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Protein

Zinc finger MYND domain-containing protein 19

Gene

ZMYND19

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved as a regulatory molecule in GPR24/MCH-R1 signaling.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri164 – 212MYND-typePROSITE-ProRule annotationAdd BLAST49

GO - Molecular functioni

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger MYND domain-containing protein 19
Alternative name(s):
Melanin-concentrating hormone receptor 1-interacting zinc finger protein
Short name:
MCH-R1-interacting zinc finger protein
Gene namesi
Name:ZMYND19
Synonyms:MIZIP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:21146. ZMYND19.

Subcellular locationi

  • Cytoplasm 1 Publication
  • Cell membrane 1 Publication; Peripheral membrane protein 1 Publication

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000165724.
PharmGKBiPA134878875.

Polymorphism and mutation databases

BioMutaiZMYND19.
DMDMi46397255.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002183191 – 227Zinc finger MYND domain-containing protein 19Add BLAST227

Proteomic databases

EPDiQ96E35.
MaxQBiQ96E35.
PaxDbiQ96E35.
PeptideAtlasiQ96E35.
PRIDEiQ96E35.

PTM databases

PhosphoSitePlusiQ96E35.

Expressioni

Tissue specificityi

Expressed in brain, testis, placenta, heart, liver, skeletal muscle, kidney and stomach.1 Publication

Gene expression databases

BgeeiENSG00000165724.
CleanExiHS_ZMYND19.
GenevisibleiQ96E35. HS.

Organism-specific databases

HPAiHPA020642.
HPA050761.

Interactioni

Subunit structurei

Interacts with GPR24/MCH-R1.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi125490. 39 interactors.
IntActiQ96E35. 44 interactors.
MINTiMINT-246545.
STRINGi9606.ENSP00000298585.

Structurei

3D structure databases

ProteinModelPortaliQ96E35.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi158 – 161Poly-Glu4

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri164 – 212MYND-typePROSITE-ProRule annotationAdd BLAST49

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG410IF0H. Eukaryota.
ENOG410YJQA. LUCA.
GeneTreeiENSGT00390000012479.
HOGENOMiHOG000231532.
HOVERGENiHBG058268.
InParanoidiQ96E35.
OMAiESSCTYY.
OrthoDBiEOG091G0O2G.
PhylomeDBiQ96E35.
TreeFamiTF329209.

Family and domain databases

InterProiView protein in InterPro
IPR003615. HNH_nuc.
IPR032978. ZMYND19.
IPR002893. Znf_MYND.
PANTHERiPTHR13244:SF11. PTHR13244:SF11. 1 hit.
PfamiView protein in Pfam
PF13392. HNH_3. 1 hit.
PF01753. zf-MYND. 1 hit.
PROSITEiView protein in PROSITE
PS01360. ZF_MYND_1. 1 hit.
PS50865. ZF_MYND_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q96E35-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDFKLGIVR LGRVAGKTKY TLIDEQDIPL VESYSFEARM EVDADGNGAK
60 70 80 90 100
IFAYAFDKNR GRGSGRLLHE LLWERHRGGV APGFQVVHLN AVTVDNRLDN
110 120 130 140 150
LQLVPWGWRP KAEETSSKQR EQSLYWLAIQ QLPTDPIEEQ FPVLNVTRYY
160 170 180 190 200
NANGDVVEEE ENSCTYYECH YPPCTVIEKQ LREFNICGRC QVARYCGSQC
210 220
QQKDWPAHKK HCRERKRPFQ HELEPER
Length:227
Mass (Da):26,433
Last modified:December 1, 2001 - v1
Checksum:i906F0B51B670063A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ298882 mRNA. Translation: CAC16691.1.
AL365502 Genomic DNA. No translation available.
BC012948 mRNA. Translation: AAH12948.1.
CCDSiCCDS7048.1.
RefSeqiNP_612471.1. NM_138462.2.
UniGeneiHs.128096.

Genome annotation databases

EnsembliENST00000298585; ENSP00000298585; ENSG00000165724.
GeneIDi116225.
KEGGihsa:116225.
UCSCiuc004cno.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ298882 mRNA. Translation: CAC16691.1.
AL365502 Genomic DNA. No translation available.
BC012948 mRNA. Translation: AAH12948.1.
CCDSiCCDS7048.1.
RefSeqiNP_612471.1. NM_138462.2.
UniGeneiHs.128096.

3D structure databases

ProteinModelPortaliQ96E35.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125490. 39 interactors.
IntActiQ96E35. 44 interactors.
MINTiMINT-246545.
STRINGi9606.ENSP00000298585.

PTM databases

PhosphoSitePlusiQ96E35.

Polymorphism and mutation databases

BioMutaiZMYND19.
DMDMi46397255.

Proteomic databases

EPDiQ96E35.
MaxQBiQ96E35.
PaxDbiQ96E35.
PeptideAtlasiQ96E35.
PRIDEiQ96E35.

Protocols and materials databases

DNASUi116225.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000298585; ENSP00000298585; ENSG00000165724.
GeneIDi116225.
KEGGihsa:116225.
UCSCiuc004cno.2. human.

Organism-specific databases

CTDi116225.
GeneCardsiZMYND19.
HGNCiHGNC:21146. ZMYND19.
HPAiHPA020642.
HPA050761.
MIMi611424. gene.
neXtProtiNX_Q96E35.
OpenTargetsiENSG00000165724.
PharmGKBiPA134878875.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IF0H. Eukaryota.
ENOG410YJQA. LUCA.
GeneTreeiENSGT00390000012479.
HOGENOMiHOG000231532.
HOVERGENiHBG058268.
InParanoidiQ96E35.
OMAiESSCTYY.
OrthoDBiEOG091G0O2G.
PhylomeDBiQ96E35.
TreeFamiTF329209.

Miscellaneous databases

ChiTaRSiZMYND19. human.
GenomeRNAii116225.
PROiPR:Q96E35.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000165724.
CleanExiHS_ZMYND19.
GenevisibleiQ96E35. HS.

Family and domain databases

InterProiView protein in InterPro
IPR003615. HNH_nuc.
IPR032978. ZMYND19.
IPR002893. Znf_MYND.
PANTHERiPTHR13244:SF11. PTHR13244:SF11. 1 hit.
PfamiView protein in Pfam
PF13392. HNH_3. 1 hit.
PF01753. zf-MYND. 1 hit.
PROSITEiView protein in PROSITE
PS01360. ZF_MYND_1. 1 hit.
PS50865. ZF_MYND_2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiZMY19_HUMAN
AccessioniPrimary (citable) accession number: Q96E35
Secondary accession number(s): Q5T366
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: December 1, 2001
Last modified: May 10, 2017
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.