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Protein

CKLF-like MARVEL transmembrane domain-containing protein 5

Gene

CMTM5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis

Names & Taxonomyi

Protein namesi
Recommended name:
CKLF-like MARVEL transmembrane domain-containing protein 5
Alternative name(s):
Chemokine-like factor superfamily member 5
Gene namesi
Name:CMTM5
Synonyms:CKLFSF5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:19176. CMTM5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei35 – 5521HelicalSequence analysisAdd
BLAST
Transmembranei56 – 7621HelicalSequence analysisAdd
BLAST
Transmembranei162 – 18221HelicalSequence analysisAdd
BLAST
Transmembranei186 – 20621HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38815.

Polymorphism and mutation databases

BioMutaiCMTM5.
DMDMi34922025.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 223223CKLF-like MARVEL transmembrane domain-containing protein 5PRO_0000186105Add
BLAST

Proteomic databases

PaxDbiQ96DZ9.
PRIDEiQ96DZ9.

PTM databases

PhosphoSiteiQ96DZ9.
SwissPalmiQ96DZ9.

Expressioni

Tissue specificityi

Highly expressed in the brain.1 Publication

Gene expression databases

BgeeiQ96DZ9.
CleanExiHS_CMTM5.
ExpressionAtlasiQ96DZ9. baseline and differential.
GenevisibleiQ96DZ9. HS.

Organism-specific databases

HPAiHPA052338.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
AACSQ86V213EBI-2548702,EBI-10259474
ACSF2Q96CM84EBI-2548702,EBI-2876502
ALDH18A1P548863EBI-2548702,EBI-1210304
APOA1P026473EBI-2548702,EBI-701692
ARMC9Q7Z3E5-23EBI-2548702,EBI-10256990
C12orf10Q86UA33EBI-2548702,EBI-10258793
CYP1A1P047983EBI-2548702,EBI-10194262
DDA1Q9BW613EBI-2548702,EBI-2510241
ECM29Q5VYK33EBI-2548702,EBI-521451
FAM114A1Q8IWE23EBI-2548702,EBI-2686288
FARS2O953633EBI-2548702,EBI-2513774
GAD1Q8IVA83EBI-2548702,EBI-10209663
GAD1Q992594EBI-2548702,EBI-743184
GAD2Q053293EBI-2548702,EBI-9304251
GLTPQ9NZD23EBI-2548702,EBI-2859814
GTF3C1Q127893EBI-2548702,EBI-357956
LMO2P257913EBI-2548702,EBI-739696
MCEEQ96PE73EBI-2548702,EBI-10292326
MTERF3Q96E293EBI-2548702,EBI-7825321
NDRG4Q9ULP03EBI-2548702,EBI-10323810
PITPNC1Q9UKF73EBI-2548702,EBI-749241
PLIN3O606643EBI-2548702,EBI-725795
PPIFP304053EBI-2548702,EBI-5544229
PPP2R3CQ969Q63EBI-2548702,EBI-2561661
PTPN9P433784EBI-2548702,EBI-742898
PTPN9Q6IQ433EBI-2548702,EBI-10250413
RBFAQ8N0V33EBI-2548702,EBI-3232108
RMDN2Q96LZ73EBI-2548702,EBI-2806908
RNF185Q96GF13EBI-2548702,EBI-2340249
RSRC2Q7L4I2-23EBI-2548702,EBI-10256202
SDCBPO005603EBI-2548702,EBI-727004
SH3GLB1Q9Y3713EBI-2548702,EBI-2623095
SHMT2P348973EBI-2548702,EBI-352908
SNX1Q135963EBI-2548702,EBI-2822329
SPATA8Q6RVD63EBI-2548702,EBI-8635958
SPG21Q9NZD83EBI-2548702,EBI-742688
SSX3Q999093EBI-2548702,EBI-10295431
SUCLA2E5KS603EBI-2548702,EBI-10176959
SYNE4Q8N2053EBI-2548702,EBI-7131783
TIMM44O436153EBI-2548702,EBI-861737
TPD52L3Q96J773EBI-2548702,EBI-932162
TTPAP496383EBI-2548702,EBI-10210710
TUBBQ5SU163EBI-2548702,EBI-10245038
TUBBQ6P6023EBI-2548702,EBI-10253109
TUFMP494113EBI-2548702,EBI-359097
VARS2Q5ST30-33EBI-2548702,EBI-10244969

Protein-protein interaction databases

BioGridi125486. 50 interactions.
IntActiQ96DZ9. 51 interactions.
STRINGi9606.ENSP00000352270.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini29 – 213185MARVELPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the chemokine-like factor family.Curated
Contains 1 MARVEL domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4788. Eukaryota.
ENOG4111IAF. LUCA.
GeneTreeiENSGT00530000063326.
HOGENOMiHOG000290654.
HOVERGENiHBG053619.
InParanoidiQ96DZ9.
OMAiYRTEMAP.
OrthoDBiEOG73BVFC.
PhylomeDBiQ96DZ9.
TreeFamiTF317387.

Family and domain databases

InterProiIPR008253. Marvel.
[Graphical view]
PfamiPF01284. MARVEL. 1 hit.
[Graphical view]
PROSITEiPS51225. MARVEL. 1 hit.
[Graphical view]

Sequences (6)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96DZ9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLSARDRRDR HPEEGVVAEL QGFAVDKAFL TSHKGILLET ELALTLIIFI
60 70 80 90 100
CFTASISAYM AAALLEFFIT LAFLFLYATQ YYQRFDRINW PCLLQGHGQS
110 120 130 140 150
GGPHPLDLLS HSAKVQPQPW PGLTPPGWHT PAAVPWVPAP APGFWSWLLW
160 170 180 190 200
FICFHSLGSS DFLRCVSAII IFLVVSFAAV TSRDGAAIAA FVFGIILVSI
210 220
FAYDAFKIYR TEMAPGASQG DQQ
Length:223
Mass (Da):24,653
Last modified:September 19, 2003 - v2
Checksum:i26AC880FFC8E1F50
GO
Isoform 2 (identifier: Q96DZ9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     94-160: Missing.

Show »
Length:156
Mass (Da):17,444
Checksum:iBF066295563A63F9
GO
Isoform 3 (identifier: Q96DZ9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     43-81: ALTLIIFICFTASISAYMAAALLEFFITLAFLFLYATQY → D
     94-160: Missing.

Show »
Length:118
Mass (Da):13,190
Checksum:iE96F4E1AC5898106
GO
Isoform 4 (identifier: Q96DZ9-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     43-191: Missing.

Show »
Length:74
Mass (Da):8,255
Checksum:i0B09C89A6339756C
GO
Isoform 5 (identifier: Q96DZ9-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     43-160: Missing.

Show »
Length:105
Mass (Da):11,482
Checksum:i0A61A85D1B903076
GO
Isoform 6 (identifier: Q96DZ9-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     94-191: Missing.

Show »
Length:125
Mass (Da):14,218
Checksum:i4AAF5DCA6BAD1838
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti192 – 1921V → D in AAV69870 (PubMed:12782130).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei43 – 191149Missing in isoform 4. 1 PublicationVSP_008264Add
BLAST
Alternative sequencei43 – 160118Missing in isoform 5. 1 PublicationVSP_008263Add
BLAST
Alternative sequencei43 – 8139ALTLI…YATQY → D in isoform 3. 1 PublicationVSP_008262Add
BLAST
Alternative sequencei94 – 19198Missing in isoform 6. 1 PublicationVSP_047120Add
BLAST
Alternative sequencei94 – 16067Missing in isoform 2 and isoform 3. 3 PublicationsVSP_008265Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF479262 mRNA. Translation: AAN73040.1.
AY820135 mRNA. Translation: AAV69870.1.
AF527413 mRNA. Translation: AAQ08985.1.
AF527414 mRNA. Translation: AAQ08986.1.
AF527948 mRNA. Translation: AAQ09008.2.
AF527949 mRNA. Translation: AAQ09009.1.
AL049829 Genomic DNA. No translation available.
BC013109 mRNA. Translation: AAH13109.1.
CCDSiCCDS32050.1. [Q96DZ9-6]
CCDS73617.1. [Q96DZ9-1]
CCDS73618.1. [Q96DZ9-5]
CCDS73619.1. [Q96DZ9-4]
CCDS9598.1. [Q96DZ9-2]
RefSeqiNP_001032365.1. NM_001037288.1. [Q96DZ9-6]
NP_001275673.1. NM_001288744.1. [Q96DZ9-5]
NP_001275674.1. NM_001288745.1. [Q96DZ9-4]
NP_001275675.1. NM_001288746.1. [Q96DZ9-1]
NP_612469.1. NM_138460.2. [Q96DZ9-2]
UniGeneiHs.99272.

Genome annotation databases

EnsembliENST00000339180; ENSP00000344819; ENSG00000166091. [Q96DZ9-1]
ENST00000342473; ENSP00000344160; ENSG00000166091. [Q96DZ9-4]
ENST00000359320; ENSP00000352270; ENSG00000166091. [Q96DZ9-2]
ENST00000382809; ENSP00000372259; ENSG00000166091. [Q96DZ9-6]
ENST00000397227; ENSP00000380404; ENSG00000166091. [Q96DZ9-5]
GeneIDi116173.
KEGGihsa:116173.
UCSCiuc001wjs.3. human. [Q96DZ9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF479262 mRNA. Translation: AAN73040.1.
AY820135 mRNA. Translation: AAV69870.1.
AF527413 mRNA. Translation: AAQ08985.1.
AF527414 mRNA. Translation: AAQ08986.1.
AF527948 mRNA. Translation: AAQ09008.2.
AF527949 mRNA. Translation: AAQ09009.1.
AL049829 Genomic DNA. No translation available.
BC013109 mRNA. Translation: AAH13109.1.
CCDSiCCDS32050.1. [Q96DZ9-6]
CCDS73617.1. [Q96DZ9-1]
CCDS73618.1. [Q96DZ9-5]
CCDS73619.1. [Q96DZ9-4]
CCDS9598.1. [Q96DZ9-2]
RefSeqiNP_001032365.1. NM_001037288.1. [Q96DZ9-6]
NP_001275673.1. NM_001288744.1. [Q96DZ9-5]
NP_001275674.1. NM_001288745.1. [Q96DZ9-4]
NP_001275675.1. NM_001288746.1. [Q96DZ9-1]
NP_612469.1. NM_138460.2. [Q96DZ9-2]
UniGeneiHs.99272.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125486. 50 interactions.
IntActiQ96DZ9. 51 interactions.
STRINGi9606.ENSP00000352270.

PTM databases

PhosphoSiteiQ96DZ9.
SwissPalmiQ96DZ9.

Polymorphism and mutation databases

BioMutaiCMTM5.
DMDMi34922025.

Proteomic databases

PaxDbiQ96DZ9.
PRIDEiQ96DZ9.

Protocols and materials databases

DNASUi116173.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000339180; ENSP00000344819; ENSG00000166091. [Q96DZ9-1]
ENST00000342473; ENSP00000344160; ENSG00000166091. [Q96DZ9-4]
ENST00000359320; ENSP00000352270; ENSG00000166091. [Q96DZ9-2]
ENST00000382809; ENSP00000372259; ENSG00000166091. [Q96DZ9-6]
ENST00000397227; ENSP00000380404; ENSG00000166091. [Q96DZ9-5]
GeneIDi116173.
KEGGihsa:116173.
UCSCiuc001wjs.3. human. [Q96DZ9-1]

Organism-specific databases

CTDi116173.
GeneCardsiCMTM5.
H-InvDBHIX0011540.
HGNCiHGNC:19176. CMTM5.
HPAiHPA052338.
MIMi607888. gene.
neXtProtiNX_Q96DZ9.
PharmGKBiPA38815.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4788. Eukaryota.
ENOG4111IAF. LUCA.
GeneTreeiENSGT00530000063326.
HOGENOMiHOG000290654.
HOVERGENiHBG053619.
InParanoidiQ96DZ9.
OMAiYRTEMAP.
OrthoDBiEOG73BVFC.
PhylomeDBiQ96DZ9.
TreeFamiTF317387.

Miscellaneous databases

GenomeRNAii116173.
PROiQ96DZ9.
SOURCEiSearch...

Gene expression databases

BgeeiQ96DZ9.
CleanExiHS_CMTM5.
ExpressionAtlasiQ96DZ9. baseline and differential.
GenevisibleiQ96DZ9. HS.

Family and domain databases

InterProiIPR008253. Marvel.
[Graphical view]
PfamiPF01284. MARVEL. 1 hit.
[Graphical view]
PROSITEiPS51225. MARVEL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of eight genes encoding chemokine-like factor superfamily members 1-8 (CKLFSF1-8) by in silico cloning and experimental validation."
    Han W., Ding P., Xu M., Wang L., Rui M., Shi S., Liu Y., Zheng Y., Chen Y., Yang T., Ma D.
    Genomics 81:609-617(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 6), TISSUE SPECIFICITY.
    Tissue: Brain.
  2. Shi S., Han W., Ding P., Yang T., Song Q., Zhang Y., Ma D.
    Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 3; 4 AND 5).
    Tissue: Brain, Pancreas and Prostatic carcinoma.
  3. "The DNA sequence and analysis of human chromosome 14."
    Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
    , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
    Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.

Entry informationi

Entry nameiCKLF5_HUMAN
AccessioniPrimary (citable) accession number: Q96DZ9
Secondary accession number(s): E9PH91, Q5PY48
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: September 19, 2003
Last modified: June 8, 2016
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.