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Q96EG3 (ZN837_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc finger protein 837
Gene names
Name:ZNF837
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length531 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May be involved in transcriptional regulation By similarity.

Subcellular location

Nucleus Potential.

Sequence similarities

Belongs to the krueppel C2H2-type zinc-finger protein family.

Contains 8 C2H2-type zinc fingers.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   Coding sequence diversityPolymorphism
   DomainRepeat
Zinc-finger
   LigandDNA-binding
Metal-binding
Zinc
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processregulation of transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 531531Zinc finger protein 837
PRO_0000321906

Regions

Zinc finger271 – 29323C2H2-type 1
Zinc finger299 – 32123C2H2-type 2
Zinc finger363 – 38523C2H2-type 3
Zinc finger391 – 41323C2H2-type 4
Zinc finger419 – 44123C2H2-type 5
Zinc finger447 – 46923C2H2-type 6
Zinc finger475 – 49723C2H2-type 7
Zinc finger503 – 52523C2H2-type 8

Natural variations

Natural variant1531Q → R.
Corresponds to variant rs7256940 [ dbSNP | Ensembl ].
VAR_039373
Natural variant2421A → T.
Corresponds to variant rs7255596 [ dbSNP | Ensembl ].
VAR_061979

Sequences

Sequence LengthMass (Da)Tools
Q96EG3 [UniParc].

Last modified September 19, 2006. Version 2.
Checksum: 40329D17EDD39737

FASTA53158,078
        10         20         30         40         50         60 
MEAPAQKAGQ GGLPKADAQG ASGAREKRPE EPRPLEEDRA GSRPTQKGDL RGAAGGRTTP 

        70         80         90        100        110        120 
PGGGSRGCSL GVSPGPGTRH SAGTRPLVRE PCGPTSSQNP ELVIPEGLQA REGPCRSPAR 

       130        140        150        160        170        180 
GGDCSRNSCL AWHRGAPAGE TPPVCDPCPE RIQNHPRTQL CEVHTDCWPC QPGTGAPTCP 

       190        200        210        220        230        240 
RTPKPTSRGR NPLVEQPRAC ACGEAFAWRA LRIPQERLQA TEEPRPCARC GKRFRPNQQQ 

       250        260        270        280        290        300 
QAGKSPPVCP ECGQTSRPRP IVPDPPAQRL YACDECGKAF TRTSSLLQHQ RIHTGERPYE 

       310        320        330        340        350        360 
CAECGKAFVR CSGLYRHQKT HSAERHRRGP VLARRAFRLG CPPCGDYSER SPRRGSGAGE 

       370        380        390        400        410        420 
KPYECADCAK AFGLFSHLVE HRRVHTGEKP YACPECGKAF NQRSNLSRHQ RTHSSAKPYA 

       430        440        450        460        470        480 
CPLCEKAFKG RSGLVQHQRA HTGERPYGCS ECGKTFRGCS ELRQHERLHS GEKPYICRDC 

       490        500        510        520        530 
GKAFVRNCSL VRHLRTHTGE RPYACGDCGR AFSQRSNLNE HRKRHGGRAA P 

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: B-cell.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC012365 mRNA. Translation: AAH12365.2.
RefSeqNP_612475.1. NM_138466.1.
UniGeneHs.222236.

3D structure databases

ProteinModelPortalQ96EG3.
SMRQ96EG3. Positions 32-525.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ96EG3.

Polymorphism databases

DMDM121946273.

Proteomic databases

PaxDbQ96EG3.
PRIDEQ96EG3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000427624; ENSP00000405699; ENSG00000152475.
ENST00000597582; ENSP00000471478; ENSG00000152475.
GeneID116412.
KEGGhsa:116412.
UCSCuc002qsl.4. human.

Organism-specific databases

CTD116412.
GeneCardsGC19M058878.
HGNCHGNC:25164. ZNF837.
HPAHPA042833.
neXtProtNX_Q96EG3.
PharmGKBPA162410789.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5048.
HOGENOMHOG000234617.
InParanoidQ96EG3.
OMALYACDEC.
OrthoDBEOG7KSX7Q.
PhylomeDBQ96EG3.
TreeFamTF337005.

Gene expression databases

BgeeQ96EG3.
CleanExHS_ZNF837.
GenevestigatorQ96EG3.

Family and domain databases

Gene3D3.30.160.60. 8 hits.
InterProIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTSM00355. ZnF_C2H2. 8 hits.
[Graphical view]
PROSITEPS00028. ZINC_FINGER_C2H2_1. 8 hits.
PS50157. ZINC_FINGER_C2H2_2. 8 hits.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi116412.
NextBio79901.
PROQ96EG3.

Entry information

Entry nameZN837_HUMAN
AccessionPrimary (citable) accession number: Q96EG3
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: September 19, 2006
Last modified: April 16, 2014
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM