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Protein

F-box only protein 17

Gene

FBXO17

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Able to recognize and bind denatured glycoproteins, which are modified with complex-type oligosaccharides. Also recognizes sulfated glycans. Does not bind high-mannose glycoproteins.

GO - Molecular functioni

  1. glycoprotein binding Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiREACT_75842. Antigen processing: Ubiquitination & Proteasome degradation.

Names & Taxonomyi

Protein namesi
Recommended name:
F-box only protein 17
Alternative name(s):
F-box only protein 26
Gene namesi
Name:FBXO17
Synonyms:FBG4, FBX17, FBX26, FBXO26
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:18754. FBXO17.

Subcellular locationi

GO - Cellular componenti

  1. SCF ubiquitin ligase complex Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi257 – 2582SW → AA: Reduces interaction with glycosylated concanavalin-A in vitro. 1 Publication

Organism-specific databases

PharmGKBiPA38676.

Polymorphism and mutation databases

BioMutaiFBXO17.
DMDMi21263617.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 278278F-box only protein 17PRO_0000119898Add
BLAST

Proteomic databases

MaxQBiQ96EF6.
PaxDbiQ96EF6.
PRIDEiQ96EF6.

Expressioni

Tissue specificityi

Expressed in heart, skeletal muscle, liver and kidney. Expressed at lower levels in spleen and brain.1 Publication

Gene expression databases

BgeeiQ96EF6.
CleanExiHS_FBXO17.
ExpressionAtlasiQ96EF6. baseline and differential.
GenevestigatoriQ96EF6.

Interactioni

Subunit structurei

Part of a SCF (SKP1-cullin-F-box) protein ligase complex. Interacts with SKP1 and CUL1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
SKP1P632085EBI-2510157,EBI-307486

Protein-protein interaction databases

BioGridi125424. 21 interactions.
IntActiQ96EF6. 3 interactions.
STRINGi9606.ENSP00000221431.

Structurei

3D structure databases

ProteinModelPortaliQ96EF6.
SMRiQ96EF6. Positions 28-273.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini15 – 6248F-boxPROSITE-ProRule annotationAdd
BLAST
Domaini99 – 275177FBAPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 F-box domain.PROSITE-ProRule annotation
Contains 1 FBA (F-box associated) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0172.
GeneTreeiENSGT00390000003865.
HOGENOMiHOG000231084.
HOVERGENiHBG003593.
InParanoidiQ96EF6.
KOiK10101.
OMAiVTRCRPV.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
InterProiIPR007397. F-box-assoc_dom.
IPR001810. F-box_dom.
IPR008979. Galactose-bd-like.
[Graphical view]
PfamiPF12937. F-box-like. 1 hit.
PF04300. FBA. 1 hit.
[Graphical view]
SMARTiSM00256. FBOX. 1 hit.
[Graphical view]
SUPFAMiSSF49785. SSF49785. 1 hit.
SSF81383. SSF81383. 1 hit.
PROSITEiPS51114. FBA. 1 hit.
PS50181. FBOX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96EF6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGARLSRRRL PADPSLALDA LPPELLVQVL SHVPPRSLVT RCRPVCRAWR
60 70 80 90 100
DIVDGPTVWL LQLARDRSAE GRALYAVAQR CLPSNEDKEE FPLCALARYC
110 120 130 140 150
LRAPFGRNLI FNSCGEQGFR GWEVEHGGNG WAIEKNLTPV PGAPSQTCFV
160 170 180 190 200
TSFEWCSKRQ LVDLVMEGVW QELLDSAQIE ICVADWWGAR ENCGCVYQLR
210 220 230 240 250
VRLLDVYEKE VVKFSASPDP VLQWTERGCR QVSHVFTNFG KGIRYVSFEQ
260 270
YGRDVSSWVG HYGALVTHSS VRVRIRLS
Length:278
Mass (Da):31,479
Last modified:December 1, 2001 - v1
Checksum:iB44E577D6F3529D4
GO

Sequence cautioni

The sequence BAB71616.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF386743 mRNA. Translation: AAL37625.1.
AK057934 mRNA. Translation: BAB71616.1. Different initiation.
BC012385 mRNA. Translation: AAH12385.1.
CCDSiCCDS12526.1.
RefSeqiNP_079183.4. NM_024907.6.
NP_680474.1. NM_148169.2.
UniGeneiHs.531770.

Genome annotation databases

EnsembliENST00000292852; ENSP00000292852; ENSG00000269190.
ENST00000595329; ENSP00000470361; ENSG00000269190.
GeneIDi115290.
KEGGihsa:115290.
UCSCiuc002okf.1. human.

Polymorphism and mutation databases

BioMutaiFBXO17.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF386743 mRNA. Translation: AAL37625.1.
AK057934 mRNA. Translation: BAB71616.1. Different initiation.
BC012385 mRNA. Translation: AAH12385.1.
CCDSiCCDS12526.1.
RefSeqiNP_079183.4. NM_024907.6.
NP_680474.1. NM_148169.2.
UniGeneiHs.531770.

3D structure databases

ProteinModelPortaliQ96EF6.
SMRiQ96EF6. Positions 28-273.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125424. 21 interactions.
IntActiQ96EF6. 3 interactions.
STRINGi9606.ENSP00000221431.

Polymorphism and mutation databases

BioMutaiFBXO17.
DMDMi21263617.

Proteomic databases

MaxQBiQ96EF6.
PaxDbiQ96EF6.
PRIDEiQ96EF6.

Protocols and materials databases

DNASUi115290.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000292852; ENSP00000292852; ENSG00000269190.
ENST00000595329; ENSP00000470361; ENSG00000269190.
GeneIDi115290.
KEGGihsa:115290.
UCSCiuc002okf.1. human.

Organism-specific databases

CTDi115290.
GeneCardsiGC19M039432.
HGNCiHGNC:18754. FBXO17.
MIMi609094. gene.
neXtProtiNX_Q96EF6.
PharmGKBiPA38676.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG0172.
GeneTreeiENSGT00390000003865.
HOGENOMiHOG000231084.
HOVERGENiHBG003593.
InParanoidiQ96EF6.
KOiK10101.
OMAiVTRCRPV.

Enzyme and pathway databases

ReactomeiREACT_75842. Antigen processing: Ubiquitination & Proteasome degradation.

Miscellaneous databases

GenomeRNAii115290.
NextBioi79556.
PROiQ96EF6.
SOURCEiSearch...

Gene expression databases

BgeeiQ96EF6.
CleanExiHS_FBXO17.
ExpressionAtlasiQ96EF6. baseline and differential.
GenevestigatoriQ96EF6.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
InterProiIPR007397. F-box-assoc_dom.
IPR001810. F-box_dom.
IPR008979. Galactose-bd-like.
[Graphical view]
PfamiPF12937. F-box-like. 1 hit.
PF04300. FBA. 1 hit.
[Graphical view]
SMARTiSM00256. FBOX. 1 hit.
[Graphical view]
SUPFAMiSSF49785. SSF49785. 1 hit.
SSF81383. SSF81383. 1 hit.
PROSITEiPS51114. FBA. 1 hit.
PS50181. FBOX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A new subfamily of structurally related human F-box proteins."
    Ilyin G.P., Serandour A.L., Pigeon C., Rialland M., Glaise D., Guguen-Guillouzo C.
    Gene 296:11-20(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Ovary.
  4. "Diversity in tissue expression, substrate binding, and SCF complex formation for a lectin family of ubiquitin ligases."
    Glenn K.A., Nelson R.F., Wen H.M., Mallinger A.J., Paulson H.L.
    J. Biol. Chem. 283:12717-12729(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUGAR-BINDING, INTERACTION WITH CUL1 AND SKP1, IDENTIFICATION IN SCF-COMPLEX, MUTAGENESIS OF 257-SER-TRP-258.

Entry informationi

Entry nameiFBX17_HUMAN
AccessioniPrimary (citable) accession number: Q96EF6
Secondary accession number(s): Q96LQ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: December 1, 2001
Last modified: April 29, 2015
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.