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Protein

Zinc finger protein 837

Gene

ZNF837

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri271 – 293C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri299 – 321C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri363 – 385C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri391 – 413C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri419 – 441C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri447 – 469C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri475 – 497C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri503 – 525C2H2-type 8PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000152475-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 837
Gene namesi
Name:ZNF837
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:25164. ZNF837.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000152475.
PharmGKBiPA162410789.

Polymorphism and mutation databases

BioMutaiZNF837.
DMDMi121946273.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003219061 – 531Zinc finger protein 837Add BLAST531

Proteomic databases

MaxQBiQ96EG3.
PaxDbiQ96EG3.
PeptideAtlasiQ96EG3.
PRIDEiQ96EG3.

PTM databases

iPTMnetiQ96EG3.
PhosphoSitePlusiQ96EG3.

Expressioni

Gene expression databases

BgeeiENSG00000152475.
CleanExiHS_ZNF837.
GenevisibleiQ96EG3. HS.

Organism-specific databases

HPAiHPA042833.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
RBMY1JQ154154EBI-11962574,EBI-8642021
ZNF587Q96SQ54EBI-11962574,EBI-6427977
ZNF792Q3KQV34EBI-11962574,EBI-10240849

Protein-protein interaction databases

IntActiQ96EG3. 55 interactors.
STRINGi9606.ENSP00000405699.

Structurei

3D structure databases

ProteinModelPortaliQ96EG3.
SMRiQ96EG3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 8 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri271 – 293C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri299 – 321C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri363 – 385C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri391 – 413C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri419 – 441C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri447 – 469C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri475 – 497C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri503 – 525C2H2-type 8PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00850000132629.
HOGENOMiHOG000234617.
InParanoidiQ96EG3.
OMAiCEVHTDC.
OrthoDBiEOG091G02KC.
PhylomeDBiQ96EG3.
TreeFamiTF337005.

Family and domain databases

Gene3Di3.30.160.60. 8 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 4 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 8 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 8 hits.
PS50157. ZINC_FINGER_C2H2_2. 8 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96EG3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEAPAQKAGQ GGLPKADAQG ASGAREKRPE EPRPLEEDRA GSRPTQKGDL
60 70 80 90 100
RGAAGGRTTP PGGGSRGCSL GVSPGPGTRH SAGTRPLVRE PCGPTSSQNP
110 120 130 140 150
ELVIPEGLQA REGPCRSPAR GGDCSRNSCL AWHRGAPAGE TPPVCDPCPE
160 170 180 190 200
RIQNHPRTQL CEVHTDCWPC QPGTGAPTCP RTPKPTSRGR NPLVEQPRAC
210 220 230 240 250
ACGEAFAWRA LRIPQERLQA TEEPRPCARC GKRFRPNQQQ QAGKSPPVCP
260 270 280 290 300
ECGQTSRPRP IVPDPPAQRL YACDECGKAF TRTSSLLQHQ RIHTGERPYE
310 320 330 340 350
CAECGKAFVR CSGLYRHQKT HSAERHRRGP VLARRAFRLG CPPCGDYSER
360 370 380 390 400
SPRRGSGAGE KPYECADCAK AFGLFSHLVE HRRVHTGEKP YACPECGKAF
410 420 430 440 450
NQRSNLSRHQ RTHSSAKPYA CPLCEKAFKG RSGLVQHQRA HTGERPYGCS
460 470 480 490 500
ECGKTFRGCS ELRQHERLHS GEKPYICRDC GKAFVRNCSL VRHLRTHTGE
510 520 530
RPYACGDCGR AFSQRSNLNE HRKRHGGRAA P
Length:531
Mass (Da):58,078
Last modified:September 19, 2006 - v2
Checksum:i40329D17EDD39737
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_039373153Q → R.Corresponds to variant rs7256940dbSNPEnsembl.1
Natural variantiVAR_061979242A → T.Corresponds to variant rs7255596dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC012365 mRNA. Translation: AAH12365.2.
CCDSiCCDS46216.1.
RefSeqiNP_612475.1. NM_138466.1.
XP_016881731.1. XM_017026242.1.
UniGeneiHs.222236.

Genome annotation databases

EnsembliENST00000427624; ENSP00000405699; ENSG00000152475.
ENST00000597582; ENSP00000471478; ENSG00000152475.
GeneIDi116412.
KEGGihsa:116412.
UCSCiuc002qsl.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC012365 mRNA. Translation: AAH12365.2.
CCDSiCCDS46216.1.
RefSeqiNP_612475.1. NM_138466.1.
XP_016881731.1. XM_017026242.1.
UniGeneiHs.222236.

3D structure databases

ProteinModelPortaliQ96EG3.
SMRiQ96EG3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ96EG3. 55 interactors.
STRINGi9606.ENSP00000405699.

PTM databases

iPTMnetiQ96EG3.
PhosphoSitePlusiQ96EG3.

Polymorphism and mutation databases

BioMutaiZNF837.
DMDMi121946273.

Proteomic databases

MaxQBiQ96EG3.
PaxDbiQ96EG3.
PeptideAtlasiQ96EG3.
PRIDEiQ96EG3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000427624; ENSP00000405699; ENSG00000152475.
ENST00000597582; ENSP00000471478; ENSG00000152475.
GeneIDi116412.
KEGGihsa:116412.
UCSCiuc002qsl.5. human.

Organism-specific databases

CTDi116412.
GeneCardsiZNF837.
HGNCiHGNC:25164. ZNF837.
HPAiHPA042833.
neXtProtiNX_Q96EG3.
OpenTargetsiENSG00000152475.
PharmGKBiPA162410789.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00850000132629.
HOGENOMiHOG000234617.
InParanoidiQ96EG3.
OMAiCEVHTDC.
OrthoDBiEOG091G02KC.
PhylomeDBiQ96EG3.
TreeFamiTF337005.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000152475-MONOMER.

Miscellaneous databases

GenomeRNAii116412.
PROiQ96EG3.

Gene expression databases

BgeeiENSG00000152475.
CleanExiHS_ZNF837.
GenevisibleiQ96EG3. HS.

Family and domain databases

Gene3Di3.30.160.60. 8 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 4 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 8 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 8 hits.
PS50157. ZINC_FINGER_C2H2_2. 8 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN837_HUMAN
AccessioniPrimary (citable) accession number: Q96EG3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: September 19, 2006
Last modified: November 30, 2016
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.