ID   FBX17_HUMAN             Reviewed;         278 AA.
AC   Q96EF6; Q96LQ4;
DT   27-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   27-MAR-2024, entry version 159.
DE   RecName: Full=F-box only protein 17;
DE   AltName: Full=F-box only protein 26;
GN   Name=FBXO17; Synonyms=FBG4, FBX17, FBX26, FBXO26;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX   PubMed=12383498; DOI=10.1016/s0378-1119(02)00867-3;
RA   Ilyin G.P., Serandour A.L., Pigeon C., Rialland M., Glaise D.,
RA   Guguen-Guillouzo C.;
RT   "A new subfamily of structurally related human F-box proteins.";
RL   Gene 296:11-20(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Ovary;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   SUGAR-BINDING, INTERACTION WITH CUL1 AND SKP1, IDENTIFICATION IN
RP   SCF-COMPLEX, AND MUTAGENESIS OF 257-SER-TRP-258.
RX   PubMed=18203720; DOI=10.1074/jbc.m709508200;
RA   Glenn K.A., Nelson R.F., Wen H.M., Mallinger A.J., Paulson H.L.;
RT   "Diversity in tissue expression, substrate binding, and SCF complex
RT   formation for a lectin family of ubiquitin ligases.";
RL   J. Biol. Chem. 283:12717-12729(2008).
CC   -!- FUNCTION: Substrate-recognition component of the SCF (SKP1-CUL1-F-box
CC       protein)-type E3 ubiquitin ligase complex. Able to recognize and bind
CC       denatured glycoproteins, which are modified with complex-type
CC       oligosaccharides. Also recognizes sulfated glycans. Does not bind high-
CC       mannose glycoproteins.
CC   -!- SUBUNIT: Part of a SCF (SKP1-cullin-F-box) protein ligase complex.
CC       Interacts with SKP1 and CUL1. {ECO:0000269|PubMed:18203720}.
CC   -!- INTERACTION:
CC       Q96EF6; Q6UY14-3: ADAMTSL4; NbExp=3; IntAct=EBI-2510157, EBI-10173507;
CC       Q96EF6; Q8NA61-2: CBY2; NbExp=3; IntAct=EBI-2510157, EBI-11524851;
CC       Q96EF6; Q53HL2: CDCA8; NbExp=3; IntAct=EBI-2510157, EBI-979174;
CC       Q96EF6; Q13616: CUL1; NbExp=8; IntAct=EBI-2510157, EBI-359390;
CC       Q96EF6; Q86Y13: DZIP3; NbExp=3; IntAct=EBI-2510157, EBI-948630;
CC       Q96EF6; Q15056-2: EIF4H; NbExp=3; IntAct=EBI-2510157, EBI-12222405;
CC       Q96EF6; O75564-2: JRK; NbExp=3; IntAct=EBI-2510157, EBI-17181882;
CC       Q96EF6; Q5T749: KPRP; NbExp=3; IntAct=EBI-2510157, EBI-10981970;
CC       Q96EF6; O95678: KRT75; NbExp=3; IntAct=EBI-2510157, EBI-2949715;
CC       Q96EF6; Q52LG2: KRTAP13-2; NbExp=3; IntAct=EBI-2510157, EBI-11953846;
CC       Q96EF6; Q14847-2: LASP1; NbExp=5; IntAct=EBI-2510157, EBI-9088686;
CC       Q96EF6; P29728-2: OAS2; NbExp=3; IntAct=EBI-2510157, EBI-12270678;
CC       Q96EF6; Q16825: PTPN21; NbExp=3; IntAct=EBI-2510157, EBI-2860264;
CC       Q96EF6; Q7L804: RAB11FIP2; NbExp=3; IntAct=EBI-2510157, EBI-1049676;
CC       Q96EF6; Q01196-8: RUNX1; NbExp=3; IntAct=EBI-2510157, EBI-12001422;
CC       Q96EF6; Q8IYX7: SAXO1; NbExp=3; IntAct=EBI-2510157, EBI-3957636;
CC       Q96EF6; Q658L1: SAXO2; NbExp=3; IntAct=EBI-2510157, EBI-18394432;
CC       Q96EF6; P63208: SKP1; NbExp=16; IntAct=EBI-2510157, EBI-307486;
CC       Q96EF6; Q70EL1-9: USP54; NbExp=3; IntAct=EBI-2510157, EBI-11975223;
CC       Q96EF6; O14771: ZNF213; NbExp=3; IntAct=EBI-2510157, EBI-12838388;
CC       Q96EF6; Q3KNS6-3: ZNF829; NbExp=3; IntAct=EBI-2510157, EBI-18036029;
CC       Q96EF6; O15535: ZSCAN9; NbExp=3; IntAct=EBI-2510157, EBI-751531;
CC   -!- TISSUE SPECIFICITY: Expressed in heart, skeletal muscle, liver and
CC       kidney. Expressed at lower levels in spleen and brain.
CC       {ECO:0000269|PubMed:12383498}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAB71616.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AF386743; AAL37625.1; -; mRNA.
DR   EMBL; AK057934; BAB71616.1; ALT_INIT; mRNA.
DR   EMBL; BC012385; AAH12385.1; -; mRNA.
DR   CCDS; CCDS12526.1; -.
DR   RefSeq; NP_079183.4; NM_024907.6.
DR   RefSeq; NP_680474.1; NM_148169.2.
DR   AlphaFoldDB; Q96EF6; -.
DR   SMR; Q96EF6; -.
DR   BioGRID; 125424; 59.
DR   ComplexPortal; CPX-7927; SCF E3 ubiquitin ligase complex, FBXO17 variant.
DR   CORUM; Q96EF6; -.
DR   IntAct; Q96EF6; 36.
DR   MINT; Q96EF6; -.
DR   STRING; 9606.ENSP00000292852; -.
DR   BioMuta; FBXO17; -.
DR   DMDM; 21263617; -.
DR   EPD; Q96EF6; -.
DR   jPOST; Q96EF6; -.
DR   MassIVE; Q96EF6; -.
DR   MaxQB; Q96EF6; -.
DR   PaxDb; 9606-ENSP00000292852; -.
DR   PeptideAtlas; Q96EF6; -.
DR   ProteomicsDB; 76403; -.
DR   Pumba; Q96EF6; -.
DR   Antibodypedia; 68422; 65 antibodies from 18 providers.
DR   DNASU; 115290; -.
DR   Ensembl; ENST00000292852.9; ENSP00000292852.3; ENSG00000269190.6.
DR   Ensembl; ENST00000595329.5; ENSP00000470361.1; ENSG00000269190.6.
DR   Ensembl; ENST00000634982.2; ENSP00000488997.1; ENSG00000282954.2.
DR   Ensembl; ENST00000635115.1; ENSP00000489327.1; ENSG00000282954.2.
DR   GeneID; 115290; -.
DR   KEGG; hsa:115290; -.
DR   MANE-Select; ENST00000292852.9; ENSP00000292852.3; NM_024907.7; NP_079183.4.
DR   UCSC; uc002okg.3; human.
DR   AGR; HGNC:18754; -.
DR   CTD; 115290; -.
DR   DisGeNET; 115290; -.
DR   GeneCards; FBXO17; -.
DR   HGNC; HGNC:18754; FBXO17.
DR   HPA; ENSG00000269190; Tissue enhanced (liver).
DR   MIM; 609094; gene.
DR   neXtProt; NX_Q96EF6; -.
DR   OpenTargets; ENSG00000269190; -.
DR   PharmGKB; PA38676; -.
DR   VEuPathDB; HostDB:ENSG00000269190; -.
DR   eggNOG; ENOG502RZA6; Eukaryota.
DR   GeneTree; ENSGT00940000162455; -.
DR   HOGENOM; CLU_068548_0_0_1; -.
DR   InParanoid; Q96EF6; -.
DR   OMA; YAVVQRC; -.
DR   OrthoDB; 587001at2759; -.
DR   PhylomeDB; Q96EF6; -.
DR   PathwayCommons; Q96EF6; -.
DR   Reactome; R-HSA-8951664; Neddylation.
DR   Reactome; R-HSA-983168; Antigen processing: Ubiquitination & Proteasome degradation.
DR   SignaLink; Q96EF6; -.
DR   BioGRID-ORCS; 115290; 16 hits in 1193 CRISPR screens.
DR   GenomeRNAi; 115290; -.
DR   Pharos; Q96EF6; Tbio.
DR   PRO; PR:Q96EF6; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   RNAct; Q96EF6; Protein.
DR   Bgee; ENSG00000269190; Expressed in right lobe of liver and 97 other cell types or tissues.
DR   ExpressionAtlas; Q96EF6; baseline and differential.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005829; C:cytosol; TAS:Reactome.
DR   GO; GO:0019005; C:SCF ubiquitin ligase complex; IDA:UniProtKB.
DR   GO; GO:0006516; P:glycoprotein catabolic process; IBA:GO_Central.
DR   GO; GO:0031146; P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR   GO; GO:0030433; P:ubiquitin-dependent ERAD pathway; IBA:GO_Central.
DR   CDD; cd22169; F-box_FBXO17-like; 1.
DR   Gene3D; 1.20.1280.50; -; 1.
DR   Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR   InterPro; IPR007397; F-box-assoc_dom.
DR   InterPro; IPR036047; F-box-like_dom_sf.
DR   InterPro; IPR001810; F-box_dom.
DR   InterPro; IPR039752; F-box_only.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   PANTHER; PTHR12125:SF7; F-BOX ONLY PROTEIN 17; 1.
DR   PANTHER; PTHR12125; F-BOX ONLY PROTEIN 6-LIKE PROTEIN; 1.
DR   Pfam; PF12937; F-box-like; 1.
DR   Pfam; PF04300; FBA; 1.
DR   SMART; SM01198; FBA; 1.
DR   SMART; SM00256; FBOX; 1.
DR   SUPFAM; SSF81383; F-box domain; 1.
DR   SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR   PROSITE; PS51114; FBA; 1.
DR   PROSITE; PS50181; FBOX; 1.
DR   Genevisible; Q96EF6; HS.
PE   1: Evidence at protein level;
KW   Reference proteome; Ubl conjugation pathway.
FT   CHAIN           1..278
FT                   /note="F-box only protein 17"
FT                   /id="PRO_0000119898"
FT   DOMAIN          15..62
FT                   /note="F-box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00080"
FT   DOMAIN          99..275
FT                   /note="FBA"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00482"
FT   MUTAGEN         257..258
FT                   /note="SW->AA: Reduces interaction with glycosylated
FT                   concanavalin-A in vitro."
FT                   /evidence="ECO:0000269|PubMed:18203720"
SQ   SEQUENCE   278 AA;  31479 MW;  B44E577D6F3529D4 CRC64;
     MGARLSRRRL PADPSLALDA LPPELLVQVL SHVPPRSLVT RCRPVCRAWR DIVDGPTVWL
     LQLARDRSAE GRALYAVAQR CLPSNEDKEE FPLCALARYC LRAPFGRNLI FNSCGEQGFR
     GWEVEHGGNG WAIEKNLTPV PGAPSQTCFV TSFEWCSKRQ LVDLVMEGVW QELLDSAQIE
     ICVADWWGAR ENCGCVYQLR VRLLDVYEKE VVKFSASPDP VLQWTERGCR QVSHVFTNFG
     KGIRYVSFEQ YGRDVSSWVG HYGALVTHSS VRVRIRLS
//