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Q96E35

- ZMY19_HUMAN

UniProt

Q96E35 - ZMY19_HUMAN

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Protein

Zinc finger MYND domain-containing protein 19

Gene

ZMYND19

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

May be involved as a regulatory molecule in GPR24/MCH-R1 signaling.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri164 – 21249MYND-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger MYND domain-containing protein 19
Alternative name(s):
Melanin-concentrating hormone receptor 1-interacting zinc finger protein
Short name:
MCH-R1-interacting zinc finger protein
Gene namesi
Name:ZMYND19
Synonyms:MIZIP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:21146. ZMYND19.

Subcellular locationi

Cytoplasm 1 Publication. Cell membrane 1 Publication; Peripheral membrane protein 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
  3. synapse Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134878875.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 227227Zinc finger MYND domain-containing protein 19PRO_0000218319Add
BLAST

Proteomic databases

MaxQBiQ96E35.
PaxDbiQ96E35.
PRIDEiQ96E35.

PTM databases

PhosphoSiteiQ96E35.

Expressioni

Tissue specificityi

Expressed in brain, testis, placenta, heart, liver, skeletal muscle, kidney and stomach.1 Publication

Gene expression databases

BgeeiQ96E35.
CleanExiHS_ZMYND19.
GenevestigatoriQ96E35.

Organism-specific databases

HPAiHPA020642.

Interactioni

Subunit structurei

Interacts with GPR24/MCH-R1.1 Publication

Protein-protein interaction databases

BioGridi125490. 13 interactions.
IntActiQ96E35. 6 interactions.
MINTiMINT-246545.
STRINGi9606.ENSP00000298585.

Structurei

3D structure databases

ProteinModelPortaliQ96E35.
SMRiQ96E35. Positions 178-213.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi158 – 1614Poly-Glu

Sequence similaritiesi

Contains 1 MYND-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri164 – 21249MYND-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiNOG72014.
GeneTreeiENSGT00390000012479.
HOGENOMiHOG000231532.
HOVERGENiHBG058268.
InParanoidiQ96E35.
OMAiVEGYSFE.
OrthoDBiEOG7DJSND.
PhylomeDBiQ96E35.
TreeFamiTF329209.

Family and domain databases

InterProiIPR003615. HNH_nuc.
IPR002893. Znf_MYND.
[Graphical view]
PfamiPF13392. HNH_3. 1 hit.
PF01753. zf-MYND. 1 hit.
[Graphical view]
PROSITEiPS01360. ZF_MYND_1. 1 hit.
PS50865. ZF_MYND_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96E35-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTDFKLGIVR LGRVAGKTKY TLIDEQDIPL VESYSFEARM EVDADGNGAK
60 70 80 90 100
IFAYAFDKNR GRGSGRLLHE LLWERHRGGV APGFQVVHLN AVTVDNRLDN
110 120 130 140 150
LQLVPWGWRP KAEETSSKQR EQSLYWLAIQ QLPTDPIEEQ FPVLNVTRYY
160 170 180 190 200
NANGDVVEEE ENSCTYYECH YPPCTVIEKQ LREFNICGRC QVARYCGSQC
210 220
QQKDWPAHKK HCRERKRPFQ HELEPER
Length:227
Mass (Da):26,433
Last modified:December 1, 2001 - v1
Checksum:i906F0B51B670063A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ298882 mRNA. Translation: CAC16691.1.
AL365502 Genomic DNA. Translation: CAI14585.1.
BC012948 mRNA. Translation: AAH12948.1.
CCDSiCCDS7048.1.
RefSeqiNP_612471.1. NM_138462.2.
UniGeneiHs.128096.

Genome annotation databases

EnsembliENST00000298585; ENSP00000298585; ENSG00000165724.
GeneIDi116225.
KEGGihsa:116225.
UCSCiuc004cno.1. human.

Polymorphism databases

DMDMi46397255.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ298882 mRNA. Translation: CAC16691.1 .
AL365502 Genomic DNA. Translation: CAI14585.1 .
BC012948 mRNA. Translation: AAH12948.1 .
CCDSi CCDS7048.1.
RefSeqi NP_612471.1. NM_138462.2.
UniGenei Hs.128096.

3D structure databases

ProteinModelPortali Q96E35.
SMRi Q96E35. Positions 178-213.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 125490. 13 interactions.
IntActi Q96E35. 6 interactions.
MINTi MINT-246545.
STRINGi 9606.ENSP00000298585.

PTM databases

PhosphoSitei Q96E35.

Polymorphism databases

DMDMi 46397255.

Proteomic databases

MaxQBi Q96E35.
PaxDbi Q96E35.
PRIDEi Q96E35.

Protocols and materials databases

DNASUi 116225.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000298585 ; ENSP00000298585 ; ENSG00000165724 .
GeneIDi 116225.
KEGGi hsa:116225.
UCSCi uc004cno.1. human.

Organism-specific databases

CTDi 116225.
GeneCardsi GC09M140476.
HGNCi HGNC:21146. ZMYND19.
HPAi HPA020642.
MIMi 611424. gene.
neXtProti NX_Q96E35.
PharmGKBi PA134878875.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG72014.
GeneTreei ENSGT00390000012479.
HOGENOMi HOG000231532.
HOVERGENi HBG058268.
InParanoidi Q96E35.
OMAi VEGYSFE.
OrthoDBi EOG7DJSND.
PhylomeDBi Q96E35.
TreeFami TF329209.

Miscellaneous databases

ChiTaRSi ZMYND19. human.
GenomeRNAii 116225.
NextBioi 79837.
PROi Q96E35.
SOURCEi Search...

Gene expression databases

Bgeei Q96E35.
CleanExi HS_ZMYND19.
Genevestigatori Q96E35.

Family and domain databases

InterProi IPR003615. HNH_nuc.
IPR002893. Znf_MYND.
[Graphical view ]
Pfami PF13392. HNH_3. 1 hit.
PF01753. zf-MYND. 1 hit.
[Graphical view ]
PROSITEi PS01360. ZF_MYND_1. 1 hit.
PS50865. ZF_MYND_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "MIZIP, a highly conserved, vertebrate specific melanin-concentrating hormone receptor 1 interacting zinc-finger protein."
    Baechner D., Kreienkamp H.-J., Richter D.
    FEBS Lett. 526:124-128(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, SUBCELLULAR LOCATION, INTERACTION WITH GPR24.
    Tissue: Brain.
  2. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Prostate.

Entry informationi

Entry nameiZMY19_HUMAN
AccessioniPrimary (citable) accession number: Q96E35
Secondary accession number(s): Q5T366
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: December 1, 2001
Last modified: November 26, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3