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Protein

Protein FAM122A

Gene

FAM122A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM122A
Gene namesi
Name:FAM122A
Synonyms:C9orf42
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000187866.7
HGNCiHGNC:23490 FAM122A
neXtProtiNX_Q96E09

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134861471

Polymorphism and mutation databases

BioMutaiFAM122A
DMDMi68565254

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000896891 – 287Protein FAM122AAdd BLAST287

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei35PhosphoserineCombined sources1
Modified residuei37PhosphoserineCombined sources1
Modified residuei45PhosphoserineCombined sources1
Modified residuei47PhosphothreonineCombined sources1
Modified residuei48PhosphoserineCombined sources1
Modified residuei62PhosphoserineCombined sources1
Modified residuei76PhosphoserineCombined sources1
Cross-linki89Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)Combined sources
Modified residuei143PhosphoserineCombined sources1
Modified residuei147PhosphoserineCombined sources1
Modified residuei149PhosphothreonineCombined sources1
Modified residuei187PhosphoserineCombined sources1
Modified residuei189PhosphoserineCombined sources1
Modified residuei267PhosphoserineBy similarity1
Modified residuei270PhosphoserineCombined sources1
Modified residuei276PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ96E09
MaxQBiQ96E09
PaxDbiQ96E09
PeptideAtlasiQ96E09
PRIDEiQ96E09
ProteomicsDBi76353

PTM databases

iPTMnetiQ96E09
PhosphoSitePlusiQ96E09

Expressioni

Gene expression databases

BgeeiENSG00000187866
CleanExiHS_FAM122A
GenevisibleiQ96E09 HS

Organism-specific databases

HPAiHPA056646

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
TERF2IPQ9NYB02EBI-9355758,EBI-750109

Protein-protein interaction databases

BioGridi125489, 20 interactors
IntActiQ96E09, 10 interactors
STRINGi9606.ENSP00000377807

Structurei

3D structure databases

ProteinModelPortaliQ96E09
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi23 – 31Poly-Gly9

Sequence similaritiesi

Belongs to the FAM122 family.Curated

Phylogenomic databases

eggNOGiENOG410IF6F Eukaryota
ENOG410ZUHK LUCA
HOGENOMiHOG000294073
HOVERGENiHBG073694
InParanoidiQ96E09
OMAiSPFIPVD
OrthoDBiEOG091G0EDK
PhylomeDBiQ96E09
TreeFamiTF330808

Family and domain databases

InterProiView protein in InterPro
IPR026716 FAM122
PANTHERiPTHR22227 PTHR22227, 1 hit

Sequencei

Sequence statusi: Complete.

Q96E09-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQEKMELDL ELPPGTGGSP AEGGGSGGGG GLRRSNSAPL IHGLSDTSPV
60 70 80 90 100
FQAEAPSARR NSTTFPSRHG LLLPASPVRM HSSRLHQIKQ EEGMDLINRE
110 120 130 140 150
TVHEREVQTA MQISHSWEES FSLSDNDVEK SASPKRIDFI PVSPAPSPTR
160 170 180 190 200
GIGKQCFSPS LQSFVSSNGL PPSPIPSPTT RFTTRRSQSP INCIRPSVLG
210 220 230 240 250
PLKRKCEMET EYQPKRFFQG ITNMLSSDVA QLSDPGVCVS SDTLDGNSSS
260 270 280
AGSSCNSPAK VSTTTDSPVS PAQAASPFIP LDELSSK
Length:287
Mass (Da):30,529
Last modified:December 1, 2001 - v1
Checksum:iD5517157F72C398F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL354794 Genomic DNA No translation available.
BC013062 mRNA Translation: AAH13062.1
RefSeqiNP_612206.4, NM_138333.4
UniGeneiHs.655572

Genome annotation databases

EnsembliENST00000394264; ENSP00000377807; ENSG00000187866
GeneIDi116224
KEGGihsa:116224
UCSCiuc004agw.2 human

Similar proteinsi

Entry informationi

Entry nameiF122A_HUMAN
AccessioniPrimary (citable) accession number: Q96E09
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: December 1, 2001
Last modified: June 20, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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