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Q96EF6 (FBX17_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
F-box only protein 17
Alternative name(s):
F-box only protein 26
Gene names
Name:FBXO17
Synonyms:FBG4, FBX17, FBX26, FBXO26
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length278 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Able to recognize and bind denatured glycoproteins, which are modified with complex-type oligosaccharides. Also recognizes sulfated glycans. Does not bind high-mannose glycoproteins.

Subunit structure

Part of a SCF (SKP1-cullin-F-box) protein ligase complex. Interacts with SKP1 and CUL1. Ref.4

Tissue specificity

Expressed in heart, skeletal muscle, liver and kidney. Expressed at lower levels in spleen and brain. Ref.1

Sequence similarities

Contains 1 F-box domain.

Contains 1 FBA (F-box associated) domain.

Sequence caution

The sequence BAB71616.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processUbl conjugation pathway
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processprotein catabolic process

Inferred from electronic annotation. Source: InterPro

   Cellular_componentSCF ubiquitin ligase complex

Inferred from direct assay Ref.4. Source: UniProtKB

   Molecular_functionglycoprotein binding

Inferred from direct assay Ref.4. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 278278F-box only protein 17
PRO_0000119898

Regions

Domain15 – 6248F-box
Domain99 – 275177FBA

Experimental info

Mutagenesis257 – 2582SW → AA: Reduces interaction with glycosylated concanavalin-A in vitro. Ref.4

Sequences

Sequence LengthMass (Da)Tools
Q96EF6 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: B44E577D6F3529D4

FASTA27831,479
        10         20         30         40         50         60 
MGARLSRRRL PADPSLALDA LPPELLVQVL SHVPPRSLVT RCRPVCRAWR DIVDGPTVWL 

        70         80         90        100        110        120 
LQLARDRSAE GRALYAVAQR CLPSNEDKEE FPLCALARYC LRAPFGRNLI FNSCGEQGFR 

       130        140        150        160        170        180 
GWEVEHGGNG WAIEKNLTPV PGAPSQTCFV TSFEWCSKRQ LVDLVMEGVW QELLDSAQIE 

       190        200        210        220        230        240 
ICVADWWGAR ENCGCVYQLR VRLLDVYEKE VVKFSASPDP VLQWTERGCR QVSHVFTNFG 

       250        260        270 
KGIRYVSFEQ YGRDVSSWVG HYGALVTHSS VRVRIRLS 

« Hide

References

« Hide 'large scale' references
[1]"A new subfamily of structurally related human F-box proteins."
Ilyin G.P., Serandour A.L., Pigeon C., Rialland M., Glaise D., Guguen-Guillouzo C.
Gene 296:11-20(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Ovary.
[4]"Diversity in tissue expression, substrate binding, and SCF complex formation for a lectin family of ubiquitin ligases."
Glenn K.A., Nelson R.F., Wen H.M., Mallinger A.J., Paulson H.L.
J. Biol. Chem. 283:12717-12729(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: SUGAR-BINDING, INTERACTION WITH CUL1 AND SKP1, IDENTIFICATION IN SCF-COMPLEX, MUTAGENESIS OF 257-SER-TRP-258.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF386743 mRNA. Translation: AAL37625.1.
AK057934 mRNA. Translation: BAB71616.1. Different initiation.
BC012385 mRNA. Translation: AAH12385.1.
RefSeqNP_079183.4. NM_024907.6.
NP_680474.1. NM_148169.2.
UniGeneHs.531770.

3D structure databases

ProteinModelPortalQ96EF6.
SMRQ96EF6. Positions 28-273.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid125424. 10 interactions.
IntActQ96EF6. 2 interactions.
STRING9606.ENSP00000221431.

Polymorphism databases

DMDM21263617.

Proteomic databases

PaxDbQ96EF6.
PRIDEQ96EF6.

Protocols and materials databases

DNASU115290.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000292852; ENSP00000292852; ENSG00000269190.
ENST00000595329; ENSP00000470361; ENSG00000269190.
GeneID115290.
KEGGhsa:115290.
UCSCuc002okf.1. human.

Organism-specific databases

CTD115290.
GeneCardsGC19M039432.
HGNCHGNC:18754. FBXO17.
MIM609094. gene.
neXtProtNX_Q96EF6.
PharmGKBPA38676.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0172.
HOGENOMHOG000231084.
HOVERGENHBG003593.
InParanoidQ96EF6.
KOK10101.
OMARPVCRAW.
PhylomeDBQ96EF6.

Enzyme and pathway databases

ReactomeREACT_6900. Immune System.

Gene expression databases

ArrayExpressQ96EF6.
BgeeQ96EF6.
CleanExHS_FBXO17.
GenevestigatorQ96EF6.

Family and domain databases

Gene3D2.60.120.260. 1 hit.
InterProIPR007397. F-box-assoc_dom.
IPR001810. F-box_dom.
IPR008979. Galactose-bd-like.
[Graphical view]
PfamPF04300. FBA. 1 hit.
[Graphical view]
SMARTSM00256. FBOX. 1 hit.
[Graphical view]
SUPFAMSSF49785. SSF49785. 1 hit.
SSF81383. SSF81383. 1 hit.
PROSITEPS51114. FBA. 1 hit.
PS50181. FBOX. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi115290.
NextBio79556.
PROQ96EF6.
SOURCESearch...

Entry information

Entry nameFBX17_HUMAN
AccessionPrimary (citable) accession number: Q96EF6
Secondary accession number(s): Q96LQ4
Entry history
Integrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: December 1, 2001
Last modified: February 19, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM