Q96EG3 (ZN837_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Zinc finger protein 837

Gene names

Name:

ZNF837

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	531 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May be involved in transcriptional regulation By similarity.
Subcellular location	Nucleus Potential.
Sequence similarities	Belongs to the krueppel C2H2-type zinc-finger protein family. Contains 8 C2H2-type zinc fingers.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Polymorphism
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 531	531	Zinc finger protein 837		PRO_0000321906
Regions
	Zinc finger	271 – 293	23	C2H2-type 1
	Zinc finger	299 – 321	23	C2H2-type 2
	Zinc finger	363 – 385	23	C2H2-type 3
	Zinc finger	391 – 413	23	C2H2-type 4
	Zinc finger	419 – 441	23	C2H2-type 5
	Zinc finger	447 – 469	23	C2H2-type 6
	Zinc finger	475 – 497	23	C2H2-type 7
	Zinc finger	503 – 525	23	C2H2-type 8
Natural variations
	Natural variant	153	1	Q → R. Corresponds to variant rs7256940 [ dbSNP | Ensembl ].		VAR_039373
	Natural variant	242	1	A → T. Corresponds to variant rs7255596 [ dbSNP | Ensembl ].		VAR_061979

Sequences

	Sequence		Length	Mass (Da)
	Q96EG3 [UniParc]. Last modified September 19, 2006. Version 2. Checksum: 40329D17EDD39737	FASTA	531	58,078
	10 20 30 40 50 60 MEAPAQKAGQ GGLPKADAQG ASGAREKRPE EPRPLEEDRA GSRPTQKGDL RGAAGGRTTP 70 80 90 100 110 120 PGGGSRGCSL GVSPGPGTRH SAGTRPLVRE PCGPTSSQNP ELVIPEGLQA REGPCRSPAR 130 140 150 160 170 180 GGDCSRNSCL AWHRGAPAGE TPPVCDPCPE RIQNHPRTQL CEVHTDCWPC QPGTGAPTCP 190 200 210 220 230 240 RTPKPTSRGR NPLVEQPRAC ACGEAFAWRA LRIPQERLQA TEEPRPCARC GKRFRPNQQQ 250 260 270 280 290 300 QAGKSPPVCP ECGQTSRPRP IVPDPPAQRL YACDECGKAF TRTSSLLQHQ RIHTGERPYE 310 320 330 340 350 360 CAECGKAFVR CSGLYRHQKT HSAERHRRGP VLARRAFRLG CPPCGDYSER SPRRGSGAGE 370 380 390 400 410 420 KPYECADCAK AFGLFSHLVE HRRVHTGEKP YACPECGKAF NQRSNLSRHQ RTHSSAKPYA 430 440 450 460 470 480 CPLCEKAFKG RSGLVQHQRA HTGERPYGCS ECGKTFRGCS ELRQHERLHS GEKPYICRDC 490 500 510 520 530 GKAFVRNCSL VRHLRTHTGE RPYACGDCGR AFSQRSNLNE HRKRHGGRAA P

References

[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: B-cell.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC012365 mRNA. Translation: AAH12365.2.
IPI	IPI00402014.
RefSeq	NP_612475.1. NM_138466.1.
UniGene	Hs.222236.
3D structure databases
HSSP	HSSP built from PDB template 1X6E based on UniProtKB P17028.
ProteinModelPortal	Q96EG3.
ModBase	Search...
PTM databases
PhosphoSite	Q96EG3.
Polymorphism databases
DMDM	121946273.
Proteomic databases
PaxDb	Q96EG3.
PRIDE	Q96EG3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000427624; ENSP00000405699; ENSG00000152475. ENST00000597582; ENSP00000471478; ENSG00000152475.
GeneID	116412.
KEGG	hsa:116412.
UCSC	uc002qsl.4. human.
Organism-specific databases
CTD	116412.
GeneCards	GC19M058878.
HGNC	HGNC:25164. ZNF837.
HPA	HPA042833.
neXtProt	NX_Q96EG3.
PharmGKB	PA162410789.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5048.
HOGENOM	HOG000234617.
InParanoid	Q96EG3.
OMA	LYACDEC.
OrthoDB	EOG4XWFXF.
Gene expression databases
Bgee	Q96EG3.
CleanEx	HS_ZNF837.
Genevestigator	Q96EG3.
Family and domain databases
Gene3D	3.30.160.60. 8 hits.
InterPro	IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view]
SMART	SM00355. ZnF_C2H2. 8 hits. [Graphical view]
PROSITE	PS00028. ZINC_FINGER_C2H2_1. 8 hits. PS50157. ZINC_FINGER_C2H2_2. 8 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	116412.
NextBio	79901.

Entry information

Entry name

ZN837_HUMAN

Accession

Primary (citable) accession number: Q96EG3

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	September 19, 2006
Last modified:	May 1, 2013
This is version 87 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.