Q96EC8 (YIPF6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein YIPF6

Alternative name(s):
YIP1 family member 6

Gene names

Name:

YIPF6

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	236 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the YIP1 family.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	endoplasmic reticulum Inferred from direct assay. Source: LIFEdb integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 236	236	Protein YIPF6		PRO_0000242668
Regions
	Transmembrane	85 – 105	21	Helical; Potential
	Transmembrane	116 – 136	21	Helical; Potential
	Transmembrane	147 – 167	21	Helical; Potential
	Transmembrane	185 – 205	21	Helical; Potential
	Transmembrane	213 – 233	21	Helical; Potential
Amino acid modifications
	Glycosylation	55	1	N-linked (GlcNAc...) Potential
	Glycosylation	144	1	N-linked (GlcNAc...) Potential
Natural variations
	Natural variant	202	1	F → L. Ref.2 Corresponds to variant rs17850921 [ dbSNP | Ensembl ].		VAR_026855

Sequences

	Sequence		Length	Mass (Da)
	Q96EC8 [UniParc]. Last modified June 27, 2006. Version 2. Checksum: 2BAF422A0EF286AD	FASTA	236	26,256
	10 20 30 40 50 60 MAEAEESPGD PGTASPRPLF AGLSDISISQ DIPVEGEITI PMRSRIREFD SSTLNESVRN 70 80 90 100 110 120 TIMRDLKAVG KKFMHVLYPR KSNTLLRDWD LWGPLILCVT LALMLQRDSA DSEKDGGPQF 130 140 150 160 170 180 AEVFVIVWFG AVTITLNSKL LGGNISFFQS LCVLGYCILP LTVAMLICRL VLLADPGPVN 190 200 210 220 230 FMVRLFVVIV MFAWSIVAST AFLADSQPPN RRALAVYPVF LFYFVISWMI LTFTPQ

References

[1]	"The DNA sequence of the human X chromosome." Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R. Nature 434:325-337(2005) [PubMed: 15772651] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LEU-202. Tissue: Kidney.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL928603, AL672138 Genomic DNA. Translation: CAI41478.1. AL672138, AL928603 Genomic DNA. Translation: CAI41511.1. BC012469 mRNA. Translation: AAH12469.1.
IPI	IPI00061403.
RefSeq	NP_776195.2. NM_173834.3.
UniGene	Hs.82719.
3D structure databases
ProteinModelPortal	Q96EC8.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q96EC8. 3 interactions.
STRING	Q96EC8.
PTM databases
PhosphoSite	Q96EC8.
Polymorphism databases
DMDM	109896316.
Proteomic databases
PRIDE	Q96EC8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000462683; ENSP00000417573; ENSG00000181704.
GeneID	286451.
KEGG	hsa:286451.
UCSC	uc004dwy.1. human.
Organism-specific databases
CTD	286451.
GeneCards	GC0XP067718.
HGNC	HGNC:28304. YIPF6.
HPA	HPA003720.
neXtProt	NX_Q96EC8.
PharmGKB	PA142670549.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG07807.
GeneTree	ENSGT00530000063514.
HOGENOM	HBG559170.
HOVERGEN	HBG080248.
InParanoid	Q96EC8.
OMA	GTISFFQ.
OrthoDB	EOG45DWQB.
PhylomeDB	Q96EC8.
Enzyme and pathway databases
Reactome	REACT_11123. Membrane Trafficking.
Gene expression databases
ArrayExpress	Q96EC8.
Bgee	Q96EC8.
CleanEx	HS_YIPF6.
Genevestigator	Q96EC8.
GermOnline	ENSG00000181704. Homo sapiens.
Family and domain databases
InterPro	IPR006977. Yip1. [Graphical view]
Pfam	PF04893. Yip1. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	96218.

Entry information

Entry name

YIPF6_HUMAN

Accession

Primary (citable) accession number: Q96EC8
Secondary accession number(s): Q5JP08

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 27, 2006
Last sequence update:	June 27, 2006
Last modified:	January 25, 2012
This is version 68 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.