Reviewed,
UniProtKB/Swiss-Prot Q96DT6 (ATG4C_HUMAN)
Last modified
September 2, 2008.
Version 46.
History...
Clusters with 100%,
90%,
50% identity |
Documents (5) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Cysteine protease ATG4C EC=3.4.22.- Alternative name(s): Autophagy-related protein 4 homolog C Autophagin-3 Autophagy-related cysteine endopeptidase 3 AUT-like 3 cysteine endopeptidase | ||||
| Gene names |
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| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 458 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Cysteine protease required for autophagy, which cleaves the C-terminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, with a revealed C-terminal glycine, is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes. |
| Enzyme regulation | Inhibited by N-ethylmaleimide. |
| Subcellular location | CytoplasmProbable. |
| Tissue specificity | Highly expressed in skeletal muscle, heart, liver and testis. |
| Sequence similarities | Belongs to the peptidase C54 family. |
| Sequence caution | The sequence BAB55356.1 differs from that shown. Reason: Frameshift at position 420. |
Ontologies
Sequence annotation (Features)
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Human autophagins, a family of cysteine proteinases potentially implicated in cell degradation by autophagy." Marino G., Uria J.A., Puente X.S., Quesada V., Bordallo J., Lopez-Otin C. J. Biol. Chem. 278:3671-3678(2003) [PubMed: 12446702] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY. Tissue: Brain. |
| [2] | "Cloning and sequencing of a human homologue of the yeast Apg4 cysteine endopeptidase involved in autophagy." Chen J.M., Barrett A.J. Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Heart. |
| [3] | "Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S.Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta. |
| [4] | "The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. Bentley D.R.Nature 441:315-321(2006) [PubMed: 16710414] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [5] | Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. Venter J.C.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [6] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis. |
Cross-references
Sequence databases | |
|---|---|
| AJ312234 mRNA. Translation: CAC85556.1. AJ320169 mRNA. Translation: CAC43939.1. AK027773 mRNA. Translation: BAB55356.1. Frameshift. AC103923 Genomic DNA. No translation available. CH471059 Genomic DNA. Translation: EAX06579.1. BC033024 mRNA. Translation: AAH33024.1. | |
| RefSeq | NP_116241.2. NP_835739.1. |
| UniGene | Hs.7353 |
3D structure databases | |
| ModBase | Search... |
Protein family/group databases | |
| MEROPS | C54.004. |
PTM databases | |
| PhosphoSite | Q96DT6. |
Genome annotation databases | |
| Ensembl | ENSG00000125703. Homo sapiens. [Contig view] |
| GeneID | 84938. |
| KEGG | hsa:84938. |
Organism-specific databases | |
| H-InvDB | HIX0000660. |
| HGNC | HGNC:16040. ATG4C. |
| HPA | HPA007049. |
| MIM | 611339. gene. |
| PharmGKB | PA25183. |
| GenAtlas | Search... |
| GeneCards | Search... |
Phylogenomic databases | |
| HOGENOM | Q96DT6. |
| HOVERGEN | Q96DT6. |
Gene expression databases | |
| ArrayExpress | Q96DT6. |
| CleanEx | HS_ATG4C. |
| GermOnline | ENSG00000125703. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR005078. Peptidase_C54. [Graphical view] |
| PANTHER | PTHR22624. Peptidase_C54. 1 hit. |
| Pfam | PF03416. Peptidase_C54. 1 hit. [Graphical view] |
| ProDom | Q96DT6. [Graphical view] [Entries sharing at least one domain] |
| BLOCKS | Search... |
Other Resources | |
| SOURCE | Search... |
| ProtoNet | Search... |
Entry information
| Entry name | ATG4C_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q96DT6 Secondary accession number(s): A6NLR8, Q96K04 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 1 Human chromosome 1: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| Peptidase families Classification of peptidase families and list of entries |
| UniProtKB secondary accession numbers Index of UniProtKB secondary accession numbers |
| SIMILARITY comments Index of protein domains and families |

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