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Q96E16

- SMI19_HUMAN

UniProt

Q96E16 - SMI19_HUMAN

Protein

Small integral membrane protein 19

Gene

SMIM19

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
  1. Names & Taxonomyi

    Protein namesi
    Recommended name:
    Small integral membrane protein 19
    Gene namesi
    Name:SMIM19
    Synonyms:C8orf40
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 8

    Organism-specific databases

    HGNCiHGNC:25166. SMIM19.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142672359.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 107107Small integral membrane protein 19PRO_0000264626Add
    BLAST

    Proteomic databases

    PRIDEiQ96E16.

    PTM databases

    PhosphoSiteiQ96E16.

    Expressioni

    Gene expression databases

    ArrayExpressiQ96E16.
    BgeeiQ96E16.
    CleanExiHS_C8orf40.
    GenevestigatoriQ96E16.

    Organism-specific databases

    HPAiHPA011145.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000390750.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96E16.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei25 – 4319HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the SMIM19 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG28250.
    HOGENOMiHOG000111615.
    HOVERGENiHBG081137.
    InParanoidiQ96E16.
    OMAiSVHEAWN.
    OrthoDBiEOG7HHWVM.
    PhylomeDBiQ96E16.
    TreeFamiTF332548.

    Family and domain databases

    InterProiIPR029368. SMIM19.
    [Graphical view]
    PANTHERiPTHR31888. PTHR31888. 1 hit.
    PfamiPF15117. UPF0697. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q96E16-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAGGYGVMGD DGSIDYTVHE AWNEATNVYL IVILVSFGLF MYAKRNKRRI    50
    MRIFSVPPTE ETLSEPNFYD TISKIRLRQQ LEMYSISRKY DYQQPQNQAD 100
    SVQLSLE 107
    Length:107
    Mass (Da):12,439
    Last modified:April 20, 2010 - v2
    Checksum:iBC12D67B91DDD321
    GO

    Sequence cautioni

    The sequence AAH13035.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence BAG34873.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK311932 mRNA. Translation: BAG34873.1. Different initiation.
    AC090739 Genomic DNA. No translation available.
    CH471080 Genomic DNA. Translation: EAW63211.1.
    CH471080 Genomic DNA. Translation: EAW63212.1.
    BC013035 mRNA. Translation: AAH13035.1. Different initiation.
    CCDSiCCDS6133.2.
    RefSeqiNP_001129146.1. NM_001135674.1.
    NP_001129147.1. NM_001135675.1.
    NP_001129148.1. NM_001135676.1.
    NP_612445.2. NM_138436.3.
    UniGeneiHs.655320.

    Genome annotation databases

    EnsembliENST00000414154; ENSP00000408997; ENSG00000176209.
    ENST00000416469; ENSP00000390750; ENSG00000176209.
    ENST00000417410; ENSP00000405694; ENSG00000176209.
    ENST00000438528; ENSP00000391549; ENSG00000176209.
    ENST00000490331; ENSP00000429586; ENSG00000176209.
    GeneIDi114926.
    KEGGihsa:114926.
    UCSCiuc003xpg.3. human.

    Polymorphism databases

    DMDMi294862418.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK311932 mRNA. Translation: BAG34873.1 . Different initiation.
    AC090739 Genomic DNA. No translation available.
    CH471080 Genomic DNA. Translation: EAW63211.1 .
    CH471080 Genomic DNA. Translation: EAW63212.1 .
    BC013035 mRNA. Translation: AAH13035.1 . Different initiation.
    CCDSi CCDS6133.2.
    RefSeqi NP_001129146.1. NM_001135674.1.
    NP_001129147.1. NM_001135675.1.
    NP_001129148.1. NM_001135676.1.
    NP_612445.2. NM_138436.3.
    UniGenei Hs.655320.

    3D structure databases

    ProteinModelPortali Q96E16.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000390750.

    PTM databases

    PhosphoSitei Q96E16.

    Polymorphism databases

    DMDMi 294862418.

    Proteomic databases

    PRIDEi Q96E16.

    Protocols and materials databases

    DNASUi 114926.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000414154 ; ENSP00000408997 ; ENSG00000176209 .
    ENST00000416469 ; ENSP00000390750 ; ENSG00000176209 .
    ENST00000417410 ; ENSP00000405694 ; ENSG00000176209 .
    ENST00000438528 ; ENSP00000391549 ; ENSG00000176209 .
    ENST00000490331 ; ENSP00000429586 ; ENSG00000176209 .
    GeneIDi 114926.
    KEGGi hsa:114926.
    UCSCi uc003xpg.3. human.

    Organism-specific databases

    CTDi 114926.
    GeneCardsi GC08P042397.
    HGNCi HGNC:25166. SMIM19.
    HPAi HPA011145.
    neXtProti NX_Q96E16.
    PharmGKBi PA142672359.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG28250.
    HOGENOMi HOG000111615.
    HOVERGENi HBG081137.
    InParanoidi Q96E16.
    OMAi SVHEAWN.
    OrthoDBi EOG7HHWVM.
    PhylomeDBi Q96E16.
    TreeFami TF332548.

    Miscellaneous databases

    GenomeRNAii 114926.
    NextBioi 79444.

    Gene expression databases

    ArrayExpressi Q96E16.
    Bgeei Q96E16.
    CleanExi HS_C8orf40.
    Genevestigatori Q96E16.

    Family and domain databases

    InterProi IPR029368. SMIM19.
    [Graphical view ]
    PANTHERi PTHR31888. PTHR31888. 1 hit.
    Pfami PF15117. UPF0697. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Tongue.
    2. "DNA sequence and analysis of human chromosome 8."
      Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
      , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
      Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung.

    Entry informationi

    Entry nameiSMI19_HUMAN
    AccessioniPrimary (citable) accession number: Q96E16
    Secondary accession number(s): B2R4S6, D3DSY4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 12, 2006
    Last sequence update: April 20, 2010
    Last modified: October 1, 2014
    This is version 86 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 8
      Human chromosome 8: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3