Q96DT7 (ZBT10_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Zinc finger and BTB domain-containing protein 10

Alternative name(s):
Zinc finger protein RIN ZF

Gene names

Name:	ZBTB10
Synonyms:	RINZF, RINZFC

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	871 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May be involved in transcriptional regulation.
Subcellular location	Nucleus Potential.
Post-translational modification	Phosphorylated upon DNA damage, probably by ATM or ATR. Ref.6 Ref.7
Sequence similarities	Contains 1 BTB (POZ) domain. Contains 2 C2H2-type zinc fingers.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from direct assay. Source: HPA
Molecular function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q96DT7-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q96DT7-2)

The sequence of this isoform differs from the canonical sequence as follows:
     665-688: Missing.

Isoform 3 (identifier: Q96DT7-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-173: Missing.

Isoform 4 (identifier: Q96DT7-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-292: Missing.
     293-324: DELSRGTRNYKKTLLLRHHVSTEHKLHEANAQ → MTRLERSSHRTVICKVPGELVAREGKCASRAR

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 871	871	Zinc finger and BTB domain-containing protein 10		PRO_0000047725
Regions
	Domain	364 – 433	70	BTB
	Zinc finger	722 – 744	23	C2H2-type 1
	Zinc finger	750 – 772	23	C2H2-type 2
	Compositional bias	39 – 58	20	Pro-rich
	Compositional bias	101 – 228	128	Gly-rich
Amino acid modifications
	Modified residue	210	1	Phosphoserine Ref.7
	Modified residue	565	1	Phosphoserine Ref.6
	Modified residue	647	1	Phosphoserine Ref.6
	Modified residue	745	1	Phosphothreonine Ref.7
Natural variations
	Alternative sequence	1 – 292	292	Missing in isoform 4.		VSP_040316
	Alternative sequence	1 – 173	173	Missing in isoform 3.		VSP_040317
	Alternative sequence	293 – 324	32	DELSR…EANAQ → MTRLERSSHRTVICKVPGEL VAREGKCASRAR in isoform 4.		VSP_040318
	Alternative sequence	665 – 688	24	Missing in isoform 2.		VSP_040319
	Natural variant	50	1	P → T. Ref.1 Corresponds to variant rs591989 [ dbSNP | Ensembl ].		VAR_018384
	Natural variant	174	1	M → I. Ref.1 Corresponds to variant rs593747 [ dbSNP | Ensembl ].		VAR_018385
Experimental info
	Sequence conflict	324	1	Q → P in CAC40989. Ref.1
	Sequence conflict	335	1	C → W in CAC40989. Ref.1
	Sequence conflict	339	1	S → R in CAC40989. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified January 11, 2011. Version 2. Checksum: A823948FDC3D6AC1	FASTA	871	94,894
	10 20 30 40 50 60 MSFSEMNRRT LAFRGGGLVT ASGGGSTNNN AGGEASAWPP QPQPRQPPPP APPALQPPNG 70 80 90 100 110 120 RGADEEVELE GLEPQDLEAS AGPAAGAAEE AKELLLPQDA GGPTSLGGGA GGPLLAERNR 130 140 150 160 170 180 RTLAFRGGGG GGLGNNGSSR GRPETSVWPL RHFNGRGPAT VDLELDALEG KELMQDGASL 190 200 210 220 230 240 SDSTEDEEEG ASLGDGSGAE GGSCSSSRRS GGDGGDEVEG SGVGAGEGET VQHFPLARPK 250 260 270 280 290 300 SLMQKLQCSF QTSWLKDFPW LRYSKDTGLM SCGWCQKTPA DGGSVDLPPV GHDELSRGTR 310 320 330 340 350 360 NYKKTLLLRH HVSTEHKLHE ANAQESEIPS EEGYCDFNSR PNENSYCYQL LRQLNEQRKK 370 380 390 400 410 420 GILCDVSIVV SGKIFKAHKN ILVAGSRFFK TLYCFSNKES PNQNNTTHLD IAAVQGFSVI 430 440 450 460 470 480 LDFLYSGNLV LTSQNAIEVM TVASYLQMSE VVQTCRNFIK DALNISIKSE APESVVVDYN 490 500 510 520 530 540 NRKPVNRDGL SSSRDQKIAS FWATRNLTNL ASNVKIENDG CNVDEGQIEN YQMNDSSWVQ 550 560 570 580 590 600 DGSPEMAENE SEGQTKVFIW NNMGSQGIQE TGKTRRKNQT TKRFIYNIPP NNETNLEDCS 610 620 630 640 650 660 VMQPPVAYPE ENTLLIKEEP DLDGALLSGP DGDRNVNANL LAEAGTSQDG GDAGTSHDFK 670 680 690 700 710 720 YGLMPGPSND FKYGLIPGTS NDFKYGLIPG ASNDFKYGLL PESWPKQETW ENGESSLIMN 730 740 750 760 770 780 KLKCPHCSYV AKYRRTLKRH LLIHTGVRSF SCDICGKLFT RREHVKRHSL VHKKDKKYKC 790 800 810 820 830 840 MVCKKIFMLA ASVGIRHGSR RYGVCVDCAD KSQPGGQEGV DQGQDTEFPR DEEYEENEVG 850 860 870 EADEELVDDG EDQNDPSRWD ESGEVCMSLD D
	Isoform 2 [UniParc]. Checksum: CB68F78A442C1B61	FASTA	847	92,311
	10 20 30 40 50 60 MSFSEMNRRT LAFRGGGLVT ASGGGSTNNN AGGEASAWPP QPQPRQPPPP APPALQPPNG 70 80 90 100 110 120 RGADEEVELE GLEPQDLEAS AGPAAGAAEE AKELLLPQDA GGPTSLGGGA GGPLLAERNR 130 140 150 160 170 180 RTLAFRGGGG GGLGNNGSSR GRPETSVWPL RHFNGRGPAT VDLELDALEG KELMQDGASL 190 200 210 220 230 240 SDSTEDEEEG ASLGDGSGAE GGSCSSSRRS GGDGGDEVEG SGVGAGEGET VQHFPLARPK 250 260 270 280 290 300 SLMQKLQCSF QTSWLKDFPW LRYSKDTGLM SCGWCQKTPA DGGSVDLPPV GHDELSRGTR 310 320 330 340 350 360 NYKKTLLLRH HVSTEHKLHE ANAQESEIPS EEGYCDFNSR PNENSYCYQL LRQLNEQRKK 370 380 390 400 410 420 GILCDVSIVV SGKIFKAHKN ILVAGSRFFK TLYCFSNKES PNQNNTTHLD IAAVQGFSVI 430 440 450 460 470 480 LDFLYSGNLV LTSQNAIEVM TVASYLQMSE VVQTCRNFIK DALNISIKSE APESVVVDYN 490 500 510 520 530 540 NRKPVNRDGL SSSRDQKIAS FWATRNLTNL ASNVKIENDG CNVDEGQIEN YQMNDSSWVQ 550 560 570 580 590 600 DGSPEMAENE SEGQTKVFIW NNMGSQGIQE TGKTRRKNQT TKRFIYNIPP NNETNLEDCS 610 620 630 640 650 660 VMQPPVAYPE ENTLLIKEEP DLDGALLSGP DGDRNVNANL LAEAGTSQDG GDAGTSHDFK 670 680 690 700 710 720 YGLMPGASND FKYGLLPESW PKQETWENGE SSLIMNKLKC PHCSYVAKYR RTLKRHLLIH 730 740 750 760 770 780 TGVRSFSCDI CGKLFTRREH VKRHSLVHKK DKKYKCMVCK KIFMLAASVG IRHGSRRYGV 790 800 810 820 830 840 CVDCADKSQP GGQEGVDQGQ DTEFPRDEEY EENEVGEADE ELVDDGEDQN DPSRWDESGE VCMSLDD
	Isoform 3 [UniParc]. Checksum: 1E67257D9A9BE0F0	FASTA	698	77,424
	10 20 30 40 50 60 MQDGASLSDS TEDEEEGASL GDGSGAEGGS CSSSRRSGGD GGDEVEGSGV GAGEGETVQH 70 80 90 100 110 120 FPLARPKSLM QKLQCSFQTS WLKDFPWLRY SKDTGLMSCG WCQKTPADGG SVDLPPVGHD 130 140 150 160 170 180 ELSRGTRNYK KTLLLRHHVS TEHKLHEANA QESEIPSEEG YCDFNSRPNE NSYCYQLLRQ 190 200 210 220 230 240 LNEQRKKGIL CDVSIVVSGK IFKAHKNILV AGSRFFKTLY CFSNKESPNQ NNTTHLDIAA 250 260 270 280 290 300 VQGFSVILDF LYSGNLVLTS QNAIEVMTVA SYLQMSEVVQ TCRNFIKDAL NISIKSEAPE 310 320 330 340 350 360 SVVVDYNNRK PVNRDGLSSS RDQKIASFWA TRNLTNLASN VKIENDGCNV DEGQIENYQM 370 380 390 400 410 420 NDSSWVQDGS PEMAENESEG QTKVFIWNNM GSQGIQETGK TRRKNQTTKR FIYNIPPNNE 430 440 450 460 470 480 TNLEDCSVMQ PPVAYPEENT LLIKEEPDLD GALLSGPDGD RNVNANLLAE AGTSQDGGDA 490 500 510 520 530 540 GTSHDFKYGL MPGPSNDFKY GLIPGTSNDF KYGLIPGASN DFKYGLLPES WPKQETWENG 550 560 570 580 590 600 ESSLIMNKLK CPHCSYVAKY RRTLKRHLLI HTGVRSFSCD ICGKLFTRRE HVKRHSLVHK 610 620 630 640 650 660 KDKKYKCMVC KKIFMLAASV GIRHGSRRYG VCVDCADKSQ PGGQEGVDQG QDTEFPRDEE 670 680 690 YEENEVGEAD EELVDDGEDQ NDPSRWDESG EVCMSLDD
	Isoform 4 [UniParc]. Checksum: A1120EF9F0EC58AC	FASTA	579	64,941
	10 20 30 40 50 60 MTRLERSSHR TVICKVPGEL VAREGKCASR ARESEIPSEE GYCDFNSRPN ENSYCYQLLR 70 80 90 100 110 120 QLNEQRKKGI LCDVSIVVSG KIFKAHKNIL VAGSRFFKTL YCFSNKESPN QNNTTHLDIA 130 140 150 160 170 180 AVQGFSVILD FLYSGNLVLT SQNAIEVMTV ASYLQMSEVV QTCRNFIKDA LNISIKSEAP 190 200 210 220 230 240 ESVVVDYNNR KPVNRDGLSS SRDQKIASFW ATRNLTNLAS NVKIENDGCN VDEGQIENYQ 250 260 270 280 290 300 MNDSSWVQDG SPEMAENESE GQTKVFIWNN MGSQGIQETG KTRRKNQTTK RFIYNIPPNN 310 320 330 340 350 360 ETNLEDCSVM QPPVAYPEEN TLLIKEEPDL DGALLSGPDG DRNVNANLLA EAGTSQDGGD 370 380 390 400 410 420 AGTSHDFKYG LMPGPSNDFK YGLIPGTSND FKYGLIPGAS NDFKYGLLPE SWPKQETWEN 430 440 450 460 470 480 GESSLIMNKL KCPHCSYVAK YRRTLKRHLL IHTGVRSFSC DICGKLFTRR EHVKRHSLVH 490 500 510 520 530 540 KKDKKYKCMV CKKIFMLAAS VGIRHGSRRY GVCVDCADKS QPGGQEGVDQ GQDTEFPRDE 550 560 570 EYEENEVGEA DEELVDDGED QNDPSRWDES GEVCMSLDD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Kashuba V.I., Protopopov A.I., Zabarovsky E.R. Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), VARIANTS THR-50 AND ILE-174. Tissue: Brain.
[2]	"Identification of four genes on human chromosome 3 homologous to the known genes on other chromosomes by in silico analysis." Rakhmanaliev E.R. Thesis (2002), Novosibirsk Institute of Cytology and Genetics, Russia Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 2).
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4). Tissue: Prostate.
[4]	"DNA sequence and analysis of human chromosome 8." Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T. , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S. Nature 439:331-335(2006) [PubMed: 16421571] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 368-871 (ISOFORMS 1/3/4). Tissue: Testis.
[6]	"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage." Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J. Science 316:1160-1166(2007) [PubMed: 17525332] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-565 AND SER-647, MASS SPECTROMETRY. Tissue: Embryonic kidney.
[7]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-210 AND THR-745, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[8]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed: 21269460] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ319673 mRNA. Translation: CAC40989.1. AJ507398 Genomic DNA. Translation: CAD45447.1. AK056913 mRNA. Translation: BAB71309.1. AC009812 Genomic DNA. No translation available. BC050061 mRNA. Translation: AAH50061.1. BC127098 mRNA. Translation: AAI27099.1.
IPI	IPI00383132. IPI00410712. IPI00973561. IPI00973578.
RefSeq	NP_001099009.1. NM_001105539.1. NP_076418.3. NM_023929.3.
UniGene	Hs.591868.
3D structure databases
ProteinModelPortal	Q96DT7.
SMR	Q96DT7. Positions 344-462, 714-794.
ModBase	Search...
Protein-protein interaction databases
STRING	Q96DT7.
PTM databases
PhosphoSite	Q96DT7.
Polymorphism databases
DMDM	46577535.
Proteomic databases
PRIDE	Q96DT7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000379085; ENSP00000368378; ENSG00000205189. ENST00000426744; ENSP00000416134; ENSG00000205189. ENST00000430430; ENSP00000387462; ENSG00000205189.
GeneID	65986.
KEGG	hsa:65986.
UCSC	uc003ybv.2. human. uc003ybw.2. human.
Organism-specific databases
CTD	65986.
GeneCards	GC08P081448.
H-InvDB	HIX0007613.
HGNC	HGNC:30953. ZBTB10.
HPA	HPA021554.
neXtProt	NX_Q96DT7.
PharmGKB	PA134883318.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	HBG099147.
InParanoid	Q96DT7.
OMA	KTPADGG.
Gene expression databases
ArrayExpress	Q96DT7.
Bgee	Q96DT7.
CleanEx	HS_ZBTB10.
Genevestigator	Q96DT7.
GermOnline	ENSG00000205189. Homo sapiens.
Family and domain databases
InterPro	IPR000210. BTB/POZ-like. IPR011333. BTB/POZ_fold. IPR013069. BTB_POZ. IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view]
Gene3D	G3DSA:3.30.710.10. BTB/POZ_fold. 1 hit. G3DSA:3.30.160.60. Znf_C2H2/integrase_DNA-bd. 1 hit.
KO	K10497.
Pfam	PF00651. BTB. 1 hit. [Graphical view]
SMART	SM00225. BTB. 1 hit. SM00355. ZnF_C2H2. 2 hits. [Graphical view]
SUPFAM	SSF54695. BTB/POZ_fold. 1 hit.
PROSITE	PS50097. BTB. 1 hit. PS00028. ZINC_FINGER_C2H2_1. 1 hit. PS50157. ZINC_FINGER_C2H2_2. 2 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	67455.

Entry information

Entry name

ZBT10_HUMAN

Accession

Primary (citable) accession number: Q96DT7
Secondary accession number(s): A4FVD0 , Q86W96, Q8IXI9, Q96MH9

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 26, 2004
Last sequence update:	January 11, 2011
Last modified:	January 25, 2012
This is version 83 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.