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Q96EF6

- FBX17_HUMAN

UniProt

Q96EF6 - FBX17_HUMAN

Protein

F-box only protein 17

Gene

FBXO17

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Able to recognize and bind denatured glycoproteins, which are modified with complex-type oligosaccharides. Also recognizes sulfated glycans. Does not bind high-mannose glycoproteins.

    GO - Molecular functioni

    1. glycoprotein binding Source: UniProtKB
    2. protein binding Source: UniProtKB

    Keywords - Biological processi

    Ubl conjugation pathway

    Enzyme and pathway databases

    ReactomeiREACT_75842. Antigen processing: Ubiquitination & Proteasome degradation.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    F-box only protein 17
    Alternative name(s):
    F-box only protein 26
    Gene namesi
    Name:FBXO17
    Synonyms:FBG4, FBX17, FBX26, FBXO26
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:18754. FBXO17.

    Subcellular locationi

    GO - Cellular componenti

    1. SCF ubiquitin ligase complex Source: UniProtKB

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi257 – 2582SW → AA: Reduces interaction with glycosylated concanavalin-A in vitro. 1 Publication

    Organism-specific databases

    PharmGKBiPA38676.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 278278F-box only protein 17PRO_0000119898Add
    BLAST

    Proteomic databases

    MaxQBiQ96EF6.
    PaxDbiQ96EF6.
    PRIDEiQ96EF6.

    Expressioni

    Tissue specificityi

    Expressed in heart, skeletal muscle, liver and kidney. Expressed at lower levels in spleen and brain.1 Publication

    Gene expression databases

    ArrayExpressiQ96EF6.
    BgeeiQ96EF6.
    CleanExiHS_FBXO17.
    GenevestigatoriQ96EF6.

    Interactioni

    Subunit structurei

    Part of a SCF (SKP1-cullin-F-box) protein ligase complex. Interacts with SKP1 and CUL1.1 Publication

    Protein-protein interaction databases

    BioGridi125424. 10 interactions.
    IntActiQ96EF6. 2 interactions.
    STRINGi9606.ENSP00000221431.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96EF6.
    SMRiQ96EF6. Positions 28-273.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini15 – 6248F-boxPROSITE-ProRule annotationAdd
    BLAST
    Domaini99 – 275177FBAPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 F-box domain.PROSITE-ProRule annotation
    Contains 1 FBA (F-box associated) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0172.
    HOGENOMiHOG000231084.
    HOVERGENiHBG003593.
    InParanoidiQ96EF6.
    KOiK10101.
    OMAiRPVCRAW.

    Family and domain databases

    Gene3Di2.60.120.260. 1 hit.
    InterProiIPR007397. F-box-assoc_dom.
    IPR001810. F-box_dom.
    IPR008979. Galactose-bd-like.
    [Graphical view]
    PfamiPF12937. F-box-like. 1 hit.
    PF04300. FBA. 1 hit.
    [Graphical view]
    SMARTiSM00256. FBOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF49785. SSF49785. 1 hit.
    SSF81383. SSF81383. 1 hit.
    PROSITEiPS51114. FBA. 1 hit.
    PS50181. FBOX. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q96EF6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGARLSRRRL PADPSLALDA LPPELLVQVL SHVPPRSLVT RCRPVCRAWR    50
    DIVDGPTVWL LQLARDRSAE GRALYAVAQR CLPSNEDKEE FPLCALARYC 100
    LRAPFGRNLI FNSCGEQGFR GWEVEHGGNG WAIEKNLTPV PGAPSQTCFV 150
    TSFEWCSKRQ LVDLVMEGVW QELLDSAQIE ICVADWWGAR ENCGCVYQLR 200
    VRLLDVYEKE VVKFSASPDP VLQWTERGCR QVSHVFTNFG KGIRYVSFEQ 250
    YGRDVSSWVG HYGALVTHSS VRVRIRLS 278
    Length:278
    Mass (Da):31,479
    Last modified:December 1, 2001 - v1
    Checksum:iB44E577D6F3529D4
    GO

    Sequence cautioni

    The sequence BAB71616.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF386743 mRNA. Translation: AAL37625.1.
    AK057934 mRNA. Translation: BAB71616.1. Different initiation.
    BC012385 mRNA. Translation: AAH12385.1.
    CCDSiCCDS12526.1.
    RefSeqiNP_079183.4. NM_024907.6.
    NP_680474.1. NM_148169.2.
    UniGeneiHs.531770.

    Genome annotation databases

    EnsembliENST00000292852; ENSP00000292852; ENSG00000269190.
    ENST00000595329; ENSP00000470361; ENSG00000269190.
    GeneIDi115290.
    KEGGihsa:115290.
    UCSCiuc002okf.1. human.

    Polymorphism databases

    DMDMi21263617.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF386743 mRNA. Translation: AAL37625.1 .
    AK057934 mRNA. Translation: BAB71616.1 . Different initiation.
    BC012385 mRNA. Translation: AAH12385.1 .
    CCDSi CCDS12526.1.
    RefSeqi NP_079183.4. NM_024907.6.
    NP_680474.1. NM_148169.2.
    UniGenei Hs.531770.

    3D structure databases

    ProteinModelPortali Q96EF6.
    SMRi Q96EF6. Positions 28-273.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 125424. 10 interactions.
    IntActi Q96EF6. 2 interactions.
    STRINGi 9606.ENSP00000221431.

    Polymorphism databases

    DMDMi 21263617.

    Proteomic databases

    MaxQBi Q96EF6.
    PaxDbi Q96EF6.
    PRIDEi Q96EF6.

    Protocols and materials databases

    DNASUi 115290.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000292852 ; ENSP00000292852 ; ENSG00000269190 .
    ENST00000595329 ; ENSP00000470361 ; ENSG00000269190 .
    GeneIDi 115290.
    KEGGi hsa:115290.
    UCSCi uc002okf.1. human.

    Organism-specific databases

    CTDi 115290.
    GeneCardsi GC19M039432.
    HGNCi HGNC:18754. FBXO17.
    MIMi 609094. gene.
    neXtProti NX_Q96EF6.
    PharmGKBi PA38676.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0172.
    HOGENOMi HOG000231084.
    HOVERGENi HBG003593.
    InParanoidi Q96EF6.
    KOi K10101.
    OMAi RPVCRAW.

    Enzyme and pathway databases

    Reactomei REACT_75842. Antigen processing: Ubiquitination & Proteasome degradation.

    Miscellaneous databases

    GenomeRNAii 115290.
    NextBioi 79556.
    PROi Q96EF6.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q96EF6.
    Bgeei Q96EF6.
    CleanExi HS_FBXO17.
    Genevestigatori Q96EF6.

    Family and domain databases

    Gene3Di 2.60.120.260. 1 hit.
    InterProi IPR007397. F-box-assoc_dom.
    IPR001810. F-box_dom.
    IPR008979. Galactose-bd-like.
    [Graphical view ]
    Pfami PF12937. F-box-like. 1 hit.
    PF04300. FBA. 1 hit.
    [Graphical view ]
    SMARTi SM00256. FBOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49785. SSF49785. 1 hit.
    SSF81383. SSF81383. 1 hit.
    PROSITEi PS51114. FBA. 1 hit.
    PS50181. FBOX. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A new subfamily of structurally related human F-box proteins."
      Ilyin G.P., Serandour A.L., Pigeon C., Rialland M., Glaise D., Guguen-Guillouzo C.
      Gene 296:11-20(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Ovary.
    4. "Diversity in tissue expression, substrate binding, and SCF complex formation for a lectin family of ubiquitin ligases."
      Glenn K.A., Nelson R.F., Wen H.M., Mallinger A.J., Paulson H.L.
      J. Biol. Chem. 283:12717-12729(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUGAR-BINDING, INTERACTION WITH CUL1 AND SKP1, IDENTIFICATION IN SCF-COMPLEX, MUTAGENESIS OF 257-SER-TRP-258.

    Entry informationi

    Entry nameiFBX17_HUMAN
    AccessioniPrimary (citable) accession number: Q96EF6
    Secondary accession number(s): Q96LQ4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 27, 2002
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 103 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3