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Q96E35 (ZMY19_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc finger MYND domain-containing protein 19
Alternative name(s):
Melanin-concentrating hormone receptor 1-interacting zinc finger protein
Short name=MCH-R1-interacting zinc finger protein
Gene names
Name:ZMYND19
Synonyms:MIZIP
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length227 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May be involved as a regulatory molecule in GPR24/MCH-R1 signaling.

Subunit structure

Interacts with GPR24/MCH-R1. Ref.1

Subcellular location

Cytoplasm. Cell membrane; Peripheral membrane protein Ref.1.

Tissue specificity

Expressed in brain, testis, placenta, heart, liver, skeletal muscle, kidney and stomach. Ref.1

Sequence similarities

Contains 1 MYND-type zinc finger.

Ontologies

Keywords
   Cellular componentCell membrane
Cytoplasm
Membrane
   DomainZinc-finger
   LigandMetal-binding
Zinc
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

synapse

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionmetal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 227227Zinc finger MYND domain-containing protein 19
PRO_0000218319

Regions

Zinc finger164 – 21249MYND-type
Compositional bias158 – 1614Poly-Glu

Sequences

Sequence LengthMass (Da)Tools
Q96E35 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 906F0B51B670063A

FASTA22726,433
        10         20         30         40         50         60 
MTDFKLGIVR LGRVAGKTKY TLIDEQDIPL VESYSFEARM EVDADGNGAK IFAYAFDKNR 

        70         80         90        100        110        120 
GRGSGRLLHE LLWERHRGGV APGFQVVHLN AVTVDNRLDN LQLVPWGWRP KAEETSSKQR 

       130        140        150        160        170        180 
EQSLYWLAIQ QLPTDPIEEQ FPVLNVTRYY NANGDVVEEE ENSCTYYECH YPPCTVIEKQ 

       190        200        210        220 
LREFNICGRC QVARYCGSQC QQKDWPAHKK HCRERKRPFQ HELEPER 

« Hide

References

« Hide 'large scale' references
[1]"MIZIP, a highly conserved, vertebrate specific melanin-concentrating hormone receptor 1 interacting zinc-finger protein."
Baechner D., Kreienkamp H.-J., Richter D.
FEBS Lett. 526:124-128(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, SUBCELLULAR LOCATION, INTERACTION WITH GPR24.
Tissue: Brain.
[2]"DNA sequence and analysis of human chromosome 9."
Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. expand/collapse author list , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Prostate.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ298882 mRNA. Translation: CAC16691.1.
AL365502 Genomic DNA. Translation: CAI14585.1.
BC012948 mRNA. Translation: AAH12948.1.
CCDSCCDS7048.1.
RefSeqNP_612471.1. NM_138462.2.
UniGeneHs.128096.

3D structure databases

ProteinModelPortalQ96E35.
SMRQ96E35. Positions 178-213.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid125490. 6 interactions.
IntActQ96E35. 6 interactions.
MINTMINT-246545.
STRING9606.ENSP00000298585.

PTM databases

PhosphoSiteQ96E35.

Polymorphism databases

DMDM46397255.

Proteomic databases

MaxQBQ96E35.
PaxDbQ96E35.
PRIDEQ96E35.

Protocols and materials databases

DNASU116225.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000298585; ENSP00000298585; ENSG00000165724.
GeneID116225.
KEGGhsa:116225.
UCSCuc004cno.1. human.

Organism-specific databases

CTD116225.
GeneCardsGC09M140476.
HGNCHGNC:21146. ZMYND19.
HPAHPA020642.
MIM611424. gene.
neXtProtNX_Q96E35.
PharmGKBPA134878875.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG72014.
HOGENOMHOG000231532.
HOVERGENHBG058268.
InParanoidQ96E35.
OMAVEGYSFE.
OrthoDBEOG7DJSND.
PhylomeDBQ96E35.
TreeFamTF329209.

Gene expression databases

BgeeQ96E35.
CleanExHS_ZMYND19.
GenevestigatorQ96E35.

Family and domain databases

InterProIPR003615. HNH_nuc.
IPR002893. Znf_MYND.
[Graphical view]
PfamPF13392. HNH_3. 1 hit.
PF01753. zf-MYND. 1 hit.
[Graphical view]
PROSITEPS01360. ZF_MYND_1. 1 hit.
PS50865. ZF_MYND_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi116225.
NextBio79837.
PROQ96E35.
SOURCESearch...

Entry information

Entry nameZMY19_HUMAN
AccessionPrimary (citable) accession number: Q96E35
Secondary accession number(s): Q5T366
Entry history
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: December 1, 2001
Last modified: July 9, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 9

Human chromosome 9: entries, gene names and cross-references to MIM