PABPC5

Functionⁱ

Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo (By similarity).By similarity

GO - Molecular functionⁱ

RNA binding Source: UniProtKB-KW

Complete GO annotation...

Keywordsⁱ

Molecular function	RNA-binding

Molecular function

RNA-binding

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Polyadenylate-binding protein 5 Short name: PABP-5 Short name: Poly(A)-binding protein 5
Gene namesⁱ	Name:PABPC5 Synonyms:PABP5
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome X

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:13629. PABPC5.

HGNCⁱ

HGNC:13629. PABPC5.

Subcellular locationⁱ

Cytoplasm By similarity

Isoform 2 :

Mitochondrion matrix
1 Publication
Manual assertion based on experiment inⁱ
- Ref.7
  "Alternative translation initiation augments the human mitochondrial proteome."
  Kazak L., Reyes A., Duncan A.L., Rorbach J., Wood S.R., Brea-Calvo G., Gammage P.A., Robinson A.J., Minczuk M., Holt I.J.
  Nucleic Acids Res. 41:2354-2369(2013) [PubMed] [Europe PMC] [Abstract]
  Cited for: ALTERNATIVE INITIATION (ISOFORM 2), SUBCELLULAR LOCATION (ISOFORM 2).

Note:

Co-fractionates with mtDNA and co-immunoprecipitates with the mitochondrial poly(A) polymerase.

GO - Cellular componentⁱ

mitochondrial matrix Source: UniProtKB-SubCell

Complete GO annotation...

Keywords - Cellular componentⁱ

Cytoplasm, Mitochondrion

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000174740.
PharmGKBⁱ	PA32884.

Polymorphism and mutation databases

BioMutaⁱ	PABPC5.
DMDMⁱ	28201851.

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000081705	1 – 382	Polyadenylate-binding protein 5Add BLAST		382

Proteomic databases

EPDⁱ	Q96DU9.
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q96DU9.
PaxDbⁱ	Q96DU9.
PeptideAtlas More...PeptideAtlasⁱ	Q96DU9.
PRIDEⁱ	Q96DU9.

PTM databases

iPTMnetⁱ	Q96DU9.
PhosphoSitePlusⁱ	Q96DU9.

Expressionⁱ

Tissue specificityⁱ

Expressed in fetal brain and in a range of adult tissues.

Gene expression databases

Bgeeⁱ	ENSG00000174740.
CleanExⁱ	HS_PABPC5.
ExpressionAtlasⁱ	Q96DU9. baseline and differential.
Genevisibleⁱ	Q96DU9. HS.

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA000164. HPA000165.

HPAⁱ

HPA000164.
HPA000165.

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	126753. 2 interactors.
IntActⁱ	Q96DU9. 3 interactors.
STRINGⁱ	9606.ENSP00000308012.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q96DU9.
SMRⁱ	Q96DU9.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	18 – 96	RRM 1PROSITE-ProRule annotationAdd BLAST	79
Domainⁱ	106 – 182	RRM 2PROSITE-ProRule annotationAdd BLAST	77
Domainⁱ	199 – 276	RRM 3PROSITE-ProRule annotationAdd BLAST	78
Domainⁱ	302 – 378	RRM 4PROSITE-ProRule annotationAdd BLAST	77

Keywords - Domainⁱ

Repeat

Phylogenomic databases

eggNOGⁱ	KOG0123. Eukaryota. ENOG410XR5X. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118913.
HOGENOMⁱ	HOG000217922.
HOVERGENⁱ	HBG002295.
InParanoidⁱ	Q96DU9.
KEGG Orthology (KO) More...KOⁱ	K13126.
OMAⁱ	FSEYGPT.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G03ZE.
PhylomeDBⁱ	Q96DU9.
TreeFamⁱ	TF300458.

Family and domain databases

InterProⁱ	View protein in InterPro IPR006515. PABP_1234. IPR000504. RRM_dom. IPR003954. RRM_dom_euk.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00076. RRM_1. 4 hits.
SMARTⁱ	View protein in SMART SM00360. RRM. 4 hits. SM00361. RRM_1. 3 hits.
SUPFAMⁱ	SSF54928. SSF54928. 2 hits.
TIGRFAMsⁱ	TIGR01628. PABP-1234. 1 hit.
PROSITEⁱ	View protein in PROSITE PS50102. RRM. 4 hits.

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative initiation. Align Add to basket Added to basket

Isoform 1 (identifier: Q96DU9-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGSGEPNPAG KKKKYLKAAL YVGDLDPDVT EDMLYKKFRP AGPLRFTRIC 
        60         70         80         90        100
RDPVTRSPLG YGYVNFRFPA DAEWALNTMN FDLINGKPFR LMWSQPDDRL 
       110        120        130        140        150
RKSGVGNIFI KNLDKSIDNR ALFYLFSAFG NILSCKVVCD DNGSKGYAYV 
       160        170        180        190        200
HFDSLAAANR AIWHMNGVRL NNRQVYVGRF KFPEERAAEV RTRDRATFTN 
       210        220        230        240        250
VFVKNIGDDI DDEKLKELFC EYGPTESVKV IRDASGKSKG FGFVRYETHE 
       260        270        280        290        300
AAQKAVLDLH GKSIDGKVLY VGRAQKKIER LAELRRRFER LRLKEKSRPP 
       310        320        330        340        350
GVPIYIKNLD ETINDEKLKE EFSSFGSISR AKVMMEVGQG KGFGVVCFSS 
       360        370        380 
FEEATKAVDE MNGRIVGSKP LHVTLGQARR RC

Length:382

Mass (Da):43,331

Last modified:December 1, 2001 - v1

Checksum:ⁱ23B34751780C602B

GO

Isoform 2 (identifier: Q96DU9-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-32: Missing.

« Hide

        10         20         30         40         50
MLYKKFRPAG PLRFTRICRD PVTRSPLGYG YVNFRFPADA EWALNTMNFD 
        60         70         80         90        100
LINGKPFRLM WSQPDDRLRK SGVGNIFIKN LDKSIDNRAL FYLFSAFGNI 
       110        120        130        140        150
LSCKVVCDDN GSKGYAYVHF DSLAAANRAI WHMNGVRLNN RQVYVGRFKF 
       160        170        180        190        200
PEERAAEVRT RDRATFTNVF VKNIGDDIDD EKLKELFCEY GPTESVKVIR 
       210        220        230        240        250
DASGKSKGFG FVRYETHEAA QKAVLDLHGK SIDGKVLYVG RAQKKIERLA 
       260        270        280        290        300
ELRRRFERLR LKEKSRPPGV PIYIKNLDET INDEKLKEEF SSFGSISRAK 
       310        320        330        340        350
VMMEVGQGKG FGVVCFSSFE EATKAVDEMN GRIVGSKPLH VTLGQARRRC

Show »

Length:350

Mass (Da):39,941

Checksum:ⁱ18B7A6317A54FFCF

GO

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_054049	314	N → S. Corresponds to variant dbSNP:rs7050077Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_047456	1 – 32	Missing in isoform 2. CuratedAdd BLAST		32

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ278963 Genomic DNA. Translation: CAC42826.1. AK290105 mRNA. Translation: BAF82794.1. AL662874 Genomic DNA. Translation: CAI41475.1. CH471115 Genomic DNA. Translation: EAX02776.1. BC063113 mRNA. Translation: AAH63113.1. AL122118 mRNA. Translation: CAB59276.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS14460.1. [Q96DU9-1]
PIRⁱ	T34543.
NCBI Reference Sequences More...RefSeqⁱ	NP_543022.1. NM_080832.2. [Q96DU9-1]
UniGeneⁱ	Hs.246590.

Genome annotation databases

Ensemblⁱ	ENST00000312600; ENSP00000308012; ENSG00000174740. [Q96DU9-1]
GeneIDⁱ	140886.
KEGGⁱ	hsa:140886.
UCSC genome browser More...UCSCⁱ	uc004efg.4. human. [Q96DU9-1]

Keywords - Coding sequence diversityⁱ

Alternative initiation, Polymorphism

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ278963 Genomic DNA. Translation: CAC42826.1. AK290105 mRNA. Translation: BAF82794.1. AL662874 Genomic DNA. Translation: CAI41475.1. CH471115 Genomic DNA. Translation: EAX02776.1. BC063113 mRNA. Translation: AAH63113.1. AL122118 mRNA. Translation: CAB59276.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS14460.1. [Q96DU9-1]
PIRⁱ	T34543.
NCBI Reference Sequences More...RefSeqⁱ	NP_543022.1. NM_080832.2. [Q96DU9-1]
UniGeneⁱ	Hs.246590.

3D structure databases

ProteinModelPortalⁱ	Q96DU9.
SMRⁱ	Q96DU9.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	126753. 2 interactors.
IntActⁱ	Q96DU9. 3 interactors.
STRINGⁱ	9606.ENSP00000308012.

PTM databases

iPTMnetⁱ	Q96DU9.
PhosphoSitePlusⁱ	Q96DU9.

Polymorphism and mutation databases

BioMutaⁱ	PABPC5.
DMDMⁱ	28201851.

Proteomic databases

EPDⁱ	Q96DU9.
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q96DU9.
PaxDbⁱ	Q96DU9.
PeptideAtlas More...PeptideAtlasⁱ	Q96DU9.
PRIDEⁱ	Q96DU9.

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	140886.
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000312600; ENSP00000308012; ENSG00000174740. [Q96DU9-1]
GeneIDⁱ	140886.
KEGGⁱ	hsa:140886.
UCSC genome browser More...UCSCⁱ	uc004efg.4. human. [Q96DU9-1]

Organism-specific databases

CTDⁱ	140886.
GeneCardsⁱ	PABPC5.
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:13629. PABPC5.
Human Protein Atlas More...HPAⁱ	HPA000164. HPA000165.
MIMⁱ	300407. gene.
neXtProtⁱ	NX_Q96DU9.
Open Targets More...OpenTargetsⁱ	ENSG00000174740.
PharmGKBⁱ	PA32884.
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0123. Eukaryota. ENOG410XR5X. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118913.
HOGENOMⁱ	HOG000217922.
HOVERGENⁱ	HBG002295.
InParanoidⁱ	Q96DU9.
KEGG Orthology (KO) More...KOⁱ	K13126.
OMAⁱ	FSEYGPT.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G03ZE.
PhylomeDBⁱ	Q96DU9.
TreeFamⁱ	TF300458.

Miscellaneous databases

GenomeRNAiⁱ	140886.
Protein Ontology More...PROⁱ	PR:Q96DU9.
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000174740.
CleanExⁱ	HS_PABPC5.
ExpressionAtlasⁱ	Q96DU9. baseline and differential.
Genevisibleⁱ	Q96DU9. HS.

Family and domain databases

InterProⁱ	View protein in InterPro IPR006515. PABP_1234. IPR000504. RRM_dom. IPR003954. RRM_dom_euk.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00076. RRM_1. 4 hits.
SMARTⁱ	View protein in SMART SM00360. RRM. 4 hits. SM00361. RRM_1. 3 hits.
SUPFAMⁱ	SSF54928. SSF54928. 2 hits.
TIGRFAMsⁱ	TIGR01628. PABP-1234. 1 hit.
PROSITEⁱ	View protein in PROSITE PS50102. RRM. 4 hits.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PABP5_HUMAN
Accessionⁱ	Q96DU9Primary (citable) accession number: Q96DU9 Secondary accession number(s): A8K240 , Q5JQF4, Q6P529, Q9UFE5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 1, 2003
	Last sequence update:	December 1, 2001
	Last modified:	June 7, 2017
	This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q96DU9 (PABP5_HUMAN)

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Polyadenylate-binding protein 5

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequences (2)ⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ