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Protein

Protein FAM122A

Gene

FAM122A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM122A
Gene namesi
Name:FAM122A
Synonyms:C9orf42
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:23490. FAM122A.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134861471.

Polymorphism and mutation databases

BioMutaiFAM122A.
DMDMi68565254.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 287287Protein FAM122APRO_0000089689Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei35 – 351PhosphoserineCombined sources
Modified residuei37 – 371PhosphoserineCombined sources
Modified residuei45 – 451PhosphoserineCombined sources
Modified residuei47 – 471PhosphothreonineCombined sources
Modified residuei48 – 481PhosphoserineCombined sources
Modified residuei62 – 621PhosphoserineCombined sources
Modified residuei76 – 761PhosphoserineCombined sources
Modified residuei143 – 1431PhosphoserineCombined sources
Modified residuei147 – 1471PhosphoserineCombined sources
Modified residuei149 – 1491PhosphothreonineCombined sources
Modified residuei189 – 1891PhosphoserineBy similarity
Modified residuei267 – 2671PhosphoserineBy similarity
Modified residuei270 – 2701PhosphoserineCombined sources
Modified residuei276 – 2761PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ96E09.
MaxQBiQ96E09.
PaxDbiQ96E09.
PRIDEiQ96E09.

PTM databases

iPTMnetiQ96E09.
PhosphoSiteiQ96E09.

Expressioni

Gene expression databases

BgeeiQ96E09.
CleanExiHS_FAM122A.
GenevisibleiQ96E09. HS.

Organism-specific databases

HPAiHPA056646.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
TERF2IPQ9NYB02EBI-9355758,EBI-750109

Protein-protein interaction databases

BioGridi125489. 18 interactions.
IntActiQ96E09. 9 interactions.
STRINGi9606.ENSP00000377807.

Structurei

3D structure databases

ProteinModelPortaliQ96E09.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi23 – 319Poly-Gly

Sequence similaritiesi

Belongs to the FAM122 family.Curated

Phylogenomic databases

eggNOGiENOG410IF6F. Eukaryota.
ENOG410ZUHK. LUCA.
GeneTreeiENSGT00390000015476.
HOGENOMiHOG000294073.
HOVERGENiHBG073694.
InParanoidiQ96E09.
OMAiSPFIPVD.
OrthoDBiEOG7F24TT.
PhylomeDBiQ96E09.
TreeFamiTF330808.

Family and domain databases

InterProiIPR026716. FAM122.
[Graphical view]
PANTHERiPTHR22227. PTHR22227. 1 hit.

Sequencei

Sequence statusi: Complete.

Q96E09-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQEKMELDL ELPPGTGGSP AEGGGSGGGG GLRRSNSAPL IHGLSDTSPV
60 70 80 90 100
FQAEAPSARR NSTTFPSRHG LLLPASPVRM HSSRLHQIKQ EEGMDLINRE
110 120 130 140 150
TVHEREVQTA MQISHSWEES FSLSDNDVEK SASPKRIDFI PVSPAPSPTR
160 170 180 190 200
GIGKQCFSPS LQSFVSSNGL PPSPIPSPTT RFTTRRSQSP INCIRPSVLG
210 220 230 240 250
PLKRKCEMET EYQPKRFFQG ITNMLSSDVA QLSDPGVCVS SDTLDGNSSS
260 270 280
AGSSCNSPAK VSTTTDSPVS PAQAASPFIP LDELSSK
Length:287
Mass (Da):30,529
Last modified:December 1, 2001 - v1
Checksum:iD5517157F72C398F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL354794 Genomic DNA. Translation: CAI12619.1.
BC013062 mRNA. Translation: AAH13062.1.
RefSeqiNP_612206.4. NM_138333.4.
UniGeneiHs.655572.

Genome annotation databases

EnsembliENST00000394264; ENSP00000377807; ENSG00000187866.
GeneIDi116224.
KEGGihsa:116224.
UCSCiuc004agw.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL354794 Genomic DNA. Translation: CAI12619.1.
BC013062 mRNA. Translation: AAH13062.1.
RefSeqiNP_612206.4. NM_138333.4.
UniGeneiHs.655572.

3D structure databases

ProteinModelPortaliQ96E09.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125489. 18 interactions.
IntActiQ96E09. 9 interactions.
STRINGi9606.ENSP00000377807.

PTM databases

iPTMnetiQ96E09.
PhosphoSiteiQ96E09.

Polymorphism and mutation databases

BioMutaiFAM122A.
DMDMi68565254.

Proteomic databases

EPDiQ96E09.
MaxQBiQ96E09.
PaxDbiQ96E09.
PRIDEiQ96E09.

Protocols and materials databases

DNASUi116224.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000394264; ENSP00000377807; ENSG00000187866.
GeneIDi116224.
KEGGihsa:116224.
UCSCiuc004agw.2. human.

Organism-specific databases

CTDi116224.
GeneCardsiFAM122A.
H-InvDBHIX0008081.
HGNCiHGNC:23490. FAM122A.
HPAiHPA056646.
neXtProtiNX_Q96E09.
PharmGKBiPA134861471.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IF6F. Eukaryota.
ENOG410ZUHK. LUCA.
GeneTreeiENSGT00390000015476.
HOGENOMiHOG000294073.
HOVERGENiHBG073694.
InParanoidiQ96E09.
OMAiSPFIPVD.
OrthoDBiEOG7F24TT.
PhylomeDBiQ96E09.
TreeFamiTF330808.

Miscellaneous databases

GenomeRNAii116224.
PROiQ96E09.

Gene expression databases

BgeeiQ96E09.
CleanExiHS_FAM122A.
GenevisibleiQ96E09. HS.

Family and domain databases

InterProiIPR026716. FAM122.
[Graphical view]
PANTHERiPTHR22227. PTHR22227. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Cervix.
  3. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-76 AND SER-143, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  4. "Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."
    Yu L.R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.
    J. Proteome Res. 6:4150-4162(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-76, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  5. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
    Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
    J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-143, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-45; SER-48; SER-143; SER-147; THR-149 AND SER-270, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-35; SER-37; THR-47; SER-48; SER-76; SER-143; SER-270 AND SER-276, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  9. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-62; SER-76; SER-143 AND SER-147, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-76; SER-143 AND SER-147, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-45 AND SER-76, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiF122A_HUMAN
AccessioniPrimary (citable) accession number: Q96E09
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: December 1, 2001
Last modified: June 8, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.