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Protein

Zinc finger and BTB domain-containing protein 10

Gene

ZBTB10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri722 – 74423C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri750 – 77223C2H2-type 2PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger and BTB domain-containing protein 10
Alternative name(s):
Zinc finger protein RIN ZF
Gene namesi
Name:ZBTB10
Synonyms:RINZF, RINZFC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:30953. ZBTB10.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134883318.

Polymorphism and mutation databases

DMDMi317373300.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 871871Zinc finger and BTB domain-containing protein 10PRO_0000047725Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei210 – 2101PhosphoserineCombined sources
Cross-linki468 – 468Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei565 – 5651PhosphoserineCombined sources
Cross-linki684 – 684Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ96DT7.
MaxQBiQ96DT7.
PaxDbiQ96DT7.
PeptideAtlasiQ96DT7.
PRIDEiQ96DT7.

PTM databases

iPTMnetiQ96DT7.
PhosphoSiteiQ96DT7.

Expressioni

Gene expression databases

BgeeiENSG00000205189.
CleanExiHS_ZBTB10.
GenevisibleiQ96DT7. HS.

Organism-specific databases

HPAiHPA021554.
HPA050569.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
LSM4Q9Y4Z03EBI-10235384,EBI-372521
MOB3CQ70IA83EBI-10235384,EBI-9679267
MORF4L1Q9UBU83EBI-10235384,EBI-399246
MORF4L2Q150143EBI-10235384,EBI-399257
ZNF417Q8TAU33EBI-10235384,EBI-740727

Protein-protein interaction databases

BioGridi122435. 33 interactions.
IntActiQ96DT7. 11 interactions.
STRINGi9606.ENSP00000387462.

Structurei

3D structure databases

ProteinModelPortaliQ96DT7.
SMRiQ96DT7. Positions 350-460, 723-787.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini364 – 43370BTBPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi39 – 5820Pro-richAdd
BLAST
Compositional biasi101 – 228128Gly-richAdd
BLAST

Sequence similaritiesi

Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
Contains 2 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri722 – 74423C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri750 – 77223C2H2-type 2PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129682.
HOGENOMiHOG000231953.
HOVERGENiHBG099147.
InParanoidiQ96DT7.
KOiK10497.
OMAiNGRGPAT.
OrthoDBiEOG091G05WK.
PhylomeDBiQ96DT7.
TreeFamiTF330979.

Family and domain databases

Gene3Di3.30.160.60. 2 hits.
InterProiIPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 2 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 1 hit.
PS50157. ZINC_FINGER_C2H2_2. 2 hits.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96DT7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSFSEMNRRT LAFRGGGLVT ASGGGSTNNN AGGEASAWPP QPQPRQPPPP
60 70 80 90 100
APPALQPPNG RGADEEVELE GLEPQDLEAS AGPAAGAAEE AKELLLPQDA
110 120 130 140 150
GGPTSLGGGA GGPLLAERNR RTLAFRGGGG GGLGNNGSSR GRPETSVWPL
160 170 180 190 200
RHFNGRGPAT VDLELDALEG KELMQDGASL SDSTEDEEEG ASLGDGSGAE
210 220 230 240 250
GGSCSSSRRS GGDGGDEVEG SGVGAGEGET VQHFPLARPK SLMQKLQCSF
260 270 280 290 300
QTSWLKDFPW LRYSKDTGLM SCGWCQKTPA DGGSVDLPPV GHDELSRGTR
310 320 330 340 350
NYKKTLLLRH HVSTEHKLHE ANAQESEIPS EEGYCDFNSR PNENSYCYQL
360 370 380 390 400
LRQLNEQRKK GILCDVSIVV SGKIFKAHKN ILVAGSRFFK TLYCFSNKES
410 420 430 440 450
PNQNNTTHLD IAAVQGFSVI LDFLYSGNLV LTSQNAIEVM TVASYLQMSE
460 470 480 490 500
VVQTCRNFIK DALNISIKSE APESVVVDYN NRKPVNRDGL SSSRDQKIAS
510 520 530 540 550
FWATRNLTNL ASNVKIENDG CNVDEGQIEN YQMNDSSWVQ DGSPEMAENE
560 570 580 590 600
SEGQTKVFIW NNMGSQGIQE TGKTRRKNQT TKRFIYNIPP NNETNLEDCS
610 620 630 640 650
VMQPPVAYPE ENTLLIKEEP DLDGALLSGP DGDRNVNANL LAEAGTSQDG
660 670 680 690 700
GDAGTSHDFK YGLMPGPSND FKYGLIPGTS NDFKYGLIPG ASNDFKYGLL
710 720 730 740 750
PESWPKQETW ENGESSLIMN KLKCPHCSYV AKYRRTLKRH LLIHTGVRSF
760 770 780 790 800
SCDICGKLFT RREHVKRHSL VHKKDKKYKC MVCKKIFMLA ASVGIRHGSR
810 820 830 840 850
RYGVCVDCAD KSQPGGQEGV DQGQDTEFPR DEEYEENEVG EADEELVDDG
860 870
EDQNDPSRWD ESGEVCMSLD D
Length:871
Mass (Da):94,894
Last modified:January 11, 2011 - v2
Checksum:iA823948FDC3D6AC1
GO
Isoform 2 (identifier: Q96DT7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     665-688: Missing.

Show »
Length:847
Mass (Da):92,311
Checksum:iCB68F78A442C1B61
GO
Isoform 3 (identifier: Q96DT7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-173: Missing.

Show »
Length:698
Mass (Da):77,424
Checksum:i1E67257D9A9BE0F0
GO
Isoform 4 (identifier: Q96DT7-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-292: Missing.
     293-324: DELSRGTRNYKKTLLLRHHVSTEHKLHEANAQ → MTRLERSSHRTVICKVPGELVAREGKCASRAR

Show »
Length:579
Mass (Da):64,941
Checksum:iA1120EF9F0EC58AC
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti324 – 3241Q → P in CAC40989 (Ref. 1) Curated
Sequence conflicti335 – 3351C → W in CAC40989 (Ref. 1) Curated
Sequence conflicti339 – 3391S → R in CAC40989 (Ref. 1) Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti50 – 501P → T.1 Publication
Corresponds to variant rs591989 [ dbSNP | Ensembl ].
VAR_018384
Natural varianti174 – 1741M → I.1 Publication
Corresponds to variant rs593747 [ dbSNP | Ensembl ].
VAR_018385

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 292292Missing in isoform 4. 1 PublicationVSP_040316Add
BLAST
Alternative sequencei1 – 173173Missing in isoform 3. 1 PublicationVSP_040317Add
BLAST
Alternative sequencei293 – 32432DELSR…EANAQ → MTRLERSSHRTVICKVPGEL VAREGKCASRAR in isoform 4. 1 PublicationVSP_040318Add
BLAST
Alternative sequencei665 – 68824Missing in isoform 2. 1 PublicationVSP_040319Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ319673 mRNA. Translation: CAC40989.1.
AJ507398 Genomic DNA. Translation: CAD45447.1.
AK056913 mRNA. Translation: BAB71309.1.
AC009812 Genomic DNA. No translation available.
BC050061 mRNA. Translation: AAH50061.1.
BC127098 mRNA. Translation: AAI27099.1.
CCDSiCCDS47880.1. [Q96DT7-1]
CCDS64920.1. [Q96DT7-4]
RefSeqiNP_001099009.1. NM_001105539.2. [Q96DT7-1]
NP_001264074.1. NM_001277145.1. [Q96DT7-4]
NP_076418.3. NM_023929.4. [Q96DT7-2]
UniGeneiHs.591868.

Genome annotation databases

EnsembliENST00000379091; ENSP00000368384; ENSG00000205189. [Q96DT7-4]
ENST00000426744; ENSP00000416134; ENSG00000205189. [Q96DT7-2]
ENST00000430430; ENSP00000387462; ENSG00000205189. [Q96DT7-1]
ENST00000455036; ENSP00000412036; ENSG00000205189. [Q96DT7-1]
ENST00000610895; ENSP00000484716; ENSG00000205189. [Q96DT7-3]
GeneIDi65986.
KEGGihsa:65986.
UCSCiuc003ybv.6. human. [Q96DT7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ319673 mRNA. Translation: CAC40989.1.
AJ507398 Genomic DNA. Translation: CAD45447.1.
AK056913 mRNA. Translation: BAB71309.1.
AC009812 Genomic DNA. No translation available.
BC050061 mRNA. Translation: AAH50061.1.
BC127098 mRNA. Translation: AAI27099.1.
CCDSiCCDS47880.1. [Q96DT7-1]
CCDS64920.1. [Q96DT7-4]
RefSeqiNP_001099009.1. NM_001105539.2. [Q96DT7-1]
NP_001264074.1. NM_001277145.1. [Q96DT7-4]
NP_076418.3. NM_023929.4. [Q96DT7-2]
UniGeneiHs.591868.

3D structure databases

ProteinModelPortaliQ96DT7.
SMRiQ96DT7. Positions 350-460, 723-787.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122435. 33 interactions.
IntActiQ96DT7. 11 interactions.
STRINGi9606.ENSP00000387462.

PTM databases

iPTMnetiQ96DT7.
PhosphoSiteiQ96DT7.

Polymorphism and mutation databases

DMDMi317373300.

Proteomic databases

EPDiQ96DT7.
MaxQBiQ96DT7.
PaxDbiQ96DT7.
PeptideAtlasiQ96DT7.
PRIDEiQ96DT7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000379091; ENSP00000368384; ENSG00000205189. [Q96DT7-4]
ENST00000426744; ENSP00000416134; ENSG00000205189. [Q96DT7-2]
ENST00000430430; ENSP00000387462; ENSG00000205189. [Q96DT7-1]
ENST00000455036; ENSP00000412036; ENSG00000205189. [Q96DT7-1]
ENST00000610895; ENSP00000484716; ENSG00000205189. [Q96DT7-3]
GeneIDi65986.
KEGGihsa:65986.
UCSCiuc003ybv.6. human. [Q96DT7-1]

Organism-specific databases

CTDi65986.
GeneCardsiZBTB10.
HGNCiHGNC:30953. ZBTB10.
HPAiHPA021554.
HPA050569.
neXtProtiNX_Q96DT7.
PharmGKBiPA134883318.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129682.
HOGENOMiHOG000231953.
HOVERGENiHBG099147.
InParanoidiQ96DT7.
KOiK10497.
OMAiNGRGPAT.
OrthoDBiEOG091G05WK.
PhylomeDBiQ96DT7.
TreeFamiTF330979.

Miscellaneous databases

GenomeRNAii65986.
PROiQ96DT7.

Gene expression databases

BgeeiENSG00000205189.
CleanExiHS_ZBTB10.
GenevisibleiQ96DT7. HS.

Family and domain databases

Gene3Di3.30.160.60. 2 hits.
InterProiIPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 2 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 1 hit.
PS50157. ZINC_FINGER_C2H2_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZBT10_HUMAN
AccessioniPrimary (citable) accession number: Q96DT7
Secondary accession number(s): A4FVD0
, Q86W96, Q8IXI9, Q96MH9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: January 11, 2011
Last modified: September 7, 2016
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.