Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Sperm acrosome-associated protein 9

Gene

SPACA9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Sperm acrosome-associated protein 9
Gene namesi
Name:SPACA9Imported
Synonyms:C9orf9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:1367. SPACA9.

Subcellular locationi

  • Cytoplasm By similarity
  • Cytoplasmic vesiclesecretory vesicleacrosome By similarity

  • Note: In caudal sperms localizes onto sperm head. Is also present on midpiece and principle piece of sperm tails. Acrosome and sperm tail localization is regulated by Y-chromosome.By similarity

GO - Cellular componenti

  • acrosomal vesicle Source: UniProtKB-SubCell
  • cytoplasmic microtubule Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25983.

Polymorphism and mutation databases

BioMutaiC9orf9.
DMDMi68565255.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 222222Sperm acrosome-associated protein 9PRO_0000089673Add
BLAST

Proteomic databases

MaxQBiQ96E40.
PaxDbiQ96E40.
PeptideAtlasiQ96E40.
PRIDEiQ96E40.

PTM databases

iPTMnetiQ96E40.
PhosphoSiteiQ96E40.

Expressioni

Gene expression databases

BgeeiENSG00000165698.
CleanExiHS_C9orf9.
ExpressionAtlasiQ96E40. baseline and differential.
GenevisibleiQ96E40. HS.

Organism-specific databases

HPAiHPA022243.

Interactioni

Subunit structurei

Interacts with CABP1 AND CALR.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
EXOC5Q8IW243EBI-722584,EBI-10171392
KRTAP10-5P603703EBI-722584,EBI-10172150
KRTAP10-7P604093EBI-722584,EBI-10172290
KRTAP10-8P604103EBI-722584,EBI-10171774
KRTAP10-9P604113EBI-722584,EBI-10172052

Protein-protein interaction databases

BioGridi116273. 11 interactions.
IntActiQ96E40. 9 interactions.
MINTiMINT-1399419.
STRINGi9606.ENSP00000298546.

Structurei

3D structure databases

ProteinModelPortaliQ96E40.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi19 – 224Poly-Gln

Phylogenomic databases

eggNOGiENOG410IGPD. Eukaryota.
ENOG4111PX9. LUCA.
GeneTreeiENSGT00390000007746.
HOGENOMiHOG000231485.
HOVERGENiHBG061624.
InParanoidiQ96E40.
OMAiSKPPWRP.
OrthoDBiEOG091G0MZL.
PhylomeDBiQ96E40.
TreeFamiTF328897.

Family and domain databases

InterProiIPR027818. DUF4561.
[Graphical view]
PfamiPF15120. DUF4561. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96E40-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNEVKESLRS IEQKYKLFQQ QQLTFTAALE HCRENAHDKI RPISSIGQVQ
60 70 80 90 100
SYMEHYCNSS TDRRVLLMFL DICSELNKLC QHFEAVHSGT PVTNNLLEKC
110 120 130 140 150
KTLVSQSNDL SSLRAKYPHD VVNHLSCDEA RNHYGGVVSL IPLILDLMKE
160 170 180 190 200
WIAHSEKLPR KVLQHVSEPQ AHQESTRGAA RPAQAIGTQP RATKHKCRQL
210 220
TKASLKPRGC SKPPWRPPGG KL
Length:222
Mass (Da):25,166
Last modified:December 1, 2001 - v1
Checksum:iF052332EB5E6EC96
GO
Isoform 2 (identifier: Q96E40-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     166-168: VSE → GTT
     169-222: Missing.

Show »
Length:168
Mass (Da):19,289
Checksum:i3F2BEB99132B7631
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti104 – 1041V → I.
Corresponds to variant rs2231406 [ dbSNP | Ensembl ].
VAR_056817

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei166 – 1683VSE → GTT in isoform 2. 2 PublicationsVSP_014456
Alternative sequencei169 – 22254Missing in isoform 2. 2 PublicationsVSP_014457Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ011375 mRNA. Translation: CAB66158.1.
AK075259 mRNA. Translation: BAC11503.1.
CR457210 mRNA. Translation: CAG33491.1.
AL445645 Genomic DNA. Translation: CAH72110.1.
AL445645 Genomic DNA. Translation: CAH72111.1.
BC012940 mRNA. Translation: AAH12940.1.
CCDSiCCDS6955.1. [Q96E40-2]
RefSeqiNP_001303826.1. NM_001316897.1. [Q96E40-1]
NP_001303827.1. NM_001316898.1. [Q96E40-1]
NP_001303829.1. NM_001316900.1.
NP_061829.3. NM_018956.4. [Q96E40-2]
UniGeneiHs.62595.

Genome annotation databases

EnsembliENST00000350499; ENSP00000298546; ENSG00000165698. [Q96E40-2]
ENST00000356311; ENSP00000348659; ENSG00000165698. [Q96E40-1]
ENST00000372136; ENSP00000361209; ENSG00000165698. [Q96E40-1]
GeneIDi11092.
KEGGihsa:11092.
UCSCiuc004cbx.2. human. [Q96E40-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ011375 mRNA. Translation: CAB66158.1.
AK075259 mRNA. Translation: BAC11503.1.
CR457210 mRNA. Translation: CAG33491.1.
AL445645 Genomic DNA. Translation: CAH72110.1.
AL445645 Genomic DNA. Translation: CAH72111.1.
BC012940 mRNA. Translation: AAH12940.1.
CCDSiCCDS6955.1. [Q96E40-2]
RefSeqiNP_001303826.1. NM_001316897.1. [Q96E40-1]
NP_001303827.1. NM_001316898.1. [Q96E40-1]
NP_001303829.1. NM_001316900.1.
NP_061829.3. NM_018956.4. [Q96E40-2]
UniGeneiHs.62595.

3D structure databases

ProteinModelPortaliQ96E40.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116273. 11 interactions.
IntActiQ96E40. 9 interactions.
MINTiMINT-1399419.
STRINGi9606.ENSP00000298546.

PTM databases

iPTMnetiQ96E40.
PhosphoSiteiQ96E40.

Polymorphism and mutation databases

BioMutaiC9orf9.
DMDMi68565255.

Proteomic databases

MaxQBiQ96E40.
PaxDbiQ96E40.
PeptideAtlasiQ96E40.
PRIDEiQ96E40.

Protocols and materials databases

DNASUi11092.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000350499; ENSP00000298546; ENSG00000165698. [Q96E40-2]
ENST00000356311; ENSP00000348659; ENSG00000165698. [Q96E40-1]
ENST00000372136; ENSP00000361209; ENSG00000165698. [Q96E40-1]
GeneIDi11092.
KEGGihsa:11092.
UCSCiuc004cbx.2. human. [Q96E40-1]

Organism-specific databases

CTDi11092.
GeneCardsiC9orf9.
HGNCiHGNC:1367. SPACA9.
HPAiHPA022243.
neXtProtiNX_Q96E40.
PharmGKBiPA25983.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGPD. Eukaryota.
ENOG4111PX9. LUCA.
GeneTreeiENSGT00390000007746.
HOGENOMiHOG000231485.
HOVERGENiHBG061624.
InParanoidiQ96E40.
OMAiSKPPWRP.
OrthoDBiEOG091G0MZL.
PhylomeDBiQ96E40.
TreeFamiTF328897.

Miscellaneous databases

ChiTaRSiC9orf9. human.
GenomeRNAii11092.
PROiQ96E40.

Gene expression databases

BgeeiENSG00000165698.
CleanExiHS_C9orf9.
ExpressionAtlasiQ96E40. baseline and differential.
GenevisibleiQ96E40. HS.

Family and domain databases

InterProiIPR027818. DUF4561.
[Graphical view]
PfamiPF15120. DUF4561. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSACA9_HUMAN
AccessioniPrimary (citable) accession number: Q96E40
Secondary accession number(s): Q9UGQ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: December 1, 2001
Last modified: September 7, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.