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Q96E16

- SMI19_HUMAN

UniProt

Q96E16 - SMI19_HUMAN

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Protein

Small integral membrane protein 19

Gene

SMIM19

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Small integral membrane protein 19
Gene namesi
Name:SMIM19
Synonyms:C8orf40
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 8

Organism-specific databases

HGNCiHGNC:25166. SMIM19.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei25 – 4319HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672359.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 107107Small integral membrane protein 19PRO_0000264626Add
BLAST

Proteomic databases

MaxQBiQ96E16.
PRIDEiQ96E16.

PTM databases

PhosphoSiteiQ96E16.

Expressioni

Gene expression databases

BgeeiQ96E16.
CleanExiHS_C8orf40.
ExpressionAtlasiQ96E16. baseline and differential.
GenevestigatoriQ96E16.

Organism-specific databases

HPAiHPA011145.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000390750.

Structurei

3D structure databases

ProteinModelPortaliQ96E16.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SMIM19 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG28250.
GeneTreeiENSGT00390000000436.
HOGENOMiHOG000111615.
HOVERGENiHBG081137.
InParanoidiQ96E16.
OMAiSVHEAWN.
OrthoDBiEOG7HHWVM.
PhylomeDBiQ96E16.
TreeFamiTF332548.

Family and domain databases

InterProiIPR029368. SMIM19.
[Graphical view]
PANTHERiPTHR31888. PTHR31888. 1 hit.
PfamiPF15117. UPF0697. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96E16-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAGGYGVMGD DGSIDYTVHE AWNEATNVYL IVILVSFGLF MYAKRNKRRI
60 70 80 90 100
MRIFSVPPTE ETLSEPNFYD TISKIRLRQQ LEMYSISRKY DYQQPQNQAD

SVQLSLE
Length:107
Mass (Da):12,439
Last modified:April 20, 2010 - v2
Checksum:iBC12D67B91DDD321
GO

Sequence cautioni

The sequence AAH13035.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAG34873.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK311932 mRNA. Translation: BAG34873.1. Different initiation.
AC090739 Genomic DNA. No translation available.
CH471080 Genomic DNA. Translation: EAW63211.1.
CH471080 Genomic DNA. Translation: EAW63212.1.
BC013035 mRNA. Translation: AAH13035.1. Different initiation.
CCDSiCCDS6133.2.
RefSeqiNP_001129146.1. NM_001135674.1.
NP_001129147.1. NM_001135675.1.
NP_001129148.1. NM_001135676.1.
NP_612445.2. NM_138436.3.
UniGeneiHs.655320.

Genome annotation databases

EnsembliENST00000414154; ENSP00000408997; ENSG00000176209.
ENST00000416469; ENSP00000390750; ENSG00000176209.
ENST00000417410; ENSP00000405694; ENSG00000176209.
ENST00000438528; ENSP00000391549; ENSG00000176209.
ENST00000490331; ENSP00000429586; ENSG00000176209.
GeneIDi114926.
KEGGihsa:114926.
UCSCiuc003xpg.3. human.

Polymorphism databases

DMDMi294862418.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK311932 mRNA. Translation: BAG34873.1 . Different initiation.
AC090739 Genomic DNA. No translation available.
CH471080 Genomic DNA. Translation: EAW63211.1 .
CH471080 Genomic DNA. Translation: EAW63212.1 .
BC013035 mRNA. Translation: AAH13035.1 . Different initiation.
CCDSi CCDS6133.2.
RefSeqi NP_001129146.1. NM_001135674.1.
NP_001129147.1. NM_001135675.1.
NP_001129148.1. NM_001135676.1.
NP_612445.2. NM_138436.3.
UniGenei Hs.655320.

3D structure databases

ProteinModelPortali Q96E16.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000390750.

PTM databases

PhosphoSitei Q96E16.

Polymorphism databases

DMDMi 294862418.

Proteomic databases

MaxQBi Q96E16.
PRIDEi Q96E16.

Protocols and materials databases

DNASUi 114926.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000414154 ; ENSP00000408997 ; ENSG00000176209 .
ENST00000416469 ; ENSP00000390750 ; ENSG00000176209 .
ENST00000417410 ; ENSP00000405694 ; ENSG00000176209 .
ENST00000438528 ; ENSP00000391549 ; ENSG00000176209 .
ENST00000490331 ; ENSP00000429586 ; ENSG00000176209 .
GeneIDi 114926.
KEGGi hsa:114926.
UCSCi uc003xpg.3. human.

Organism-specific databases

CTDi 114926.
GeneCardsi GC08P042397.
HGNCi HGNC:25166. SMIM19.
HPAi HPA011145.
neXtProti NX_Q96E16.
PharmGKBi PA142672359.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG28250.
GeneTreei ENSGT00390000000436.
HOGENOMi HOG000111615.
HOVERGENi HBG081137.
InParanoidi Q96E16.
OMAi SVHEAWN.
OrthoDBi EOG7HHWVM.
PhylomeDBi Q96E16.
TreeFami TF332548.

Miscellaneous databases

GenomeRNAii 114926.
NextBioi 79444.

Gene expression databases

Bgeei Q96E16.
CleanExi HS_C8orf40.
ExpressionAtlasi Q96E16. baseline and differential.
Genevestigatori Q96E16.

Family and domain databases

InterProi IPR029368. SMIM19.
[Graphical view ]
PANTHERi PTHR31888. PTHR31888. 1 hit.
Pfami PF15117. UPF0697. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Tongue.
  2. "DNA sequence and analysis of human chromosome 8."
    Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
    , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
    Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.

Entry informationi

Entry nameiSMI19_HUMAN
AccessioniPrimary (citable) accession number: Q96E16
Secondary accession number(s): B2R4S6, D3DSY4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: April 20, 2010
Last modified: October 29, 2014
This is version 87 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3