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Q96DU3

- SLAF6_HUMAN

UniProt

Q96DU3 - SLAF6_HUMAN

Protein

SLAM family member 6

Gene

SLAMF6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 119 (01 Oct 2014)
      Sequence version 3 (22 Jul 2008)
      Previous versions | rss
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    Functioni

    Triggers cytolytic activity only in natural killer cells (NK) expressing high surface densities of natural cytotoxicity receptors.1 Publication

    GO - Molecular functioni

    1. receptor activity Source: InterPro

    Keywords - Molecular functioni

    Receptor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    SLAM family member 6
    Alternative name(s):
    Activating NK receptor
    NK-T-B-antigen
    Short name:
    NTB-A
    CD_antigen: CD352
    Gene namesi
    Name:SLAMF6
    Synonyms:KALI
    ORF Names:UNQ6123/PRO20080
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:21392. SLAMF6.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular vesicular exosome Source: UniProt
    2. integral component of membrane Source: UniProtKB-KW
    3. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi108 – 1081R → A: Inhibits dimerization. 1 Publication
    Mutagenesisi110 – 1101Q → A: Inhibits dimerization. 1 Publication
    Mutagenesisi112 – 1121S → A: Inhibits dimerization. 1 Publication

    Organism-specific databases

    PharmGKBiPA134959277.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 21211 PublicationAdd
    BLAST
    Chaini22 – 332311SLAM family member 6PRO_0000014961Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi58 – 581N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi87 – 871N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi137 – 1371N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi144 – 1441N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi147 ↔ 2141 PublicationPROSITE-ProRule annotation
    Disulfide bondi153 ↔ 1951 PublicationPROSITE-ProRule annotation
    Glycosylationi161 – 1611N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi171 – 1711N-linked (GlcNAc...); atypical1 Publication
    Glycosylationi178 – 1781N-linked (GlcNAc...)1 Publication
    Glycosylationi203 – 2031N-linked (GlcNAc...)Sequence Analysis
    Modified residuei274 – 2741Phosphotyrosine2 Publications
    Modified residuei278 – 2781Phosphoserine2 Publications
    Modified residuei309 – 3091Phosphotyrosine2 Publications

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    MaxQBiQ96DU3.
    PaxDbiQ96DU3.
    PRIDEiQ96DU3.

    PTM databases

    PhosphoSiteiQ96DU3.

    Expressioni

    Tissue specificityi

    Expressed by all (resting and activated) natural killer cells (NK), T- and B-lymphocytes.1 Publication

    Gene expression databases

    BgeeiQ96DU3.
    CleanExiHS_SLAMF6.
    GenevestigatoriQ96DU3.

    Organism-specific databases

    HPAiHPA051363.
    HPA051903.

    Interactioni

    Subunit structurei

    Homodimer. Interacts with PTN6 and, upon phosphorylation, with PTN11 and SH2D1A/SAP.2 Publications

    Protein-protein interaction databases

    BioGridi125378. 3 interactions.
    STRINGi9606.ENSP00000357038.

    Structurei

    Secondary structure

    1
    332
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi28 – 336
    Beta strandi38 – 403
    Beta strandi52 – 576
    Beta strandi60 – 667
    Beta strandi69 – 713
    Beta strandi74 – 774
    Helixi80 – 834
    Beta strandi86 – 883
    Beta strandi94 – 963
    Helixi101 – 1033
    Beta strandi105 – 1128
    Beta strandi117 – 12711
    Beta strandi131 – 1377
    Beta strandi145 – 15713
    Beta strandi163 – 1686
    Beta strandi171 – 18313
    Turni185 – 1873
    Beta strandi192 – 1998
    Beta strandi202 – 2098
    Helixi210 – 2134

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2IF7X-ray3.00A/B/C/D24-215[»]
    ProteinModelPortaliQ96DU3.
    SMRiQ96DU3. Positions 24-215.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ96DU3.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini22 – 226205ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini248 – 33184CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei227 – 24721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini35 – 12086Ig-like V-typeAdd
    BLAST
    Domaini132 – 20978Ig-like C2-typeAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG45125.
    HOGENOMiHOG000059581.
    HOVERGENiHBG055054.
    InParanoidiQ96DU3.
    KOiK16852.
    OMAiEIHLTCS.
    OrthoDBiEOG77HDFC.
    PhylomeDBiQ96DU3.
    TreeFamiTF334964.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR013106. Ig_V-set.
    IPR015631. SLAM_fam_rcpts.
    [Graphical view]
    PANTHERiPTHR12080. PTHR12080. 1 hit.
    PfamiPF07686. V-set. 1 hit.
    [Graphical view]
    SMARTiSM00409. IG. 1 hit.
    [Graphical view]
    PROSITEiPS50835. IG_LIKE. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q96DU3-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MLWLFQSLLF VFCFGPGNVV SQSSLTPLMV NGILGESVTL PLEFPAGEKV    50
    NFITWLFNET SLAFIVPHET KSPEIHVTNP KQGKRLNFTQ SYSLQLSNLK 100
    MEDTGSYRAQ ISTKTSAKLS SYTLRILRQL RNIQVTNHSQ LFQNMTCELH 150
    LTCSVEDADD NVSFRWEALG NTLSSQPNLT VSWDPRISSE QDYTCIAENA 200
    VSNLSFSVSA QKLCEDVKIQ YTDTKMILFM VSGICIVFGF IILLLLVLRK 250
    RRDSLSLSTQ RTQGPAESAR NLEYVSVSPT NNTVYASVTH SNRETEIWTP 300
    RENDTITIYS TINHSKESKP TFSRATALDN VV 332
    Length:332
    Mass (Da):37,345
    Last modified:July 22, 2008 - v3
    Checksum:i46D8141A0D198091
    GO
    Isoform 2 (identifier: Q96DU3-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         266-266: Missing.

    Show »
    Length:331
    Mass (Da):37,274
    Checksum:i16E2727CEF8306F4
    GO
    Isoform 3 (identifier: Q96DU3-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         18-128: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:221
    Mass (Da):24,976
    Checksum:i71CACAED7B8FDDEC
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei18 – 128111Missing in isoform 3. 1 PublicationVSP_043230Add
    BLAST
    Alternative sequencei266 – 2661Missing in isoform 2. 3 PublicationsVSP_034620

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ277141 mRNA. Translation: CAC59749.1.
    AJ306388 mRNA. Translation: CAC59750.1.
    AY358159 mRNA. Translation: AAQ88526.1.
    AL832854 mRNA. Translation: CAI46161.1.
    AK125624 mRNA. Translation: BAG54223.1.
    AK301026 mRNA. Translation: BAG62642.1.
    AK313549 mRNA. Translation: BAG36325.1.
    AL138930 Genomic DNA. Translation: CAI15155.1.
    AL138930 Genomic DNA. Translation: CAI15156.1.
    AL138930 Genomic DNA. Translation: CAI15157.1.
    CH471121 Genomic DNA. Translation: EAW52713.1.
    CH471121 Genomic DNA. Translation: EAW52715.1.
    BC113893 mRNA. Translation: AAI13894.1.
    BC114495 mRNA. Translation: AAI14496.1.
    CCDSiCCDS1205.1. [Q96DU3-2]
    CCDS53393.1. [Q96DU3-3]
    CCDS53394.1. [Q96DU3-1]
    RefSeqiNP_001171643.1. NM_001184714.1. [Q96DU3-1]
    NP_001171644.1. NM_001184715.1.
    NP_001171645.1. NM_001184716.1. [Q96DU3-3]
    NP_443163.1. NM_052931.4. [Q96DU3-2]
    UniGeneiHs.492348.

    Genome annotation databases

    EnsembliENST00000368055; ENSP00000357034; ENSG00000162739. [Q96DU3-3]
    ENST00000368057; ENSP00000357036; ENSG00000162739. [Q96DU3-1]
    ENST00000368059; ENSP00000357038; ENSG00000162739. [Q96DU3-2]
    GeneIDi114836.
    KEGGihsa:114836.
    UCSCiuc001fwd.2. human. [Q96DU3-2]
    uc001fwe.2. human. [Q96DU3-1]
    uc010pji.2. human. [Q96DU3-3]

    Polymorphism databases

    DMDMi205830927.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ277141 mRNA. Translation: CAC59749.1 .
    AJ306388 mRNA. Translation: CAC59750.1 .
    AY358159 mRNA. Translation: AAQ88526.1 .
    AL832854 mRNA. Translation: CAI46161.1 .
    AK125624 mRNA. Translation: BAG54223.1 .
    AK301026 mRNA. Translation: BAG62642.1 .
    AK313549 mRNA. Translation: BAG36325.1 .
    AL138930 Genomic DNA. Translation: CAI15155.1 .
    AL138930 Genomic DNA. Translation: CAI15156.1 .
    AL138930 Genomic DNA. Translation: CAI15157.1 .
    CH471121 Genomic DNA. Translation: EAW52713.1 .
    CH471121 Genomic DNA. Translation: EAW52715.1 .
    BC113893 mRNA. Translation: AAI13894.1 .
    BC114495 mRNA. Translation: AAI14496.1 .
    CCDSi CCDS1205.1. [Q96DU3-2 ]
    CCDS53393.1. [Q96DU3-3 ]
    CCDS53394.1. [Q96DU3-1 ]
    RefSeqi NP_001171643.1. NM_001184714.1. [Q96DU3-1 ]
    NP_001171644.1. NM_001184715.1.
    NP_001171645.1. NM_001184716.1. [Q96DU3-3 ]
    NP_443163.1. NM_052931.4. [Q96DU3-2 ]
    UniGenei Hs.492348.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2IF7 X-ray 3.00 A/B/C/D 24-215 [» ]
    ProteinModelPortali Q96DU3.
    SMRi Q96DU3. Positions 24-215.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 125378. 3 interactions.
    STRINGi 9606.ENSP00000357038.

    PTM databases

    PhosphoSitei Q96DU3.

    Polymorphism databases

    DMDMi 205830927.

    Proteomic databases

    MaxQBi Q96DU3.
    PaxDbi Q96DU3.
    PRIDEi Q96DU3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000368055 ; ENSP00000357034 ; ENSG00000162739 . [Q96DU3-3 ]
    ENST00000368057 ; ENSP00000357036 ; ENSG00000162739 . [Q96DU3-1 ]
    ENST00000368059 ; ENSP00000357038 ; ENSG00000162739 . [Q96DU3-2 ]
    GeneIDi 114836.
    KEGGi hsa:114836.
    UCSCi uc001fwd.2. human. [Q96DU3-2 ]
    uc001fwe.2. human. [Q96DU3-1 ]
    uc010pji.2. human. [Q96DU3-3 ]

    Organism-specific databases

    CTDi 114836.
    GeneCardsi GC01M160454.
    HGNCi HGNC:21392. SLAMF6.
    HPAi HPA051363.
    HPA051903.
    MIMi 606446. gene.
    neXtProti NX_Q96DU3.
    PharmGKBi PA134959277.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG45125.
    HOGENOMi HOG000059581.
    HOVERGENi HBG055054.
    InParanoidi Q96DU3.
    KOi K16852.
    OMAi EIHLTCS.
    OrthoDBi EOG77HDFC.
    PhylomeDBi Q96DU3.
    TreeFami TF334964.

    Miscellaneous databases

    EvolutionaryTracei Q96DU3.
    GeneWikii SLAMF6.
    GenomeRNAii 114836.
    NextBioi 79337.
    PROi Q96DU3.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q96DU3.
    CleanExi HS_SLAMF6.
    Genevestigatori Q96DU3.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR013106. Ig_V-set.
    IPR015631. SLAM_fam_rcpts.
    [Graphical view ]
    PANTHERi PTHR12080. PTHR12080. 1 hit.
    Pfami PF07686. V-set. 1 hit.
    [Graphical view ]
    SMARTi SM00409. IG. 1 hit.
    [Graphical view ]
    PROSITEi PS50835. IG_LIKE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "NTB-A, a novel SH2D1A-associated surface molecule contributing to the inability of natural killer cells to kill Epstein-Barr virus-infected B cells in X-linked Lymphoproliferative disease."
      Bottino C., Falco M., Parolini S., Marcenaro E., Augugliaro R., Sivori S., Landi E., Biassoni R., Notarangelo L.D., Moretta L., Moretta A.
      J. Exp. Med. 194:235-246(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, PHOSPHORYLATION, TISSUE SPECIFICITY, INTERACTION WITH SH2D1A; PTN6 AND PTN11.
      Tissue: Lymphoid tissue.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
      Tissue: Spleen.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Lymph node.
    5. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    8. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
      Zhang Z., Henzel W.J.
      Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 22-36.
    9. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
      Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
      Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-171 AND ASN-178.
      Tissue: Leukemic T-cell.
    10. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-274; SER-278 AND TYR-309, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    11. "NTB-A receptor crystal structure: insights into homophilic interactions in the signaling lymphocytic activation molecule receptor family."
      Cao E., Ramagopal U.A., Fedorov A., Fedorov E., Yan Q., Lary J.W., Cole J.L., Nathenson S.G., Almo S.C.
      Immunity 25:559-570(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF 24-215, SUBUNIT, DISULFIDE BONDS, MUTAGENESIS OF ARG-108; GLN-110 AND SER-112.

    Entry informationi

    Entry nameiSLAF6_HUMAN
    AccessioniPrimary (citable) accession number: Q96DU3
    Secondary accession number(s): A6NMW2
    , B2R8X8, Q14CF0, Q5TAS4, Q5TAS6, Q5TAT3, Q96DV0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 24, 2004
    Last sequence update: July 22, 2008
    Last modified: October 1, 2014
    This is version 119 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human cell differentiation molecules
      CD nomenclature of surface proteins of human leucocytes and list of entries
    2. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    3. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    4. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3