Q96EF6 (FBX17_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
F-box only protein 17

Alternative name(s):
F-box only protein 26

Gene names

Name:	FBXO17
Synonyms:	FBG4, FBX17, FBX26, FBXO26

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	278 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Able to recognize and bind denatured glycoproteins, which are modified with complex-type oligosaccharides. Also recognizes sulfated glycans. Does not bind high-mannose glycoproteins.
Subunit structure	Part of a SCF (SKP1-cullin-F-box) protein ligase complex. Interacts with SKP1 and CUL1. Ref.4
Tissue specificity	Expressed in heart, skeletal muscle, liver and kidney. Expressed at lower levels in spleen and brain. Ref.1
Sequence similarities	Contains 1 F-box domain. Contains 1 FBA (F-box associated) domain.
Sequence caution	The sequence BAB71616.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Ubl conjugation pathway
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	protein catabolic process Inferred from electronic annotation. Source: InterPro
Cellular_component	SCF ubiquitin ligase complex Inferred from direct assay Ref.4. Source: UniProtKB
Molecular_function	glycoprotein binding Inferred from direct assay Ref.4. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 278	278	F-box only protein 17		PRO_0000119898
Regions
	Domain	15 – 62	48	F-box
	Domain	99 – 275	177	FBA
Experimental info
	Mutagenesis	257 – 258	2	SW → AA: Reduces interaction with glycosylated concanavalin-A in vitro. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Q96EF6 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: B44E577D6F3529D4	FASTA	278	31,479
	10 20 30 40 50 60 MGARLSRRRL PADPSLALDA LPPELLVQVL SHVPPRSLVT RCRPVCRAWR DIVDGPTVWL 70 80 90 100 110 120 LQLARDRSAE GRALYAVAQR CLPSNEDKEE FPLCALARYC LRAPFGRNLI FNSCGEQGFR 130 140 150 160 170 180 GWEVEHGGNG WAIEKNLTPV PGAPSQTCFV TSFEWCSKRQ LVDLVMEGVW QELLDSAQIE 190 200 210 220 230 240 ICVADWWGAR ENCGCVYQLR VRLLDVYEKE VVKFSASPDP VLQWTERGCR QVSHVFTNFG 250 260 270 KGIRYVSFEQ YGRDVSSWVG HYGALVTHSS VRVRIRLS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A new subfamily of structurally related human F-box proteins." Ilyin G.P., Serandour A.L., Pigeon C., Rialland M., Glaise D., Guguen-Guillouzo C. Gene 296:11-20(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Ovary.
[4]	"Diversity in tissue expression, substrate binding, and SCF complex formation for a lectin family of ubiquitin ligases." Glenn K.A., Nelson R.F., Wen H.M., Mallinger A.J., Paulson H.L. J. Biol. Chem. 283:12717-12729(2008) [PubMed] [Europe PMC] [Abstract] Cited for: SUGAR-BINDING, INTERACTION WITH CUL1 AND SKP1, IDENTIFICATION IN SCF-COMPLEX, MUTAGENESIS OF 257-SER-TRP-258.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF386743 mRNA. Translation: AAL37625.1. AK057934 mRNA. Translation: BAB71616.1. Different initiation. BC012385 mRNA. Translation: AAH12385.1.
IPI	IPI00061460.
RefSeq	NP_079183.4. NM_024907.5. NP_680474.1. NM_148169.1.
UniGene	Hs.531770.
3D structure databases
ProteinModelPortal	Q96EF6.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q96EF6. 2 interactions.
STRING	9606.ENSP00000221431.
Polymorphism databases
DMDM	21263617.
Proteomic databases
PaxDb	Q96EF6.
PRIDE	Q96EF6.
Protocols and materials databases
DNASU	115290.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000292852; ENSP00000292852; ENSG00000269190. ENST00000595329; ENSP00000470361; ENSG00000269190.
GeneID	115290.
KEGG	hsa:115290.
UCSC	uc002okf.1. human.
Organism-specific databases
CTD	115290.
GeneCards	GC19M039406.
HGNC	HGNC:18754. FBXO17.
MIM	609094. gene.
neXtProt	NX_Q96EF6.
PharmGKB	PA38676.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0172.
HOGENOM	HOG000231084.
HOVERGEN	HBG003593.
InParanoid	Q96EF6.
KO	K10101.
PhylomeDB	Q96EF6.
Enzyme and pathway databases
Reactome	REACT_6900. Immune System.
Gene expression databases
ArrayExpress	Q96EF6.
Bgee	Q96EF6.
CleanEx	HS_FBXO17.
Genevestigator	Q96EF6.
GermOnline	ENSG00000161241. Homo sapiens.
Family and domain databases
InterPro	IPR007397. F-box-assoc_dom. IPR001810. F-box_dom_cyclin-like. IPR008979. Galactose-bd-like. [Graphical view]
Pfam	PF04300. FBA. 1 hit. [Graphical view]
SMART	SM00256. FBOX. 1 hit. [Graphical view]
SUPFAM	SSF81383. F-box_dom_Skp2-like. 1 hit. SSF49785. Gal_bind_like. 1 hit.
PROSITE	PS51114. FBA. 1 hit. PS50181. FBOX. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	115290.
NextBio	79556.
SOURCE	Search...

Entry information

Entry name

FBX17_HUMAN

Accession

Primary (citable) accession number: Q96EF6
Secondary accession number(s): Q96LQ4

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 27, 2002
Last sequence update:	December 1, 2001
Last modified:	May 1, 2013
This is version 92 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.