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Protein

Transcription termination factor 3, mitochondrial

Gene

MTERF3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds promoter DNA and regulates initiation of transcription. Required for normal mitochondrial transcription, and for normal assembly of mitochondrial respiratory complexes. Required for normal mitochondrial function (By similarity).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000156469-MONOMER.
ReactomeiR-HSA-5205685. Pink/Parkin Mediated Mitophagy.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription termination factor 3, mitochondrial
Alternative name(s):
Mitochondrial transcription termination factor 3
Short name:
mTERF3
mTERF domain-containing protein 1, mitochondrial
Gene namesi
Name:MTERF3
Synonyms:MTERFD1
ORF Names:CGI-12
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:24258. MTERF3.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial outer membrane Source: Reactome
  • mitochondrion Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000156469.
PharmGKBiPA142671309.

Polymorphism and mutation databases

BioMutaiMTERFD1.
DMDMi74731522.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 68MitochondrionAdd BLAST68
ChainiPRO_000025545769 – 417Transcription termination factor 3, mitochondrialAdd BLAST349

Proteomic databases

EPDiQ96E29.
MaxQBiQ96E29.
PaxDbiQ96E29.
PeptideAtlasiQ96E29.
PRIDEiQ96E29.

PTM databases

iPTMnetiQ96E29.
PhosphoSitePlusiQ96E29.

Expressioni

Tissue specificityi

Highly expressed in heart, liver, kidney and testis. Detected at lower levels in brain, spleen and lung.1 Publication

Gene expression databases

BgeeiENSG00000156469.
CleanExiHS_MTERFD1.
ExpressionAtlasiQ96E29. baseline and differential.
GenevisibleiQ96E29. HS.

Organism-specific databases

HPAiHPA002966.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
AGTRAPQ6RW133EBI-7825321,EBI-741181
ARL6IP1Q150413EBI-7825321,EBI-714543
CMTM5Q96DZ93EBI-7825321,EBI-2548702
FUNDC1Q8IVP53EBI-7825321,EBI-3059266

Protein-protein interaction databases

BioGridi119209. 31 interactors.
IntActiQ96E29. 7 interactors.
MINTiMINT-3052237.
STRINGi9606.ENSP00000287025.

Structurei

Secondary structure

1417
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi149 – 161Combined sources13
Helixi166 – 169Combined sources4
Helixi173 – 180Combined sources8
Helixi184 – 187Combined sources4
Helixi189 – 198Combined sources10
Helixi202 – 204Combined sources3
Helixi205 – 211Combined sources7
Helixi215 – 217Combined sources3
Helixi220 – 232Combined sources13
Helixi237 – 246Combined sources10
Helixi250 – 252Combined sources3
Helixi255 – 269Combined sources15
Helixi273 – 282Combined sources10
Helixi284 – 287Combined sources4
Helixi292 – 303Combined sources12
Helixi309 – 318Combined sources10
Helixi320 – 323Combined sources4
Helixi327 – 338Combined sources12
Helixi345 – 350Combined sources6
Helixi352 – 356Combined sources5
Helixi359 – 371Combined sources13
Beta strandi381 – 383Combined sources3
Helixi387 – 392Combined sources6
Helixi395 – 401Combined sources7
Helixi407 – 414Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3M66X-ray1.60A148-417[»]
ProteinModelPortaliQ96E29.
SMRiQ96E29.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ96E29.

Family & Domainsi

Domaini

Contains seven structural repeats of about 35 residues, where each repeat contains three helices. The repeats form a superhelical structure with a solenoid shape.1 Publication

Sequence similaritiesi

Belongs to the mTERF family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1267. Eukaryota.
ENOG410XT49. LUCA.
GeneTreeiENSGT00390000005801.
HOGENOMiHOG000044443.
HOVERGENiHBG062577.
InParanoidiQ96E29.
KOiK15032.
OMAiYFVRNVA.
OrthoDBiEOG091G0AZ7.
PhylomeDBiQ96E29.
TreeFamiTF317943.

Family and domain databases

InterProiIPR003690. MTERF.
[Graphical view]
PfamiPF02536. mTERF. 1 hit.
[Graphical view]
SMARTiSM00733. Mterf. 6 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96E29-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MALSAQQIPR WFNSVKLRSL INAAQLTKRF TRPARTLLHG FSAQPQISSD
60 70 80 90 100
NCFLQWGFKT YRTSSLWNSS QSTSSSSQEN NSAQSSLLPS MNEQSQKTQN
110 120 130 140 150
ISSFDSELFL EELDELPPLS PMQPISEEEA IQIIADPPLP PASFTLRDYV
160 170 180 190 200
DHSETLQKLV LLGVDLSKIE KHPEAANLLL RLDFEKDIKQ MLLFLKDVGI
210 220 230 240 250
EDNQLGAFLT KNHAIFSEDL ENLKTRVAYL HSKNFSKADV AQMVRKAPFL
260 270 280 290 300
LNFSVERLDN RLGFFQKELE LSVKKTRDLV VRLPRLLTGS LEPVKENMKV
310 320 330 340 350
YRLELGFKHN EIQHMITRIP KMLTANKMKL TETFDFVHNV MSIPHHIIVK
360 370 380 390 400
FPQVFNTRLF KVKERHLFLT YLGRAQYDPA KPNYISLDKL VSIPDEIFCE
410
EIAKASVQDF EKFLKTL
Length:417
Mass (Da):47,971
Last modified:March 1, 2004 - v2
Checksum:i2062EFE902584696
GO
Isoform 2 (identifier: Q96E29-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-90: Missing.

Show »
Length:327
Mass (Da):37,907
Checksum:i3C396BD9DC336AE6
GO
Isoform 3 (identifier: Q96E29-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-121: Missing.

Note: No experimental confirmation available.
Show »
Length:296
Mass (Da):34,358
Checksum:i539D802B0FB47ABE
GO

Sequence cautioni

The sequence AAD27721 differs from that shown. Reason: Frameshift at positions 261 and 262.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti153S → P in BAG50978 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053786396E → G.Corresponds to variant rs7461970dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0539851 – 121Missing in isoform 3. 1 PublicationAdd BLAST121
Alternative sequenceiVSP_0212921 – 90Missing in isoform 2. 1 PublicationAdd BLAST90

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF132946 mRNA. Translation: AAD27721.1. Frameshift.
AK001801 mRNA. Translation: BAG50978.1.
AP003465 Genomic DNA. No translation available.
CH471060 Genomic DNA. Translation: EAW91752.1.
BC012995 mRNA. Translation: AAH12995.2.
CCDSiCCDS6270.1. [Q96E29-1]
RefSeqiNP_057026.3. NM_015942.4. [Q96E29-1]
UniGeneiHs.308613.

Genome annotation databases

EnsembliENST00000287025; ENSP00000287025; ENSG00000156469. [Q96E29-1]
ENST00000522822; ENSP00000430138; ENSG00000156469. [Q96E29-3]
GeneIDi51001.
KEGGihsa:51001.
UCSCiuc003yhr.3. human. [Q96E29-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF132946 mRNA. Translation: AAD27721.1. Frameshift.
AK001801 mRNA. Translation: BAG50978.1.
AP003465 Genomic DNA. No translation available.
CH471060 Genomic DNA. Translation: EAW91752.1.
BC012995 mRNA. Translation: AAH12995.2.
CCDSiCCDS6270.1. [Q96E29-1]
RefSeqiNP_057026.3. NM_015942.4. [Q96E29-1]
UniGeneiHs.308613.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3M66X-ray1.60A148-417[»]
ProteinModelPortaliQ96E29.
SMRiQ96E29.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119209. 31 interactors.
IntActiQ96E29. 7 interactors.
MINTiMINT-3052237.
STRINGi9606.ENSP00000287025.

PTM databases

iPTMnetiQ96E29.
PhosphoSitePlusiQ96E29.

Polymorphism and mutation databases

BioMutaiMTERFD1.
DMDMi74731522.

Proteomic databases

EPDiQ96E29.
MaxQBiQ96E29.
PaxDbiQ96E29.
PeptideAtlasiQ96E29.
PRIDEiQ96E29.

Protocols and materials databases

DNASUi51001.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000287025; ENSP00000287025; ENSG00000156469. [Q96E29-1]
ENST00000522822; ENSP00000430138; ENSG00000156469. [Q96E29-3]
GeneIDi51001.
KEGGihsa:51001.
UCSCiuc003yhr.3. human. [Q96E29-1]

Organism-specific databases

CTDi51001.
GeneCardsiMTERF3.
HGNCiHGNC:24258. MTERF3.
HPAiHPA002966.
MIMi616930. gene.
neXtProtiNX_Q96E29.
OpenTargetsiENSG00000156469.
PharmGKBiPA142671309.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1267. Eukaryota.
ENOG410XT49. LUCA.
GeneTreeiENSGT00390000005801.
HOGENOMiHOG000044443.
HOVERGENiHBG062577.
InParanoidiQ96E29.
KOiK15032.
OMAiYFVRNVA.
OrthoDBiEOG091G0AZ7.
PhylomeDBiQ96E29.
TreeFamiTF317943.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000156469-MONOMER.
ReactomeiR-HSA-5205685. Pink/Parkin Mediated Mitophagy.

Miscellaneous databases

EvolutionaryTraceiQ96E29.
GenomeRNAii51001.
PROiQ96E29.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000156469.
CleanExiHS_MTERFD1.
ExpressionAtlasiQ96E29. baseline and differential.
GenevisibleiQ96E29. HS.

Family and domain databases

InterProiIPR003690. MTERF.
[Graphical view]
PfamiPF02536. mTERF. 1 hit.
[Graphical view]
SMARTiSM00733. Mterf. 6 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMTEF3_HUMAN
AccessioniPrimary (citable) accession number: Q96E29
Secondary accession number(s): B3KMG6, G3V130, Q9Y301
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: March 1, 2004
Last modified: November 30, 2016
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.