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Protein

Protein YIPF6

Gene

YIPF6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-432722. Golgi Associated Vesicle Biogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein YIPF6
Alternative name(s):
YIP1 family member 6
Gene namesi
Name:YIPF6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:28304. YIPF6.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei85 – 105HelicalSequence analysisAdd BLAST21
Transmembranei116 – 136HelicalSequence analysisAdd BLAST21
Transmembranei147 – 167HelicalSequence analysisAdd BLAST21
Transmembranei185 – 205HelicalSequence analysisAdd BLAST21
Transmembranei213 – 233HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000181704.
PharmGKBiPA142670549.

Polymorphism and mutation databases

BioMutaiYIPF6.
DMDMi109896316.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002426682 – 236Protein YIPF6Add BLAST235

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei7PhosphoserineBy similarity1
Glycosylationi55N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi144N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Acetylation, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ96EC8.
MaxQBiQ96EC8.
PaxDbiQ96EC8.
PeptideAtlasiQ96EC8.
PRIDEiQ96EC8.

PTM databases

iPTMnetiQ96EC8.
PhosphoSitePlusiQ96EC8.

Expressioni

Gene expression databases

BgeeiENSG00000181704.
CleanExiHS_YIPF6.
ExpressionAtlasiQ96EC8. baseline and differential.
GenevisibleiQ96EC8. HS.

Organism-specific databases

HPAiHPA003720.

Interactioni

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi130382. 8 interactors.
IntActiQ96EC8. 21 interactors.
MINTiMINT-3052363.
STRINGi9606.ENSP00000417573.

Structurei

3D structure databases

ProteinModelPortaliQ96EC8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the YIP1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2946. Eukaryota.
COG5080. LUCA.
GeneTreeiENSGT00730000111156.
HOGENOMiHOG000163579.
HOVERGENiHBG080248.
InParanoidiQ96EC8.
OMAiTYASFVF.
OrthoDBiEOG091G0HTE.
PhylomeDBiQ96EC8.
TreeFamiTF314563.

Family and domain databases

InterProiView protein in InterPro
IPR006977. Yip1.
PfamiView protein in Pfam
PF04893. Yip1. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96EC8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAEAEESPGD PGTASPRPLF AGLSDISISQ DIPVEGEITI PMRSRIREFD
60 70 80 90 100
SSTLNESVRN TIMRDLKAVG KKFMHVLYPR KSNTLLRDWD LWGPLILCVT
110 120 130 140 150
LALMLQRDSA DSEKDGGPQF AEVFVIVWFG AVTITLNSKL LGGNISFFQS
160 170 180 190 200
LCVLGYCILP LTVAMLICRL VLLADPGPVN FMVRLFVVIV MFAWSIVAST
210 220 230
AFLADSQPPN RRALAVYPVF LFYFVISWMI LTFTPQ
Length:236
Mass (Da):26,256
Last modified:June 27, 2006 - v2
Checksum:i2BAF422A0EF286AD
GO
Isoform 2 (identifier: Q96EC8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     20-62: Missing.

Show »
Length:193
Mass (Da):21,479
Checksum:i38E1C24F0DF330C1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti95L → S in BAG64909 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_026855202F → L1 PublicationCorresponds to variant dbSNP:rs17850921Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04712120 – 62Missing in isoform 2. 1 PublicationAdd BLAST43

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK303992 mRNA. Translation: BAG64909.1.
AL928603, AL672138 Genomic DNA. Translation: CAI41478.1.
AL672138, AL928603 Genomic DNA. Translation: CAI41511.1.
CH471132 Genomic DNA. Translation: EAX05376.1.
BC012469 mRNA. Translation: AAH12469.1.
CCDSiCCDS14389.1. [Q96EC8-1]
CCDS56604.1. [Q96EC8-2]
RefSeqiNP_001182143.1. NM_001195214.1. [Q96EC8-2]
NP_776195.2. NM_173834.3. [Q96EC8-1]
UniGeneiHs.82719.

Genome annotation databases

EnsembliENST00000374622; ENSP00000363751; ENSG00000181704. [Q96EC8-2]
ENST00000462683; ENSP00000417573; ENSG00000181704. [Q96EC8-1]
GeneIDi286451.
KEGGihsa:286451.
UCSCiuc004dwz.4. human. [Q96EC8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK303992 mRNA. Translation: BAG64909.1.
AL928603, AL672138 Genomic DNA. Translation: CAI41478.1.
AL672138, AL928603 Genomic DNA. Translation: CAI41511.1.
CH471132 Genomic DNA. Translation: EAX05376.1.
BC012469 mRNA. Translation: AAH12469.1.
CCDSiCCDS14389.1. [Q96EC8-1]
CCDS56604.1. [Q96EC8-2]
RefSeqiNP_001182143.1. NM_001195214.1. [Q96EC8-2]
NP_776195.2. NM_173834.3. [Q96EC8-1]
UniGeneiHs.82719.

3D structure databases

ProteinModelPortaliQ96EC8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi130382. 8 interactors.
IntActiQ96EC8. 21 interactors.
MINTiMINT-3052363.
STRINGi9606.ENSP00000417573.

PTM databases

iPTMnetiQ96EC8.
PhosphoSitePlusiQ96EC8.

Polymorphism and mutation databases

BioMutaiYIPF6.
DMDMi109896316.

Proteomic databases

EPDiQ96EC8.
MaxQBiQ96EC8.
PaxDbiQ96EC8.
PeptideAtlasiQ96EC8.
PRIDEiQ96EC8.

Protocols and materials databases

DNASUi286451.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000374622; ENSP00000363751; ENSG00000181704. [Q96EC8-2]
ENST00000462683; ENSP00000417573; ENSG00000181704. [Q96EC8-1]
GeneIDi286451.
KEGGihsa:286451.
UCSCiuc004dwz.4. human. [Q96EC8-1]

Organism-specific databases

CTDi286451.
GeneCardsiYIPF6.
HGNCiHGNC:28304. YIPF6.
HPAiHPA003720.
neXtProtiNX_Q96EC8.
OpenTargetsiENSG00000181704.
PharmGKBiPA142670549.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2946. Eukaryota.
COG5080. LUCA.
GeneTreeiENSGT00730000111156.
HOGENOMiHOG000163579.
HOVERGENiHBG080248.
InParanoidiQ96EC8.
OMAiTYASFVF.
OrthoDBiEOG091G0HTE.
PhylomeDBiQ96EC8.
TreeFamiTF314563.

Enzyme and pathway databases

ReactomeiR-HSA-432722. Golgi Associated Vesicle Biogenesis.

Miscellaneous databases

GeneWikiiYIPF6.
GenomeRNAii286451.
PROiPR:Q96EC8.

Gene expression databases

BgeeiENSG00000181704.
CleanExiHS_YIPF6.
ExpressionAtlasiQ96EC8. baseline and differential.
GenevisibleiQ96EC8. HS.

Family and domain databases

InterProiView protein in InterPro
IPR006977. Yip1.
PfamiView protein in Pfam
PF04893. Yip1. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiYIPF6_HUMAN
AccessioniPrimary (citable) accession number: Q96EC8
Secondary accession number(s): B4E1U7, G5E997, Q5JP08
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 27, 2006
Last modified: June 7, 2017
This is version 112 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.