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Q96E17

- RAB3C_HUMAN

UniProt

Q96E17 - RAB3C_HUMAN

Protein

Ras-related protein Rab-3C

Gene

RAB3C

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 122 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Protein transport. Probably involved in vesicular traffic By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi37 – 448GTPBy similarity
    Nucleotide bindingi85 – 895GTPBy similarity
    Nucleotide bindingi143 – 1464GTPBy similarity

    GO - Molecular functioni

    1. GTP binding Source: UniProtKB-KW

    GO - Biological processi

    1. antigen processing and presentation Source: UniProt
    2. protein transport Source: UniProtKB-KW
    3. regulation of exocytosis Source: Ensembl
    4. small GTPase mediated signal transduction Source: InterPro

    Keywords - Biological processi

    Protein transport, Transport

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ras-related protein Rab-3C
    Gene namesi
    Name:RAB3C
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:30269. RAB3C.

    Subcellular locationi

    Cell membrane Curated; Lipid-anchor Curated; Cytoplasmic side Curated

    GO - Cellular componenti

    1. cytosol Source: Ensembl
    2. perinuclear region of cytoplasm Source: UniProt
    3. plasma membrane Source: UniProtKB-SubCell
    4. synaptic vesicle Source: Ensembl
    5. vesicle Source: UniProt

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134874100.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 227227Ras-related protein Rab-3CPRO_0000121085Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Lipidationi225 – 2251S-geranylgeranyl cysteineBy similarity
    Modified residuei227 – 2271Cysteine methyl esterBy similarity
    Lipidationi227 – 2271S-geranylgeranyl cysteineBy similarity

    Keywords - PTMi

    Lipoprotein, Methylation, Prenylation

    Proteomic databases

    PaxDbiQ96E17.
    PRIDEiQ96E17.

    PTM databases

    PhosphoSiteiQ96E17.

    Expressioni

    Tissue specificityi

    Expressed in brain, placenta and lung.1 Publication

    Gene expression databases

    BgeeiQ96E17.
    CleanExiHS_RAB3C.
    GenevestigatoriQ96E17.

    Organism-specific databases

    HPAiHPA003160.
    HPA048156.

    Interactioni

    Subunit structurei

    Interacts with RIMS1, RIMS2, RPH3A and RPH3AL.By similarity

    Protein-protein interaction databases

    BioGridi125459. 5 interactions.
    IntActiQ96E17. 1 interaction.
    STRINGi9606.ENSP00000282878.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96E17.
    SMRiQ96E17. Positions 26-194.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi59 – 679Effector regionBy similarity

    Sequence similaritiesi

    Belongs to the small GTPase superfamily. Rab family.Curated

    Phylogenomic databases

    eggNOGiCOG1100.
    HOGENOMiHOG000233968.
    HOVERGENiHBG009351.
    InParanoidiQ96E17.
    KOiK07883.
    OMAiQMASSQD.
    OrthoDBiEOG7JQBPC.
    PhylomeDBiQ96E17.
    TreeFamiTF313199.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR003579. Small_GTPase_Rab_type.
    [Graphical view]
    PfamiPF00071. Ras. 1 hit.
    [Graphical view]
    PRINTSiPR00449. RASTRNSFRMNG.
    SMARTiSM00175. RAB. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00231. small_GTP. 1 hit.
    PROSITEiPS51419. RAB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q96E17-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRHEAPMQMA SAQDARYGQK DSSDQNFDYM FKLLIIGNSS VGKTSFLFRY    50
    ADDSFTSAFV STVGIDFKVK TVFKNEKRIK LQIWDTAGQE RYRTITTAYY 100
    RGAMGFILMY DITNEESFNA VQDWSTQIKT YSWDNAQVIL VGNKCDMEDE 150
    RVISTERGQH LGEQLGFEFF ETSAKDNINV KQTFERLVDI ICDKMSESLE 200
    TDPAITAAKQ NTRLKETPPP PQPNCAC 227
    Length:227
    Mass (Da):25,952
    Last modified:December 1, 2001 - v1
    Checksum:i7352E205DEFAC72D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY026936 mRNA. Translation: AAK08968.1.
    BC013033 mRNA. Translation: AAH13033.1.
    CCDSiCCDS3976.1.
    RefSeqiNP_612462.1. NM_138453.2.
    UniGeneiHs.4290.
    Hs.482173.

    Genome annotation databases

    EnsembliENST00000282878; ENSP00000282878; ENSG00000152932.
    GeneIDi115827.
    KEGGihsa:115827.
    UCSCiuc003jrp.3. human.

    Polymorphism databases

    DMDMi23396832.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY026936 mRNA. Translation: AAK08968.1 .
    BC013033 mRNA. Translation: AAH13033.1 .
    CCDSi CCDS3976.1.
    RefSeqi NP_612462.1. NM_138453.2.
    UniGenei Hs.4290.
    Hs.482173.

    3D structure databases

    ProteinModelPortali Q96E17.
    SMRi Q96E17. Positions 26-194.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 125459. 5 interactions.
    IntActi Q96E17. 1 interaction.
    STRINGi 9606.ENSP00000282878.

    PTM databases

    PhosphoSitei Q96E17.

    Polymorphism databases

    DMDMi 23396832.

    Proteomic databases

    PaxDbi Q96E17.
    PRIDEi Q96E17.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000282878 ; ENSP00000282878 ; ENSG00000152932 .
    GeneIDi 115827.
    KEGGi hsa:115827.
    UCSCi uc003jrp.3. human.

    Organism-specific databases

    CTDi 115827.
    GeneCardsi GC05P057914.
    HGNCi HGNC:30269. RAB3C.
    HPAi HPA003160.
    HPA048156.
    MIMi 612829. gene.
    neXtProti NX_Q96E17.
    PharmGKBi PA134874100.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1100.
    HOGENOMi HOG000233968.
    HOVERGENi HBG009351.
    InParanoidi Q96E17.
    KOi K07883.
    OMAi QMASSQD.
    OrthoDBi EOG7JQBPC.
    PhylomeDBi Q96E17.
    TreeFami TF313199.

    Miscellaneous databases

    GeneWikii RAB3C.
    GenomeRNAii 115827.
    NextBioi 79698.
    PROi Q96E17.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q96E17.
    CleanExi HS_RAB3C.
    Genevestigatori Q96E17.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR003579. Small_GTPase_Rab_type.
    [Graphical view ]
    Pfami PF00071. Ras. 1 hit.
    [Graphical view ]
    PRINTSi PR00449. RASTRNSFRMNG.
    SMARTi SM00175. RAB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00231. small_GTP. 1 hit.
    PROSITEi PS51419. RAB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning, mapping, and characterization of the human Rab3C gene."
      Cheng H., Ma Y., Ni X., Jiang M., Luo Y., Ying K., Xie Y., Ma Y.
      Biochem. Genet. 40:263-272(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Tissue: Fetal brain.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung.

    Entry informationi

    Entry nameiRAB3C_HUMAN
    AccessioniPrimary (citable) accession number: Q96E17
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 19, 2002
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 122 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3