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Protein

Small integral membrane protein 19

Gene

SMIM19

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Enzyme and pathway databases

BioCyciZFISH:ENSG00000176209-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Small integral membrane protein 19
Gene namesi
Name:SMIM19
Synonyms:C8orf40
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:25166. SMIM19.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei25 – 43HelicalSequence analysisAdd BLAST19

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi114926.
OpenTargetsiENSG00000176209.
PharmGKBiPA142672359.

Polymorphism and mutation databases

BioMutaiSMIM19.
DMDMi294862418.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002646261 – 107Small integral membrane protein 19Add BLAST107

Proteomic databases

EPDiQ96E16.
MaxQBiQ96E16.
PaxDbiQ96E16.
PeptideAtlasiQ96E16.
PRIDEiQ96E16.

PTM databases

iPTMnetiQ96E16.
PhosphoSitePlusiQ96E16.

Expressioni

Gene expression databases

BgeeiENSG00000176209.
CleanExiHS_C8orf40.
ExpressionAtlasiQ96E16. baseline and differential.
GenevisibleiQ96E16. HS.

Organism-specific databases

HPAiHPA011145.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000390750.

Structurei

3D structure databases

ProteinModelPortaliQ96E16.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SMIM19 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IYEJ. Eukaryota.
ENOG4111RIC. LUCA.
GeneTreeiENSGT00390000000436.
HOGENOMiHOG000111615.
HOVERGENiHBG081137.
InParanoidiQ96E16.
OMAiSVHEAWN.
OrthoDBiEOG091G14QM.
PhylomeDBiQ96E16.
TreeFamiTF332548.

Family and domain databases

InterProiIPR029368. SMIM19.
[Graphical view]
PANTHERiPTHR31888. PTHR31888. 1 hit.
PfamiPF15117. UPF0697. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96E16-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGGYGVMGD DGSIDYTVHE AWNEATNVYL IVILVSFGLF MYAKRNKRRI
60 70 80 90 100
MRIFSVPPTE ETLSEPNFYD TISKIRLRQQ LEMYSISRKY DYQQPQNQAD

SVQLSLE
Length:107
Mass (Da):12,439
Last modified:April 20, 2010 - v2
Checksum:iBC12D67B91DDD321
GO

Sequence cautioni

The sequence AAH13035 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAG34873 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK311932 mRNA. Translation: BAG34873.1. Different initiation.
AC090739 Genomic DNA. No translation available.
CH471080 Genomic DNA. Translation: EAW63211.1.
CH471080 Genomic DNA. Translation: EAW63212.1.
BC013035 mRNA. Translation: AAH13035.1. Different initiation.
CCDSiCCDS6133.2.
RefSeqiNP_001129146.1. NM_001135674.1.
NP_001129147.1. NM_001135675.1.
NP_001129148.1. NM_001135676.1.
NP_612445.2. NM_138436.3.
UniGeneiHs.655320.

Genome annotation databases

EnsembliENST00000414154; ENSP00000408997; ENSG00000176209.
ENST00000416469; ENSP00000390750; ENSG00000176209.
ENST00000417410; ENSP00000405694; ENSG00000176209.
ENST00000438528; ENSP00000391549; ENSG00000176209.
ENST00000490331; ENSP00000429586; ENSG00000176209.
GeneIDi114926.
KEGGihsa:114926.
UCSCiuc003xpg.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK311932 mRNA. Translation: BAG34873.1. Different initiation.
AC090739 Genomic DNA. No translation available.
CH471080 Genomic DNA. Translation: EAW63211.1.
CH471080 Genomic DNA. Translation: EAW63212.1.
BC013035 mRNA. Translation: AAH13035.1. Different initiation.
CCDSiCCDS6133.2.
RefSeqiNP_001129146.1. NM_001135674.1.
NP_001129147.1. NM_001135675.1.
NP_001129148.1. NM_001135676.1.
NP_612445.2. NM_138436.3.
UniGeneiHs.655320.

3D structure databases

ProteinModelPortaliQ96E16.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000390750.

PTM databases

iPTMnetiQ96E16.
PhosphoSitePlusiQ96E16.

Polymorphism and mutation databases

BioMutaiSMIM19.
DMDMi294862418.

Proteomic databases

EPDiQ96E16.
MaxQBiQ96E16.
PaxDbiQ96E16.
PeptideAtlasiQ96E16.
PRIDEiQ96E16.

Protocols and materials databases

DNASUi114926.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000414154; ENSP00000408997; ENSG00000176209.
ENST00000416469; ENSP00000390750; ENSG00000176209.
ENST00000417410; ENSP00000405694; ENSG00000176209.
ENST00000438528; ENSP00000391549; ENSG00000176209.
ENST00000490331; ENSP00000429586; ENSG00000176209.
GeneIDi114926.
KEGGihsa:114926.
UCSCiuc003xpg.4. human.

Organism-specific databases

CTDi114926.
DisGeNETi114926.
GeneCardsiSMIM19.
HGNCiHGNC:25166. SMIM19.
HPAiHPA011145.
neXtProtiNX_Q96E16.
OpenTargetsiENSG00000176209.
PharmGKBiPA142672359.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IYEJ. Eukaryota.
ENOG4111RIC. LUCA.
GeneTreeiENSGT00390000000436.
HOGENOMiHOG000111615.
HOVERGENiHBG081137.
InParanoidiQ96E16.
OMAiSVHEAWN.
OrthoDBiEOG091G14QM.
PhylomeDBiQ96E16.
TreeFamiTF332548.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000176209-MONOMER.

Miscellaneous databases

GenomeRNAii114926.
PROiQ96E16.

Gene expression databases

BgeeiENSG00000176209.
CleanExiHS_C8orf40.
ExpressionAtlasiQ96E16. baseline and differential.
GenevisibleiQ96E16. HS.

Family and domain databases

InterProiIPR029368. SMIM19.
[Graphical view]
PANTHERiPTHR31888. PTHR31888. 1 hit.
PfamiPF15117. UPF0697. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSMI19_HUMAN
AccessioniPrimary (citable) accession number: Q96E16
Secondary accession number(s): B2R4S6, D3DSY4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: April 20, 2010
Last modified: November 2, 2016
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.