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Q96E17 (RAB3C_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 120. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ras-related protein Rab-3C
Gene names
Name:RAB3C
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length227 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Protein transport. Probably involved in vesicular traffic By similarity.

Subunit structure

Interacts with RIMS1, RIMS2, RPH3A and RPH3AL By similarity.

Subcellular location

Cell membrane; Lipid-anchor; Cytoplasmic side Potential.

Tissue specificity

Expressed in brain, placenta and lung. Ref.1

Sequence similarities

Belongs to the small GTPase superfamily. Rab family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 227227Ras-related protein Rab-3C
PRO_0000121085

Regions

Nucleotide binding37 – 448GTP By similarity
Nucleotide binding85 – 895GTP By similarity
Nucleotide binding143 – 1464GTP By similarity
Motif59 – 679Effector region By similarity

Amino acid modifications

Modified residue2271Cysteine methyl ester By similarity
Lipidation2251S-geranylgeranyl cysteine By similarity
Lipidation2271S-geranylgeranyl cysteine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q96E17 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 7352E205DEFAC72D

FASTA22725,952
        10         20         30         40         50         60 
MRHEAPMQMA SAQDARYGQK DSSDQNFDYM FKLLIIGNSS VGKTSFLFRY ADDSFTSAFV 

        70         80         90        100        110        120 
STVGIDFKVK TVFKNEKRIK LQIWDTAGQE RYRTITTAYY RGAMGFILMY DITNEESFNA 

       130        140        150        160        170        180 
VQDWSTQIKT YSWDNAQVIL VGNKCDMEDE RVISTERGQH LGEQLGFEFF ETSAKDNINV 

       190        200        210        220 
KQTFERLVDI ICDKMSESLE TDPAITAAKQ NTRLKETPPP PQPNCAC 

« Hide

References

« Hide 'large scale' references
[1]"Cloning, mapping, and characterization of the human Rab3C gene."
Cheng H., Ma Y., Ni X., Jiang M., Luo Y., Ying K., Xie Y., Ma Y.
Biochem. Genet. 40:263-272(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
Tissue: Fetal brain.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Lung.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY026936 mRNA. Translation: AAK08968.1.
BC013033 mRNA. Translation: AAH13033.1.
RefSeqNP_612462.1. NM_138453.2.
UniGeneHs.4290.
Hs.482173.

3D structure databases

ProteinModelPortalQ96E17.
SMRQ96E17. Positions 26-194.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid125459. 5 interactions.
IntActQ96E17. 1 interaction.
STRING9606.ENSP00000282878.

PTM databases

PhosphoSiteQ96E17.

Polymorphism databases

DMDM23396832.

Proteomic databases

PaxDbQ96E17.
PRIDEQ96E17.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000282878; ENSP00000282878; ENSG00000152932.
GeneID115827.
KEGGhsa:115827.
UCSCuc003jrp.3. human.

Organism-specific databases

CTD115827.
GeneCardsGC05P057914.
HGNCHGNC:30269. RAB3C.
HPAHPA003160.
HPA048156.
MIM612829. gene.
neXtProtNX_Q96E17.
PharmGKBPA134874100.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG1100.
HOGENOMHOG000233968.
HOVERGENHBG009351.
InParanoidQ96E17.
KOK07883.
OMAQMASSQD.
OrthoDBEOG7JQBPC.
PhylomeDBQ96E17.
TreeFamTF313199.

Gene expression databases

BgeeQ96E17.
CleanExHS_RAB3C.
GenevestigatorQ96E17.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
InterProIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view]
PfamPF00071. Ras. 1 hit.
[Graphical view]
PRINTSPR00449. RASTRNSFRMNG.
SMARTSM00175. RAB. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR00231. small_GTP. 1 hit.
PROSITEPS51419. RAB. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiRAB3C.
GenomeRNAi115827.
NextBio79698.
PROQ96E17.
SOURCESearch...

Entry information

Entry nameRAB3C_HUMAN
AccessionPrimary (citable) accession number: Q96E17
Entry history
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: December 1, 2001
Last modified: April 16, 2014
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM