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Protein

Tripartite motif-containing protein 44

Gene

TRIM44

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in the process of differentiation and maturation of neuronal cells (By similarity). May regulate the activity of TRIM17.By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri174 – 215B box-typePROSITE-ProRule annotationAdd BLAST42

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000166326-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Tripartite motif-containing protein 44
Alternative name(s):
Protein DIPB
Gene namesi
Name:TRIM44
Synonyms:DIPB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:19016. TRIM44.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi54765.
OpenTargetsiENSG00000166326.
PharmGKBiPA134906584.

Polymorphism and mutation databases

BioMutaiTRIM44.
DMDMi56404940.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002203721 – 344Tripartite motif-containing protein 44Add BLAST344

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei336PhosphoserineBy similarity1
Modified residuei339PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ96DX7.
MaxQBiQ96DX7.
PaxDbiQ96DX7.
PeptideAtlasiQ96DX7.
PRIDEiQ96DX7.

PTM databases

iPTMnetiQ96DX7.
PhosphoSitePlusiQ96DX7.

Expressioni

Tissue specificityi

Highly expressed in testis.1 Publication

Gene expression databases

BgeeiENSG00000166326.
CleanExiHS_TRIM44.
GenevisibleiQ96DX7. HS.

Organism-specific databases

HPAiHPA049053.
HPA057633.

Interactioni

Subunit structurei

Interacts (via coiled coil) with TRIM17 (via coiled coil).1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
PBX3Q5JS983EBI-8787399,EBI-10244393
TRIM69Q86WT63EBI-8787399,EBI-749955

Protein-protein interaction databases

BioGridi120140. 53 interactors.
IntActiQ96DX7. 6 interactors.
STRINGi9606.ENSP00000299413.

Structurei

3D structure databases

ProteinModelPortaliQ96DX7.
SMRiQ96DX7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili290 – 325Sequence analysisAdd BLAST36

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi74 – 172Glu-richAdd BLAST99

Sequence similaritiesi

Contains 1 B box-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri174 – 215B box-typePROSITE-ProRule annotationAdd BLAST42

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IPQC. Eukaryota.
ENOG4111H1M. LUCA.
GeneTreeiENSGT00440000034605.
HOGENOMiHOG000134694.
HOVERGENiHBG057191.
InParanoidiQ96DX7.
KOiK12020.
OMAiYVHGAQA.
OrthoDBiEOG091G0OGW.
PhylomeDBiQ96DX7.
TreeFamiTF333911.

Family and domain databases

Gene3Di4.10.45.10. 1 hit.
InterProiIPR000315. Znf_B-box.
[Graphical view]
PfamiPF00643. zf-B_box. 1 hit.
[Graphical view]
SMARTiSM00336. BBOX. 1 hit.
[Graphical view]
PROSITEiPS50119. ZF_BBOX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96DX7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASGVGAAFE ELPHDGTCDE CEPDEAPGAE EVCRECGFCY CRRHAEAHRQ
60 70 80 90 100
KFLSHHLAEY VHGSQAWTPP ADGEGAGKEE AEVKVEQERE IESEAGEESE
110 120 130 140 150
SEEESESEEE SETEEESEDE SDEESEEDSE EEMEDEQESE AEEDNQEEGE
160 170 180 190 200
SEAEGETEAE SEFDPEIEME AERVAKRKCP DHGLDLSTYC QEDRQLICVL
210 220 230 240 250
CPVIGAHQGH QLSTLDEAFE ELRSKDSGGL KAAMIELVER LKFKSSDPKV
260 270 280 290 300
TRDQMKMFIQ QEFKKVQKVI ADEEQKALHL VDIQEAMATA HVTEILADIQ
310 320 330 340
SHMDRLMTQM AQAKEQLDTS NESAEPKAEG DEEGPSGASE EEDT
Length:344
Mass (Da):38,472
Last modified:December 1, 2001 - v1
Checksum:i5DC26DD73C347AF1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti41C → S in CAB65108 (Ref. 1) Curated1
Sequence conflicti232A → G in CAB65108 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ249128 mRNA. Translation: CAB65108.1.
AL138812 Genomic DNA. No translation available.
CH471064 Genomic DNA. Translation: EAW68133.1.
CH471064 Genomic DNA. Translation: EAW68134.1.
BC013166 mRNA. Translation: AAH13166.1.
BC024031 mRNA. Translation: AAH24031.1.
CCDSiCCDS31461.1.
RefSeqiNP_060053.2. NM_017583.5.
UniGeneiHs.192103.
Hs.715570.

Genome annotation databases

EnsembliENST00000299413; ENSP00000299413; ENSG00000166326.
GeneIDi54765.
KEGGihsa:54765.
UCSCiuc001mwi.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ249128 mRNA. Translation: CAB65108.1.
AL138812 Genomic DNA. No translation available.
CH471064 Genomic DNA. Translation: EAW68133.1.
CH471064 Genomic DNA. Translation: EAW68134.1.
BC013166 mRNA. Translation: AAH13166.1.
BC024031 mRNA. Translation: AAH24031.1.
CCDSiCCDS31461.1.
RefSeqiNP_060053.2. NM_017583.5.
UniGeneiHs.192103.
Hs.715570.

3D structure databases

ProteinModelPortaliQ96DX7.
SMRiQ96DX7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120140. 53 interactors.
IntActiQ96DX7. 6 interactors.
STRINGi9606.ENSP00000299413.

PTM databases

iPTMnetiQ96DX7.
PhosphoSitePlusiQ96DX7.

Polymorphism and mutation databases

BioMutaiTRIM44.
DMDMi56404940.

Proteomic databases

EPDiQ96DX7.
MaxQBiQ96DX7.
PaxDbiQ96DX7.
PeptideAtlasiQ96DX7.
PRIDEiQ96DX7.

Protocols and materials databases

DNASUi54765.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000299413; ENSP00000299413; ENSG00000166326.
GeneIDi54765.
KEGGihsa:54765.
UCSCiuc001mwi.3. human.

Organism-specific databases

CTDi54765.
DisGeNETi54765.
GeneCardsiTRIM44.
HGNCiHGNC:19016. TRIM44.
HPAiHPA049053.
HPA057633.
MIMi612298. gene.
neXtProtiNX_Q96DX7.
OpenTargetsiENSG00000166326.
PharmGKBiPA134906584.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IPQC. Eukaryota.
ENOG4111H1M. LUCA.
GeneTreeiENSGT00440000034605.
HOGENOMiHOG000134694.
HOVERGENiHBG057191.
InParanoidiQ96DX7.
KOiK12020.
OMAiYVHGAQA.
OrthoDBiEOG091G0OGW.
PhylomeDBiQ96DX7.
TreeFamiTF333911.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000166326-MONOMER.

Miscellaneous databases

ChiTaRSiTRIM44. human.
GenomeRNAii54765.
PROiQ96DX7.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000166326.
CleanExiHS_TRIM44.
GenevisibleiQ96DX7. HS.

Family and domain databases

Gene3Di4.10.45.10. 1 hit.
InterProiIPR000315. Znf_B-box.
[Graphical view]
PfamiPF00643. zf-B_box. 1 hit.
[Graphical view]
SMARTiSM00336. BBOX. 1 hit.
[Graphical view]
PROSITEiPS50119. ZF_BBOX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTRI44_HUMAN
AccessioniPrimary (citable) accession number: Q96DX7
Secondary accession number(s): D3DR14, Q96QY2, Q9UGK0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: December 1, 2001
Last modified: November 30, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.