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Protein

Receptor-transporting protein 4

Gene

RTP4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Probable chaperone protein which facilitates trafficking and functional cell surface expression of some G-protein coupled receptors (GPCRs). Promotes functional expression of the bitter taste receptor TAS2R16 (PubMed:16720576). Also promotes functional expression of the opioid receptor heterodimer OPRD1-OPRM1 (By similarity).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

  • detection of chemical stimulus involved in sensory perception of bitter taste Source: HGNC
  • protein insertion into membrane Source: GO_Central
  • protein targeting to membrane Source: HGNC
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor-transporting protein 4
Alternative name(s):
28 kDa interferon-responsive protein
3CxxC-type zinc finger protein 4
Gene namesi
Name:RTP4
Synonyms:IFRG28, Z3CXXC4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:23992. RTP4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 224224CytoplasmicSequence analysisAdd
BLAST
Transmembranei225 – 24521HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • cytoplasm Source: HGNC
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA143485606.

Polymorphism and mutation databases

BioMutaiRTP4.
DMDMi313104193.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 246246Receptor-transporting protein 4PRO_0000181995Add
BLAST

Proteomic databases

PaxDbiQ96DX8.
PeptideAtlasiQ96DX8.
PRIDEiQ96DX8.

PTM databases

iPTMnetiQ96DX8.
PhosphoSiteiQ96DX8.

Expressioni

Tissue specificityi

Expressed in circumvallate papillae and testis.1 Publication

Inductioni

By interferons.

Gene expression databases

BgeeiENSG00000136514.
CleanExiHS_RTP4.
GenevisibleiQ96DX8. HS.

Organism-specific databases

HPAiHPA064887.
HPA071189.

Interactioni

Subunit structurei

Interacts with TASR16 (PubMed:16720576). Interacts with OPRD1 and OPRM1; the interaction promotes cell surface localization of the OPDR1-OPRM1 heterodimer (By similarity).By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9606.ENSP00000259030.

Structurei

3D structure databases

ProteinModelPortaliQ96DX8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM7 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IH22. Eukaryota.
ENOG4111X4F. LUCA.
GeneTreeiENSGT00530000063222.
HOGENOMiHOG000236274.
InParanoidiQ96DX8.
OMAiRCQKCSW.
OrthoDBiEOG091G0DS4.
PhylomeDBiQ96DX8.
TreeFamiTF333246.

Family and domain databases

InterProiIPR026096. R-trans_p.
IPR026690. RTP4.
IPR027377. Znf-3CxxC.
[Graphical view]
PANTHERiPTHR14402. PTHR14402. 1 hit.
PTHR14402:SF8. PTHR14402:SF8. 1 hit.
PfamiPF13695. zf-3CxxC. 1 hit.
[Graphical view]
SMARTiSM01328. zf-3CxxC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96DX8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVVDFWTWEQ TFQELIQEAK PRATWTLKLD GNLQLDCLAQ GWKQYQQRAF
60 70 80 90 100
GWFRCSSCQR SWASAQVQIL CHTYWEHWTS QGQVRMRLFG QRCQKCSWSQ
110 120 130 140 150
YEMPEFSSDS TMRILSNLVQ HILKKYYGNG TRKSPEMPVI LEVSLEGSHD
160 170 180 190 200
TANCEACTLG ICGQGLKSCM TKPSKSLLPH LKTGNSSPGI GAVYLANQAK
210 220 230 240
NQSAEAKEAK GSGYEKLGPS RDPDPLNICV FILLLVFIVV KCFTSE
Length:246
Mass (Da):27,863
Last modified:November 30, 2010 - v3
Checksum:i74D61E554F1882CB
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti66 – 672QV → KL in AAT70683 (PubMed:15550249).Curated
Sequence conflicti66 – 672QV → KL in CAC14309 (Ref. 2) Curated
Sequence conflicti131 – 1311T → M in AAT70683 (PubMed:15550249).Curated
Sequence conflicti131 – 1311T → M in CAC14309 (Ref. 2) Curated
Sequence conflicti131 – 1311T → M in AAH13161 (PubMed:15489334).Curated
Sequence conflicti169 – 1691C → Y in AAT70683 (PubMed:15550249).Curated
Sequence conflicti169 – 1691C → Y in CAC14309 (Ref. 2) Curated
Sequence conflicti169 – 1691C → Y in AAH13161 (PubMed:15489334).Curated
Sequence conflicti204 – 2041A → D in AAT70683 (PubMed:15550249).Curated
Sequence conflicti204 – 2041A → D in CAC14309 (Ref. 2) Curated
Sequence conflicti204 – 2041A → D in AAH13161 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti79 – 791T → I.
Corresponds to variant rs1047584 [ dbSNP | Ensembl ].
VAR_057732
Natural varianti168 – 1681S → N.
Corresponds to variant rs35224605 [ dbSNP | Ensembl ].
VAR_057733

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY562238 mRNA. Translation: AAT70683.1.
AJ251832 mRNA. Translation: CAC14309.1.
AC068299 Genomic DNA. No translation available.
BC013161 mRNA. Translation: AAH13161.1.
CCDSiCCDS33910.1.
RefSeqiNP_071430.2. NM_022147.2.
UniGeneiHs.43388.

Genome annotation databases

EnsembliENST00000259030; ENSP00000259030; ENSG00000136514.
GeneIDi64108.
KEGGihsa:64108.
UCSCiuc003frm.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY562238 mRNA. Translation: AAT70683.1.
AJ251832 mRNA. Translation: CAC14309.1.
AC068299 Genomic DNA. No translation available.
BC013161 mRNA. Translation: AAH13161.1.
CCDSiCCDS33910.1.
RefSeqiNP_071430.2. NM_022147.2.
UniGeneiHs.43388.

3D structure databases

ProteinModelPortaliQ96DX8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000259030.

PTM databases

iPTMnetiQ96DX8.
PhosphoSiteiQ96DX8.

Polymorphism and mutation databases

BioMutaiRTP4.
DMDMi313104193.

Proteomic databases

PaxDbiQ96DX8.
PeptideAtlasiQ96DX8.
PRIDEiQ96DX8.

Protocols and materials databases

DNASUi64108.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000259030; ENSP00000259030; ENSG00000136514.
GeneIDi64108.
KEGGihsa:64108.
UCSCiuc003frm.4. human.

Organism-specific databases

CTDi64108.
GeneCardsiRTP4.
H-InvDBHIX0003937.
HGNCiHGNC:23992. RTP4.
HPAiHPA064887.
HPA071189.
MIMi609350. gene.
neXtProtiNX_Q96DX8.
PharmGKBiPA143485606.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IH22. Eukaryota.
ENOG4111X4F. LUCA.
GeneTreeiENSGT00530000063222.
HOGENOMiHOG000236274.
InParanoidiQ96DX8.
OMAiRCQKCSW.
OrthoDBiEOG091G0DS4.
PhylomeDBiQ96DX8.
TreeFamiTF333246.

Miscellaneous databases

GenomeRNAii64108.
PROiQ96DX8.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000136514.
CleanExiHS_RTP4.
GenevisibleiQ96DX8. HS.

Family and domain databases

InterProiIPR026096. R-trans_p.
IPR026690. RTP4.
IPR027377. Znf-3CxxC.
[Graphical view]
PANTHERiPTHR14402. PTHR14402. 1 hit.
PTHR14402:SF8. PTHR14402:SF8. 1 hit.
PfamiPF13695. zf-3CxxC. 1 hit.
[Graphical view]
SMARTiSM01328. zf-3CxxC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRTP4_HUMAN
AccessioniPrimary (citable) accession number: Q96DX8
Secondary accession number(s): Q9H4F3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: November 30, 2010
Last modified: September 7, 2016
This is version 110 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.