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Q96EG3

- ZN837_HUMAN

UniProt

Q96EG3 - ZN837_HUMAN

Protein

Zinc finger protein 837

Gene

ZNF837

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 2 (19 Sep 2006)
      Previous versions | rss
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    Functioni

    May be involved in transcriptional regulation.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri271 – 29323C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri299 – 32123C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri363 – 38523C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri391 – 41323C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri419 – 44123C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri447 – 46923C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri475 – 49723C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri503 – 52523C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger protein 837
    Gene namesi
    Name:ZNF837
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:25164. ZNF837.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162410789.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 531531Zinc finger protein 837PRO_0000321906Add
    BLAST

    Proteomic databases

    PaxDbiQ96EG3.
    PRIDEiQ96EG3.

    PTM databases

    PhosphoSiteiQ96EG3.

    Expressioni

    Gene expression databases

    BgeeiQ96EG3.
    CleanExiHS_ZNF837.
    GenevestigatoriQ96EG3.

    Organism-specific databases

    HPAiHPA042833.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96EG3.
    SMRiQ96EG3. Positions 80-146, 202-525.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 8 C2H2-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri271 – 29323C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri299 – 32123C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri363 – 38523C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri391 – 41323C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri419 – 44123C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri447 – 46923C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri475 – 49723C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri503 – 52523C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    HOGENOMiHOG000234617.
    InParanoidiQ96EG3.
    OMAiLYACDEC.
    OrthoDBiEOG7KSX7Q.
    PhylomeDBiQ96EG3.
    TreeFamiTF337005.

    Family and domain databases

    Gene3Di3.30.160.60. 8 hits.
    InterProiIPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    SMARTiSM00355. ZnF_C2H2. 8 hits.
    [Graphical view]
    PROSITEiPS00028. ZINC_FINGER_C2H2_1. 8 hits.
    PS50157. ZINC_FINGER_C2H2_2. 8 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q96EG3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEAPAQKAGQ GGLPKADAQG ASGAREKRPE EPRPLEEDRA GSRPTQKGDL    50
    RGAAGGRTTP PGGGSRGCSL GVSPGPGTRH SAGTRPLVRE PCGPTSSQNP 100
    ELVIPEGLQA REGPCRSPAR GGDCSRNSCL AWHRGAPAGE TPPVCDPCPE 150
    RIQNHPRTQL CEVHTDCWPC QPGTGAPTCP RTPKPTSRGR NPLVEQPRAC 200
    ACGEAFAWRA LRIPQERLQA TEEPRPCARC GKRFRPNQQQ QAGKSPPVCP 250
    ECGQTSRPRP IVPDPPAQRL YACDECGKAF TRTSSLLQHQ RIHTGERPYE 300
    CAECGKAFVR CSGLYRHQKT HSAERHRRGP VLARRAFRLG CPPCGDYSER 350
    SPRRGSGAGE KPYECADCAK AFGLFSHLVE HRRVHTGEKP YACPECGKAF 400
    NQRSNLSRHQ RTHSSAKPYA CPLCEKAFKG RSGLVQHQRA HTGERPYGCS 450
    ECGKTFRGCS ELRQHERLHS GEKPYICRDC GKAFVRNCSL VRHLRTHTGE 500
    RPYACGDCGR AFSQRSNLNE HRKRHGGRAA P 531
    Length:531
    Mass (Da):58,078
    Last modified:September 19, 2006 - v2
    Checksum:i40329D17EDD39737
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti153 – 1531Q → R.
    Corresponds to variant rs7256940 [ dbSNP | Ensembl ].
    VAR_039373
    Natural varianti242 – 2421A → T.
    Corresponds to variant rs7255596 [ dbSNP | Ensembl ].
    VAR_061979

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC012365 mRNA. Translation: AAH12365.2.
    CCDSiCCDS46216.1.
    RefSeqiNP_612475.1. NM_138466.1.
    UniGeneiHs.222236.

    Genome annotation databases

    EnsembliENST00000427624; ENSP00000405699; ENSG00000152475.
    ENST00000597582; ENSP00000471478; ENSG00000152475.
    GeneIDi116412.
    KEGGihsa:116412.
    UCSCiuc002qsl.4. human.

    Polymorphism databases

    DMDMi121946273.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC012365 mRNA. Translation: AAH12365.2 .
    CCDSi CCDS46216.1.
    RefSeqi NP_612475.1. NM_138466.1.
    UniGenei Hs.222236.

    3D structure databases

    ProteinModelPortali Q96EG3.
    SMRi Q96EG3. Positions 80-146, 202-525.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q96EG3.

    Polymorphism databases

    DMDMi 121946273.

    Proteomic databases

    PaxDbi Q96EG3.
    PRIDEi Q96EG3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000427624 ; ENSP00000405699 ; ENSG00000152475 .
    ENST00000597582 ; ENSP00000471478 ; ENSG00000152475 .
    GeneIDi 116412.
    KEGGi hsa:116412.
    UCSCi uc002qsl.4. human.

    Organism-specific databases

    CTDi 116412.
    GeneCardsi GC19M058878.
    HGNCi HGNC:25164. ZNF837.
    HPAi HPA042833.
    neXtProti NX_Q96EG3.
    PharmGKBi PA162410789.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5048.
    HOGENOMi HOG000234617.
    InParanoidi Q96EG3.
    OMAi LYACDEC.
    OrthoDBi EOG7KSX7Q.
    PhylomeDBi Q96EG3.
    TreeFami TF337005.

    Miscellaneous databases

    GenomeRNAii 116412.
    NextBioi 79901.
    PROi Q96EG3.

    Gene expression databases

    Bgeei Q96EG3.
    CleanExi HS_ZNF837.
    Genevestigatori Q96EG3.

    Family and domain databases

    Gene3Di 3.30.160.60. 8 hits.
    InterProi IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    SMARTi SM00355. ZnF_C2H2. 8 hits.
    [Graphical view ]
    PROSITEi PS00028. ZINC_FINGER_C2H2_1. 8 hits.
    PS50157. ZINC_FINGER_C2H2_2. 8 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: B-cell.

    Entry informationi

    Entry nameiZN837_HUMAN
    AccessioniPrimary (citable) accession number: Q96EG3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 26, 2008
    Last sequence update: September 19, 2006
    Last modified: October 1, 2014
    This is version 98 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3