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Protein

IQ domain-containing protein D

Gene

IQCD

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
IQ domain-containing protein D
Gene namesi
Name:IQCD
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:25168. IQCD.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134901058.

Polymorphism and mutation databases

BioMutaiIQCD.
DMDMi143340095.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 449449IQ domain-containing protein DPRO_0000282548Add
BLAST

Proteomic databases

EPDiQ96DY2.
MaxQBiQ96DY2.
PaxDbiQ96DY2.
PeptideAtlasiQ96DY2.
PRIDEiQ96DY2.

PTM databases

iPTMnetiQ96DY2.
PhosphoSiteiQ96DY2.

Expressioni

Gene expression databases

BgeeiENSG00000166578.
CleanExiHS_IQCD.
ExpressionAtlasiQ96DY2. baseline and differential.
GenevisibleiQ96DY2. HS.

Organism-specific databases

HPAiHPA046810.
HPA048782.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000299732.

Structurei

3D structure databases

ProteinModelPortaliQ96DY2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini400 – 42930IQPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili90 – 12536Sequence analysisAdd
BLAST

Sequence similaritiesi

Contains 1 IQ domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IF8Y. Eukaryota.
ENOG410XT1P. LUCA.
GeneTreeiENSGT00730000111354.
HOGENOMiHOG000060107.
HOVERGENiHBG108008.
InParanoidiQ96DY2.
OMAiALWKGYL.
OrthoDBiEOG091G09F0.
PhylomeDBiQ96DY2.
TreeFamiTF326203.

Family and domain databases

InterProiIPR000048. IQ_motif_EF-hand-BS.
[Graphical view]
PfamiPF00612. IQ. 1 hit.
[Graphical view]
SMARTiSM00015. IQ. 1 hit.
[Graphical view]
PROSITEiPS50096. IQ. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96DY2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MALDILAMAP LYQAPAINRI GPKTDPSKRP ADPLKPLVLS RTKLTTIEAK
60 70 80 90 100
RIMSILDEAI YKVELVTLLS YVASNREDME GMLGEDVMRA VREHEDLCQV
110 120 130 140 150
LLENVRCLKE KERQLQEQKE AEEEGWLRDR LLSIELQKSS LSPLMQQIKD
160 170 180 190 200
STKNVLRLLL SNPQAARLLQ MQTQGRSAEA QNFIDSLIEL RGFLFEKLLT
210 220 230 240 250
SPMEARDKAQ FLQDISRQNS NNQQIIDTLE KELAERMKNR NAEVEKENFV
260 270 280 290 300
IQELKNHLHQ VLKFSENSLV RTKQEAEKQQ KADFRASQAR VAKIQQEILQ
310 320 330 340 350
LQSQFYNLVM ENREAEQALR KKKYKVETEI ENWIQKYDTE MGEKQEELED
360 370 380 390 400
LDAVHREEKI SLEELRRRHK VLVGEFAQIR EEREINSKKR MEAEQEMVRM
410 420 430 440
VRAATLIQAL WKGYLVRSLL RSKKKRGKGK AKDKEKGKQK GKEKGKGKK
Length:449
Mass (Da):52,359
Last modified:April 3, 2007 - v2
Checksum:i559F1BD39CB8CB11
GO
Isoform 2 (identifier: Q96DY2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     244-345: Missing.

Note: No experimental confirmation available.
Show »
Length:347
Mass (Da):40,094
Checksum:i597F86E32161856F
GO
Isoform 3 (identifier: Q96DY2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     244-327: VEKENFVIQE...ALRKKKYKVE → VLFHSIAEIT...PPRPANFLYF
     328-449: Missing.

Note: No experimental confirmation available.
Show »
Length:327
Mass (Da):37,958
Checksum:iC71356DAB061A1F8
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti136 – 1361L → V.
Corresponds to variant rs7966313 [ dbSNP | Ensembl ].
VAR_056921

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei244 – 345102Missing in isoform 2. 1 PublicationVSP_024178Add
BLAST
Alternative sequencei244 – 32784VEKEN…KYKVE → VLFHSIAEITEEATQIFCWL GFSSMIDFFFKMESRSVVQT RVQWCNLDSLQPLPPRFKRF SHHSLPSSWDYRRMPPRPAN FLYF in isoform 3. 1 PublicationVSP_024179Add
BLAST
Alternative sequencei328 – 449122Missing in isoform 3. 1 PublicationVSP_024180Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK127152 mRNA. Translation: BAC86856.1.
AC089999 Genomic DNA. No translation available.
BC013151 mRNA. Translation: AAH13151.1.
CCDSiCCDS9167.1. [Q96DY2-2]
RefSeqiNP_612460.1. NM_138451.2. [Q96DY2-2]
XP_005253889.1. XM_005253832.4. [Q96DY2-1]
XP_005253890.1. XM_005253833.4. [Q96DY2-1]
XP_011536164.1. XM_011537862.2. [Q96DY2-1]
XP_011536165.1. XM_011537863.2. [Q96DY2-1]
UniGeneiHs.568276.

Genome annotation databases

EnsembliENST00000299732; ENSP00000299732; ENSG00000166578. [Q96DY2-2]
ENST00000416617; ENSP00000400669; ENSG00000166578. [Q96DY2-1]
GeneIDi115811.
KEGGihsa:115811.
UCSCiuc001tuu.4. human. [Q96DY2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK127152 mRNA. Translation: BAC86856.1.
AC089999 Genomic DNA. No translation available.
BC013151 mRNA. Translation: AAH13151.1.
CCDSiCCDS9167.1. [Q96DY2-2]
RefSeqiNP_612460.1. NM_138451.2. [Q96DY2-2]
XP_005253889.1. XM_005253832.4. [Q96DY2-1]
XP_005253890.1. XM_005253833.4. [Q96DY2-1]
XP_011536164.1. XM_011537862.2. [Q96DY2-1]
XP_011536165.1. XM_011537863.2. [Q96DY2-1]
UniGeneiHs.568276.

3D structure databases

ProteinModelPortaliQ96DY2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000299732.

PTM databases

iPTMnetiQ96DY2.
PhosphoSiteiQ96DY2.

Polymorphism and mutation databases

BioMutaiIQCD.
DMDMi143340095.

Proteomic databases

EPDiQ96DY2.
MaxQBiQ96DY2.
PaxDbiQ96DY2.
PeptideAtlasiQ96DY2.
PRIDEiQ96DY2.

Protocols and materials databases

DNASUi115811.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000299732; ENSP00000299732; ENSG00000166578. [Q96DY2-2]
ENST00000416617; ENSP00000400669; ENSG00000166578. [Q96DY2-1]
GeneIDi115811.
KEGGihsa:115811.
UCSCiuc001tuu.4. human. [Q96DY2-1]

Organism-specific databases

CTDi115811.
GeneCardsiIQCD.
HGNCiHGNC:25168. IQCD.
HPAiHPA046810.
HPA048782.
neXtProtiNX_Q96DY2.
PharmGKBiPA134901058.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IF8Y. Eukaryota.
ENOG410XT1P. LUCA.
GeneTreeiENSGT00730000111354.
HOGENOMiHOG000060107.
HOVERGENiHBG108008.
InParanoidiQ96DY2.
OMAiALWKGYL.
OrthoDBiEOG091G09F0.
PhylomeDBiQ96DY2.
TreeFamiTF326203.

Miscellaneous databases

ChiTaRSiIQCD. human.
GenomeRNAii115811.
PROiQ96DY2.

Gene expression databases

BgeeiENSG00000166578.
CleanExiHS_IQCD.
ExpressionAtlasiQ96DY2. baseline and differential.
GenevisibleiQ96DY2. HS.

Family and domain databases

InterProiIPR000048. IQ_motif_EF-hand-BS.
[Graphical view]
PfamiPF00612. IQ. 1 hit.
[Graphical view]
SMARTiSM00015. IQ. 1 hit.
[Graphical view]
PROSITEiPS50096. IQ. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIQCD_HUMAN
AccessioniPrimary (citable) accession number: Q96DY2
Secondary accession number(s): Q6ZSU0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: April 3, 2007
Last modified: September 7, 2016
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.