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Q96E11

- RRFM_HUMAN

UniProt

Q96E11 - RRFM_HUMAN

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Protein

Ribosome-recycling factor, mitochondrial

Gene

MRRF

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity).By similarity

GO - Biological processi

  1. ribosome disassembly Source: UniProtKB
  2. translation Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Protein biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosome-recycling factor, mitochondrial
Short name:
RRF
Alternative name(s):
Ribosome-releasing factor, mitochondrial
Gene namesi
Name:MRRF
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:7234. MRRF.

Subcellular locationi

Mitochondrion By similarity

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31029.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 5555MitochondrionSequence AnalysisAdd
BLAST
Chaini56 – 262207Ribosome-recycling factor, mitochondrialPRO_0000031080Add
BLAST

Proteomic databases

MaxQBiQ96E11.
PaxDbiQ96E11.
PRIDEiQ96E11.

PTM databases

PhosphoSiteiQ96E11.

Expressioni

Gene expression databases

BgeeiQ96E11.
ExpressionAtlasiQ96E11. baseline and differential.
GenevestigatoriQ96E11.

Organism-specific databases

HPAiHPA047177.
HPA049987.

Interactioni

Protein-protein interaction databases

BioGridi124944. 23 interactions.
IntActiQ96E11. 2 interactions.
MINTiMINT-3052093.

Structurei

3D structure databases

ProteinModelPortaliQ96E11.
SMRiQ96E11. Positions 86-261.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RRF family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0233.
GeneTreeiENSGT00390000005084.
HOVERGENiHBG061516.
InParanoidiQ96E11.
KOiK02838.
OMAiYRRITDN.
OrthoDBiEOG7G4QGH.
PhylomeDBiQ96E11.
TreeFamiTF323691.

Family and domain databases

Gene3Di3.30.1360.40. 1 hit.
InterProiIPR024946. Arg_repress_C-like.
IPR002661. Ribosome_recyc_fac.
IPR023584. Ribosome_recyc_fac_dom.
[Graphical view]
PANTHERiPTHR20982. PTHR20982. 1 hit.
PfamiPF01765. RRF. 1 hit.
[Graphical view]
SUPFAMiSSF55194. SSF55194. 1 hit.

Sequences (8)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 8 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q96E11-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MALGLKCFRM VHPTFRNYLA ASIRPVSEVT LKTVHERQHG HRQYMAYSAV
60 70 80 90 100
PVRHFATKKA KAKGKGQSQT RVNINAALVE DIINLEEVNE EMKSVIEALK
110 120 130 140 150
DNFNKTLNIR TSPGSLDKIA VVTADGKLAL NQISQISMKS PQLILVNMAS
160 170 180 190 200
FPECTAAAIK AIRESGMNLN PEVEGTLIRV PIPQVTREHR EMLVKLAKQN
210 220 230 240 250
TNKAKDSLRK VRTNSMNKLK KSKDTVSEDT IRLIEKQISQ MADDTVAELD
260
RHLAVKTKEL LG
Length:262
Mass (Da):29,277
Last modified:December 1, 2001 - v1
Checksum:iA4343465B5C9F5DE
GO
Isoform 2 (identifier: Q96E11-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     185-201: VTREHREMLVKLAKQNT → SAKWPMTQWQNWTGIWQ
     202-262: Missing.

Note: No experimental confirmation available.

Show »
Length:201
Mass (Da):22,450
Checksum:i9965A98B2AD33AC5
GO
Isoform 3 (identifier: Q96E11-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-44: Missing.

Note: Derived from EST data. No experimental confirmation available.

Show »
Length:218
Mass (Da):24,115
Checksum:iD2393AB713FD04FB
GO
Isoform 4 (identifier: Q96E11-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     154-262: CTAAAIKAIR...LAVKTKELLG → ELAWIRSLRVPGIRSHLYHQLAV

Note: Derived from EST data. No experimental confirmation available.

Show »
Length:176
Mass (Da):19,742
Checksum:iFEDFE00D670084CF
GO
Isoform 5 (identifier: Q96E11-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     154-158: CTAAA → VRWPC
     159-262: Missing.

Note: Derived from EST data. No experimental confirmation available.

Show »
Length:158
Mass (Da):17,687
Checksum:i395151EF011182AB
GO
Isoform 6 (identifier: Q96E11-6) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     154-168: CTAAAIKAIRESGMN → TMKQIKQYFNGPNVA
     169-262: Missing.

Note: Derived from EST data. No experimental confirmation available.

Show »
Length:168
Mass (Da):18,766
Checksum:i51468DB2F03B79FB
GO
Isoform 7 (identifier: Q96E11-7) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-44: Missing.
     154-168: CTAAAIKAIRESGMN → TMKQIKQYFNGPNVA
     169-262: Missing.

Note: Derived from EST data. No experimental confirmation available.

Show »
Length:124
Mass (Da):13,604
Checksum:iC8C91CFD6BF33A9F
GO
Isoform 8 (identifier: Q96E11-8) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     62-113: Missing.

Note: Derived from EST data. No experimental confirmation available.

Show »
Length:210
Mass (Da):23,511
Checksum:iF8CEBCB81AAE3D4E
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti216 – 2161M → V.
Corresponds to variant rs2297483 [ dbSNP | Ensembl ].
VAR_051885

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 4444Missing in isoform 3 and isoform 7. CuratedVSP_013483Add
BLAST
Alternative sequencei62 – 11352Missing in isoform 8. 1 PublicationVSP_042019Add
BLAST
Alternative sequencei154 – 262109CTAAA…KELLG → ELAWIRSLRVPGIRSHLYHQ LAV in isoform 4. CuratedVSP_013484Add
BLAST
Alternative sequencei154 – 16815CTAAA…ESGMN → TMKQIKQYFNGPNVA in isoform 6 and isoform 7. 1 PublicationVSP_013485Add
BLAST
Alternative sequencei154 – 1585CTAAA → VRWPC in isoform 5. 1 PublicationVSP_013486
Alternative sequencei159 – 262104Missing in isoform 5. 1 PublicationVSP_013487Add
BLAST
Alternative sequencei169 – 26294Missing in isoform 6 and isoform 7. 1 PublicationVSP_013488Add
BLAST
Alternative sequencei185 – 20117VTREH…AKQNT → SAKWPMTQWQNWTGIWQ in isoform 2. 1 PublicationVSP_013489Add
BLAST
Alternative sequencei202 – 26261Missing in isoform 2. 1 PublicationVSP_013490Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK291603 mRNA. Translation: BAF84292.1.
AK298046 mRNA. Translation: BAH12711.1.
AK291809 mRNA. Translation: BAF84498.1.
AK292790 mRNA. Translation: BAF85479.1.
AK300718 mRNA. Translation: BAH13333.1.
AK316266 mRNA. Translation: BAH14637.1.
AL162424 Genomic DNA. Translation: CAI14707.1.
AL162424 Genomic DNA. Translation: CAI14708.1.
AL162424 Genomic DNA. Translation: CAI14711.1.
AL162424 Genomic DNA. Translation: CAI14712.1.
AL162424 Genomic DNA. Translation: CAI14713.1.
CH471090 Genomic DNA. Translation: EAW87525.1.
BC013049 mRNA. Translation: AAH13049.1.
BC053604 mRNA. Translation: AAH53604.1.
CCDSiCCDS48013.1. [Q96E11-2]
CCDS55336.1. [Q96E11-8]
CCDS6840.1. [Q96E11-1]
RefSeqiNP_001166983.1. NM_001173512.1. [Q96E11-8]
NP_620132.1. NM_138777.3. [Q96E11-1]
NP_954646.1. NM_199177.2. [Q96E11-2]
UniGeneiHs.368011.

Genome annotation databases

EnsembliENST00000297908; ENSP00000297908; ENSG00000148187. [Q96E11-8]
ENST00000344641; ENSP00000343867; ENSG00000148187. [Q96E11-1]
ENST00000373723; ENSP00000362828; ENSG00000148187. [Q96E11-2]
ENST00000373729; ENSP00000362834; ENSG00000148187. [Q96E11-3]
ENST00000394315; ENSP00000377850; ENSG00000148187. [Q96E11-2]
ENST00000467864; ENSP00000433288; ENSG00000148187. [Q96E11-4]
ENST00000470366; ENSP00000434807; ENSG00000148187. [Q96E11-6]
ENST00000489572; ENSP00000436360; ENSG00000148187. [Q96E11-6]
GeneIDi92399.
KEGGihsa:92399.
UCSCiuc010mwa.3. human. [Q96E11-1]
uc011lyq.2. human. [Q96E11-5]
uc011lyr.2. human. [Q96E11-8]
uc022bmy.1. human. [Q96E11-2]

Polymorphism databases

DMDMi62901043.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK291603 mRNA. Translation: BAF84292.1 .
AK298046 mRNA. Translation: BAH12711.1 .
AK291809 mRNA. Translation: BAF84498.1 .
AK292790 mRNA. Translation: BAF85479.1 .
AK300718 mRNA. Translation: BAH13333.1 .
AK316266 mRNA. Translation: BAH14637.1 .
AL162424 Genomic DNA. Translation: CAI14707.1 .
AL162424 Genomic DNA. Translation: CAI14708.1 .
AL162424 Genomic DNA. Translation: CAI14711.1 .
AL162424 Genomic DNA. Translation: CAI14712.1 .
AL162424 Genomic DNA. Translation: CAI14713.1 .
CH471090 Genomic DNA. Translation: EAW87525.1 .
BC013049 mRNA. Translation: AAH13049.1 .
BC053604 mRNA. Translation: AAH53604.1 .
CCDSi CCDS48013.1. [Q96E11-2 ]
CCDS55336.1. [Q96E11-8 ]
CCDS6840.1. [Q96E11-1 ]
RefSeqi NP_001166983.1. NM_001173512.1. [Q96E11-8 ]
NP_620132.1. NM_138777.3. [Q96E11-1 ]
NP_954646.1. NM_199177.2. [Q96E11-2 ]
UniGenei Hs.368011.

3D structure databases

ProteinModelPortali Q96E11.
SMRi Q96E11. Positions 86-261.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 124944. 23 interactions.
IntActi Q96E11. 2 interactions.
MINTi MINT-3052093.

PTM databases

PhosphoSitei Q96E11.

Polymorphism databases

DMDMi 62901043.

Proteomic databases

MaxQBi Q96E11.
PaxDbi Q96E11.
PRIDEi Q96E11.

Protocols and materials databases

DNASUi 92399.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000297908 ; ENSP00000297908 ; ENSG00000148187 . [Q96E11-8 ]
ENST00000344641 ; ENSP00000343867 ; ENSG00000148187 . [Q96E11-1 ]
ENST00000373723 ; ENSP00000362828 ; ENSG00000148187 . [Q96E11-2 ]
ENST00000373729 ; ENSP00000362834 ; ENSG00000148187 . [Q96E11-3 ]
ENST00000394315 ; ENSP00000377850 ; ENSG00000148187 . [Q96E11-2 ]
ENST00000467864 ; ENSP00000433288 ; ENSG00000148187 . [Q96E11-4 ]
ENST00000470366 ; ENSP00000434807 ; ENSG00000148187 . [Q96E11-6 ]
ENST00000489572 ; ENSP00000436360 ; ENSG00000148187 . [Q96E11-6 ]
GeneIDi 92399.
KEGGi hsa:92399.
UCSCi uc010mwa.3. human. [Q96E11-1 ]
uc011lyq.2. human. [Q96E11-5 ]
uc011lyr.2. human. [Q96E11-8 ]
uc022bmy.1. human. [Q96E11-2 ]

Organism-specific databases

CTDi 92399.
GeneCardsi GC09P125026.
HGNCi HGNC:7234. MRRF.
HPAi HPA047177.
HPA049987.
MIMi 604602. gene.
neXtProti NX_Q96E11.
PharmGKBi PA31029.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0233.
GeneTreei ENSGT00390000005084.
HOVERGENi HBG061516.
InParanoidi Q96E11.
KOi K02838.
OMAi YRRITDN.
OrthoDBi EOG7G4QGH.
PhylomeDBi Q96E11.
TreeFami TF323691.

Miscellaneous databases

GenomeRNAii 92399.
NextBioi 77750.
PROi Q96E11.
SOURCEi Search...

Gene expression databases

Bgeei Q96E11.
ExpressionAtlasi Q96E11. baseline and differential.
Genevestigatori Q96E11.

Family and domain databases

Gene3Di 3.30.1360.40. 1 hit.
InterProi IPR024946. Arg_repress_C-like.
IPR002661. Ribosome_recyc_fac.
IPR023584. Ribosome_recyc_fac_dom.
[Graphical view ]
PANTHERi PTHR20982. PTHR20982. 1 hit.
Pfami PF01765. RRF. 1 hit.
[Graphical view ]
SUPFAMi SSF55194. SSF55194. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 5; 6 AND 8).
    Tissue: Brain, Lung, Placenta, Prostate, Skeletal muscle and Trachea.
  2. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ISOFORMS 1; 3; 4; 5; 6 AND 7).
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Lung.
  5. "Identification and cloning of human mitochondrial translational release factor 1 and the ribosome recycling factor."
    Zhang Y., Spremulli L.L.
    Biochim. Biophys. Acta 1443:245-250(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiRRFM_HUMAN
AccessioniPrimary (citable) accession number: Q96E11
Secondary accession number(s): A8K6D8
, A8K6Z4, B7Z4X5, B7Z6P7, Q5RKT1, Q5T7T0, Q5T7T1, Q5T7T2, Q5T7T3, Q5T7T4, Q5T7T5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: December 1, 2001
Last modified: October 29, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3