Q96E17 (RAB3C_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ras-related protein Rab-3C

Gene names

Name:

RAB3C

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	227 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Protein transport. Probably involved in vesicular traffic By similarity.
Subunit structure	Interacts with RIMS1, RIMS2, RPH3A and RPH3AL By similarity.
Subcellular location	Cell membrane; Lipid-anchor; Cytoplasmic side Potential.
Tissue specificity	Expressed in brain, placenta and lung. Ref.1
Sequence similarities	Belongs to the small GTPase superfamily. Rab family.

Ontologies

Keywords
Biological process	Protein transport Transport
Cellular component	Cell membrane Membrane
Ligand	GTP-binding Nucleotide-binding
PTM	Lipoprotein Methylation Prenylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	protein transport Inferred from electronic annotation. Source: UniProtKB-KW regulation of exocytosis Inferred from electronic annotation. Source: Compara small GTPase mediated signal transduction Inferred from electronic annotation. Source: InterPro
Cellular_component	cytosol Inferred from electronic annotation. Source: Compara plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell synaptic vesicle Inferred from electronic annotation. Source: Compara
Molecular_function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 227	227	Ras-related protein Rab-3C		PRO_0000121085
Regions
	Nucleotide binding	37 – 44	8	GTP By similarity
	Nucleotide binding	85 – 89	5	GTP By similarity
	Nucleotide binding	143 – 146	4	GTP By similarity
	Motif	59 – 67	9	Effector region By similarity
Amino acid modifications
	Modified residue	227	1	Cysteine methyl ester By similarity
	Lipidation	225	1	S-geranylgeranyl cysteine By similarity
	Lipidation	227	1	S-geranylgeranyl cysteine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q96E17 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 7352E205DEFAC72D	FASTA	227	25,952
	10 20 30 40 50 60 MRHEAPMQMA SAQDARYGQK DSSDQNFDYM FKLLIIGNSS VGKTSFLFRY ADDSFTSAFV 70 80 90 100 110 120 STVGIDFKVK TVFKNEKRIK LQIWDTAGQE RYRTITTAYY RGAMGFILMY DITNEESFNA 130 140 150 160 170 180 VQDWSTQIKT YSWDNAQVIL VGNKCDMEDE RVISTERGQH LGEQLGFEFF ETSAKDNINV 190 200 210 220 KQTFERLVDI ICDKMSESLE TDPAITAAKQ NTRLKETPPP PQPNCAC

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning, mapping, and characterization of the human Rab3C gene." Cheng H., Ma Y., Ni X., Jiang M., Luo Y., Ying K., Xie Y., Ma Y. Biochem. Genet. 40:263-272(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY. Tissue: Fetal brain.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY026936 mRNA. Translation: AAK08968.1. BC013033 mRNA. Translation: AAH13033.1.
IPI	IPI00061114.
RefSeq	NP_612462.1. NM_138453.2.
UniGene	Hs.482173.
3D structure databases
ProteinModelPortal	Q96E17.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q96E17. 1 interaction.
STRING	9606.ENSP00000282878.
PTM databases
PhosphoSite	Q96E17.
Polymorphism databases
DMDM	23396832.
Proteomic databases
PaxDb	Q96E17.
PRIDE	Q96E17.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000282878; ENSP00000282878; ENSG00000152932.
GeneID	115827.
KEGG	hsa:115827.
UCSC	uc003jrp.3. human.
Organism-specific databases
CTD	115827.
GeneCards	GC05P057914.
HGNC	HGNC:30269. RAB3C.
HPA	HPA003160.
MIM	612829. gene.
neXtProt	NX_Q96E17.
PharmGKB	PA134874100.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG1100.
HOGENOM	HOG000233968.
HOVERGEN	HBG009351.
InParanoid	Q96E17.
KO	K07883.
OMA	QMASSQD.
OrthoDB	EOG4TB4C6.
PhylomeDB	Q96E17.
Gene expression databases
Bgee	Q96E17.
CleanEx	HS_RAB3C.
Genevestigator	Q96E17.
GermOnline	ENSG00000152932. Homo sapiens.
Family and domain databases
InterPro	IPR005225. Small_GTP-bd_dom. IPR001806. Small_GTPase. IPR003579. Small_GTPase_Rab_type. [Graphical view]
Pfam	PF00071. Ras. 1 hit. [Graphical view]
PRINTS	PR00449. RASTRNSFRMNG.
SMART	SM00175. RAB. 1 hit. [Graphical view]
TIGRFAMs	TIGR00231. small_GTP. 1 hit.
PROSITE	PS51419. RAB. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	115827.
NextBio	79698.
SOURCE	Search...

Entry information

Entry name

RAB3C_HUMAN

Accession

Primary (citable) accession number: Q96E17

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 19, 2002
Last sequence update:	December 1, 2001
Last modified:	May 1, 2013
This is version 111 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.