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Q96DT0 (LEG12_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 109. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Galectin-12

Short name=Gal-12
Alternative name(s):
Galectin-related inhibitor of proliferation
Gene names
Name:LGALS12
Synonyms:GRIP1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length336 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Binds lactose. May participate in the apoptosis of adipocytes.

Subcellular location

Nucleus.

Tissue specificity

Not widely expressed. Predominantly expressed in adipose tissue.

Domain

Contains two homologous but distinct carbohydrate-binding domains.

Sequence similarities

Contains 2 galectin domains.

Ontologies

Keywords
   Biological processApoptosis
   Cellular componentNucleus
   Coding sequence diversityAlternative splicing
   DomainRepeat
   LigandLectin
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processintrinsic apoptotic signaling pathway

Inferred from direct assay Ref.1. Source: MGI

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionlactose binding

Inferred from direct assay Ref.1. Source: MGI

Complete GO annotation...

Alternative products

This entry describes 6 isoforms produced by alternative splicing. [Align] [Select]
Isoform A (identifier: Q96DT0-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform B (identifier: Q96DT0-2)

Also known as: GRIP1a;

The sequence of this isoform differs from the canonical sequence as follows:
     1-61: Missing.
Isoform C (identifier: Q96DT0-3)

The sequence of this isoform differs from the canonical sequence as follows:
     200-208: Missing.
Isoform D (identifier: Q96DT0-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-61: Missing.
     200-208: Missing.
Isoform E (identifier: Q96DT0-5)

Also known as: 1;

The sequence of this isoform differs from the canonical sequence as follows:
     1-22: Missing.
Isoform F (identifier: Q96DT0-6)

Also known as: 2;

The sequence of this isoform differs from the canonical sequence as follows:
     1-22: Missing.
     74-74: H → HS

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 336336Galectin-12
PRO_0000076949

Regions

Domain49 – 183135Galectin 1
Domain212 – 336125Galectin 2

Natural variations

Alternative sequence1 – 6161Missing in isoform B and isoform D.
VSP_003100
Alternative sequence1 – 2222Missing in isoform E and isoform F.
VSP_003099
Alternative sequence741H → HS in isoform F.
VSP_003101
Alternative sequence200 – 2089Missing in isoform C and isoform D.
VSP_003102

Sequences

Sequence LengthMass (Da)Tools
Isoform A [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: F35D0A0CE509E795

FASTA33637,542
        10         20         30         40         50         60 
MSQPSGGRAP GTRIYSWSCP TVMSPGEKLD PIPDSFILQP PVFHPVVPYV TTIFGGLHAG 

        70         80         90        100        110        120 
KMVMLQGVVP LDAHRFQVDF QCGCSLCPRP DIAFHFNPRF HTTKPHVICN TLHGGRWQRE 

       130        140        150        160        170        180 
ARWPHLALRR GSSFLILFLF GNEEVKVSVN GQHFLHFRYR LPLSHVDTLG IFGDILVEAV 

       190        200        210        220        230        240 
GFLNINPFVE GSREYPAGHP FLLMSPRLEV PCSHALPQGL SPGQVIIVRG LVLQEPKHFT 

       250        260        270        280        290        300 
VSLRDQAAHA PVTLRASFAD RTLAWISRWG QKKLISAPFL FYPQRFFEVL LLFQEGGLKL 

       310        320        330 
ALNGQGLGAT SMNQQALEQL RELRISGSVQ LYCVHS 

« Hide

Isoform B (GRIP1a) [UniParc].

Checksum: 425CD0F6A36D2CBB
Show »

FASTA27531,036
Isoform C [UniParc].

Checksum: AE8E558D1C913ACF
Show »

FASTA32736,486
Isoform D [UniParc].

Checksum: F4A7CA07F89D79D7
Show »

FASTA26629,981
Isoform E (1) [UniParc].

Checksum: 0171723B2C7B8780
Show »

FASTA31435,221
Isoform F (2) [UniParc].

Checksum: 27B1024D57C65938
Show »

FASTA31535,308

References

« Hide 'large scale' references
[1]"Galectin-12, an adipose-expressed galectin-like molecule possessing apoptosis-inducing activity."
Hotta K., Funahashi T., Matsukawa Y., Takahashi M., Nishizawa H., Kishida K., Matsuda M., Kuriyama H., Kihara S., Nakamura T., Tochino Y., Bodkin N.L., Hansen B.C., Matsuzawa Y.
J. Biol. Chem. 276:34089-34097(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A; B; C AND D), CHARACTERIZATION.
Tissue: Adipose tissue.
[2]"Cell cycle regulation by galectin-12, a new member of the galectin superfamily."
Yang R.-Y., Hsu D.K., Yu L., Ni J., Liu F.-T.
J. Biol. Chem. 276:20252-20260(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS B; E AND F).
Tissue: Retina.
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A).
Tissue: Rectum.
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A).
Tissue: Blood.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF244974 mRNA. Translation: AAK77328.1.
AF244975 mRNA. Translation: AAK77329.1.
AF244976 mRNA. Translation: AAK77330.1.
AF244977 mRNA. Translation: AAK77331.1.
AF310686 mRNA. Translation: AAG40863.1.
AF310687 mRNA. Translation: AAG40864.1.
AK313851 mRNA. Translation: BAG36579.1.
AF222695 mRNA. Translation: AAF34677.1.
CH471076 Genomic DNA. Translation: EAW74155.1.
BC028222 mRNA. Translation: AAH28222.1.
CCDSCCDS44634.1. [Q96DT0-2]
CCDS44635.1. [Q96DT0-4]
CCDS53648.1. [Q96DT0-3]
CCDS8045.1. [Q96DT0-1]
RefSeqNP_001136007.1. NM_001142535.1.
NP_001136008.1. NM_001142536.1. [Q96DT0-3]
NP_001136009.1. NM_001142537.1. [Q96DT0-2]
NP_001136010.1. NM_001142538.1. [Q96DT0-4]
NP_149092.2. NM_033101.3. [Q96DT0-1]
UniGeneHs.502774.

3D structure databases

ProteinModelPortalQ96DT0.
SMRQ96DT0. Positions 38-336.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid124475. 1 interaction.

PTM databases

PhosphoSiteQ96DT0.

Polymorphism databases

DMDM20138669.

Proteomic databases

MaxQBQ96DT0.
PaxDbQ96DT0.
PRIDEQ96DT0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000255684; ENSP00000255684; ENSG00000133317. [Q96DT0-3]
ENST00000394618; ENSP00000378116; ENSG00000133317. [Q96DT0-1]
ENST00000415491; ENSP00000394659; ENSG00000133317. [Q96DT0-2]
ENST00000425950; ENSP00000399093; ENSG00000133317. [Q96DT0-4]
GeneID85329.
KEGGhsa:85329.
UCSCuc001nxa.2. human. [Q96DT0-1]
uc001nxb.2. human. [Q96DT0-3]
uc001nxe.2. human. [Q96DT0-4]

Organism-specific databases

CTD85329.
GeneCardsGC11P063273.
HGNCHGNC:15788. LGALS12.
HPACAB012971.
MIM606096. gene.
neXtProtNX_Q96DT0.
PharmGKBPA30338.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG245014.
HOVERGENHBG105732.
InParanoidQ96DT0.
KOK10095.
OrthoDBEOG73Z2TM.
PhylomeDBQ96DT0.

Gene expression databases

ArrayExpressQ96DT0.
BgeeQ96DT0.
CleanExHS_GRIP1.
HS_LGALS12.
GenevestigatorQ96DT0.

Family and domain databases

Gene3D2.60.120.200. 2 hits.
InterProIPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR001079. Galectin_CRD.
[Graphical view]
PfamPF00337. Gal-bind_lectin. 2 hits.
[Graphical view]
SMARTSM00908. Gal-bind_lectin. 2 hits.
SM00276. GLECT. 1 hit.
[Graphical view]
SUPFAMSSF49899. SSF49899. 2 hits.
PROSITEPS51304. GALECTIN. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi85329.
NextBio75839.
PROQ96DT0.
SOURCESearch...

Entry information

Entry nameLEG12_HUMAN
AccessionPrimary (citable) accession number: Q96DT0
Secondary accession number(s): B2R9N2 expand/collapse secondary AC list , Q96DS9, Q96PR9, Q9H258, Q9H259, Q9NZ02
Entry history
Integrated into UniProtKB/Swiss-Prot: April 3, 2002
Last sequence update: December 1, 2001
Last modified: July 9, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM