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Protein

Transmembrane 4 L6 family member 19

Gene

TM4SF19

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Enzyme and pathway databases

BioCyciZFISH:ENSG00000145107-MONOMER.

Protein family/group databases

TCDBi8.A.75.1.3. the transmembrane 4 superfamily 4 (tm4sf4) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane 4 L6 family member 19
Alternative name(s):
Osteoclast maturation-associated gene 4 protein
Tetraspan membrane protein OCTM4
Gene namesi
Name:TM4SF19
Synonyms:OCTM4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:25167. TM4SF19.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 16CytoplasmicSequence analysisAdd BLAST16
Transmembranei17 – 37HelicalSequence analysisAdd BLAST21
Topological domaini38 – 59ExtracellularSequence analysisAdd BLAST22
Transmembranei60 – 80HelicalSequence analysisAdd BLAST21
Topological domaini81 – 93CytoplasmicSequence analysisAdd BLAST13
Transmembranei94 – 114HelicalSequence analysisAdd BLAST21
Topological domaini115 – 175ExtracellularSequence analysisAdd BLAST61
Transmembranei176 – 196HelicalSequence analysisAdd BLAST21
Topological domaini197 – 209CytoplasmicSequence analysisAdd BLAST13

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000145107.
ENSG00000273331.
PharmGKBiPA142670802.

Polymorphism and mutation databases

BioMutaiTM4SF19.
DMDMi269849470.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002193051 – 209Transmembrane 4 L6 family member 19Add BLAST209

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi133N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ96DZ7.
PeptideAtlasiQ96DZ7.
PRIDEiQ96DZ7.

PTM databases

iPTMnetiQ96DZ7.
PhosphoSitePlusiQ96DZ7.

Expressioni

Gene expression databases

BgeeiENSG00000145107.
CleanExiHS_TM4SF19.
ExpressionAtlasiQ96DZ7. baseline and differential.

Interactioni

Protein-protein interaction databases

BioGridi125488. 5 interactors.
IntActiQ96DZ7. 6 interactors.
STRINGi9606.ENSP00000273695.

Structurei

3D structure databases

ProteinModelPortaliQ96DZ7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the L6 tetraspanin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJUZ. Eukaryota.
ENOG4111996. LUCA.
GeneTreeiENSGT00390000010992.
HOGENOMiHOG000030899.
HOVERGENiHBG000076.
InParanoidiQ96DZ7.
PhylomeDBiQ96DZ7.
TreeFamiTF331371.

Family and domain databases

InterProiIPR008661. L6_membrane.
[Graphical view]
PfamiPF05805. L6_membrane. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96DZ7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVSSPCTQAS SRTCSRILGL SLGTAALFAA GANVALLLPN WDVTYLLRGL
60 70 80 90 100
LGRHAMLGTG LWGGGLMVLT AAILISLMGW RYGCFSKSGL CRSVLTALLS
110 120 130 140 150
GGLALLGALI CFVTSGVALK DGPFCMFDVS SFNQTQAWKY GYPFKDLHSR
160 170 180 190 200
NYLYDRSLWN SVCLEPSAAV VWHVSLFSAL LCISLLQLLL VVVHVINSLL

GLFCSLCEK
Length:209
Mass (Da):22,433
Last modified:November 24, 2009 - v2
Checksum:iA2AD036CEC966690
GO
Isoform 2 (identifier: Q96DZ7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     72-97: Missing.

Note: No experimental confirmation available.
Show »
Length:183
Mass (Da):19,617
Checksum:i31C2FF7A6CFFD312
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0605468Q → P.2 PublicationsCorresponds to variant rs6785339dbSNPEnsembl.1
Natural variantiVAR_057280162V → I.Corresponds to variant rs35643777dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04589572 – 97Missing in isoform 2. 1 PublicationAdd BLAST26

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF192910 mRNA. Translation: AAQ13824.1.
AC069257 Genomic DNA. No translation available.
CH471191 Genomic DNA. Translation: EAW53661.1.
BC146985 mRNA. Translation: AAI46986.1.
BC146993 mRNA. Translation: AAI46994.1.
BC147021 mRNA. Translation: AAI47022.1.
CA489370 mRNA. No translation available.
CCDSiCCDS3316.1. [Q96DZ7-1]
CCDS56299.1. [Q96DZ7-2]
RefSeqiNP_001191827.1. NM_001204898.1. [Q96DZ7-2]
NP_612470.2. NM_138461.3. [Q96DZ7-1]
UniGeneiHs.733264.

Genome annotation databases

EnsembliENST00000273695; ENSP00000273695; ENSG00000145107. [Q96DZ7-1]
ENST00000454715; ENSP00000387728; ENSG00000145107. [Q96DZ7-2]
GeneIDi116211.
KEGGihsa:116211.
UCSCiuc003fwl.3. human. [Q96DZ7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF192910 mRNA. Translation: AAQ13824.1.
AC069257 Genomic DNA. No translation available.
CH471191 Genomic DNA. Translation: EAW53661.1.
BC146985 mRNA. Translation: AAI46986.1.
BC146993 mRNA. Translation: AAI46994.1.
BC147021 mRNA. Translation: AAI47022.1.
CA489370 mRNA. No translation available.
CCDSiCCDS3316.1. [Q96DZ7-1]
CCDS56299.1. [Q96DZ7-2]
RefSeqiNP_001191827.1. NM_001204898.1. [Q96DZ7-2]
NP_612470.2. NM_138461.3. [Q96DZ7-1]
UniGeneiHs.733264.

3D structure databases

ProteinModelPortaliQ96DZ7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125488. 5 interactors.
IntActiQ96DZ7. 6 interactors.
STRINGi9606.ENSP00000273695.

Protein family/group databases

TCDBi8.A.75.1.3. the transmembrane 4 superfamily 4 (tm4sf4) family.

PTM databases

iPTMnetiQ96DZ7.
PhosphoSitePlusiQ96DZ7.

Polymorphism and mutation databases

BioMutaiTM4SF19.
DMDMi269849470.

Proteomic databases

PaxDbiQ96DZ7.
PeptideAtlasiQ96DZ7.
PRIDEiQ96DZ7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000273695; ENSP00000273695; ENSG00000145107. [Q96DZ7-1]
ENST00000454715; ENSP00000387728; ENSG00000145107. [Q96DZ7-2]
GeneIDi116211.
KEGGihsa:116211.
UCSCiuc003fwl.3. human. [Q96DZ7-1]

Organism-specific databases

CTDi116211.
GeneCardsiTM4SF19.
HGNCiHGNC:25167. TM4SF19.
neXtProtiNX_Q96DZ7.
OpenTargetsiENSG00000145107.
ENSG00000273331.
PharmGKBiPA142670802.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJUZ. Eukaryota.
ENOG4111996. LUCA.
GeneTreeiENSGT00390000010992.
HOGENOMiHOG000030899.
HOVERGENiHBG000076.
InParanoidiQ96DZ7.
PhylomeDBiQ96DZ7.
TreeFamiTF331371.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000145107-MONOMER.

Miscellaneous databases

ChiTaRSiTM4SF19. human.
GenomeRNAii116211.
PROiQ96DZ7.

Gene expression databases

BgeeiENSG00000145107.
CleanExiHS_TM4SF19.
ExpressionAtlasiQ96DZ7. baseline and differential.

Family and domain databases

InterProiIPR008661. L6_membrane.
[Graphical view]
PfamiPF05805. L6_membrane. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiT4S19_HUMAN
AccessioniPrimary (citable) accession number: Q96DZ7
Secondary accession number(s): B2RV20, E9PH22, Q336K7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: November 24, 2009
Last modified: November 2, 2016
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.