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Protein

RING finger protein 112

Gene

Rnf112

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri80 – 121RING-typePROSITE-ProRule annotationAdd BLAST42

GO - Molecular functioni

GO - Biological processi

  • positive regulation of cell cycle arrest Source: MGI
  • positive regulation of glial cell differentiation Source: MGI
  • positive regulation of neuron differentiation Source: MGI
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
RING finger protein 112
Alternative name(s):
Brain finger protein
Zinc finger protein 179
Gene namesi
Name:Rnf112
Synonyms:Bfp, Znf179
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:106611. Rnf112.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei570 – 590HelicalSequence analysisAdd BLAST21
Transmembranei603 – 623HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • cytoplasm Source: MGI
  • integral component of membrane Source: UniProtKB-KW
  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004158171 – 654RING finger protein 112Add BLAST654

Proteomic databases

PaxDbiQ96DY5.
PRIDEiQ96DY5.

PTM databases

iPTMnetiQ96DY5.
PhosphoSitePlusiQ96DY5.

Expressioni

Tissue specificityi

Expressed in neural cells of the cerebral cortex, hippocampus, lateral amygdaloid nucleus, and ventromedial hypothalamus. Also expressed strongly in the marginal zone of brain vesicles, optic stalk, and cartilage primordium.1 Publication

Gene expression databases

BgeeiENSMUSG00000010086.
GenevisibleiQ96DY5. MM.

Interactioni

Protein-protein interaction databases

BioGridi204645. 2 interactors.
STRINGi10090.ENSMUSP00000056464.

Structurei

3D structure databases

ProteinModelPortaliQ96DY5.
SMRiQ96DY5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini189 – 420GB1/RHD3-type GAdd BLAST232

Sequence similaritiesi

Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri80 – 121RING-typePROSITE-ProRule annotationAdd BLAST42

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix, Zinc-finger

Phylogenomic databases

eggNOGiKOG2037. Eukaryota.
KOG2177. Eukaryota.
ENOG410XR6Z. LUCA.
GeneTreeiENSGT00390000008959.
HOGENOMiHOG000139175.
HOVERGENiHBG056662.
InParanoidiQ96DY5.
OMAiMGAINRC.
OrthoDBiEOG091G0GYC.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR030386. G_GB1_RHD3_dom.
IPR015894. Guanylate-bd_N.
IPR027417. P-loop_NTPase.
IPR018957. Znf_C3HC4_RING-type.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF02263. GBP. 1 hit.
PF00097. zf-C3HC4. 1 hit.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51715. G_GB1_RHD3. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96DY5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPRPVLSVTA FCHRLGKRES KRSFMGNSSN SWVLPREEAQ GWMGQAVQGG
60 70 80 90 100
TRTSRSHASF PKLELGLGHR PSPTREPPTC SICLERLREP ISLDCGHDFC
110 120 130 140 150
IRCFSTHRIP GCELPCCPEC RKICKQRKGL RSLGERMKLL PQRPLPPALQ
160 170 180 190 200
ETCAVRAERL LLVRINASGG LILRMGAINR CLKHPLARDT PVCLLAVLGE
210 220 230 240 250
QHSGKSFLLD HLLSGLPSLE SGDSGRPRAE GSLPGIRWGA NGLTRGIWMW
260 270 280 290 300
SHPFLLGKEG KKVAVFLVDT GDVMSPELSK ETRVKLCALT MMLSSYQILN
310 320 330 340 350
TSQELKDTDL GYLEMFVHVA EVMGKHYGMV PIQHLDLLVR DSSHHNKSGQ
360 370 380 390 400
GHVGDILQKL SGKYPKVQEL LLGKRARCYL LPAPERQWVN KDQASPRGNT
410 420 430 440 450
EDDFSHHFRA YILDVLSTAP QHAKSRCQGY WSEGRAVARG DRRLLTGQQL
460 470 480 490 500
AQEIKNLSGW MGKTGPSFNS PDEMAAQLHD LRKVEAAKKE FEEYVRQQDI
510 520 530 540 550
ATKRIFSALR VLPDTMRNLL STQKDAILAR HGVALLCKER EQTLEALEAE
560 570 580 590 600
LQAEAKAFMD SYTMRFCGHL AAVGGAVGAG LMGLAGGVVG AGMAAAALAA
610 620 630 640 650
EAGMVAAGAA VGATGAAVVG GGVGAGLAAT VGCMEKEEDE RVQGGDREPL

LQEE
Length:654
Mass (Da):71,275
Last modified:December 1, 2001 - v1
Checksum:i491B4A0BCF4F5D72
GO
Isoform 2 (identifier: Q96DY5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     33-55: Missing.

Note: No experimental confirmation available.
Show »
Length:631
Mass (Da):68,778
Checksum:i0274B5E550100039
GO
Isoform 3 (identifier: Q96DY5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     332-332: I → IQVRQFLVSSILTHQSRLPVSGPFLF

Show »
Length:679
Mass (Da):74,115
Checksum:iD34A119EC1DE0740
GO

Sequence cautioni

The sequence BAA34180 differs from that shown. Reason: Frameshift at position 324.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti72S → P in BAA34180 (PubMed:9806830).Curated1
Sequence conflicti151E → K in BAA34180 (PubMed:9806830).Curated1
Sequence conflicti170G → A in BAA34180 (PubMed:9806830).Curated1
Sequence conflicti399N → D in BAE38012 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04239233 – 55Missing in isoform 2. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_042393332I → IQVRQFLVSSILTHQSRLPV SGPFLF in isoform 3. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB013097 mRNA. Translation: BAA34180.1. Frameshift.
AL604029 Genomic DNA. Translation: CAI24177.1.
AL604029 Genomic DNA. Translation: CAI24178.1.
AL604029 Genomic DNA. Translation: CAI24179.1.
BC013139 mRNA. Translation: AAH13139.1.
BC037118 mRNA. Translation: AAH37118.1.
AK165038 mRNA. Translation: BAE38012.1.
CCDSiCCDS24812.1. [Q96DY5-1]
CCDS78960.1. [Q96DY5-2]
RefSeqiNP_001277953.1. NM_001291024.1. [Q96DY5-2]
NP_033574.2. NM_009548.3. [Q96DY5-1]
XP_006533241.1. XM_006533178.2. [Q96DY5-3]
XP_006533242.1. XM_006533179.2. [Q96DY5-3]
XP_006533245.1. XM_006533182.3. [Q96DY5-1]
XP_006533246.1. XM_006533183.2. [Q96DY5-2]
UniGeneiMm.488127.
Mm.89201.

Genome annotation databases

EnsembliENSMUST00000054927; ENSMUSP00000056464; ENSMUSG00000010086. [Q96DY5-1]
ENSMUST00000060255; ENSMUSP00000059903; ENSMUSG00000010086. [Q96DY5-3]
ENSMUST00000102661; ENSMUSP00000099722; ENSMUSG00000010086. [Q96DY5-2]
GeneIDi22671.
KEGGimmu:22671.
UCSCiuc007jhj.2. mouse. [Q96DY5-1]
uc007jhk.2. mouse. [Q96DY5-3]
uc007jhl.2. mouse. [Q96DY5-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB013097 mRNA. Translation: BAA34180.1. Frameshift.
AL604029 Genomic DNA. Translation: CAI24177.1.
AL604029 Genomic DNA. Translation: CAI24178.1.
AL604029 Genomic DNA. Translation: CAI24179.1.
BC013139 mRNA. Translation: AAH13139.1.
BC037118 mRNA. Translation: AAH37118.1.
AK165038 mRNA. Translation: BAE38012.1.
CCDSiCCDS24812.1. [Q96DY5-1]
CCDS78960.1. [Q96DY5-2]
RefSeqiNP_001277953.1. NM_001291024.1. [Q96DY5-2]
NP_033574.2. NM_009548.3. [Q96DY5-1]
XP_006533241.1. XM_006533178.2. [Q96DY5-3]
XP_006533242.1. XM_006533179.2. [Q96DY5-3]
XP_006533245.1. XM_006533182.3. [Q96DY5-1]
XP_006533246.1. XM_006533183.2. [Q96DY5-2]
UniGeneiMm.488127.
Mm.89201.

3D structure databases

ProteinModelPortaliQ96DY5.
SMRiQ96DY5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204645. 2 interactors.
STRINGi10090.ENSMUSP00000056464.

PTM databases

iPTMnetiQ96DY5.
PhosphoSitePlusiQ96DY5.

Proteomic databases

PaxDbiQ96DY5.
PRIDEiQ96DY5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000054927; ENSMUSP00000056464; ENSMUSG00000010086. [Q96DY5-1]
ENSMUST00000060255; ENSMUSP00000059903; ENSMUSG00000010086. [Q96DY5-3]
ENSMUST00000102661; ENSMUSP00000099722; ENSMUSG00000010086. [Q96DY5-2]
GeneIDi22671.
KEGGimmu:22671.
UCSCiuc007jhj.2. mouse. [Q96DY5-1]
uc007jhk.2. mouse. [Q96DY5-3]
uc007jhl.2. mouse. [Q96DY5-2]

Organism-specific databases

CTDi7732.
MGIiMGI:106611. Rnf112.

Phylogenomic databases

eggNOGiKOG2037. Eukaryota.
KOG2177. Eukaryota.
ENOG410XR6Z. LUCA.
GeneTreeiENSGT00390000008959.
HOGENOMiHOG000139175.
HOVERGENiHBG056662.
InParanoidiQ96DY5.
OMAiMGAINRC.
OrthoDBiEOG091G0GYC.

Miscellaneous databases

PROiQ96DY5.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000010086.
GenevisibleiQ96DY5. MM.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR030386. G_GB1_RHD3_dom.
IPR015894. Guanylate-bd_N.
IPR027417. P-loop_NTPase.
IPR018957. Znf_C3HC4_RING-type.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF02263. GBP. 1 hit.
PF00097. zf-C3HC4. 1 hit.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51715. G_GB1_RHD3. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRN112_MOUSE
AccessioniPrimary (citable) accession number: Q96DY5
Secondary accession number(s): Q3TNS6
, Q5NCN2, Q8JZT5, Q9Z328
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 22, 2012
Last sequence update: December 1, 2001
Last modified: November 2, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.