Q96DU9 (PABP5_HUMAN) Reviewed, UniProtKB/Swiss-Prot
Last modified
December 14, 2011.
Version 84.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Polyadenylate-binding protein 5 Short name=PABP-5 Short name=Poly(A)-binding protein 5 | ||||
| Gene names |
| ||||
| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 382 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Function | Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo By similarity. |
| Subcellular location | Cytoplasm By similarity. |
| Tissue specificity | Expressed in fetal brain and in a range of adult tissues. |
| Sequence similarities | Contains 4 RRM (RNA recognition motif) domains. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Cytoplasm |
| Coding sequence diversity | Polymorphism |
| Domain | Repeat |
| Ligand | RNA-binding |
| PTM | Acetylation |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | RNA binding Inferred from electronic annotation. Source: UniProtKB-KW nucleotide bindingInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 382 | 382 | Polyadenylate-binding protein 5 | PRO_0000081705 | |||||
Regions | |||||||||
| Domain | 18 – 96 | 79 | RRM 1 | ||||||
| Domain | 106 – 182 | 77 | RRM 2 | ||||||
| Domain | 199 – 276 | 78 | RRM 3 | ||||||
| Domain | 302 – 378 | 77 | RRM 4 | ||||||
Amino acid modifications | |||||||||
| Modified residue | 111 | 1 | N6-acetyllysine Ref.7 | ||||||
Natural variations | |||||||||
| Natural variant | 314 | 1 | N → S. Corresponds to variant rs7050077 [ dbSNP | Ensembl ]. | VAR_054049 | |||||
Sequences
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References
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AJ278963 Genomic DNA. Translation: CAC42826.1. AK290105 mRNA. Translation: BAF82794.1. AL662874 Genomic DNA. Translation: CAI41475.1. CH471115 Genomic DNA. Translation: EAX02776.1. BC063113 mRNA. Translation: AAH63113.1. AL122118 mRNA. Translation: CAB59276.1. |
| IPI | IPI00061206. |
| PIR | T34543. |
| RefSeq | NP_543022.1. NM_080832.2. |
| UniGene | Hs.246590. |
3D structure databases | |
| ProteinModelPortal | Q96DU9. |
| SMR | Q96DU9. Positions 18-379. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | Q96DU9. 2 interactions. |
| STRING | Q96DU9. |
PTM databases | |
| PhosphoSite | Q96DU9. |
Polymorphism databases | |
| DMDM | 28201851. |
Proteomic databases | |
| PRIDE | Q96DU9. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| Ensembl | ENST00000312600; ENSP00000308012; ENSG00000174740. ENST00000402906; ENSP00000385644; ENSG00000174740. |
| GeneID | 140886. |
| KEGG | hsa:140886. |
| UCSC | uc004efg.1. human. |
Organism-specific databases | |
| CTD | 140886. |
| GeneCards | GC0XP090689. |
| H-InvDB | HIX0016907. |
| HGNC | HGNC:13629. PABPC5. |
| HPA | HPA000164. HPA000165. |
| MIM | 300407. gene. |
| neXtProt | NX_Q96DU9. |
| PharmGKB | PA32884. |
| GenAtlas | Search... |
Phylogenomic databases | |
| GeneTree | ENSGT00590000082738. |
| HOGENOM | HBG756718. |
| HOVERGEN | HBG002295. |
| InParanoid | Q96DU9. |
| OMA | GEPNTAG. |
| PhylomeDB | Q96DU9. |
Gene expression databases | |
| ArrayExpress | Q96DU9. |
| Bgee | Q96DU9. |
| CleanEx | HS_PABPC5. |
| Genevestigator | Q96DU9. |
| GermOnline | ENSG00000174740. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR012677. Nucleotide-bd_a/b_plait. IPR006515. PABP_1234. IPR000504. RRM_dom. [Graphical view] |
| Gene3D | G3DSA:3.30.70.330. a_b_plait_nuc_bd. 4 hits. |
| KO | K13126. |
| Pfam | PF00076. RRM_1. 4 hits. [Graphical view] |
| SMART | SM00360. RRM. 4 hits. [Graphical view] |
| TIGRFAMs | TIGR01628. PABP-1234. 1 hit. |
| PROSITE | PS50102. RRM. 4 hits. [Graphical view] |
| ProtoNet | Search... |
Other | |
| SOURCE | Search... |
Entry information
| Entry name | PABP5_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q96DU9 Secondary accession number(s): A8K240 Q9UFE5 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome X Human chromosome X: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with