Q96E35 (ZMY19_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Zinc finger MYND domain-containing protein 19

Alternative name(s):
Melanin-concentrating hormone receptor 1-interacting zinc finger protein
Short name=MCH-R1-interacting zinc finger protein

Gene names

Name:	ZMYND19
Synonyms:	MIZIP

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	227 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May be involved as a regulatory molecule in GPR24/MCH-R1 signaling.
Subunit structure	Interacts with GPR24/MCH-R1. Ref.1
Subcellular location	Cytoplasm. Cell membrane; Peripheral membrane protein Ref.1.
Tissue specificity	Expressed in brain, testis, placenta, heart, liver, skeletal muscle, kidney and stomach. Ref.1
Sequence similarities	Contains 1 MYND-type zinc finger.

Ontologies

Keywords
Cellular component	Cell membrane Cytoplasm Membrane
Domain	Zinc-finger
Ligand	Metal-binding Zinc
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	Golgi apparatus Inferred from direct assay. Source: HPA plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell synapse Inferred from electronic annotation. Source: Compara
Molecular_function	zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 227	227	Zinc finger MYND domain-containing protein 19		PRO_0000218319
Regions
	Zinc finger	164 – 212	49	MYND-type
	Compositional bias	158 – 161	4	Poly-Glu

Sequences

	Sequence		Length	Mass (Da)
	Q96E35 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 906F0B51B670063A	FASTA	227	26,433
	10 20 30 40 50 60 MTDFKLGIVR LGRVAGKTKY TLIDEQDIPL VESYSFEARM EVDADGNGAK IFAYAFDKNR 70 80 90 100 110 120 GRGSGRLLHE LLWERHRGGV APGFQVVHLN AVTVDNRLDN LQLVPWGWRP KAEETSSKQR 130 140 150 160 170 180 EQSLYWLAIQ QLPTDPIEEQ FPVLNVTRYY NANGDVVEEE ENSCTYYECH YPPCTVIEKQ 190 200 210 220 LREFNICGRC QVARYCGSQC QQKDWPAHKK HCRERKRPFQ HELEPER

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"MIZIP, a highly conserved, vertebrate specific melanin-concentrating hormone receptor 1 interacting zinc-finger protein." Baechner D., Kreienkamp H.-J., Richter D. FEBS Lett. 526:124-128(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, SUBCELLULAR LOCATION, INTERACTION WITH GPR24. Tissue: Brain.
[2]	"DNA sequence and analysis of human chromosome 9." Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I. Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Prostate.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ298882 mRNA. Translation: CAC16691.1. AL365502 Genomic DNA. Translation: CAI14585.1. BC012948 mRNA. Translation: AAH12948.1.
IPI	IPI00061171.
RefSeq	NP_612471.1. NM_138462.2.
UniGene	Hs.128096.
3D structure databases
ProteinModelPortal	Q96E35.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q96E35. 3 interactions.
MINT	MINT-246545.
STRING	9606.ENSP00000298585.
PTM databases
PhosphoSite	Q96E35.
Polymorphism databases
DMDM	46397255.
Proteomic databases
PaxDb	Q96E35.
PRIDE	Q96E35.
Protocols and materials databases
DNASU	116225.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000298585; ENSP00000298585; ENSG00000165724.
GeneID	116225.
KEGG	hsa:116225.
UCSC	uc004cno.1. human.
Organism-specific databases
CTD	116225.
GeneCards	GC09M140476.
HGNC	HGNC:21146. ZMYND19.
HPA	HPA020642.
MIM	611424. gene.
neXtProt	NX_Q96E35.
PharmGKB	PA134878875.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG72014.
HOGENOM	HOG000231532.
HOVERGEN	HBG058268.
InParanoid	Q96E35.
OMA	VEGYSFE.
OrthoDB	EOG49ZXQ3.
Gene expression databases
Bgee	Q96E35.
CleanEx	HS_ZMYND19.
Genevestigator	Q96E35.
GermOnline	ENSG00000165724. Homo sapiens.
Family and domain databases
InterPro	IPR002893. Znf_MYND. [Graphical view]
Pfam	PF01753. zf-MYND. 1 hit. [Graphical view]
PROSITE	PS01360. ZF_MYND_1. 1 hit. PS50865. ZF_MYND_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	116225.
NextBio	79837.
SOURCE	Search...

Entry information

Entry name

ZMY19_HUMAN

Accession

Primary (citable) accession number: Q96E35
Secondary accession number(s): Q5T366

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 13, 2004
Last sequence update:	December 1, 2001
Last modified:	May 1, 2013
This is version 85 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.