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Q96DY7

- MTBP_HUMAN

UniProt

Q96DY7 - MTBP_HUMAN

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Protein

Mdm2-binding protein

Gene

MTBP

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Inhibits cell migration in vitro and suppresses the invasive behavior of tumor cells (By similarity). May play a role in MDM2-dependent p53/TP53 homeostasis in unstressed cells. Inhibits autoubiquitination of MDM2, thereby enhancing MDM2 stability. This promotes MDM2-mediated ubiquitination of p53/TP53 and its subsequent degradation.By similarity1 Publication

GO - Biological processi

  1. cell cycle arrest Source: UniProtKB-KW
  2. mitotic spindle checkpoint Source: MGI
  3. negative regulation of cell proliferation Source: Ensembl
  4. protein localization to kinetochore Source: MGI
  5. traversing start control point of mitotic cell cycle Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Growth arrest, Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Mdm2-binding protein
Short name:
hMTBP
Gene namesi
Name:MTBP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 8

Organism-specific databases

HGNCiHGNC:7417. MTBP.

Subcellular locationi

GO - Cellular componenti

  1. chromatin Source: MGI
  2. kinetochore Source: MGI
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31224.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 904904Mdm2-binding proteinPRO_0000323745Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei639 – 6391Phosphoserine2 Publications
Modified residuei703 – 7031Phosphoserine1 Publication
Modified residuei707 – 7071Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ96DY7.
PaxDbiQ96DY7.
PRIDEiQ96DY7.

PTM databases

PhosphoSiteiQ96DY7.

Expressioni

Gene expression databases

BgeeiQ96DY7.
CleanExiHS_MTBP.
ExpressionAtlasiQ96DY7. baseline and differential.
GenevestigatoriQ96DY7.

Organism-specific databases

HPAiHPA025694.

Interactioni

Subunit structurei

Interacts with MDM2.1 Publication

Protein-protein interaction databases

BioGridi117988. 4 interactions.
IntActiQ96DY7. 1 interaction.
STRINGi9606.ENSP00000303398.

Structurei

3D structure databases

ProteinModelPortaliQ96DY7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni521 – 904384Interaction with MDM2By similarityAdd
BLAST

Sequence similaritiesi

Belongs to the MTBP family.Curated

Phylogenomic databases

eggNOGiNOG45076.
GeneTreeiENSGT00390000003305.
HOGENOMiHOG000113675.
HOVERGENiHBG108152.
InParanoidiQ96DY7.
OMAiFPEFCLK.
OrthoDBiEOG7K0ZBM.
PhylomeDBiQ96DY7.
TreeFamiTF331503.

Family and domain databases

InterProiIPR029418. MTBP_C.
IPR029420. MTBP_central.
IPR029421. MTBP_N.
[Graphical view]
PfamiPF14920. MTBP_C. 1 hit.
PF14919. MTBP_mid. 1 hit.
PF14918. MTBP_N. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q96DY7-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDRYLLLVIW GEGKFPSAAS REAEHGPEVS SGEGTENQPD FTAANVYHLL
60 70 80 90 100
KRSISASINP EDSTFPACSV GGIPGSKKWF FAVQAIYGFY QFCSSDWQEI
110 120 130 140 150
HFDTEKDKIE DVLQTNIEEC LGAVECFEEE DSNSRESLSL ADLYEEAAEN
160 170 180 190 200
LHQLSDKLPA PGRAMVDIIL LLSDKDPPKL KDYLPTVGAL KHLREWYSAK
210 220 230 240 250
ITIAGNHCEI NCQKIAEYLS ANVVSLEDLR NVIDSKELWR GKIQIWERKF
260 270 280 290 300
GFEISFPEFC LKGVTLKNFS TSNLNTDFLA KKIIPSKDKN ILPKVFHYYG
310 320 330 340 350
PALEFVQMIK LSDLPSCYMS DIEFELGLTN STKQNSVLLL EQISSLCSKV
360 370 380 390 400
GALFVLPCTI SNILIPPPNQ LSSRKWKEYI AKKPKTISVP DVEVKGECSS
410 420 430 440 450
YYLLLQGNGN RRCKATLIHS ANQINGSFAL NLIHGKMKTK TEEAKLSFPF
460 470 480 490 500
DLLSLPHFSG EQIVQREKQL ANVQVLALEE CLKRRKLAKQ PETVSVAELK
510 520 530 540 550
SLLVLTRKHF LDYFDAVIPK MILRKMDKIK TFNILNDFSP VEPNSSSLME
560 570 580 590 600
TNPLEWPERH VLQNLETFEK TKQKMRTGSL PHSSEQLLGH KEGPRDSITL
610 620 630 640 650
LDAKELLKYF TSDGLPIGDL QPLPIQKGEK TFVLTPELSP GKLQVLPFEK
660 670 680 690 700
ASVCHYHGIE YCLDDRKALE RDGGFSELQS RLIRYETQTT CTRESFPVPT
710 720 730 740 750
VLSPLPSPVV SSDPGSVPDG EVLQNELRTE VSRLKRRSKD LNCLYPRKRL
760 770 780 790 800
VKSESSESLL SQTTGNSNHY HHHVTSRKPQ TERSLPVTCP LVPIPSCETP
810 820 830 840 850
KLATKTSSGQ KSMHESKTSR QIKESRSQKH TRILKEVVTE TLKKHSITET
860 870 880 890 900
HECFTACSQR LFEISKFYLK DLKTSRGLFE EMKKTANNNA VQVIDWVLEK

TSKK
Length:904
Mass (Da):102,193
Last modified:December 1, 2001 - v1
Checksum:i753DF4A98AB62E4F
GO
Isoform 2 (identifier: Q96DY7-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     326-329: LGLT → FTED
     330-904: Missing.

Note: No experimental confirmation available.

Show »
Length:329
Mass (Da):37,253
Checksum:iAB75C6597A082DAC
GO

Sequence cautioni

The sequence BAB13965.1 differs from that shown. Reason: Probable cloning artifact. May result from internal priming due to genomic poly-A tracts.Curated
The sequence EAW92007.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei326 – 3294LGLT → FTED in isoform 2. 1 PublicationVSP_056108
Alternative sequencei330 – 904575Missing in isoform 2. 1 PublicationVSP_056109Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK022122 mRNA. Translation: BAB13965.1. Sequence problems.
AK300762 mRNA. Translation: BAG62427.1.
AC105142 Genomic DNA. No translation available.
AC107877 Genomic DNA. No translation available.
CH471060 Genomic DNA. Translation: EAW92006.1.
CH471060 Genomic DNA. Translation: EAW92007.1. Sequence problems.
BC013136 mRNA. Translation: AAH13136.1.
CCDSiCCDS6333.1. [Q96DY7-1]
RefSeqiNP_071328.2. NM_022045.4. [Q96DY7-1]
UniGeneiHs.657656.

Genome annotation databases

EnsembliENST00000305949; ENSP00000303398; ENSG00000172167. [Q96DY7-1]
ENST00000523373; ENSP00000430771; ENSG00000172167. [Q96DY7-3]
GeneIDi27085.
KEGGihsa:27085.
UCSCiuc003ypc.2. human. [Q96DY7-1]

Polymorphism databases

DMDMi74731509.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK022122 mRNA. Translation: BAB13965.1 . Sequence problems.
AK300762 mRNA. Translation: BAG62427.1 .
AC105142 Genomic DNA. No translation available.
AC107877 Genomic DNA. No translation available.
CH471060 Genomic DNA. Translation: EAW92006.1 .
CH471060 Genomic DNA. Translation: EAW92007.1 . Sequence problems.
BC013136 mRNA. Translation: AAH13136.1 .
CCDSi CCDS6333.1. [Q96DY7-1 ]
RefSeqi NP_071328.2. NM_022045.4. [Q96DY7-1 ]
UniGenei Hs.657656.

3D structure databases

ProteinModelPortali Q96DY7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 117988. 4 interactions.
IntActi Q96DY7. 1 interaction.
STRINGi 9606.ENSP00000303398.

PTM databases

PhosphoSitei Q96DY7.

Polymorphism databases

DMDMi 74731509.

Proteomic databases

MaxQBi Q96DY7.
PaxDbi Q96DY7.
PRIDEi Q96DY7.

Protocols and materials databases

DNASUi 27085.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000305949 ; ENSP00000303398 ; ENSG00000172167 . [Q96DY7-1 ]
ENST00000523373 ; ENSP00000430771 ; ENSG00000172167 . [Q96DY7-3 ]
GeneIDi 27085.
KEGGi hsa:27085.
UCSCi uc003ypc.2. human. [Q96DY7-1 ]

Organism-specific databases

CTDi 27085.
GeneCardsi GC08P121458.
HGNCi HGNC:7417. MTBP.
HPAi HPA025694.
MIMi 605927. gene.
neXtProti NX_Q96DY7.
PharmGKBi PA31224.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG45076.
GeneTreei ENSGT00390000003305.
HOGENOMi HOG000113675.
HOVERGENi HBG108152.
InParanoidi Q96DY7.
OMAi FPEFCLK.
OrthoDBi EOG7K0ZBM.
PhylomeDBi Q96DY7.
TreeFami TF331503.

Miscellaneous databases

GenomeRNAii 27085.
NextBioi 35475255.
PROi Q96DY7.
SOURCEi Search...

Gene expression databases

Bgeei Q96DY7.
CleanExi HS_MTBP.
ExpressionAtlasi Q96DY7. baseline and differential.
Genevestigatori Q96DY7.

Family and domain databases

InterProi IPR029418. MTBP_C.
IPR029420. MTBP_central.
IPR029421. MTBP_N.
[Graphical view ]
Pfami PF14920. MTBP_C. 1 hit.
PF14919. MTBP_mid. 1 hit.
PF14918. MTBP_N. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-141 (ISOFORM 1).
    Tissue: Embryo.
  2. "DNA sequence and analysis of human chromosome 8."
    Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
    , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
    Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Prostate.
  5. "Regulation of p53 and MDM2 activity by MTBP."
    Brady M., Vlatkovic N., Boyd M.T.
    Mol. Cell. Biol. 25:545-553(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH MDM2.
  6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-639, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-703 AND SER-707, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  9. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-639, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiMTBP_HUMAN
AccessioniPrimary (citable) accession number: Q96DY7
Secondary accession number(s): B4DUR5, Q9HA89
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: December 1, 2001
Last modified: November 26, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3