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Q96DY7

- MTBP_HUMAN

UniProt

Q96DY7 - MTBP_HUMAN

Protein

Mdm2-binding protein

Gene

MTBP

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Inhibits cell migration in vitro and suppresses the invasive behavior of tumor cells By similarity. May play a role in MDM2-dependent p53/TP53 homeostasis in unstressed cells. Inhibits autoubiquitination of MDM2, thereby enhancing MDM2 stability. This promotes MDM2-mediated ubiquitination of p53/TP53 and its subsequent degradation.By similarity1 Publication

    GO - Biological processi

    1. cell cycle arrest Source: UniProtKB-KW
    2. mitotic spindle checkpoint Source: MGI
    3. negative regulation of cell proliferation Source: Ensembl
    4. protein localization to kinetochore Source: MGI
    5. traversing start control point of mitotic cell cycle Source: Ensembl

    Keywords - Biological processi

    Cell cycle, Growth arrest, Ubl conjugation pathway

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mdm2-binding protein
    Short name:
    hMTBP
    Gene namesi
    Name:MTBP
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 8

    Organism-specific databases

    HGNCiHGNC:7417. MTBP.

    Subcellular locationi

    GO - Cellular componenti

    1. chromatin Source: MGI
    2. kinetochore Source: MGI

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA31224.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 904904Mdm2-binding proteinPRO_0000323745Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei639 – 6391Phosphoserine2 Publications
    Modified residuei703 – 7031Phosphoserine1 Publication
    Modified residuei707 – 7071Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ96DY7.
    PaxDbiQ96DY7.
    PRIDEiQ96DY7.

    PTM databases

    PhosphoSiteiQ96DY7.

    Expressioni

    Gene expression databases

    ArrayExpressiQ96DY7.
    BgeeiQ96DY7.
    CleanExiHS_MTBP.
    GenevestigatoriQ96DY7.

    Organism-specific databases

    HPAiHPA025694.

    Interactioni

    Subunit structurei

    Interacts with MDM2.1 Publication

    Protein-protein interaction databases

    BioGridi117988. 3 interactions.
    IntActiQ96DY7. 1 interaction.
    STRINGi9606.ENSP00000303398.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96DY7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni521 – 904384Interaction with MDM2By similarityAdd
    BLAST

    Sequence similaritiesi

    Belongs to the MTBP family.Curated

    Phylogenomic databases

    eggNOGiNOG45076.
    HOGENOMiHOG000113675.
    HOVERGENiHBG108152.
    InParanoidiQ96DY7.
    OMAiFPEFCLK.
    OrthoDBiEOG7K0ZBM.
    PhylomeDBiQ96DY7.
    TreeFamiTF331503.

    Family and domain databases

    InterProiIPR029418. MTBP_C.
    IPR029420. MTBP_central.
    IPR029421. MTBP_N.
    [Graphical view]
    PfamiPF14920. MTBP_C. 1 hit.
    PF14919. MTBP_mid. 1 hit.
    PF14918. MTBP_N. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q96DY7-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MDRYLLLVIW GEGKFPSAAS REAEHGPEVS SGEGTENQPD FTAANVYHLL    50
    KRSISASINP EDSTFPACSV GGIPGSKKWF FAVQAIYGFY QFCSSDWQEI 100
    HFDTEKDKIE DVLQTNIEEC LGAVECFEEE DSNSRESLSL ADLYEEAAEN 150
    LHQLSDKLPA PGRAMVDIIL LLSDKDPPKL KDYLPTVGAL KHLREWYSAK 200
    ITIAGNHCEI NCQKIAEYLS ANVVSLEDLR NVIDSKELWR GKIQIWERKF 250
    GFEISFPEFC LKGVTLKNFS TSNLNTDFLA KKIIPSKDKN ILPKVFHYYG 300
    PALEFVQMIK LSDLPSCYMS DIEFELGLTN STKQNSVLLL EQISSLCSKV 350
    GALFVLPCTI SNILIPPPNQ LSSRKWKEYI AKKPKTISVP DVEVKGECSS 400
    YYLLLQGNGN RRCKATLIHS ANQINGSFAL NLIHGKMKTK TEEAKLSFPF 450
    DLLSLPHFSG EQIVQREKQL ANVQVLALEE CLKRRKLAKQ PETVSVAELK 500
    SLLVLTRKHF LDYFDAVIPK MILRKMDKIK TFNILNDFSP VEPNSSSLME 550
    TNPLEWPERH VLQNLETFEK TKQKMRTGSL PHSSEQLLGH KEGPRDSITL 600
    LDAKELLKYF TSDGLPIGDL QPLPIQKGEK TFVLTPELSP GKLQVLPFEK 650
    ASVCHYHGIE YCLDDRKALE RDGGFSELQS RLIRYETQTT CTRESFPVPT 700
    VLSPLPSPVV SSDPGSVPDG EVLQNELRTE VSRLKRRSKD LNCLYPRKRL 750
    VKSESSESLL SQTTGNSNHY HHHVTSRKPQ TERSLPVTCP LVPIPSCETP 800
    KLATKTSSGQ KSMHESKTSR QIKESRSQKH TRILKEVVTE TLKKHSITET 850
    HECFTACSQR LFEISKFYLK DLKTSRGLFE EMKKTANNNA VQVIDWVLEK 900
    TSKK 904
    Length:904
    Mass (Da):102,193
    Last modified:December 1, 2001 - v1
    Checksum:i753DF4A98AB62E4F
    GO
    Isoform 2 (identifier: Q96DY7-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         326-329: LGLT → FTED
         330-904: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:329
    Mass (Da):37,253
    Checksum:iAB75C6597A082DAC
    GO

    Sequence cautioni

    The sequence BAB13965.1 differs from that shown. Reason: Probable cloning artifact. May result from internal priming due to genomic poly-A tracts.
    The sequence EAW92007.1 differs from that shown. Reason: Erroneous gene model prediction.

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei326 – 3294LGLT → FTED in isoform 2. 1 PublicationVSP_056108
    Alternative sequencei330 – 904575Missing in isoform 2. 1 PublicationVSP_056109Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK022122 mRNA. Translation: BAB13965.1. Sequence problems.
    AK300762 mRNA. Translation: BAG62427.1.
    AC105142 Genomic DNA. No translation available.
    AC107877 Genomic DNA. No translation available.
    CH471060 Genomic DNA. Translation: EAW92006.1.
    CH471060 Genomic DNA. Translation: EAW92007.1. Sequence problems.
    BC013136 mRNA. Translation: AAH13136.1.
    CCDSiCCDS6333.1.
    RefSeqiNP_071328.2. NM_022045.4.
    UniGeneiHs.657656.

    Genome annotation databases

    EnsembliENST00000305949; ENSP00000303398; ENSG00000172167.
    ENST00000523373; ENSP00000430771; ENSG00000172167.
    GeneIDi27085.
    KEGGihsa:27085.
    UCSCiuc003ypc.2. human.

    Polymorphism databases

    DMDMi74731509.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK022122 mRNA. Translation: BAB13965.1 . Sequence problems.
    AK300762 mRNA. Translation: BAG62427.1 .
    AC105142 Genomic DNA. No translation available.
    AC107877 Genomic DNA. No translation available.
    CH471060 Genomic DNA. Translation: EAW92006.1 .
    CH471060 Genomic DNA. Translation: EAW92007.1 . Sequence problems.
    BC013136 mRNA. Translation: AAH13136.1 .
    CCDSi CCDS6333.1.
    RefSeqi NP_071328.2. NM_022045.4.
    UniGenei Hs.657656.

    3D structure databases

    ProteinModelPortali Q96DY7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 117988. 3 interactions.
    IntActi Q96DY7. 1 interaction.
    STRINGi 9606.ENSP00000303398.

    PTM databases

    PhosphoSitei Q96DY7.

    Polymorphism databases

    DMDMi 74731509.

    Proteomic databases

    MaxQBi Q96DY7.
    PaxDbi Q96DY7.
    PRIDEi Q96DY7.

    Protocols and materials databases

    DNASUi 27085.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000305949 ; ENSP00000303398 ; ENSG00000172167 .
    ENST00000523373 ; ENSP00000430771 ; ENSG00000172167 .
    GeneIDi 27085.
    KEGGi hsa:27085.
    UCSCi uc003ypc.2. human.

    Organism-specific databases

    CTDi 27085.
    GeneCardsi GC08P121526.
    HGNCi HGNC:7417. MTBP.
    HPAi HPA025694.
    MIMi 605927. gene.
    neXtProti NX_Q96DY7.
    PharmGKBi PA31224.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG45076.
    HOGENOMi HOG000113675.
    HOVERGENi HBG108152.
    InParanoidi Q96DY7.
    OMAi FPEFCLK.
    OrthoDBi EOG7K0ZBM.
    PhylomeDBi Q96DY7.
    TreeFami TF331503.

    Miscellaneous databases

    GenomeRNAii 27085.
    NextBioi 49689.
    PROi Q96DY7.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q96DY7.
    Bgeei Q96DY7.
    CleanExi HS_MTBP.
    Genevestigatori Q96DY7.

    Family and domain databases

    InterProi IPR029418. MTBP_C.
    IPR029420. MTBP_central.
    IPR029421. MTBP_N.
    [Graphical view ]
    Pfami PF14920. MTBP_C. 1 hit.
    PF14919. MTBP_mid. 1 hit.
    PF14918. MTBP_N. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-141 (ISOFORM 1).
      Tissue: Embryo.
    2. "DNA sequence and analysis of human chromosome 8."
      Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
      , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
      Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Prostate.
    5. "Regulation of p53 and MDM2 activity by MTBP."
      Brady M., Vlatkovic N., Boyd M.T.
      Mol. Cell. Biol. 25:545-553(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH MDM2.
    6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-639, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    7. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    8. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-703 AND SER-707, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    9. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-639, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.

    Entry informationi

    Entry nameiMTBP_HUMAN
    AccessioniPrimary (citable) accession number: Q96DY7
    Secondary accession number(s): B4DUR5, Q9HA89
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 18, 2008
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 88 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 8
      Human chromosome 8: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3