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Q96E35

- ZMY19_HUMAN

UniProt

Q96E35 - ZMY19_HUMAN

Protein

Zinc finger MYND domain-containing protein 19

Gene

ZMYND19

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    May be involved as a regulatory molecule in GPR24/MCH-R1 signaling.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri164 – 21249MYND-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger MYND domain-containing protein 19
    Alternative name(s):
    Melanin-concentrating hormone receptor 1-interacting zinc finger protein
    Short name:
    MCH-R1-interacting zinc finger protein
    Gene namesi
    Name:ZMYND19
    Synonyms:MIZIP
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:21146. ZMYND19.

    Subcellular locationi

    Cytoplasm 1 Publication. Cell membrane 1 Publication; Peripheral membrane protein 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. plasma membrane Source: UniProtKB-SubCell
    3. synapse Source: Ensembl

    Keywords - Cellular componenti

    Cell membrane, Cytoplasm, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134878875.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 227227Zinc finger MYND domain-containing protein 19PRO_0000218319Add
    BLAST

    Proteomic databases

    MaxQBiQ96E35.
    PaxDbiQ96E35.
    PRIDEiQ96E35.

    PTM databases

    PhosphoSiteiQ96E35.

    Expressioni

    Tissue specificityi

    Expressed in brain, testis, placenta, heart, liver, skeletal muscle, kidney and stomach.1 Publication

    Gene expression databases

    BgeeiQ96E35.
    CleanExiHS_ZMYND19.
    GenevestigatoriQ96E35.

    Organism-specific databases

    HPAiHPA020642.

    Interactioni

    Subunit structurei

    Interacts with GPR24/MCH-R1.1 Publication

    Protein-protein interaction databases

    BioGridi125490. 6 interactions.
    IntActiQ96E35. 6 interactions.
    MINTiMINT-246545.
    STRINGi9606.ENSP00000298585.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96E35.
    SMRiQ96E35. Positions 178-213.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi158 – 1614Poly-Glu

    Sequence similaritiesi

    Contains 1 MYND-type zinc finger.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri164 – 21249MYND-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiNOG72014.
    HOGENOMiHOG000231532.
    HOVERGENiHBG058268.
    InParanoidiQ96E35.
    OMAiVEGYSFE.
    OrthoDBiEOG7DJSND.
    PhylomeDBiQ96E35.
    TreeFamiTF329209.

    Family and domain databases

    InterProiIPR003615. HNH_nuc.
    IPR002893. Znf_MYND.
    [Graphical view]
    PfamiPF13392. HNH_3. 1 hit.
    PF01753. zf-MYND. 1 hit.
    [Graphical view]
    PROSITEiPS01360. ZF_MYND_1. 1 hit.
    PS50865. ZF_MYND_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q96E35-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTDFKLGIVR LGRVAGKTKY TLIDEQDIPL VESYSFEARM EVDADGNGAK    50
    IFAYAFDKNR GRGSGRLLHE LLWERHRGGV APGFQVVHLN AVTVDNRLDN 100
    LQLVPWGWRP KAEETSSKQR EQSLYWLAIQ QLPTDPIEEQ FPVLNVTRYY 150
    NANGDVVEEE ENSCTYYECH YPPCTVIEKQ LREFNICGRC QVARYCGSQC 200
    QQKDWPAHKK HCRERKRPFQ HELEPER 227
    Length:227
    Mass (Da):26,433
    Last modified:December 1, 2001 - v1
    Checksum:i906F0B51B670063A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ298882 mRNA. Translation: CAC16691.1.
    AL365502 Genomic DNA. Translation: CAI14585.1.
    BC012948 mRNA. Translation: AAH12948.1.
    CCDSiCCDS7048.1.
    RefSeqiNP_612471.1. NM_138462.2.
    UniGeneiHs.128096.

    Genome annotation databases

    EnsembliENST00000298585; ENSP00000298585; ENSG00000165724.
    GeneIDi116225.
    KEGGihsa:116225.
    UCSCiuc004cno.1. human.

    Polymorphism databases

    DMDMi46397255.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ298882 mRNA. Translation: CAC16691.1 .
    AL365502 Genomic DNA. Translation: CAI14585.1 .
    BC012948 mRNA. Translation: AAH12948.1 .
    CCDSi CCDS7048.1.
    RefSeqi NP_612471.1. NM_138462.2.
    UniGenei Hs.128096.

    3D structure databases

    ProteinModelPortali Q96E35.
    SMRi Q96E35. Positions 178-213.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 125490. 6 interactions.
    IntActi Q96E35. 6 interactions.
    MINTi MINT-246545.
    STRINGi 9606.ENSP00000298585.

    PTM databases

    PhosphoSitei Q96E35.

    Polymorphism databases

    DMDMi 46397255.

    Proteomic databases

    MaxQBi Q96E35.
    PaxDbi Q96E35.
    PRIDEi Q96E35.

    Protocols and materials databases

    DNASUi 116225.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000298585 ; ENSP00000298585 ; ENSG00000165724 .
    GeneIDi 116225.
    KEGGi hsa:116225.
    UCSCi uc004cno.1. human.

    Organism-specific databases

    CTDi 116225.
    GeneCardsi GC09M140476.
    HGNCi HGNC:21146. ZMYND19.
    HPAi HPA020642.
    MIMi 611424. gene.
    neXtProti NX_Q96E35.
    PharmGKBi PA134878875.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG72014.
    HOGENOMi HOG000231532.
    HOVERGENi HBG058268.
    InParanoidi Q96E35.
    OMAi VEGYSFE.
    OrthoDBi EOG7DJSND.
    PhylomeDBi Q96E35.
    TreeFami TF329209.

    Miscellaneous databases

    GenomeRNAii 116225.
    NextBioi 79837.
    PROi Q96E35.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q96E35.
    CleanExi HS_ZMYND19.
    Genevestigatori Q96E35.

    Family and domain databases

    InterProi IPR003615. HNH_nuc.
    IPR002893. Znf_MYND.
    [Graphical view ]
    Pfami PF13392. HNH_3. 1 hit.
    PF01753. zf-MYND. 1 hit.
    [Graphical view ]
    PROSITEi PS01360. ZF_MYND_1. 1 hit.
    PS50865. ZF_MYND_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "MIZIP, a highly conserved, vertebrate specific melanin-concentrating hormone receptor 1 interacting zinc-finger protein."
      Baechner D., Kreienkamp H.-J., Richter D.
      FEBS Lett. 526:124-128(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, SUBCELLULAR LOCATION, INTERACTION WITH GPR24.
      Tissue: Brain.
    2. "DNA sequence and analysis of human chromosome 9."
      Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
      , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
      Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Prostate.

    Entry informationi

    Entry nameiZMY19_HUMAN
    AccessioniPrimary (citable) accession number: Q96E35
    Secondary accession number(s): Q5T366
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 13, 2004
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 97 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3