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Protein

39S ribosomal protein L38, mitochondrial

Gene

MRPL38

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-5368286. Mitochondrial translation initiation.
R-HSA-5389840. Mitochondrial translation elongation.
R-HSA-5419276. Mitochondrial translation termination.

Names & Taxonomyi

Protein namesi
Recommended name:
39S ribosomal protein L38, mitochondrial
Short name:
L38mt
Short name:
MRP-L38
Alternative name(s):
Mitochondrial large ribosomal subunit protein mL381 Publication
Gene namesi
Name:MRPL38
ORF Names:HSPC262
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000204316.12.
HGNCiHGNC:14033. MRPL38.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000204316.
PharmGKBiPA30969.

Polymorphism and mutation databases

BioMutaiMRPL38.
DMDMi118573679.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 26MitochondrionSequence analysisAdd BLAST26
ChainiPRO_000026165227 – 38039S ribosomal protein L38, mitochondrialAdd BLAST354

Proteomic databases

EPDiQ96DV4.
MaxQBiQ96DV4.
PaxDbiQ96DV4.
PeptideAtlasiQ96DV4.
PRIDEiQ96DV4.

PTM databases

iPTMnetiQ96DV4.
PhosphoSitePlusiQ96DV4.
SwissPalmiQ96DV4.

Expressioni

Gene expression databases

BgeeiENSG00000204316.
CleanExiHS_MRPL38.
GenevisibleiQ96DV4. HS.

Organism-specific databases

HPAiHPA023054.
HPA023135.

Interactioni

Subunit structurei

Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins. mL38 is located at the central protuberance.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
GOLGA6AQ9NYA34EBI-720441,EBI-11163335

Protein-protein interaction databases

BioGridi122365. 113 interactors.
CORUMiQ96DV4.
IntActiQ96DV4. 38 interactors.
MINTiMINT-1377178.
STRINGi9606.ENSP00000308275.

Structurei

Secondary structure

1380
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi38 – 41Combined sources4
Beta strandi52 – 54Combined sources3
Helixi55 – 66Combined sources12
Helixi74 – 77Combined sources4
Helixi100 – 117Combined sources18
Turni121 – 123Combined sources3
Helixi132 – 141Combined sources10
Helixi144 – 155Combined sources12
Helixi157 – 160Combined sources4
Beta strandi162 – 164Combined sources3
Beta strandi174 – 177Combined sources4
Beta strandi180 – 182Combined sources3
Turni195 – 198Combined sources4
Beta strandi203 – 205Combined sources3
Beta strandi214 – 222Combined sources9
Beta strandi232 – 240Combined sources9
Turni245 – 247Combined sources3
Beta strandi248 – 252Combined sources5
Beta strandi266 – 277Combined sources12
Helixi293 – 296Combined sources4
Helixi300 – 305Combined sources6
Beta strandi309 – 321Combined sources13
Helixi325 – 333Combined sources9
Beta strandi339 – 342Combined sources4
Helixi363 – 368Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J7Yelectron microscopy3.4061-380[»]
3J9Melectron microscopy3.5061-380[»]
5OOLelectron microscopy3.0661-380[»]
5OOMelectron microscopy3.0361-380[»]
ProteinModelPortaliQ96DV4.
SMRiQ96DV4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili99 – 127Sequence analysisAdd BLAST29

Sequence similaritiesi

Keywords - Domaini

Coiled coil, Transit peptide

Phylogenomic databases

eggNOGiKOG3346. Eukaryota.
COG1881. LUCA.
GeneTreeiENSGT00900000141125.
HOGENOMiHOG000231107.
HOVERGENiHBG054933.
InParanoidiQ96DV4.
KOiK17419.
OMAiFSTLDFY.
OrthoDBiEOG091G09D8.
PhylomeDBiQ96DV4.
TreeFamiTF315074.

Family and domain databases

CDDicd00866. PEBP_euk. 1 hit.
Gene3Di3.90.280.10. 1 hit.
InterProiView protein in InterPro
IPR008914. PEBP.
IPR036610. PEBP-like_sf.
IPR035810. PEBP_euk.
PfamiView protein in Pfam
PF01161. PBP. 1 hit.
SUPFAMiSSF49777. SSF49777. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96DV4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAPWWRAAL CECRRWRGFS TSAVLGRRTP PLGPMPNSDI DLSNLERLEK
60 70 80 90 100
YRSFDRYRRR AEQEAQAPHW WRTYREYFGE KTDPKEKIDI GLPPPKVSRT
110 120 130 140 150
QQLLERKQAI QELRANVEEE RAARLRTASV PLDAVRAEWE RTCGPYHKQR
160 170 180 190 200
LAEYYGLYRD LFHGATFVPR VPLHVAYAVG EDDLMPVYCG NEVTPTEAAQ
210 220 230 240 250
APEVTYEAEE GSLWTLLLTS LDGHLLEPDA EYLHWLLTNI PGNRVAEGQV
260 270 280 290 300
TCPYLPPFPA RGSGIHRLAF LLFKQDQPID FSEDARPSPC YQLAQRTFRT
310 320 330 340 350
FDFYKKHQET MTPAGLSFFQ CRWDDSVTYI FHQLLDMREP VFEFVRPPPY
360 370 380
HPKQKRFPHR QPLRYLDRYR DSHEPTYGIY
Length:380
Mass (Da):44,597
Last modified:November 28, 2006 - v2
Checksum:i7BC527A7E1C06A6C
GO
Isoform 2 (identifier: Q96DV4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-184: Missing.

Note: No experimental confirmation available.
Show »
Length:196
Mass (Da):22,972
Checksum:i101CB36B1ACA6195
GO

Sequence cautioni

Q96DV4: The sequence AAH13311 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05980899R → W. Corresponds to variant dbSNP:rs34136221Ensembl.1
Natural variantiVAR_029472371D → H. Corresponds to variant dbSNP:rs9191Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0560901 – 184Missing in isoform 2. 1 PublicationAdd BLAST184

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK024058 mRNA. Translation: BAG51258.1.
AC087289 Genomic DNA. No translation available.
BC013311 mRNA. Translation: AAH13311.1. Different initiation.
AB051345 Genomic DNA. Translation: BAB54935.1.
AF161380 mRNA. Translation: AAF28940.1.
CCDSiCCDS11733.2. [Q96DV4-1]
RefSeqiNP_115867.2. NM_032478.3. [Q96DV4-1]
UniGeneiHs.442609.

Genome annotation databases

EnsembliENST00000309352; ENSP00000308275; ENSG00000204316. [Q96DV4-1]
GeneIDi64978.
KEGGihsa:64978.
UCSCiuc010wso.2. human. [Q96DV4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiRM38_HUMAN
AccessioniPrimary (citable) accession number: Q96DV4
Secondary accession number(s): B3KN96, Q96Q66, Q9P0B9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: November 28, 2006
Last modified: October 25, 2017
This is version 128 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Ribosomal proteins
    Ribosomal proteins families and list of entries
  7. SIMILARITY comments
    Index of protein domains and families