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Protein

Ras-related protein Rab-3C

Gene

RAB3C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Protein transport. Probably involved in vesicular traffic (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi37 – 448GTPBy similarity
Nucleotide bindingi85 – 895GTPBy similarity
Nucleotide bindingi143 – 1464GTPBy similarity

GO - Molecular functioni

  1. GDP binding Source: GO_Central
  2. GTPase activity Source: UniProtKB
  3. GTP binding Source: GO_Central
  4. myosin V binding Source: UniProtKB

GO - Biological processi

  1. antigen processing and presentation Source: UniProtKB
  2. intracellular protein transport Source: GO_Central
  3. metabolic process Source: GOC
  4. protein secretion Source: GO_Central
  5. Rab protein signal transduction Source: GO_Central
  6. regulation of exocytosis Source: GO_Central
  7. synaptic vesicle exocytosis Source: GO_Central
  8. vesicle docking involved in exocytosis Source: GO_Central
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-3C
Gene namesi
Name:RAB3C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:30269. RAB3C.

Subcellular locationi

Cell membrane Curated; Lipid-anchor Curated; Cytoplasmic side Curated

GO - Cellular componenti

  1. cytosol Source: Ensembl
  2. endosome Source: GO_Central
  3. perinuclear region of cytoplasm Source: UniProtKB
  4. plasma membrane Source: GO_Central
  5. secretory granule membrane Source: GO_Central
  6. synaptic vesicle Source: GO_Central
  7. vesicle Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134874100.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 227227Ras-related protein Rab-3CPRO_0000121085Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi225 – 2251S-geranylgeranyl cysteineBy similarity
Modified residuei227 – 2271Cysteine methyl esterBy similarity
Lipidationi227 – 2271S-geranylgeranyl cysteineBy similarity

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

PaxDbiQ96E17.
PRIDEiQ96E17.

PTM databases

PhosphoSiteiQ96E17.

Expressioni

Tissue specificityi

Expressed in brain, placenta and lung.1 Publication

Gene expression databases

BgeeiQ96E17.
CleanExiHS_RAB3C.
GenevestigatoriQ96E17.

Organism-specific databases

HPAiHPA003160.
HPA048156.

Interactioni

Subunit structurei

Interacts with RIMS1, RIMS2, RPH3A and RPH3AL.By similarity

Protein-protein interaction databases

BioGridi125459. 6 interactions.
IntActiQ96E17. 1 interaction.
STRINGi9606.ENSP00000282878.

Structurei

3D structure databases

ProteinModelPortaliQ96E17.
SMRiQ96E17. Positions 26-194.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi59 – 679Effector regionBy similarity

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiCOG1100.
GeneTreeiENSGT00760000118937.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiQ96E17.
KOiK07883.
OMAiQMASSQD.
OrthoDBiEOG7JQBPC.
PhylomeDBiQ96E17.
TreeFamiTF313199.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SMARTiSM00175. RAB. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96E17-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRHEAPMQMA SAQDARYGQK DSSDQNFDYM FKLLIIGNSS VGKTSFLFRY
60 70 80 90 100
ADDSFTSAFV STVGIDFKVK TVFKNEKRIK LQIWDTAGQE RYRTITTAYY
110 120 130 140 150
RGAMGFILMY DITNEESFNA VQDWSTQIKT YSWDNAQVIL VGNKCDMEDE
160 170 180 190 200
RVISTERGQH LGEQLGFEFF ETSAKDNINV KQTFERLVDI ICDKMSESLE
210 220
TDPAITAAKQ NTRLKETPPP PQPNCAC
Length:227
Mass (Da):25,952
Last modified:December 1, 2001 - v1
Checksum:i7352E205DEFAC72D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY026936 mRNA. Translation: AAK08968.1.
BC013033 mRNA. Translation: AAH13033.1.
CCDSiCCDS3976.1.
RefSeqiNP_612462.1. NM_138453.2.
UniGeneiHs.4290.
Hs.482173.

Genome annotation databases

EnsembliENST00000282878; ENSP00000282878; ENSG00000152932.
GeneIDi115827.
KEGGihsa:115827.
UCSCiuc003jrp.3. human.

Polymorphism databases

DMDMi23396832.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY026936 mRNA. Translation: AAK08968.1.
BC013033 mRNA. Translation: AAH13033.1.
CCDSiCCDS3976.1.
RefSeqiNP_612462.1. NM_138453.2.
UniGeneiHs.4290.
Hs.482173.

3D structure databases

ProteinModelPortaliQ96E17.
SMRiQ96E17. Positions 26-194.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125459. 6 interactions.
IntActiQ96E17. 1 interaction.
STRINGi9606.ENSP00000282878.

PTM databases

PhosphoSiteiQ96E17.

Polymorphism databases

DMDMi23396832.

Proteomic databases

PaxDbiQ96E17.
PRIDEiQ96E17.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000282878; ENSP00000282878; ENSG00000152932.
GeneIDi115827.
KEGGihsa:115827.
UCSCiuc003jrp.3. human.

Organism-specific databases

CTDi115827.
GeneCardsiGC05P057914.
HGNCiHGNC:30269. RAB3C.
HPAiHPA003160.
HPA048156.
MIMi612829. gene.
neXtProtiNX_Q96E17.
PharmGKBiPA134874100.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG1100.
GeneTreeiENSGT00760000118937.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiQ96E17.
KOiK07883.
OMAiQMASSQD.
OrthoDBiEOG7JQBPC.
PhylomeDBiQ96E17.
TreeFamiTF313199.

Miscellaneous databases

ChiTaRSiRAB3C. human.
GeneWikiiRAB3C.
GenomeRNAii115827.
NextBioi79698.
PROiQ96E17.
SOURCEiSearch...

Gene expression databases

BgeeiQ96E17.
CleanExiHS_RAB3C.
GenevestigatoriQ96E17.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SMARTiSM00175. RAB. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning, mapping, and characterization of the human Rab3C gene."
    Cheng H., Ma Y., Ni X., Jiang M., Luo Y., Ying K., Xie Y., Ma Y.
    Biochem. Genet. 40:263-272(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Fetal brain.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.

Entry informationi

Entry nameiRAB3C_HUMAN
AccessioniPrimary (citable) accession number: Q96E17
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: December 1, 2001
Last modified: April 1, 2015
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.