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Protein

Small integral membrane protein 19

Gene

SMIM19

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Small integral membrane protein 19
Gene namesi
Name:SMIM19
Synonyms:C8orf40
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:25166. SMIM19.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei25 – 4319HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672359.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 107107Small integral membrane protein 19PRO_0000264626Add
BLAST

Proteomic databases

MaxQBiQ96E16.
PRIDEiQ96E16.

PTM databases

PhosphoSiteiQ96E16.

Expressioni

Gene expression databases

BgeeiQ96E16.
CleanExiHS_C8orf40.
ExpressionAtlasiQ96E16. baseline and differential.
GenevestigatoriQ96E16.

Organism-specific databases

HPAiHPA011145.

Interactioni

Protein-protein interaction databases

BioGridi125398. 1 interaction.
STRINGi9606.ENSP00000390750.

Structurei

3D structure databases

ProteinModelPortaliQ96E16.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SMIM19 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG28250.
GeneTreeiENSGT00390000000436.
HOGENOMiHOG000111615.
HOVERGENiHBG081137.
InParanoidiQ96E16.
OMAiSVHEAWN.
OrthoDBiEOG7HHWVM.
PhylomeDBiQ96E16.
TreeFamiTF332548.

Family and domain databases

InterProiIPR029368. SMIM19.
[Graphical view]
PANTHERiPTHR31888. PTHR31888. 1 hit.
PfamiPF15117. UPF0697. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96E16-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGGYGVMGD DGSIDYTVHE AWNEATNVYL IVILVSFGLF MYAKRNKRRI
60 70 80 90 100
MRIFSVPPTE ETLSEPNFYD TISKIRLRQQ LEMYSISRKY DYQQPQNQAD

SVQLSLE
Length:107
Mass (Da):12,439
Last modified:April 20, 2010 - v2
Checksum:iBC12D67B91DDD321
GO

Sequence cautioni

The sequence AAH13035.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAG34873.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK311932 mRNA. Translation: BAG34873.1. Different initiation.
AC090739 Genomic DNA. No translation available.
CH471080 Genomic DNA. Translation: EAW63211.1.
CH471080 Genomic DNA. Translation: EAW63212.1.
BC013035 mRNA. Translation: AAH13035.1. Different initiation.
CCDSiCCDS6133.2.
RefSeqiNP_001129146.1. NM_001135674.1.
NP_001129147.1. NM_001135675.1.
NP_001129148.1. NM_001135676.1.
NP_612445.2. NM_138436.3.
UniGeneiHs.655320.

Genome annotation databases

EnsembliENST00000414154; ENSP00000408997; ENSG00000176209.
ENST00000416469; ENSP00000390750; ENSG00000176209.
ENST00000417410; ENSP00000405694; ENSG00000176209.
ENST00000438528; ENSP00000391549; ENSG00000176209.
ENST00000490331; ENSP00000429586; ENSG00000176209.
GeneIDi114926.
KEGGihsa:114926.
UCSCiuc003xpg.3. human.

Polymorphism databases

DMDMi294862418.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK311932 mRNA. Translation: BAG34873.1. Different initiation.
AC090739 Genomic DNA. No translation available.
CH471080 Genomic DNA. Translation: EAW63211.1.
CH471080 Genomic DNA. Translation: EAW63212.1.
BC013035 mRNA. Translation: AAH13035.1. Different initiation.
CCDSiCCDS6133.2.
RefSeqiNP_001129146.1. NM_001135674.1.
NP_001129147.1. NM_001135675.1.
NP_001129148.1. NM_001135676.1.
NP_612445.2. NM_138436.3.
UniGeneiHs.655320.

3D structure databases

ProteinModelPortaliQ96E16.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125398. 1 interaction.
STRINGi9606.ENSP00000390750.

PTM databases

PhosphoSiteiQ96E16.

Polymorphism databases

DMDMi294862418.

Proteomic databases

MaxQBiQ96E16.
PRIDEiQ96E16.

Protocols and materials databases

DNASUi114926.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000414154; ENSP00000408997; ENSG00000176209.
ENST00000416469; ENSP00000390750; ENSG00000176209.
ENST00000417410; ENSP00000405694; ENSG00000176209.
ENST00000438528; ENSP00000391549; ENSG00000176209.
ENST00000490331; ENSP00000429586; ENSG00000176209.
GeneIDi114926.
KEGGihsa:114926.
UCSCiuc003xpg.3. human.

Organism-specific databases

CTDi114926.
GeneCardsiGC08P042397.
HGNCiHGNC:25166. SMIM19.
HPAiHPA011145.
neXtProtiNX_Q96E16.
PharmGKBiPA142672359.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG28250.
GeneTreeiENSGT00390000000436.
HOGENOMiHOG000111615.
HOVERGENiHBG081137.
InParanoidiQ96E16.
OMAiSVHEAWN.
OrthoDBiEOG7HHWVM.
PhylomeDBiQ96E16.
TreeFamiTF332548.

Miscellaneous databases

GenomeRNAii114926.
NextBioi79444.

Gene expression databases

BgeeiQ96E16.
CleanExiHS_C8orf40.
ExpressionAtlasiQ96E16. baseline and differential.
GenevestigatoriQ96E16.

Family and domain databases

InterProiIPR029368. SMIM19.
[Graphical view]
PANTHERiPTHR31888. PTHR31888. 1 hit.
PfamiPF15117. UPF0697. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Tongue.
  2. "DNA sequence and analysis of human chromosome 8."
    Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
    , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
    Nature 439:331-335(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.

Entry informationi

Entry nameiSMI19_HUMAN
AccessioniPrimary (citable) accession number: Q96E16
Secondary accession number(s): B2R4S6, D3DSY4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: April 20, 2010
Last modified: January 7, 2015
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.