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Protein
Submitted name:

5'-AMP-activated protein kinase catalytic subunit alpha-1

Gene

PRKAA1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinaseUniRule annotation, Transferase

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
5'-AMP-activated protein kinase catalytic subunit alpha-1Imported
Submitted name:
PRKAA1 proteinImported
Submitted name:
Protein kinase, AMP-activated, alpha 1 catalytic subunit, isoform CRA_bImported
Gene namesi
Name:PRKAA1Imported
ORF Names:hCG_37338Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:9376. PRKAA1.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000132356.

Expressioni

Gene expression databases

BgeeiENSG00000132356.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini18 – 207Protein kinaseInterPro annotationAdd BLAST190

Sequence similaritiesi

Belongs to the protein kinase superfamily.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00790000122947.
HOGENOMiHOG000233016.
HOVERGENiHBG093722.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96E92-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATAEKQKHD GRVKIGHYIL GDTLGVGTFG KVKVGKHELT GHKVAVKILN
60 70 80 90 100
RQKIRSLDVV GKIRREIQNL KLFRHPHIIK LYQVISTPSD IFMVMEYVSG
110 120 130 140 150
GELFDYICKN GRLDEKESRR LFQQILSGVD YCHRHMVVHR DLKPENVLLD
160 170 180 190 200
AHMNAKIADF GLSNMMSDGE FLRTSCGSPN YAAPEVISGR DCNIIRILTS

QFTNYQH
Length:207
Mass (Da):23,563
Last modified:December 1, 2001 - v1
Checksum:i6AE1E17F981DAA47
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei207Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC008810 Genomic DNA. No translation available.
BC012622 mRNA. Translation: AAH12622.1.
CH471119 Genomic DNA. Translation: EAW56001.1.
UniGeneiHs.43322.

Genome annotation databases

EnsembliENST00000296800; ENSP00000296800; ENSG00000132356.
UCSCiuc063dfh.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC008810 Genomic DNA. No translation available.
BC012622 mRNA. Translation: AAH12622.1.
CH471119 Genomic DNA. Translation: EAW56001.1.
UniGeneiHs.43322.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000296800; ENSP00000296800; ENSG00000132356.
UCSCiuc063dfh.1. human.

Organism-specific databases

HGNCiHGNC:9376. PRKAA1.
OpenTargetsiENSG00000132356.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00790000122947.
HOGENOMiHOG000233016.
HOVERGENiHBG093722.

Miscellaneous databases

ChiTaRSiPRKAA1. human.

Gene expression databases

BgeeiENSG00000132356.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ96E92_HUMAN
AccessioniPrimary (citable) accession number: Q96E92
Entry historyi
Integrated into UniProtKB/TrEMBL: December 1, 2001
Last sequence update: December 1, 2001
Last modified: November 30, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.