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Q96E16 (SMI19_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Small integral membrane protein 19
Gene names
Name:SMIM19
Synonyms:C8orf40
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length107 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Membrane; Single-pass membrane protein Potential.

Sequence similarities

Belongs to the SMIM19 family.

Sequence caution

The sequence AAH13035.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence BAG34873.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
   Cellular componentMembrane
   DomainTransmembrane
Transmembrane helix
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 107107Small integral membrane protein 19
PRO_0000264626

Regions

Transmembrane25 – 4319Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q96E16 [UniParc].

Last modified April 20, 2010. Version 2.
Checksum: BC12D67B91DDD321

FASTA10712,439
        10         20         30         40         50         60 
MAGGYGVMGD DGSIDYTVHE AWNEATNVYL IVILVSFGLF MYAKRNKRRI MRIFSVPPTE 

        70         80         90        100 
ETLSEPNFYD TISKIRLRQQ LEMYSISRKY DYQQPQNQAD SVQLSLE 

« Hide

References

[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Tongue.
[2]"DNA sequence and analysis of human chromosome 8."
Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T. expand/collapse author list , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Lung.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK311932 mRNA. Translation: BAG34873.1. Different initiation.
AC090739 Genomic DNA. No translation available.
CH471080 Genomic DNA. Translation: EAW63211.1.
CH471080 Genomic DNA. Translation: EAW63212.1.
BC013035 mRNA. Translation: AAH13035.1. Different initiation.
CCDSCCDS6133.2.
RefSeqNP_001129146.1. NM_001135674.1.
NP_001129147.1. NM_001135675.1.
NP_001129148.1. NM_001135676.1.
NP_612445.2. NM_138436.3.
UniGeneHs.655320.

3D structure databases

ProteinModelPortalQ96E16.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000390750.

PTM databases

PhosphoSiteQ96E16.

Polymorphism databases

DMDM294862418.

Proteomic databases

PRIDEQ96E16.

Protocols and materials databases

DNASU114926.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000414154; ENSP00000408997; ENSG00000176209.
ENST00000416469; ENSP00000390750; ENSG00000176209.
ENST00000417410; ENSP00000405694; ENSG00000176209.
ENST00000438528; ENSP00000391549; ENSG00000176209.
ENST00000490331; ENSP00000429586; ENSG00000176209.
GeneID114926.
KEGGhsa:114926.
UCSCuc003xpg.3. human.

Organism-specific databases

CTD114926.
GeneCardsGC08P042397.
HGNCHGNC:25166. SMIM19.
HPAHPA011145.
neXtProtNX_Q96E16.
PharmGKBPA142672359.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG28250.
HOGENOMHOG000111615.
HOVERGENHBG081137.
InParanoidQ96E16.
OMASVHEAWN.
OrthoDBEOG7HHWVM.
PhylomeDBQ96E16.
TreeFamTF332548.

Gene expression databases

ArrayExpressQ96E16.
BgeeQ96E16.
CleanExHS_C8orf40.
GenevestigatorQ96E16.

Family and domain databases

InterProIPR029368. SMIM19.
[Graphical view]
PANTHERPTHR31888. PTHR31888. 1 hit.
PfamPF15117. UPF0697. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi114926.
NextBio79444.

Entry information

Entry nameSMI19_HUMAN
AccessionPrimary (citable) accession number: Q96E16
Secondary accession number(s): B2R4S6, D3DSY4
Entry history
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: April 20, 2010
Last modified: July 9, 2014
This is version 85 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 8

Human chromosome 8: entries, gene names and cross-references to MIM