UniProtKB - Q96DU9 (PABP5_HUMAN)
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Protein
Polyadenylate-binding protein 5
Gene
PABPC5
Organism
Homo sapiens (Human)
Status
Functioni
Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo (By similarity).By similarity
GO - Molecular functioni
- RNA binding Source: UniProtKB-KW
Keywordsi
Molecular function | RNA-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Polyadenylate-binding protein 5Short name: PABP-5 Short name: Poly(A)-binding protein 5 |
Gene namesi | Name:PABPC5 Synonyms:PABP5 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000174740.7. |
HGNCi | HGNC:13629. PABPC5. |
MIMi | 300407. gene. |
neXtProti | NX_Q96DU9. |
Pathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000174740. |
PharmGKBi | PA32884. |
Polymorphism and mutation databases
BioMutai | PABPC5. |
DMDMi | 28201851. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000081705 | 1 – 382 | Polyadenylate-binding protein 5Add BLAST | 382 |
Proteomic databases
EPDi | Q96DU9. |
MaxQBi | Q96DU9. |
PaxDbi | Q96DU9. |
PeptideAtlasi | Q96DU9. |
PRIDEi | Q96DU9. |
PTM databases
iPTMneti | Q96DU9. |
PhosphoSitePlusi | Q96DU9. |
Expressioni
Tissue specificityi
Expressed in fetal brain and in a range of adult tissues.
Gene expression databases
Bgeei | ENSG00000174740. |
CleanExi | HS_PABPC5. |
ExpressionAtlasi | Q96DU9. baseline and differential. |
Genevisiblei | Q96DU9. HS. |
Organism-specific databases
HPAi | HPA000164. HPA000165. |
Interactioni
Protein-protein interaction databases
BioGridi | 126753. 2 interactors. |
IntActi | Q96DU9. 3 interactors. |
STRINGi | 9606.ENSP00000308012. |
Structurei
3D structure databases
ProteinModelPortali | Q96DU9. |
SMRi | Q96DU9. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 18 – 96 | RRM 1PROSITE-ProRule annotationAdd BLAST | 79 | |
Domaini | 106 – 182 | RRM 2PROSITE-ProRule annotationAdd BLAST | 77 | |
Domaini | 199 – 276 | RRM 3PROSITE-ProRule annotationAdd BLAST | 78 | |
Domaini | 302 – 378 | RRM 4PROSITE-ProRule annotationAdd BLAST | 77 |
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG0123. Eukaryota. ENOG410XR5X. LUCA. |
GeneTreei | ENSGT00760000118913. |
HOGENOMi | HOG000217922. |
HOVERGENi | HBG002295. |
InParanoidi | Q96DU9. |
KOi | K13126. |
OMAi | FSEYGPT. |
OrthoDBi | EOG091G03ZE. |
PhylomeDBi | Q96DU9. |
TreeFami | TF300458. |
Family and domain databases
Gene3Di | 3.30.70.330. 4 hits. |
InterProi | View protein in InterPro IPR012677. Nucleotide-bd_a/b_plait_sf. IPR006515. PABP_1234. IPR035979. RBD_domain_sf. IPR000504. RRM_dom. IPR003954. RRM_dom_euk. |
Pfami | View protein in Pfam PF00076. RRM_1. 4 hits. |
SMARTi | View protein in SMART SM00360. RRM. 4 hits. SM00361. RRM_1. 3 hits. |
SUPFAMi | SSF54928. SSF54928. 2 hits. |
TIGRFAMsi | TIGR01628. PABP-1234. 1 hit. |
PROSITEi | View protein in PROSITE PS50102. RRM. 4 hits. |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative initiation. AlignAdd to basket
Isoform 1 (identifier: Q96DU9-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MGSGEPNPAG KKKKYLKAAL YVGDLDPDVT EDMLYKKFRP AGPLRFTRIC
60 70 80 90 100
RDPVTRSPLG YGYVNFRFPA DAEWALNTMN FDLINGKPFR LMWSQPDDRL
110 120 130 140 150
RKSGVGNIFI KNLDKSIDNR ALFYLFSAFG NILSCKVVCD DNGSKGYAYV
160 170 180 190 200
HFDSLAAANR AIWHMNGVRL NNRQVYVGRF KFPEERAAEV RTRDRATFTN
210 220 230 240 250
VFVKNIGDDI DDEKLKELFC EYGPTESVKV IRDASGKSKG FGFVRYETHE
260 270 280 290 300
AAQKAVLDLH GKSIDGKVLY VGRAQKKIER LAELRRRFER LRLKEKSRPP
310 320 330 340 350
GVPIYIKNLD ETINDEKLKE EFSSFGSISR AKVMMEVGQG KGFGVVCFSS
360 370 380
FEEATKAVDE MNGRIVGSKP LHVTLGQARR RC
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_054049 | 314 | N → S. Corresponds to variant dbSNP:rs7050077Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_047456 | 1 – 32 | Missing in isoform 2. CuratedAdd BLAST | 32 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ278963 Genomic DNA. Translation: CAC42826.1. AK290105 mRNA. Translation: BAF82794.1. AL662874 Genomic DNA. No translation available. CH471115 Genomic DNA. Translation: EAX02776.1. BC063113 mRNA. Translation: AAH63113.1. AL122118 mRNA. Translation: CAB59276.1. |
CCDSi | CCDS14460.1. [Q96DU9-1] |
PIRi | T34543. |
RefSeqi | NP_543022.1. NM_080832.2. [Q96DU9-1] |
UniGenei | Hs.246590. |
Genome annotation databases
Ensembli | ENST00000312600; ENSP00000308012; ENSG00000174740. [Q96DU9-1] |
GeneIDi | 140886. |
KEGGi | hsa:140886. |
UCSCi | uc004efg.4. human. [Q96DU9-1] |
Keywords - Coding sequence diversityi
Alternative initiation, PolymorphismSimilar proteinsi
Entry informationi
Entry namei | PABP5_HUMAN | |
Accessioni | Q96DU9Primary (citable) accession number: Q96DU9 Secondary accession number(s): A8K240 Q9UFE5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 2003 |
Last sequence update: | December 1, 2001 | |
Last modified: | February 28, 2018 | |
This is version 128 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |