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Q96DU3 (SLAF6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 117. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
SLAM family member 6
Alternative name(s):
Activating NK receptor
NK-T-B-antigen
Short name=NTB-A
CD_antigen=CD352
Gene names
Name:SLAMF6
Synonyms:KALI
ORF Names:UNQ6123/PRO20080
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length332 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Triggers cytolytic activity only in natural killer cells (NK) expressing high surface densities of natural cytotoxicity receptors. Ref.1

Subunit structure

Homodimer. Interacts with PTN6 and, upon phosphorylation, with PTN11 and SH2D1A/SAP. Ref.1 Ref.12

Subcellular location

Cell membrane; Single-pass type I membrane protein Probable.

Tissue specificity

Expressed by all (resting and activated) natural killer cells (NK), T- and B-lymphocytes. Ref.1

Sequence similarities

Contains 1 Ig-like (immunoglobulin-like) domain.

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q96DU3-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q96DU3-2)

The sequence of this isoform differs from the canonical sequence as follows:
     266-266: Missing.
Isoform 3 (identifier: Q96DU3-3)

The sequence of this isoform differs from the canonical sequence as follows:
     18-128: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Ref.9
Chain22 – 332311SLAM family member 6
PRO_0000014961

Regions

Topological domain22 – 226205Extracellular Potential
Transmembrane227 – 24721Helical; Potential
Topological domain248 – 33184Cytoplasmic Potential
Domain132 – 20978Ig-like

Amino acid modifications

Modified residue2741Phosphotyrosine Ref.11
Modified residue2781Phosphoserine Ref.11
Modified residue3091Phosphotyrosine Ref.11
Glycosylation581N-linked (GlcNAc...) Potential
Glycosylation871N-linked (GlcNAc...) Potential
Glycosylation1371N-linked (GlcNAc...) Potential
Glycosylation1441N-linked (GlcNAc...) Potential
Glycosylation1611N-linked (GlcNAc...) Potential
Glycosylation1711N-linked (GlcNAc...); atypical Ref.10
Glycosylation1781N-linked (GlcNAc...) Ref.10
Glycosylation2031N-linked (GlcNAc...) Potential
Disulfide bond147 ↔ 214 Ref.12
Disulfide bond153 ↔ 195 Ref.12

Natural variations

Alternative sequence18 – 128111Missing in isoform 3.
VSP_043230
Alternative sequence2661Missing in isoform 2.
VSP_034620

Experimental info

Mutagenesis1081R → A: Inhibits dimerization. Ref.12
Mutagenesis1101Q → A: Inhibits dimerization. Ref.12
Mutagenesis1121S → A: Inhibits dimerization. Ref.12

Secondary structure

........................................ 332
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified July 22, 2008. Version 3.
Checksum: 46D8141A0D198091

FASTA33237,345
        10         20         30         40         50         60 
MLWLFQSLLF VFCFGPGNVV SQSSLTPLMV NGILGESVTL PLEFPAGEKV NFITWLFNET 

        70         80         90        100        110        120 
SLAFIVPHET KSPEIHVTNP KQGKRLNFTQ SYSLQLSNLK MEDTGSYRAQ ISTKTSAKLS 

       130        140        150        160        170        180 
SYTLRILRQL RNIQVTNHSQ LFQNMTCELH LTCSVEDADD NVSFRWEALG NTLSSQPNLT 

       190        200        210        220        230        240 
VSWDPRISSE QDYTCIAENA VSNLSFSVSA QKLCEDVKIQ YTDTKMILFM VSGICIVFGF 

       250        260        270        280        290        300 
IILLLLVLRK RRDSLSLSTQ RTQGPAESAR NLEYVSVSPT NNTVYASVTH SNRETEIWTP 

       310        320        330 
RENDTITIYS TINHSKESKP TFSRATALDN VV 

« Hide

Isoform 2 [UniParc].

Checksum: 16E2727CEF8306F4
Show »

FASTA33137,274
Isoform 3 [UniParc].

Checksum: 71CACAED7B8FDDEC
Show »

FASTA22124,976

References

« Hide 'large scale' references
[1]"NTB-A, a novel SH2D1A-associated surface molecule contributing to the inability of natural killer cells to kill Epstein-Barr virus-infected B cells in X-linked Lymphoproliferative disease."
Bottino C., Falco M., Parolini S., Marcenaro E., Augugliaro R., Sivori S., Landi E., Biassoni R., Notarangelo L.D., Moretta L., Moretta A.
J. Exp. Med. 194:235-246(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, PHOSPHORYLATION, TISSUE SPECIFICITY, INTERACTION WITH SH2D1A; PTN6 AND PTN11.
Tissue: Lymphoid tissue.
[2]Erratum
Bottino C., Falco M., Parolini S., Marcenaro E., Augugliaro R., Sivori S., Landi E., Biassoni R., Notarangelo L.D., Moretta L., Moretta A.
J. Exp. Med. 194:705-705(2001)
[3]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[4]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
Tissue: Spleen.
[5]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Lymph node.
[6]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
[9]"Signal peptide prediction based on analysis of experimentally verified cleavage sites."
Zhang Z., Henzel W.J.
Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 22-36.
[10]"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-171 AND ASN-178.
Tissue: Leukemic T-cell.
[11]"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-274; SER-278 AND TYR-309, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Leukemic T-cell.
[12]"NTB-A receptor crystal structure: insights into homophilic interactions in the signaling lymphocytic activation molecule receptor family."
Cao E., Ramagopal U.A., Fedorov A., Fedorov E., Yan Q., Lary J.W., Cole J.L., Nathenson S.G., Almo S.C.
Immunity 25:559-570(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF 24-215, SUBUNIT, DISULFIDE BONDS, MUTAGENESIS OF ARG-108; GLN-110 AND SER-112.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ277141 mRNA. Translation: CAC59749.1.
AJ306388 mRNA. Translation: CAC59750.1.
AY358159 mRNA. Translation: AAQ88526.1.
AL832854 mRNA. Translation: CAI46161.1.
AK125624 mRNA. Translation: BAG54223.1.
AK301026 mRNA. Translation: BAG62642.1.
AK313549 mRNA. Translation: BAG36325.1.
AL138930 Genomic DNA. Translation: CAI15155.1.
AL138930 Genomic DNA. Translation: CAI15156.1.
AL138930 Genomic DNA. Translation: CAI15157.1.
CH471121 Genomic DNA. Translation: EAW52713.1.
CH471121 Genomic DNA. Translation: EAW52715.1.
BC113893 mRNA. Translation: AAI13894.1.
BC114495 mRNA. Translation: AAI14496.1.
CCDSCCDS1205.1. [Q96DU3-2]
CCDS53393.1. [Q96DU3-3]
CCDS53394.1. [Q96DU3-1]
RefSeqNP_001171643.1. NM_001184714.1. [Q96DU3-1]
NP_001171644.1. NM_001184715.1.
NP_001171645.1. NM_001184716.1. [Q96DU3-3]
NP_443163.1. NM_052931.4. [Q96DU3-2]
UniGeneHs.492348.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2IF7X-ray3.00A/B/C/D24-215[»]
ProteinModelPortalQ96DU3.
SMRQ96DU3. Positions 24-215.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid125378. 3 interactions.
STRING9606.ENSP00000357038.

PTM databases

PhosphoSiteQ96DU3.

Polymorphism databases

DMDM205830927.

Proteomic databases

MaxQBQ96DU3.
PaxDbQ96DU3.
PRIDEQ96DU3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000368055; ENSP00000357034; ENSG00000162739. [Q96DU3-3]
ENST00000368057; ENSP00000357036; ENSG00000162739. [Q96DU3-1]
ENST00000368059; ENSP00000357038; ENSG00000162739. [Q96DU3-2]
GeneID114836.
KEGGhsa:114836.
UCSCuc001fwd.2. human. [Q96DU3-2]
uc001fwe.2. human. [Q96DU3-1]
uc010pji.2. human. [Q96DU3-3]

Organism-specific databases

CTD114836.
GeneCardsGC01M160454.
HGNCHGNC:21392. SLAMF6.
HPAHPA051363.
HPA051903.
MIM606446. gene.
neXtProtNX_Q96DU3.
PharmGKBPA134959277.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG45125.
HOGENOMHOG000059581.
HOVERGENHBG055054.
InParanoidQ96DU3.
KOK16852.
OMAEIHLTCS.
OrthoDBEOG77HDFC.
PhylomeDBQ96DU3.
TreeFamTF334964.

Gene expression databases

BgeeQ96DU3.
CleanExHS_SLAMF6.
GenevestigatorQ96DU3.

Family and domain databases

Gene3D2.60.40.10. 1 hit.
InterProIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
IPR015631. SLAM_fam_rcpts.
[Graphical view]
PANTHERPTHR12080. PTHR12080. 1 hit.
PfamPF07686. V-set. 1 hit.
[Graphical view]
SMARTSM00409. IG. 1 hit.
[Graphical view]
PROSITEPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceQ96DU3.
GeneWikiSLAMF6.
GenomeRNAi114836.
NextBio79337.
PROQ96DU3.
SOURCESearch...

Entry information

Entry nameSLAF6_HUMAN
AccessionPrimary (citable) accession number: Q96DU3
Secondary accession number(s): A6NMW2 expand/collapse secondary AC list , B2R8X8, Q14CF0, Q5TAS4, Q5TAS6, Q5TAT3, Q96DV0
Entry history
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: July 22, 2008
Last modified: July 9, 2014
This is version 117 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM

Human cell differentiation molecules

CD nomenclature of surface proteins of human leucocytes and list of entries