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Protein

Killer cell lectin-like receptor subfamily G member 1

Gene

KLRG1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays an inhibitory role on natural killer (NK) cells and T-cell functions upon binding to their non-MHC ligands. May mediate missing self recognition by binding to a highly conserved site on classical cadherins, enabling it to monitor expression of E-cadherin/CDH1, N-cadherin/CDH2 and R-cadherin/CDH4 on target cells.1 Publication

GO - Molecular functioni

  • carbohydrate binding Source: ProtInc
  • receptor activity Source: ProtInc

GO - Biological processi

  • cell surface receptor signaling pathway Source: ProtInc
  • cellular defense response Source: ProtInc
  • inflammatory response Source: ProtInc
  • innate immune response Source: UniProtKB-KW

Keywordsi

Molecular functionReceptor
Biological processImmunity, Innate immunity
LigandLectin

Enzyme and pathway databases

ReactomeiR-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

Names & Taxonomyi

Protein namesi
Recommended name:
Killer cell lectin-like receptor subfamily G member 1
Alternative name(s):
C-type lectin domain family 15 member A
ITIM-containing receptor MAFA-L
MAFA-like receptor
Mast cell function-associated antigen
Gene namesi
Name:KLRG1
Synonyms:CLEC15A, MAFA, MAFAL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000139187.9
HGNCiHGNC:6380 KLRG1
MIMi604874 gene
neXtProtiNX_Q96E93

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 38CytoplasmicSequence analysisAdd BLAST38
Transmembranei39 – 59Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini60 – 195ExtracellularSequence analysisAdd BLAST136

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi10219
OpenTargetsiENSG00000139187
PharmGKBiPA30170

Polymorphism and mutation databases

BioMutaiKLRG1
DMDMi74731536

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003312561 – 195Killer cell lectin-like receptor subfamily G member 1Add BLAST195

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi65N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi75 ↔ 86PROSITE-ProRule annotation1 Publication
Glycosylationi97N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi103 ↔ 184PROSITE-ProRule annotation1 Publication
Glycosylationi137N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi150N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi163 ↔ 176PROSITE-ProRule annotation1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ96E93
PaxDbiQ96E93
PeptideAtlasiQ96E93
PRIDEiQ96E93

PTM databases

iPTMnetiQ96E93
PhosphoSitePlusiQ96E93

Expressioni

Tissue specificityi

Expressed specifically on natural killer (NK) cells and T-cells, mainly CD8 T-cells.2 Publications

Inductioni

By pathogens and viruses infections.1 Publication

Gene expression databases

BgeeiENSG00000139187
CleanExiHS_KLRG1
HS_MAFA
ExpressionAtlasiQ96E93 baseline and differential
GenevisibleiQ96E93 HS

Organism-specific databases

HPAiHPA051403
HPA076494

Interactioni

Subunit structurei

Forms a monomer and homodimer; disulfide-linked. Interacts (via ITIM motif) with PTPN11 and INPP5D.By similarity

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi115514, 2 interactors
IntActiQ96E93, 3 interactors
STRINGi9606.ENSP00000349477

Structurei

Secondary structure

1195
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi80 – 82Combined sources3
Beta strandi85 – 89Combined sources5
Helixi96 – 104Combined sources9
Turni105 – 107Combined sources3
Helixi116 – 123Combined sources8
Beta strandi131 – 143Combined sources13
Beta strandi163 – 167Combined sources5
Beta strandi170 – 174Combined sources5
Beta strandi180 – 185Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3FF7X-ray1.80C/D75-186[»]
ProteinModelPortaliQ96E93
SMRiQ96E93
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ96E93

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini82 – 185C-type lectinPROSITE-ProRule annotationAdd BLAST104

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi5 – 10ITIM motif6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi28 – 31Poly-Ser4

Domaini

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4297 Eukaryota
ENOG410XPJ1 LUCA
GeneTreeiENSGT00710000106527
HOGENOMiHOG000082429
HOVERGENiHBG103557
InParanoidiQ96E93
KOiK10076
OMAiNSGWRWE
OrthoDBiEOG091G0MK5
PhylomeDBiQ96E93
TreeFamiTF336674

Family and domain databases

CDDicd03593 CLECT_NK_receptors_like, 1 hit
Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR016187 CTDL_fold
IPR033992 NKR-like_CTLD
PfamiView protein in Pfam
PF00059 Lectin_C, 1 hit
SMARTiView protein in SMART
SM00034 CLECT, 1 hit
SUPFAMiSSF56436 SSF56436, 1 hit
PROSITEiView protein in PROSITE
PS50041 C_TYPE_LECTIN_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96E93-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTDSVIYSML ELPTATQAQN DYGPQQKSSS SRPSCSCLVA IALGLLTAVL
60 70 80 90 100
LSVLLYQWIL CQGSNYSTCA SCPSCPDRWM KYGNHCYYFS VEEKDWNSSL
110 120 130 140 150
EFCLARDSHL LVITDNQEMS LLQVFLSEAF CWIGLRNNSG WRWEDGSPLN
160 170 180 190
FSRISSNSFV QTCGAINKNG LQASSCEVPL HWVCKKCPFA DQALF
Length:195
Mass (Da):21,831
Last modified:December 1, 2001 - v1
Checksum:i178EE98E08EEC473
GO
Isoform 2 (identifier: Q96E93-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     187-195: CPFADQALF → VRL

Show »
Length:189
Mass (Da):21,206
Checksum:iFA9023F1523656A8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti32R → K in AAC34731 (PubMed:9765598).Curated1
Sequence conflicti42A → T in AAC34731 (PubMed:9765598).Curated1
Sequence conflicti182W → G in AAC34731 (PubMed:9765598).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04275058W → R. Corresponds to variant dbSNP:rs1805749Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_033151187 – 195CPFADQALF → VRL in isoform 2. 3 Publications9

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF034952 mRNA Translation: AAC34731.1
AF081675 mRNA Translation: AAC32200.1
AF097358 mRNA Translation: AAD03719.1
AK316337 mRNA Translation: BAH14708.1
CH471116 Genomic DNA Translation: EAW88594.1
CH471116 Genomic DNA Translation: EAW88595.1
BC012621 mRNA Translation: AAH12621.1
CCDSiCCDS8599.1 [Q96E93-2]
RefSeqiNP_001316028.1, NM_001329099.1 [Q96E93-1]
NP_005801.3, NM_005810.3 [Q96E93-2]
UniGeneiHs.558446

Genome annotation databases

EnsembliENST00000266551; ENSP00000266551; ENSG00000139187 [Q96E93-1]
ENST00000356986; ENSP00000349477; ENSG00000139187 [Q96E93-2]
GeneIDi10219
KEGGihsa:10219
UCSCiuc001qvg.4 human [Q96E93-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiKLRG1_HUMAN
AccessioniPrimary (citable) accession number: Q96E93
Secondary accession number(s): B7ZAM2, O43198, O75613
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: December 1, 2001
Last modified: February 28, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health