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Protein

Transmembrane 4 L6 family member 19

Gene

TM4SF19

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane 4 L6 family member 19
Alternative name(s):
Osteoclast maturation-associated gene 4 protein
Tetraspan membrane protein OCTM4
Gene namesi
Name:TM4SF19
Synonyms:OCTM4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:25167. TM4SF19.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1616CytoplasmicSequence analysisAdd
BLAST
Transmembranei17 – 3721HelicalSequence analysisAdd
BLAST
Topological domaini38 – 5922ExtracellularSequence analysisAdd
BLAST
Transmembranei60 – 8021HelicalSequence analysisAdd
BLAST
Topological domaini81 – 9313CytoplasmicSequence analysisAdd
BLAST
Transmembranei94 – 11421HelicalSequence analysisAdd
BLAST
Topological domaini115 – 17561ExtracellularSequence analysisAdd
BLAST
Transmembranei176 – 19621HelicalSequence analysisAdd
BLAST
Topological domaini197 – 20913CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670802.

Polymorphism and mutation databases

BioMutaiTM4SF19.
DMDMi269849470.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 209209Transmembrane 4 L6 family member 19PRO_0000219305Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi133 – 1331N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ96DZ7.
PeptideAtlasiQ96DZ7.
PRIDEiQ96DZ7.

PTM databases

iPTMnetiQ96DZ7.
PhosphoSiteiQ96DZ7.

Expressioni

Gene expression databases

BgeeiQ96DZ7.
CleanExiHS_TM4SF19.
ExpressionAtlasiQ96DZ7. baseline and differential.

Interactioni

Protein-protein interaction databases

BioGridi125488. 5 interactions.
IntActiQ96DZ7. 6 interactions.
STRINGi9606.ENSP00000273695.

Structurei

3D structure databases

ProteinModelPortaliQ96DZ7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the L6 tetraspanin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJUZ. Eukaryota.
ENOG4111996. LUCA.
GeneTreeiENSGT00390000010992.
HOGENOMiHOG000030899.
HOVERGENiHBG000076.
InParanoidiQ96DZ7.
OrthoDBiEOG7T7GVR.
PhylomeDBiQ96DZ7.
TreeFamiTF331371.

Family and domain databases

InterProiIPR008661. L6_membrane.
[Graphical view]
PfamiPF05805. L6_membrane. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96DZ7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVSSPCTQAS SRTCSRILGL SLGTAALFAA GANVALLLPN WDVTYLLRGL
60 70 80 90 100
LGRHAMLGTG LWGGGLMVLT AAILISLMGW RYGCFSKSGL CRSVLTALLS
110 120 130 140 150
GGLALLGALI CFVTSGVALK DGPFCMFDVS SFNQTQAWKY GYPFKDLHSR
160 170 180 190 200
NYLYDRSLWN SVCLEPSAAV VWHVSLFSAL LCISLLQLLL VVVHVINSLL

GLFCSLCEK
Length:209
Mass (Da):22,433
Last modified:November 24, 2009 - v2
Checksum:iA2AD036CEC966690
GO
Isoform 2 (identifier: Q96DZ7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     72-97: Missing.

Note: No experimental confirmation available.
Show »
Length:183
Mass (Da):19,617
Checksum:i31C2FF7A6CFFD312
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti8 – 81Q → P.2 Publications
Corresponds to variant rs6785339 [ dbSNP | Ensembl ].
VAR_060546
Natural varianti162 – 1621V → I.
Corresponds to variant rs35643777 [ dbSNP | Ensembl ].
VAR_057280

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei72 – 9726Missing in isoform 2. 1 PublicationVSP_045895Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF192910 mRNA. Translation: AAQ13824.1.
AC069257 Genomic DNA. No translation available.
CH471191 Genomic DNA. Translation: EAW53661.1.
BC146985 mRNA. Translation: AAI46986.1.
BC146993 mRNA. Translation: AAI46994.1.
BC147021 mRNA. Translation: AAI47022.1.
CA489370 mRNA. No translation available.
CCDSiCCDS3316.1. [Q96DZ7-1]
CCDS56299.1. [Q96DZ7-2]
RefSeqiNP_001191827.1. NM_001204898.1. [Q96DZ7-2]
NP_612470.2. NM_138461.3. [Q96DZ7-1]
UniGeneiHs.733264.

Genome annotation databases

EnsembliENST00000273695; ENSP00000273695; ENSG00000145107. [Q96DZ7-1]
ENST00000454715; ENSP00000387728; ENSG00000145107. [Q96DZ7-2]
GeneIDi116211.
KEGGihsa:116211.
UCSCiuc003fwl.3. human. [Q96DZ7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF192910 mRNA. Translation: AAQ13824.1.
AC069257 Genomic DNA. No translation available.
CH471191 Genomic DNA. Translation: EAW53661.1.
BC146985 mRNA. Translation: AAI46986.1.
BC146993 mRNA. Translation: AAI46994.1.
BC147021 mRNA. Translation: AAI47022.1.
CA489370 mRNA. No translation available.
CCDSiCCDS3316.1. [Q96DZ7-1]
CCDS56299.1. [Q96DZ7-2]
RefSeqiNP_001191827.1. NM_001204898.1. [Q96DZ7-2]
NP_612470.2. NM_138461.3. [Q96DZ7-1]
UniGeneiHs.733264.

3D structure databases

ProteinModelPortaliQ96DZ7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125488. 5 interactions.
IntActiQ96DZ7. 6 interactions.
STRINGi9606.ENSP00000273695.

PTM databases

iPTMnetiQ96DZ7.
PhosphoSiteiQ96DZ7.

Polymorphism and mutation databases

BioMutaiTM4SF19.
DMDMi269849470.

Proteomic databases

PaxDbiQ96DZ7.
PeptideAtlasiQ96DZ7.
PRIDEiQ96DZ7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000273695; ENSP00000273695; ENSG00000145107. [Q96DZ7-1]
ENST00000454715; ENSP00000387728; ENSG00000145107. [Q96DZ7-2]
GeneIDi116211.
KEGGihsa:116211.
UCSCiuc003fwl.3. human. [Q96DZ7-1]

Organism-specific databases

CTDi116211.
GeneCardsiTM4SF19.
HGNCiHGNC:25167. TM4SF19.
neXtProtiNX_Q96DZ7.
PharmGKBiPA142670802.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJUZ. Eukaryota.
ENOG4111996. LUCA.
GeneTreeiENSGT00390000010992.
HOGENOMiHOG000030899.
HOVERGENiHBG000076.
InParanoidiQ96DZ7.
OrthoDBiEOG7T7GVR.
PhylomeDBiQ96DZ7.
TreeFamiTF331371.

Miscellaneous databases

ChiTaRSiTM4SF19. human.
GenomeRNAii116211.
PROiQ96DZ7.

Gene expression databases

BgeeiQ96DZ7.
CleanExiHS_TM4SF19.
ExpressionAtlasiQ96DZ7. baseline and differential.

Family and domain databases

InterProiIPR008661. L6_membrane.
[Graphical view]
PfamiPF05805. L6_membrane. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Differential screening of human osteoclast maturation associated genes."
    Yamane S., Toyosaki-Maeda T., Tsuruta Y., Suzuki R., Ochi T.
    Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT PRO-8.
    Tissue: Osteoclast.
  2. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT PRO-8.
    Tissue: Testis.

Entry informationi

Entry nameiT4S19_HUMAN
AccessioniPrimary (citable) accession number: Q96DZ7
Secondary accession number(s): B2RV20, E9PH22, Q336K7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: November 24, 2009
Last modified: July 6, 2016
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.