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Protein

Inositol-trisphosphate 3-kinase C

Gene

ITPKC

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Can phosphorylate inositol 2,4,5-triphosphate to inositol 2,4,5,6-tetraphosphate.By similarity

Catalytic activityi

ATP + 1D-myo-inositol 1,4,5-trisphosphate = ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate.

Enzyme regulationi

Activated by calcium/calmodulin. Inhibited by high concentrations of the substrate Ins(1,2,4)P3, and allosterically activated by the product Ins(1,3,4,5)P4.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei431ATPBy similarity1
Binding sitei484ATPBy similarity1
Binding sitei486Substrate1
Binding sitei558ATPBy similarity1
Binding sitei638ATPBy similarity1
Binding sitei641Substrate1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi471 – 473ATPBy similarity3

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Calmodulin-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMetaCyc:HS01533-MONOMER.
ZFISH:HS01533-MONOMER.
ReactomeiR-HSA-1855204. Synthesis of IP3 and IP4 in the cytosol.

Names & Taxonomyi

Protein namesi
Recommended name:
Inositol-trisphosphate 3-kinase C (EC:2.7.1.127)
Alternative name(s):
Inositol 1,4,5-trisphosphate 3-kinase C
Short name:
IP3 3-kinase C
Short name:
IP3K C
Short name:
InsP 3-kinase C
Gene namesi
Name:ITPKC
Synonyms:IP3KC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:14897. ITPKC.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Involvement in diseasei

Kawasaki disease (KWD)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn acute, self-limited vasculitis of infants and children characterized by prolonged fever unresponsive to antibiotics, polymorphous skin rash, erythema of the oral mucosa, lips, and tongue, erythema of the palms and soles, bilateral conjunctival injection, and cervical lymphadenopathy.
See also OMIM:611775

Organism-specific databases

DisGeNETi80271.
MalaCardsiITPKC.
MIMi611775. phenotype.
OpenTargetsiENSG00000086544.
PharmGKBiPA29977.

Polymorphism and mutation databases

BioMutaiITPKC.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002340701 – 683Inositol-trisphosphate 3-kinase CAdd BLAST683

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei127PhosphoserineCombined sources1
Modified residuei162PhosphoserineBy similarity1
Modified residuei336PhosphothreonineCombined sources1
Modified residuei404PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ96DU7.
MaxQBiQ96DU7.
PaxDbiQ96DU7.
PeptideAtlasiQ96DU7.
PRIDEiQ96DU7.

PTM databases

iPTMnetiQ96DU7.
PhosphoSitePlusiQ96DU7.

Expressioni

Tissue specificityi

Highly expressed in pancreas, skeletal muscle, liver, placenta and weakly in kidney and brain.1 Publication

Gene expression databases

BgeeiENSG00000086544.
CleanExiHS_ITPKC.
ExpressionAtlasiQ96DU7. baseline and differential.
GenevisibleiQ96DU7. HS.

Organism-specific databases

HPAiHPA050760.
HPA053003.

Interactioni

Protein-protein interaction databases

BioGridi123209. 4 interactors.
IntActiQ96DU7. 1 interactor.
STRINGi9606.ENSP00000263370.

Structurei

Secondary structure

1683
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi427 – 432Combined sources6
Helixi435 – 444Combined sources10
Helixi450 – 452Combined sources3
Beta strandi456 – 462Combined sources7
Beta strandi465 – 471Combined sources7
Turni473 – 476Combined sources4
Beta strandi481 – 489Combined sources9
Helixi494 – 496Combined sources3
Turni500 – 502Combined sources3
Helixi508 – 515Combined sources8
Helixi524 – 529Combined sources6
Helixi534 – 544Combined sources11
Helixi547 – 550Combined sources4
Beta strandi551 – 558Combined sources8
Helixi574 – 585Combined sources12
Helixi589 – 608Combined sources20
Helixi610 – 613Combined sources4
Beta strandi615 – 617Combined sources3
Beta strandi621 – 626Combined sources6
Beta strandi632 – 637Combined sources6
Beta strandi642 – 644Combined sources3
Beta strandi653 – 655Combined sources3
Turni659 – 661Combined sources3
Helixi666 – 681Combined sources16

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2A98X-ray2.60A425-683[»]
ProteinModelPortaliQ96DU7.
SMRiQ96DU7.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ96DU7.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni507 – 513Substrate binding7
Regioni509 – 517Calmodulin-bindingBy similarity9
Regioni534 – 541Substrate binding8

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi324 – 332Nuclear export signalBy similarity9

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1621. Eukaryota.
ENOG410Y8AC. LUCA.
GeneTreeiENSGT00390000017438.
HOGENOMiHOG000113089.
HOVERGENiHBG081804.
InParanoidiQ96DU7.
KOiK00911.
OMAiSWKELYT.
OrthoDBiEOG091G03J3.
PhylomeDBiQ96DU7.
TreeFamiTF318394.

Family and domain databases

InterProiIPR005522. IPK.
[Graphical view]
PANTHERiPTHR12400. PTHR12400. 2 hits.
PfamiPF03770. IPK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96DU7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRCPCRGSL NEAEAGALPA AARMGLEAPR GGRRRQPGQQ RPGPGAGAPA
60 70 80 90 100
GRPEGGGPWA RTEGSSLHSE PERAGLGPAP GTESPQAEFW TDGQTEPAAA
110 120 130 140 150
GLGVETERPK QKTEPDRSSL RTHLEWSWSE LETTCLWTET GTDGLWTDPH
160 170 180 190 200
RSDLQFQPEE ASPWTQPGVH GPWTELETHG SQTQPERVKS WADNLWTHQN
210 220 230 240 250
SSSLQTHPEG ACPSKEPSAD GSWKELYTDG SRTQQDIEGP WTEPYTDGSQ
260 270 280 290 300
KKQDTEAARK QPGTGGFQIQ QDTDGSWTQP STDGSQTAPG TDCLLGEPED
310 320 330 340 350
GPLEEPEPGE LLTHLYSHLK CSPLCPVPRL IITPETPEPE AQPVGPPSRV
360 370 380 390 400
EGGSGGFSSA SSFDESEDDV VAGGGGASDP EDRSGSKPWK KLKTVLKYSP
410 420 430 440 450
FVVSFRKHYP WVQLSGHAGN FQAGEDGRIL KRFCQCEQRS LEQLMKDPLR
460 470 480 490 500
PFVPAYYGMV LQDGQTFNQM EDLLADFEGP SIMDCKMGSR TYLEEELVKA
510 520 530 540 550
RERPRPRKDM YEKMVAVDPG APTPEEHAQG AVTKPRYMQW RETMSSTSTL
560 570 580 590 600
GFRIEGIKKA DGTCNTNFKK TQALEQVTKV LEDFVDGDHV ILQKYVACLE
610 620 630 640 650
ELREALEISP FFKTHEVVGS SLLFVHDHTG LAKVWMIDFG KTVALPDHQT
660 670 680
LSHRLPWAEG NREDGYLWGL DNMICLLQGL AQS
Length:683
Mass (Da):75,207
Last modified:December 1, 2001 - v1
Checksum:i58093A2A8E046458
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti80 – 82PGT → NSA in BAA22524 (Ref. 3) Curated3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ290975 mRNA. Translation: CAC40815.1.
BC060788 mRNA. Translation: AAH60788.1.
D38169 mRNA. Translation: BAA22524.1.
Y11999 mRNA. Translation: CAA72728.1.
CCDSiCCDS12563.1.
RefSeqiNP_079470.1. NM_025194.2.
UniGeneiHs.515415.

Genome annotation databases

EnsembliENST00000263370; ENSP00000263370; ENSG00000086544.
GeneIDi80271.
KEGGihsa:80271.
UCSCiuc002oot.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ290975 mRNA. Translation: CAC40815.1.
BC060788 mRNA. Translation: AAH60788.1.
D38169 mRNA. Translation: BAA22524.1.
Y11999 mRNA. Translation: CAA72728.1.
CCDSiCCDS12563.1.
RefSeqiNP_079470.1. NM_025194.2.
UniGeneiHs.515415.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2A98X-ray2.60A425-683[»]
ProteinModelPortaliQ96DU7.
SMRiQ96DU7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123209. 4 interactors.
IntActiQ96DU7. 1 interactor.
STRINGi9606.ENSP00000263370.

PTM databases

iPTMnetiQ96DU7.
PhosphoSitePlusiQ96DU7.

Polymorphism and mutation databases

BioMutaiITPKC.

Proteomic databases

EPDiQ96DU7.
MaxQBiQ96DU7.
PaxDbiQ96DU7.
PeptideAtlasiQ96DU7.
PRIDEiQ96DU7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000263370; ENSP00000263370; ENSG00000086544.
GeneIDi80271.
KEGGihsa:80271.
UCSCiuc002oot.5. human.

Organism-specific databases

CTDi80271.
DisGeNETi80271.
GeneCardsiITPKC.
HGNCiHGNC:14897. ITPKC.
HPAiHPA050760.
HPA053003.
MalaCardsiITPKC.
MIMi606476. gene.
611775. phenotype.
neXtProtiNX_Q96DU7.
OpenTargetsiENSG00000086544.
PharmGKBiPA29977.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1621. Eukaryota.
ENOG410Y8AC. LUCA.
GeneTreeiENSGT00390000017438.
HOGENOMiHOG000113089.
HOVERGENiHBG081804.
InParanoidiQ96DU7.
KOiK00911.
OMAiSWKELYT.
OrthoDBiEOG091G03J3.
PhylomeDBiQ96DU7.
TreeFamiTF318394.

Enzyme and pathway databases

BioCyciMetaCyc:HS01533-MONOMER.
ZFISH:HS01533-MONOMER.
ReactomeiR-HSA-1855204. Synthesis of IP3 and IP4 in the cytosol.

Miscellaneous databases

ChiTaRSiITPKC. human.
EvolutionaryTraceiQ96DU7.
GenomeRNAii80271.
PROiQ96DU7.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000086544.
CleanExiHS_ITPKC.
ExpressionAtlasiQ96DU7. baseline and differential.
GenevisibleiQ96DU7. HS.

Family and domain databases

InterProiIPR005522. IPK.
[Graphical view]
PANTHERiPTHR12400. PTHR12400. 2 hits.
PfamiPF03770. IPK. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIP3KC_HUMAN
AccessioniPrimary (citable) accession number: Q96DU7
Secondary accession number(s): Q9UE25, Q9Y475
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: December 1, 2001
Last modified: November 2, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.