11522433;
CC       Q96EG3; P0DPK4: NOTCH2NLC; NbExp=3; IntAct=EBI-11962574, EBI-22310682;
CC       Q96EG3; Q92824-2: PCSK5; NbExp=3; IntAct=EBI-11962574, EBI-11956269;
CC       Q96EG3; Q5T6S3: PHF19; NbExp=3; IntAct=EBI-11962574, EBI-2339674;
CC       Q96EG3; Q03181-2: PPARD; NbExp=3; IntAct=EBI-11962574, EBI-10223258;
CC       Q96EG3; O75864: PPP1R37; NbExp=3; IntAct=EBI-11962574, EBI-5235692;
CC       Q96EG3; Q8WWY3: PRPF31; NbExp=3; IntAct=EBI-11962574, EBI-1567797;
CC       Q96EG3; Q15415: RBMY1J; NbExp=3; IntAct=EBI-11962574, EBI-8642021;
CC       Q96EG3; Q6UXX9-2: RSPO2; NbExp=3; IntAct=EBI-11962574, EBI-12009390;
CC       Q96EG3; Q7Z698: SPRED2; NbExp=6; IntAct=EBI-11962574, EBI-7082156;
CC       Q96EG3; O43609: SPRY1; NbExp=3; IntAct=EBI-11962574, EBI-3866665;
CC       Q96EG3; Q8N8B7-2: TCEANC; NbExp=3; IntAct=EBI-11962574, EBI-11955057;
CC       Q96EG3; Q63HR2: TNS2; NbExp=3; IntAct=EBI-11962574, EBI-949753;
CC       Q96EG3; Q8WV44: TRIM41; NbExp=3; IntAct=EBI-11962574, EBI-725997;
CC       Q96EG3; Q8IZ69: TRMT2A; NbExp=3; IntAct=EBI-11962574, EBI-2515774;
CC       Q96EG3; Q7KZS0: UBE2I; NbExp=3; IntAct=EBI-11962574, EBI-10180829;
CC       Q96EG3; Q6EMK4: VASN; NbExp=3; IntAct=EBI-11962574, EBI-10249550;
CC       Q96EG3; Q2TAL6: VWC2; NbExp=3; IntAct=EBI-11962574, EBI-11957238;
CC       Q96EG3; O43167: ZBTB24; NbExp=3; IntAct=EBI-11962574, EBI-744471;
CC       Q96EG3; P10074: ZBTB48; NbExp=3; IntAct=EBI-11962574, EBI-744864;
CC       Q96EG3; Q96BR9: ZBTB8A; NbExp=3; IntAct=EBI-11962574, EBI-742740;
CC       Q96EG3; P58317: ZNF121; NbExp=3; IntAct=EBI-11962574, EBI-1228269;
CC       Q96EG3; Q15973: ZNF124; NbExp=6; IntAct=EBI-11962574, EBI-2555767;
CC       Q96EG3; P49910: ZNF165; NbExp=3; IntAct=EBI-11962574, EBI-741694;
CC       Q96EG3; P17021: ZNF17; NbExp=3; IntAct=EBI-11962574, EBI-1105334;
CC       Q96EG3; O95125: ZNF202; NbExp=3; IntAct=EBI-11962574, EBI-751960;
CC       Q96EG3; P15622-3: ZNF250; NbExp=3; IntAct=EBI-11962574, EBI-10177272;
CC       Q96EG3; Q9NSD4: ZNF275; NbExp=3; IntAct=EBI-11962574, EBI-17263125;
CC       Q96EG3; Q96PQ6: ZNF317; NbExp=3; IntAct=EBI-11962574, EBI-1210473;
CC       Q96EG3; Q9Y3S2: ZNF330; NbExp=6; IntAct=EBI-11962574, EBI-373456;
CC       Q96EG3; Q9H9D4: ZNF408; NbExp=3; IntAct=EBI-11962574, EBI-347633;
CC       Q96EG3; Q8TAU3: ZNF417; NbExp=6; IntAct=EBI-11962574, EBI-740727;
CC       Q96EG3; Q8WTR7: ZNF473; NbExp=3; IntAct=EBI-11962574, EBI-751409;
CC       Q96EG3; Q6ZNH5: ZNF497; NbExp=3; IntAct=EBI-11962574, EBI-10486136;
CC       Q96EG3; Q96C55: ZNF524; NbExp=3; IntAct=EBI-11962574, EBI-10283126;
CC       Q96EG3; Q8TF50: ZNF526; NbExp=3; IntAct=EBI-11962574, EBI-11035148;
CC       Q96EG3; Q9H707: ZNF552; NbExp=6; IntAct=EBI-11962574, EBI-2555731;
CC       Q96EG3; Q96SQ5: ZNF587; NbExp=3; IntAct=EBI-11962574, EBI-6427977;
CC       Q96EG3; Q9UID6: ZNF639; NbExp=3; IntAct=EBI-11962574, EBI-947476;
CC       Q96EG3; Q5T619: ZNF648; NbExp=3; IntAct=EBI-11962574, EBI-11985915;
CC       Q96EG3; Q8N720: ZNF655; NbExp=3; IntAct=EBI-11962574, EBI-625509;
CC       Q96EG3; Q96H86: ZNF764; NbExp=3; IntAct=EBI-11962574, EBI-745775;
CC       Q96EG3; Q3KQV3: ZNF792; NbExp=3; IntAct=EBI-11962574, EBI-10240849;
CC       Q96EG3; Q9Y2P0: ZNF835; NbExp=3; IntAct=EBI-11962574, EBI-5667516;
CC       Q96EG3; Q96EG3: ZNF837; NbExp=3; IntAct=EBI-11962574, EBI-11962574;
CC       Q96EG3; Q9UGI0: ZRANB1; NbExp=3; IntAct=EBI-11962574, EBI-527853;
CC       Q96EG3; Q9Y5A6: ZSCAN21; NbExp=3; IntAct=EBI-11962574, EBI-10281938;
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC       family. {ECO:0000305}.
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DR   EMBL; BC012365; AAH12365.2; -; mRNA.
DR   CCDS; CCDS46216.1; -.
DR   RefSeq; NP_612475.1; NM_138466.1.
DR   RefSeq; XP_016881731.1; XM_017026242.1.
DR   AlphaFoldDB; Q96EG3; -.
DR   SMR; Q96EG3; -.
DR   BioGRID; 125504; 79.
DR   IntAct; Q96EG3; 78.
DR   STRING; 9606.ENSP00000405699; -.
DR   GlyGen; Q96EG3; 1 site, 1 O-linked glycan (1 site).
DR   iPTMnet; Q96EG3; -.
DR   PhosphoSitePlus; Q96EG3; -.
DR   BioMuta; ZNF837; -.
DR   DMDM; 121946273; -.
DR   jPOST; Q96EG3; -.
DR   MassIVE; Q96EG3; -.
DR   MaxQB; Q96EG3; -.
DR   PaxDb; 9606-ENSP00000405699; -.
DR   PeptideAtlas; Q96EG3; -.
DR   ProteomicsDB; 76406; -.
DR   Antibodypedia; 33337; 40 antibodies from 12 providers.
DR   DNASU; 116412; -.
DR   Ensembl; ENST00000427624.2; ENSP00000405699.1; ENSG00000152475.7.
DR   Ensembl; ENST00000597582.2; ENSP00000471478.1; ENSG00000152475.7.
DR   GeneID; 116412; -.
DR   KEGG; hsa:116412; -.
DR   MANE-Select; ENST00000597582.2; ENSP00000471478.1; NM_138466.2; NP_612475.1.
DR   UCSC; uc002qsl.5; human.
DR   AGR; HGNC:25164; -.
DR   CTD; 116412; -.
DR   GeneCards; ZNF837; -.
DR   HGNC; HGNC:25164; ZNF837.
DR   HPA; ENSG00000152475; Low tissue specificity.
DR   neXtProt; NX_Q96EG3; -.
DR   OpenTargets; ENSG00000152475; -.
DR   PharmGKB; PA162410789; -.
DR   VEuPathDB; HostDB:ENSG00000152475; -.
DR   eggNOG; KOG1721; Eukaryota.
DR   GeneTree; ENSGT00940000165357; -.
DR   HOGENOM; CLU_002678_84_0_1; -.
DR   InParanoid; Q96EG3; -.
DR   OMA; CGDCSER; -.
DR   OrthoDB; 4728594at2759; -.
DR   PhylomeDB; Q96EG3; -.
DR   TreeFam; TF337005; -.
DR   PathwayCommons; Q96EG3; -.
DR   SignaLink; Q96EG3; -.
DR   BioGRID-ORCS; 116412; 18 hits in 1174 CRISPR screens.
DR   GenomeRNAi; 116412; -.
DR   Pharos; Q96EG3; Tdark.
DR   PRO; PR:Q96EG3; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   RNAct; Q96EG3; Protein.
DR   Bgee; ENSG00000152475; Expressed in right uterine tube and 88 other cell types or tissues.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0042802; F:identical protein binding; IPI:IntAct.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   Gene3D; 3.30.160.60; Classic Zinc Finger; 8.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   PANTHER; PTHR23234:SF3; RIKEN CDNA 3300002I08 GENE-RELATED; 1.
DR   PANTHER; PTHR23234; ZNF44 PROTEIN; 1.
DR   Pfam; PF00096; zf-C2H2; 7.
DR   SMART; SM00355; ZnF_C2H2; 8.
DR   SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 4.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 8.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 8.
DR   Genevisible; Q96EG3; HS.
PE   1: Evidence at protein level;
KW   DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..531
FT                   /note="Zinc finger protein 837"
FT                   /id="PRO_0000321906"
FT   ZN_FING         271..293
FT                   /note="C2H2-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         299..321
FT                   /note="C2H2-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         363..385
FT                   /note="C2H2-type 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         391..413
FT                   /note="C2H2-type 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         419..441
FT                   /note="C2H2-type 5"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         447..469
FT                   /note="C2H2-type 6"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         475..497
FT                   /note="C2H2-type 7"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         503..525
FT                   /note="C2H2-type 8"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   REGION          1..101
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        21..45
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VARIANT         153
FT                   /note="Q -> R (in dbSNP:rs7256940)"
FT                   /id="VAR_039373"
FT   VARIANT         242
FT                   /note="A -> T (in dbSNP:rs7255596)"
FT                   /id="VAR_061979"
SQ   SEQUENCE   531 AA;  58078 MW;  40329D17EDD39737 CRC64;
     MEAPAQKAGQ GGLPKADAQG ASGAREKRPE EPRPLEEDRA GSRPTQKGDL RGAAGGRTTP
     PGGGSRGCSL GVSPGPGTRH SAGTRPLVRE PCGPTSSQNP ELVIPEGLQA REGPCRSPAR
     GGDCSRNSCL AWHRGAPAGE TPPVCDPCPE RIQNHPRTQL CEVHTDCWPC QPGTGAPTCP
     RTPKPTSRGR NPLVEQPRAC ACGEAFAWRA LRIPQERLQA TEEPRPCARC GKRFRPNQQQ
     QAGKSPPVCP ECGQTSRPRP IVPDPPAQRL YACDECGKAF TRTSSLLQHQ RIHTGERPYE
     CAECGKAFVR CSGLYRHQKT HSAERHRRGP VLARRAFRLG CPPCGDYSER SPRRGSGAGE
     KPYECADCAK AFGLFSHLVE HRRVHTGEKP YACPECGKAF NQRSNLSRHQ RTHSSAKPYA
     CPLCEKAFKG RSGLVQHQRA HTGERPYGCS ECGKTFRGCS ELRQHERLHS GEKPYICRDC
     GKAFVRNCSL VRHLRTHTGE RPYACGDCGR AFSQRSNLNE HRKRHGGRAA P
//