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Protein

Zinc finger protein 837

Gene

ZNF837

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri271 – 29323C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri299 – 32123C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri363 – 38523C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri391 – 41323C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri419 – 44123C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri447 – 46923C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri475 – 49723C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri503 – 52523C2H2-type 8PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 837
Gene namesi
Name:ZNF837
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:25164. ZNF837.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162410789.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 531531Zinc finger protein 837PRO_0000321906Add
BLAST

Proteomic databases

PaxDbiQ96EG3.
PRIDEiQ96EG3.

PTM databases

PhosphoSiteiQ96EG3.

Expressioni

Gene expression databases

BgeeiQ96EG3.
CleanExiHS_ZNF837.
GenevestigatoriQ96EG3.

Organism-specific databases

HPAiHPA042833.

Structurei

3D structure databases

ProteinModelPortaliQ96EG3.
SMRiQ96EG3. Positions 80-146, 202-525.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 8 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri271 – 29323C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri299 – 32123C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri363 – 38523C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri391 – 41323C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri419 – 44123C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri447 – 46923C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri475 – 49723C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri503 – 52523C2H2-type 8PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00720000108996.
HOGENOMiHOG000234617.
InParanoidiQ96EG3.
OMAiLYACDEC.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ96EG3.
TreeFamiTF337005.

Family and domain databases

Gene3Di3.30.160.60. 8 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 8 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 8 hits.
PS50157. ZINC_FINGER_C2H2_2. 8 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96EG3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEAPAQKAGQ GGLPKADAQG ASGAREKRPE EPRPLEEDRA GSRPTQKGDL
60 70 80 90 100
RGAAGGRTTP PGGGSRGCSL GVSPGPGTRH SAGTRPLVRE PCGPTSSQNP
110 120 130 140 150
ELVIPEGLQA REGPCRSPAR GGDCSRNSCL AWHRGAPAGE TPPVCDPCPE
160 170 180 190 200
RIQNHPRTQL CEVHTDCWPC QPGTGAPTCP RTPKPTSRGR NPLVEQPRAC
210 220 230 240 250
ACGEAFAWRA LRIPQERLQA TEEPRPCARC GKRFRPNQQQ QAGKSPPVCP
260 270 280 290 300
ECGQTSRPRP IVPDPPAQRL YACDECGKAF TRTSSLLQHQ RIHTGERPYE
310 320 330 340 350
CAECGKAFVR CSGLYRHQKT HSAERHRRGP VLARRAFRLG CPPCGDYSER
360 370 380 390 400
SPRRGSGAGE KPYECADCAK AFGLFSHLVE HRRVHTGEKP YACPECGKAF
410 420 430 440 450
NQRSNLSRHQ RTHSSAKPYA CPLCEKAFKG RSGLVQHQRA HTGERPYGCS
460 470 480 490 500
ECGKTFRGCS ELRQHERLHS GEKPYICRDC GKAFVRNCSL VRHLRTHTGE
510 520 530
RPYACGDCGR AFSQRSNLNE HRKRHGGRAA P
Length:531
Mass (Da):58,078
Last modified:September 18, 2006 - v2
Checksum:i40329D17EDD39737
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti153 – 1531Q → R.
Corresponds to variant rs7256940 [ dbSNP | Ensembl ].
VAR_039373
Natural varianti242 – 2421A → T.
Corresponds to variant rs7255596 [ dbSNP | Ensembl ].
VAR_061979

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC012365 mRNA. Translation: AAH12365.2.
CCDSiCCDS46216.1.
RefSeqiNP_612475.1. NM_138466.1.
UniGeneiHs.222236.

Genome annotation databases

EnsembliENST00000427624; ENSP00000405699; ENSG00000152475.
ENST00000597582; ENSP00000471478; ENSG00000152475.
GeneIDi116412.
KEGGihsa:116412.
UCSCiuc002qsl.4. human.

Polymorphism databases

DMDMi121946273.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC012365 mRNA. Translation: AAH12365.2.
CCDSiCCDS46216.1.
RefSeqiNP_612475.1. NM_138466.1.
UniGeneiHs.222236.

3D structure databases

ProteinModelPortaliQ96EG3.
SMRiQ96EG3. Positions 80-146, 202-525.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiQ96EG3.

Polymorphism databases

DMDMi121946273.

Proteomic databases

PaxDbiQ96EG3.
PRIDEiQ96EG3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000427624; ENSP00000405699; ENSG00000152475.
ENST00000597582; ENSP00000471478; ENSG00000152475.
GeneIDi116412.
KEGGihsa:116412.
UCSCiuc002qsl.4. human.

Organism-specific databases

CTDi116412.
GeneCardsiGC19M058878.
HGNCiHGNC:25164. ZNF837.
HPAiHPA042833.
neXtProtiNX_Q96EG3.
PharmGKBiPA162410789.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00720000108996.
HOGENOMiHOG000234617.
InParanoidiQ96EG3.
OMAiLYACDEC.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ96EG3.
TreeFamiTF337005.

Miscellaneous databases

GenomeRNAii116412.
NextBioi79901.
PROiQ96EG3.

Gene expression databases

BgeeiQ96EG3.
CleanExiHS_ZNF837.
GenevestigatoriQ96EG3.

Family and domain databases

Gene3Di3.30.160.60. 8 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 8 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 8 hits.
PS50157. ZINC_FINGER_C2H2_2. 8 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: B-cell.

Entry informationi

Entry nameiZN837_HUMAN
AccessioniPrimary (citable) accession number: Q96EG3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 25, 2008
Last sequence update: September 18, 2006
Last modified: January 6, 2015
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.