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Protein

RNA binding motif protein, X-linked-like-1

Gene

RBMXL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

RNA-binding protein which may be involved in pre-mRNA splicing.By similarity

Miscellaneous

According to some authors, RBMXL1 is a RBMX retrogene on chromosome X which is likely to be functional.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, RNA-binding
Biological processmRNA processing, mRNA splicing

Names & Taxonomyi

Protein namesi
Recommended name:
RNA binding motif protein, X-linked-like-1
Alternative name(s):
Heterogeneous nuclear ribonucleoprotein G-like 1
Gene namesi
Name:RBMXL1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000213516.9.
HGNCiHGNC:25073. RBMXL1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi494115.
OpenTargetsiENSG00000213516.
PharmGKBiPA165752300.

Polymorphism and mutation databases

BioMutaiRBMXL1.
DMDMi74760797.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004080051 – 390RNA binding motif protein, X-linked-like-1Add BLAST390

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki80Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei88PhosphoserineCombined sources1
Modified residuei125Asymmetric dimethylarginine; alternateBy similarity1
Modified residuei125Omega-N-methylarginine; alternateBy similarity1
Modified residuei144Omega-N-methylarginineBy similarity1
Modified residuei161PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ96E39.
MaxQBiQ96E39.
PaxDbiQ96E39.
PeptideAtlasiQ96E39.
PRIDEiQ96E39.

PTM databases

iPTMnetiQ96E39.
PhosphoSitePlusiQ96E39.
SwissPalmiQ96E39.

Expressioni

Gene expression databases

BgeeiENSG00000213516.
ExpressionAtlasiQ96E39. baseline and differential.
GenevisibleiQ96E39. HS.

Organism-specific databases

HPAiHPA057707.

Interactioni

Protein-protein interaction databases

BioGridi138936. 27 interactors.
IntActiQ96E39. 10 interactors.
MINTiMINT-4992845.

Structurei

3D structure databases

ProteinModelPortaliQ96E39.
SMRiQ96E39.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 86RRMPROSITE-ProRule annotationAdd BLAST79

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi273 – 367Ser-richAdd BLAST95

Phylogenomic databases

eggNOGiENOG410IHG3. Eukaryota.
ENOG4111GI6. LUCA.
GeneTreeiENSGT00710000106295.
HOGENOMiHOG000276235.
HOVERGENiHBG063314.
InParanoidiQ96E39.
KOiK12885.
OMAiYPDERDM.
OrthoDBiEOG091G13K0.
PhylomeDBiQ96E39.
TreeFamiTF331833.

Family and domain databases

InterProiView protein in InterPro
IPR012604. RBM1CTR.
IPR000504. RRM_dom.
IPR003954. RRM_dom_euk.
PfamiView protein in Pfam
PF08081. RBM1CTR. 1 hit.
PF00076. RRM_1. 1 hit.
SMARTiView protein in SMART
SM00360. RRM. 1 hit.
SM00361. RRM_1. 1 hit.
SUPFAMiSSF54928. SSF54928. 1 hit.
PROSITEiView protein in PROSITE
PS50102. RRM. 1 hit.

Sequencei

Sequence statusi: Complete.

Q96E39-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVEADRPGKL FIGGLNTETN EKALETVFGK YGRIVEVLLI KDRETNKSRG
60 70 80 90 100
FAFVTFESPA DAKDAARDMN GKSLDGKAIK VEQATKPSFE RGRHGPPPPP
110 120 130 140 150
RSRGPPRGFG AGRGGSGGTR GPPSRGGHMD DGGYSMNFNM SSSRGPLPVK
160 170 180 190 200
RGPPPRSGGP SPKRSAPSGL VRSSSGMGGR APLSRGRDSY GGPPRREPLP
210 220 230 240 250
SRRDVYLSPR DDGYSTKDSY SSRDYPSSRD TRDYAPPPRD YTYRDYGHSS
260 270 280 290 300
SRDDYPSRGY GDRDGYGRDR DYSDHPSGGS YRDSYESYGN SRSAPLTRGP
310 320 330 340 350
PPSYGGSSRY DDYSSSRDGY GGSRDSYSSS RSDLYSSCDR VGRQERGLPP
360 370 380 390
SVERGYPSSR DSYSSSSRGA PRGAGPGGSR SDRGGGRSRY
Length:390
Mass (Da):42,142
Last modified:December 1, 2001 - v1
Checksum:iE8D74676C3AE6420
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL832554 mRNA. Translation: CAI46148.1.
AL139416 Genomic DNA. Translation: CAI21693.1.
CH471097 Genomic DNA. Translation: EAW73155.1.
CH471097 Genomic DNA. Translation: EAW73156.1.
BC012942 mRNA. Translation: AAH12942.1.
CCDSiCCDS716.1.
RefSeqiNP_001156008.1. NM_001162536.2.
NP_062556.2. NM_019610.5.
UniGeneiHs.481898.

Genome annotation databases

EnsembliENST00000321792; ENSP00000318415; ENSG00000213516.
ENST00000399794; ENSP00000446099; ENSG00000213516.
GeneIDi494115.
KEGGihsa:494115.
UCSCiuc001dms.4. human.

Similar proteinsi

Entry informationi

Entry nameiRMXL1_HUMAN
AccessioniPrimary (citable) accession number: Q96E39
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 3, 2011
Last sequence update: December 1, 2001
Last modified: September 27, 2017
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The first non-coding exon of RBMXL1 is in common with that of CCBL2.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM