Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Zinc finger MYND domain-containing protein 19

Gene

ZMYND19

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved as a regulatory molecule in GPR24/MCH-R1 signaling.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri164 – 21249MYND-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger MYND domain-containing protein 19
Alternative name(s):
Melanin-concentrating hormone receptor 1-interacting zinc finger protein
Short name:
MCH-R1-interacting zinc finger protein
Gene namesi
Name:ZMYND19
Synonyms:MIZIP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:21146. ZMYND19.

Subcellular locationi

  • Cytoplasm 1 Publication
  • Cell membrane 1 Publication; Peripheral membrane protein 1 Publication

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134878875.

Polymorphism and mutation databases

BioMutaiZMYND19.
DMDMi46397255.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 227227Zinc finger MYND domain-containing protein 19PRO_0000218319Add
BLAST

Proteomic databases

MaxQBiQ96E35.
PaxDbiQ96E35.
PRIDEiQ96E35.

PTM databases

PhosphoSiteiQ96E35.

Expressioni

Tissue specificityi

Expressed in brain, testis, placenta, heart, liver, skeletal muscle, kidney and stomach.1 Publication

Gene expression databases

BgeeiQ96E35.
CleanExiHS_ZMYND19.
GenevisibleiQ96E35. HS.

Organism-specific databases

HPAiHPA020642.

Interactioni

Subunit structurei

Interacts with GPR24/MCH-R1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
C9orf138A8K8803EBI-746595,EBI-10174528
ENOX1Q8TC923EBI-746595,EBI-713221
FIP1L1Q6UN153EBI-746595,EBI-1021914
HACL1Q9UJ834EBI-746595,EBI-746580
INCA1Q0VD863EBI-746595,EBI-6509505
KCTD13Q8WZ194EBI-746595,EBI-742916
LZTS2Q9BRK44EBI-746595,EBI-741037
NAB2Q157424EBI-746595,EBI-8641936
PNMA5Q96PV43EBI-746595,EBI-10171633
SELVP597973EBI-746595,EBI-10216195
TOX4O948423EBI-746595,EBI-948613
TRIM27P143733EBI-746595,EBI-719493

Protein-protein interaction databases

BioGridi125490. 28 interactions.
IntActiQ96E35. 14 interactions.
MINTiMINT-246545.
STRINGi9606.ENSP00000298585.

Structurei

3D structure databases

ProteinModelPortaliQ96E35.
SMRiQ96E35. Positions 178-213.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi158 – 1614Poly-Glu

Sequence similaritiesi

Contains 1 MYND-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri164 – 21249MYND-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiNOG72014.
GeneTreeiENSGT00390000012479.
HOGENOMiHOG000231532.
HOVERGENiHBG058268.
InParanoidiQ96E35.
OMAiESSCTYY.
OrthoDBiEOG7DJSND.
PhylomeDBiQ96E35.
TreeFamiTF329209.

Family and domain databases

InterProiIPR003615. HNH_nuc.
IPR002893. Znf_MYND.
[Graphical view]
PfamiPF13392. HNH_3. 1 hit.
PF01753. zf-MYND. 1 hit.
[Graphical view]
PROSITEiPS01360. ZF_MYND_1. 1 hit.
PS50865. ZF_MYND_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96E35-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDFKLGIVR LGRVAGKTKY TLIDEQDIPL VESYSFEARM EVDADGNGAK
60 70 80 90 100
IFAYAFDKNR GRGSGRLLHE LLWERHRGGV APGFQVVHLN AVTVDNRLDN
110 120 130 140 150
LQLVPWGWRP KAEETSSKQR EQSLYWLAIQ QLPTDPIEEQ FPVLNVTRYY
160 170 180 190 200
NANGDVVEEE ENSCTYYECH YPPCTVIEKQ LREFNICGRC QVARYCGSQC
210 220
QQKDWPAHKK HCRERKRPFQ HELEPER
Length:227
Mass (Da):26,433
Last modified:December 1, 2001 - v1
Checksum:i906F0B51B670063A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ298882 mRNA. Translation: CAC16691.1.
AL365502 Genomic DNA. Translation: CAI14585.1.
BC012948 mRNA. Translation: AAH12948.1.
CCDSiCCDS7048.1.
RefSeqiNP_612471.1. NM_138462.2.
UniGeneiHs.128096.

Genome annotation databases

EnsembliENST00000298585; ENSP00000298585; ENSG00000165724.
GeneIDi116225.
KEGGihsa:116225.
UCSCiuc004cno.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ298882 mRNA. Translation: CAC16691.1.
AL365502 Genomic DNA. Translation: CAI14585.1.
BC012948 mRNA. Translation: AAH12948.1.
CCDSiCCDS7048.1.
RefSeqiNP_612471.1. NM_138462.2.
UniGeneiHs.128096.

3D structure databases

ProteinModelPortaliQ96E35.
SMRiQ96E35. Positions 178-213.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125490. 28 interactions.
IntActiQ96E35. 14 interactions.
MINTiMINT-246545.
STRINGi9606.ENSP00000298585.

PTM databases

PhosphoSiteiQ96E35.

Polymorphism and mutation databases

BioMutaiZMYND19.
DMDMi46397255.

Proteomic databases

MaxQBiQ96E35.
PaxDbiQ96E35.
PRIDEiQ96E35.

Protocols and materials databases

DNASUi116225.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000298585; ENSP00000298585; ENSG00000165724.
GeneIDi116225.
KEGGihsa:116225.
UCSCiuc004cno.1. human.

Organism-specific databases

CTDi116225.
GeneCardsiGC09M140476.
HGNCiHGNC:21146. ZMYND19.
HPAiHPA020642.
MIMi611424. gene.
neXtProtiNX_Q96E35.
PharmGKBiPA134878875.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG72014.
GeneTreeiENSGT00390000012479.
HOGENOMiHOG000231532.
HOVERGENiHBG058268.
InParanoidiQ96E35.
OMAiESSCTYY.
OrthoDBiEOG7DJSND.
PhylomeDBiQ96E35.
TreeFamiTF329209.

Miscellaneous databases

ChiTaRSiZMYND19. human.
GenomeRNAii116225.
NextBioi79837.
PROiQ96E35.
SOURCEiSearch...

Gene expression databases

BgeeiQ96E35.
CleanExiHS_ZMYND19.
GenevisibleiQ96E35. HS.

Family and domain databases

InterProiIPR003615. HNH_nuc.
IPR002893. Znf_MYND.
[Graphical view]
PfamiPF13392. HNH_3. 1 hit.
PF01753. zf-MYND. 1 hit.
[Graphical view]
PROSITEiPS01360. ZF_MYND_1. 1 hit.
PS50865. ZF_MYND_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "MIZIP, a highly conserved, vertebrate specific melanin-concentrating hormone receptor 1 interacting zinc-finger protein."
    Baechner D., Kreienkamp H.-J., Richter D.
    FEBS Lett. 526:124-128(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, SUBCELLULAR LOCATION, INTERACTION WITH GPR24.
    Tissue: Brain.
  2. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Prostate.

Entry informationi

Entry nameiZMY19_HUMAN
AccessioniPrimary (citable) accession number: Q96E35
Secondary accession number(s): Q5T366
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: December 1, 2001
Last modified: July 22, 2015
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.