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Protein

Mdm2-binding protein

Gene

MTBP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Inhibits cell migration in vitro and suppresses the invasive behavior of tumor cells (By similarity). May play a role in MDM2-dependent p53/TP53 homeostasis in unstressed cells. Inhibits autoubiquitination of MDM2, thereby enhancing MDM2 stability. This promotes MDM2-mediated ubiquitination of p53/TP53 and its subsequent degradation.By similarity1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Growth arrest, Ubl conjugation pathway

Enzyme and pathway databases

BioCyciZFISH:ENSG00000172167-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Mdm2-binding protein
Short name:
hMTBP
Gene namesi
Name:MTBP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:7417. MTBP.

Subcellular locationi

GO - Cellular componenti

  • chromatin Source: MGI
  • kinetochore Source: MGI
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi27085.
OpenTargetsiENSG00000172167.
PharmGKBiPA31224.

Polymorphism and mutation databases

DMDMi74731509.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003237451 – 904Mdm2-binding proteinAdd BLAST904

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei597PhosphoserineCombined sources1
Modified residuei639PhosphoserineCombined sources1
Modified residuei703PhosphoserineCombined sources1
Modified residuei707PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ96DY7.
MaxQBiQ96DY7.
PaxDbiQ96DY7.
PeptideAtlasiQ96DY7.
PRIDEiQ96DY7.

PTM databases

iPTMnetiQ96DY7.
PhosphoSitePlusiQ96DY7.

Expressioni

Gene expression databases

BgeeiENSG00000172167.
CleanExiHS_MTBP.
ExpressionAtlasiQ96DY7. baseline and differential.
GenevisibleiQ96DY7. HS.

Organism-specific databases

HPAiHPA025694.
HPA050594.

Interactioni

Subunit structurei

Interacts with MDM2.1 Publication

Protein-protein interaction databases

BioGridi117988. 4 interactors.
IntActiQ96DY7. 3 interactors.
STRINGi9606.ENSP00000303398.

Structurei

3D structure databases

ProteinModelPortaliQ96DY7.
SMRiQ96DY7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni521 – 904Interaction with MDM2By similarityAdd BLAST384

Sequence similaritiesi

Belongs to the MTBP family.Curated

Phylogenomic databases

eggNOGiENOG410IIA4. Eukaryota.
ENOG410YVAG. LUCA.
GeneTreeiENSGT00390000003305.
HOGENOMiHOG000113675.
HOVERGENiHBG108152.
InParanoidiQ96DY7.
OMAiFPEFCLK.
OrthoDBiEOG091G01OL.
PhylomeDBiQ96DY7.
TreeFamiTF331503.

Family and domain databases

InterProiIPR029418. MTBP_C.
IPR029420. MTBP_central.
IPR029421. MTBP_N.
[Graphical view]
PfamiPF14920. MTBP_C. 1 hit.
PF14919. MTBP_mid. 1 hit.
PF14918. MTBP_N. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96DY7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDRYLLLVIW GEGKFPSAAS REAEHGPEVS SGEGTENQPD FTAANVYHLL
60 70 80 90 100
KRSISASINP EDSTFPACSV GGIPGSKKWF FAVQAIYGFY QFCSSDWQEI
110 120 130 140 150
HFDTEKDKIE DVLQTNIEEC LGAVECFEEE DSNSRESLSL ADLYEEAAEN
160 170 180 190 200
LHQLSDKLPA PGRAMVDIIL LLSDKDPPKL KDYLPTVGAL KHLREWYSAK
210 220 230 240 250
ITIAGNHCEI NCQKIAEYLS ANVVSLEDLR NVIDSKELWR GKIQIWERKF
260 270 280 290 300
GFEISFPEFC LKGVTLKNFS TSNLNTDFLA KKIIPSKDKN ILPKVFHYYG
310 320 330 340 350
PALEFVQMIK LSDLPSCYMS DIEFELGLTN STKQNSVLLL EQISSLCSKV
360 370 380 390 400
GALFVLPCTI SNILIPPPNQ LSSRKWKEYI AKKPKTISVP DVEVKGECSS
410 420 430 440 450
YYLLLQGNGN RRCKATLIHS ANQINGSFAL NLIHGKMKTK TEEAKLSFPF
460 470 480 490 500
DLLSLPHFSG EQIVQREKQL ANVQVLALEE CLKRRKLAKQ PETVSVAELK
510 520 530 540 550
SLLVLTRKHF LDYFDAVIPK MILRKMDKIK TFNILNDFSP VEPNSSSLME
560 570 580 590 600
TNPLEWPERH VLQNLETFEK TKQKMRTGSL PHSSEQLLGH KEGPRDSITL
610 620 630 640 650
LDAKELLKYF TSDGLPIGDL QPLPIQKGEK TFVLTPELSP GKLQVLPFEK
660 670 680 690 700
ASVCHYHGIE YCLDDRKALE RDGGFSELQS RLIRYETQTT CTRESFPVPT
710 720 730 740 750
VLSPLPSPVV SSDPGSVPDG EVLQNELRTE VSRLKRRSKD LNCLYPRKRL
760 770 780 790 800
VKSESSESLL SQTTGNSNHY HHHVTSRKPQ TERSLPVTCP LVPIPSCETP
810 820 830 840 850
KLATKTSSGQ KSMHESKTSR QIKESRSQKH TRILKEVVTE TLKKHSITET
860 870 880 890 900
HECFTACSQR LFEISKFYLK DLKTSRGLFE EMKKTANNNA VQVIDWVLEK

TSKK
Length:904
Mass (Da):102,193
Last modified:December 1, 2001 - v1
Checksum:i753DF4A98AB62E4F
GO
Isoform 2 (identifier: Q96DY7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     326-329: LGLT → FTED
     330-904: Missing.

Note: No experimental confirmation available.
Show »
Length:329
Mass (Da):37,253
Checksum:iAB75C6597A082DAC
GO

Sequence cautioni

The sequence BAB13965 differs from that shown. Probable cloning artifact. May result from internal priming due to genomic poly-A tracts.Curated
The sequence EAW92007 differs from that shown. Reason: Erroneous gene model prediction.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_056108326 – 329LGLT → FTED in isoform 2. 1 Publication4
Alternative sequenceiVSP_056109330 – 904Missing in isoform 2. 1 PublicationAdd BLAST575

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK022122 mRNA. Translation: BAB13965.1. Sequence problems.
AK300762 mRNA. Translation: BAG62427.1.
AC105142 Genomic DNA. No translation available.
AC107877 Genomic DNA. No translation available.
CH471060 Genomic DNA. Translation: EAW92006.1.
CH471060 Genomic DNA. Translation: EAW92007.1. Sequence problems.
BC013136 mRNA. Translation: AAH13136.1.
CCDSiCCDS6333.1. [Q96DY7-1]
RefSeqiNP_071328.2. NM_022045.4. [Q96DY7-1]
UniGeneiHs.657656.

Genome annotation databases

EnsembliENST00000305949; ENSP00000303398; ENSG00000172167. [Q96DY7-1]
ENST00000523373; ENSP00000430771; ENSG00000172167. [Q96DY7-3]
GeneIDi27085.
KEGGihsa:27085.
UCSCiuc003ypc.3. human. [Q96DY7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK022122 mRNA. Translation: BAB13965.1. Sequence problems.
AK300762 mRNA. Translation: BAG62427.1.
AC105142 Genomic DNA. No translation available.
AC107877 Genomic DNA. No translation available.
CH471060 Genomic DNA. Translation: EAW92006.1.
CH471060 Genomic DNA. Translation: EAW92007.1. Sequence problems.
BC013136 mRNA. Translation: AAH13136.1.
CCDSiCCDS6333.1. [Q96DY7-1]
RefSeqiNP_071328.2. NM_022045.4. [Q96DY7-1]
UniGeneiHs.657656.

3D structure databases

ProteinModelPortaliQ96DY7.
SMRiQ96DY7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117988. 4 interactors.
IntActiQ96DY7. 3 interactors.
STRINGi9606.ENSP00000303398.

PTM databases

iPTMnetiQ96DY7.
PhosphoSitePlusiQ96DY7.

Polymorphism and mutation databases

DMDMi74731509.

Proteomic databases

EPDiQ96DY7.
MaxQBiQ96DY7.
PaxDbiQ96DY7.
PeptideAtlasiQ96DY7.
PRIDEiQ96DY7.

Protocols and materials databases

DNASUi27085.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000305949; ENSP00000303398; ENSG00000172167. [Q96DY7-1]
ENST00000523373; ENSP00000430771; ENSG00000172167. [Q96DY7-3]
GeneIDi27085.
KEGGihsa:27085.
UCSCiuc003ypc.3. human. [Q96DY7-1]

Organism-specific databases

CTDi27085.
DisGeNETi27085.
GeneCardsiMTBP.
HGNCiHGNC:7417. MTBP.
HPAiHPA025694.
HPA050594.
MIMi605927. gene.
neXtProtiNX_Q96DY7.
OpenTargetsiENSG00000172167.
PharmGKBiPA31224.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIA4. Eukaryota.
ENOG410YVAG. LUCA.
GeneTreeiENSGT00390000003305.
HOGENOMiHOG000113675.
HOVERGENiHBG108152.
InParanoidiQ96DY7.
OMAiFPEFCLK.
OrthoDBiEOG091G01OL.
PhylomeDBiQ96DY7.
TreeFamiTF331503.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000172167-MONOMER.

Miscellaneous databases

GenomeRNAii27085.
PROiQ96DY7.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000172167.
CleanExiHS_MTBP.
ExpressionAtlasiQ96DY7. baseline and differential.
GenevisibleiQ96DY7. HS.

Family and domain databases

InterProiIPR029418. MTBP_C.
IPR029420. MTBP_central.
IPR029421. MTBP_N.
[Graphical view]
PfamiPF14920. MTBP_C. 1 hit.
PF14919. MTBP_mid. 1 hit.
PF14918. MTBP_N. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMTBP_HUMAN
AccessioniPrimary (citable) accession number: Q96DY7
Secondary accession number(s): B4DUR5, Q9HA89
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: December 1, 2001
Last modified: November 2, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.