TRIM44

Functionⁱ

May play a role in the process of differentiation and maturation of neuronal cells (By similarity). May regulate the activity of TRIM17. Is a negative regulator of PAX6 expression (PubMed:26394807).By similarity2 Publications

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	174 – 215	B box-typePROSITE-ProRule annotationAdd BLAST		42

GO - Molecular functionⁱ

zinc ion binding Source: InterPro

Complete GO annotation...

GO - Biological processⁱ

regulation of gene expression
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 26394807

Complete GO annotation...

Keywordsⁱ

Ligand	Metal-binding, Zinc

Ligand

Metal-binding, Zinc

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Tripartite motif-containing protein 44 Alternative name(s): Protein DIPB
Gene namesⁱ	Name:TRIM44 Synonyms:DIPB
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:19016. TRIM44.

HGNCⁱ

HGNC:19016. TRIM44.

Subcellular locationⁱ

GO - Cellular componentⁱ

intracellular Source: InterPro

Complete GO annotation...

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Aniridia 3 (AN3)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA form of aniridia, a congenital, bilateral, panocular disorder characterized by complete absence of the iris or extreme iris hypoplasia. Aniridia is not just an isolated defect in iris development but it is associated with macular and optic nerve hypoplasia, cataract, corneal changes, nystagmus. Visual acuity is generally low but is unrelated to the degree of iris hypoplasia. Glaucoma is a secondary problem causing additional visual loss over time.

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_077853	155	G → R in AN3; affects function and results in increased negative regulation of PAX6 expression compared to wild-type. 1 Publication		1

Keywords - Diseaseⁱ

Disease mutation

Organism-specific databases

DisGeNET More...DisGeNETⁱ	54765.
MalaCards human disease database More...MalaCardsⁱ	TRIM44.
MIMⁱ	617142. phenotype.
Open Targets More...OpenTargetsⁱ	ENSG00000166326.
PharmGKBⁱ	PA134906584.

Polymorphism and mutation databases

BioMutaⁱ	TRIM44.
DMDMⁱ	56404940.

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000220372	1 – 344	Tripartite motif-containing protein 44Add BLAST		344

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	336	PhosphoserineBy similarity		1
Modified residueⁱ	339	PhosphoserineBy similarity		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q96DX7.
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q96DX7.
PaxDbⁱ	Q96DX7.
PeptideAtlas More...PeptideAtlasⁱ	Q96DX7.
PRIDEⁱ	Q96DX7.

PTM databases

iPTMnetⁱ	Q96DX7.
PhosphoSitePlusⁱ	Q96DX7.

Expressionⁱ

Tissue specificityⁱ

Highly expressed in testis.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000166326.
CleanExⁱ	HS_TRIM44.
Genevisibleⁱ	Q96DX7. HS.

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA049053. HPA057633.

HPAⁱ

HPA049053.
HPA057633.

Interactionⁱ

Subunit structureⁱ

Interacts (via coiled coil) with TRIM17 (via coiled coil).1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
PBX3	Q5JS98	3	EBI-8787399,EBI-10244393
TRIM69	Q86WT6	3	EBI-8787399,EBI-749955

Show more details

Protein-protein interaction databases

BioGridⁱ	120140. 53 interactors.
IntActⁱ	Q96DX7. 6 interactors.
STRINGⁱ	9606.ENSP00000299413.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q96DX7.
SMRⁱ	Q96DX7.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	290 – 325	Sequence analysisAdd BLAST		36

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	74 – 172	Glu-richAdd BLAST		99

Zinc finger

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	174 – 215	B box-typePROSITE-ProRule annotationAdd BLAST		42

Keywords - Domainⁱ

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGⁱ	ENOG410IPQC. Eukaryota. ENOG4111H1M. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00440000034605.
HOGENOMⁱ	HOG000134694.
HOVERGENⁱ	HBG057191.
InParanoidⁱ	Q96DX7.
KEGG Orthology (KO) More...KOⁱ	K12020.
OMAⁱ	YVHGAQA.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0OGW.
PhylomeDBⁱ	Q96DX7.
TreeFamⁱ	TF333911.

Family and domain databases

Gene3Dⁱ	3.30.40.10. 1 hit.
InterProⁱ	View protein in InterPro IPR000315. Znf_B-box. IPR013083. Znf_RING/FYVE/PHD.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00643. zf-B_box. 1 hit.
SMARTⁱ	View protein in SMART SM00336. BBOX. 1 hit.
PROSITEⁱ	View protein in PROSITE PS50119. ZF_BBOX. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Q96DX7-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MASGVGAAFE ELPHDGTCDE CEPDEAPGAE EVCRECGFCY CRRHAEAHRQ 
        60         70         80         90        100
KFLSHHLAEY VHGSQAWTPP ADGEGAGKEE AEVKVEQERE IESEAGEESE 
       110        120        130        140        150
SEEESESEEE SETEEESEDE SDEESEEDSE EEMEDEQESE AEEDNQEEGE 
       160        170        180        190        200
SEAEGETEAE SEFDPEIEME AERVAKRKCP DHGLDLSTYC QEDRQLICVL 
       210        220        230        240        250
CPVIGAHQGH QLSTLDEAFE ELRSKDSGGL KAAMIELVER LKFKSSDPKV 
       260        270        280        290        300
TRDQMKMFIQ QEFKKVQKVI ADEEQKALHL VDIQEAMATA HVTEILADIQ 
       310        320        330        340 
SHMDRLMTQM AQAKEQLDTS NESAEPKAEG DEEGPSGASE EEDT

Length:344

Mass (Da):38,472

Last modified:December 1, 2001 - v1

Checksum:ⁱ5DC26DD73C347AF1

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	41	C → S in CAB65108 (Ref. 1) Curated		1
Sequence conflictⁱ	232	A → G in CAB65108 (Ref. 1) Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_077852	64	S → Y Polymorphism; does not affect function in negative regulation of PAX6 expression. 1 PublicationCorresponds to variant dbSNP:rs377117775Ensembl.		1
Natural variantⁱVAR_077853	155	G → R in AN3; affects function and results in increased negative regulation of PAX6 expression compared to wild-type. 1 Publication		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ249128 mRNA. Translation: CAB65108.1. AL138812 Genomic DNA. No translation available. CH471064 Genomic DNA. Translation: EAW68133.1. CH471064 Genomic DNA. Translation: EAW68134.1. BC013166 mRNA. Translation: AAH13166.1. BC024031 mRNA. Translation: AAH24031.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS31461.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_060053.2. NM_017583.5.
UniGeneⁱ	Hs.192103. Hs.715570.

Genome annotation databases

Ensemblⁱ	ENST00000299413; ENSP00000299413; ENSG00000166326.
GeneIDⁱ	54765.
KEGGⁱ	hsa:54765.
UCSC genome browser More...UCSCⁱ	uc001mwi.3. human.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ249128 mRNA. Translation: CAB65108.1. AL138812 Genomic DNA. No translation available. CH471064 Genomic DNA. Translation: EAW68133.1. CH471064 Genomic DNA. Translation: EAW68134.1. BC013166 mRNA. Translation: AAH13166.1. BC024031 mRNA. Translation: AAH24031.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS31461.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_060053.2. NM_017583.5.
UniGeneⁱ	Hs.192103. Hs.715570.

3D structure databases

ProteinModelPortalⁱ	Q96DX7.
SMRⁱ	Q96DX7.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	120140. 53 interactors.
IntActⁱ	Q96DX7. 6 interactors.
STRINGⁱ	9606.ENSP00000299413.

PTM databases

iPTMnetⁱ	Q96DX7.
PhosphoSitePlusⁱ	Q96DX7.

Polymorphism and mutation databases

BioMutaⁱ	TRIM44.
DMDMⁱ	56404940.

Proteomic databases

EPDⁱ	Q96DX7.
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q96DX7.
PaxDbⁱ	Q96DX7.
PeptideAtlas More...PeptideAtlasⁱ	Q96DX7.
PRIDEⁱ	Q96DX7.

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	54765.
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000299413; ENSP00000299413; ENSG00000166326.
GeneIDⁱ	54765.
KEGGⁱ	hsa:54765.
UCSC genome browser More...UCSCⁱ	uc001mwi.3. human.

Organism-specific databases

CTDⁱ	54765.
DisGeNET More...DisGeNETⁱ	54765.
GeneCardsⁱ	TRIM44.
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:19016. TRIM44.
Human Protein Atlas More...HPAⁱ	HPA049053. HPA057633.
MalaCards human disease database More...MalaCardsⁱ	TRIM44.
MIMⁱ	612298. gene. 617142. phenotype.
neXtProtⁱ	NX_Q96DX7.
Open Targets More...OpenTargetsⁱ	ENSG00000166326.
PharmGKBⁱ	PA134906584.
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IPQC. Eukaryota. ENOG4111H1M. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00440000034605.
HOGENOMⁱ	HOG000134694.
HOVERGENⁱ	HBG057191.
InParanoidⁱ	Q96DX7.
KEGG Orthology (KO) More...KOⁱ	K12020.
OMAⁱ	YVHGAQA.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0OGW.
PhylomeDBⁱ	Q96DX7.
TreeFamⁱ	TF333911.

Miscellaneous databases

ChiTaRSⁱ	TRIM44. human.
GenomeRNAiⁱ	54765.
Protein Ontology More...PROⁱ	PR:Q96DX7.
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000166326.
CleanExⁱ	HS_TRIM44.
Genevisibleⁱ	Q96DX7. HS.

Family and domain databases

Gene3Dⁱ	3.30.40.10. 1 hit.
InterProⁱ	View protein in InterPro IPR000315. Znf_B-box. IPR013083. Znf_RING/FYVE/PHD.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00643. zf-B_box. 1 hit.
SMARTⁱ	View protein in SMART SM00336. BBOX. 1 hit.
PROSITEⁱ	View protein in PROSITE PS50119. ZF_BBOX. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TRI44_HUMAN
Accessionⁱ	Q96DX7Primary (citable) accession number: Q96DX7 Secondary accession number(s): D3DR14, Q96QY2, Q9UGK0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 7, 2004
	Last sequence update:	December 1, 2001
	Last modified:	April 12, 2017
	This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q96DX7 (TRI44_HUMAN)

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Tripartite motif-containing protein 44

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Compositional bias

Zinc finger

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ