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Protein

Galectin-12

Gene

LGALS12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Binds lactose. May participate in the apoptosis of adipocytes.

GO - Molecular functioni

  1. lactose binding Source: MGI

GO - Biological processi

  1. intrinsic apoptotic signaling pathway Source: MGI
Complete GO annotation...

Keywords - Biological processi

Apoptosis

Keywords - Ligandi

Lectin

Names & Taxonomyi

Protein namesi
Recommended name:
Galectin-12
Short name:
Gal-12
Alternative name(s):
Galectin-related inhibitor of proliferation
Gene namesi
Name:LGALS12
Synonyms:GRIP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:15788. LGALS12.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30338.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 336336Galectin-12PRO_0000076949Add
BLAST

Proteomic databases

MaxQBiQ96DT0.
PaxDbiQ96DT0.
PRIDEiQ96DT0.

PTM databases

PhosphoSiteiQ96DT0.

Expressioni

Tissue specificityi

Not widely expressed. Predominantly expressed in adipose tissue.

Gene expression databases

BgeeiQ96DT0.
CleanExiHS_GRIP1.
HS_LGALS12.
ExpressionAtlasiQ96DT0. baseline and differential.
GenevestigatoriQ96DT0.

Organism-specific databases

HPAiCAB012971.

Interactioni

Protein-protein interaction databases

BioGridi124475. 4 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ96DT0.
SMRiQ96DT0. Positions 29-336.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini49 – 183135Galectin 1PROSITE-ProRule annotationAdd
BLAST
Domaini212 – 336125Galectin 2PROSITE-ProRule annotationAdd
BLAST

Domaini

Contains two homologous but distinct carbohydrate-binding domains.

Sequence similaritiesi

Contains 2 galectin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG245014.
GeneTreeiENSGT00760000119105.
HOVERGENiHBG105732.
InParanoidiQ96DT0.
KOiK10095.
OMAiHFLHYRY.
OrthoDBiEOG73Z2TM.
PhylomeDBiQ96DT0.

Family and domain databases

Gene3Di2.60.120.200. 2 hits.
InterProiIPR013320. ConA-like_dom.
IPR001079. Galectin_CRD.
[Graphical view]
PfamiPF00337. Gal-bind_lectin. 2 hits.
[Graphical view]
SMARTiSM00908. Gal-bind_lectin. 2 hits.
SM00276. GLECT. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 2 hits.
PROSITEiPS51304. GALECTIN. 2 hits.
[Graphical view]

Sequences (7)i

Sequence statusi: Complete.

This entry describes 7 isoformsi produced by alternative splicing. Align

Isoform A (identifier: Q96DT0-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSQPSGGRAP GTRIYSWSCP TVMSPGEKLD PIPDSFILQP PVFHPVVPYV
60 70 80 90 100
TTIFGGLHAG KMVMLQGVVP LDAHRFQVDF QCGCSLCPRP DIAFHFNPRF
110 120 130 140 150
HTTKPHVICN TLHGGRWQRE ARWPHLALRR GSSFLILFLF GNEEVKVSVN
160 170 180 190 200
GQHFLHFRYR LPLSHVDTLG IFGDILVEAV GFLNINPFVE GSREYPAGHP
210 220 230 240 250
FLLMSPRLEV PCSHALPQGL SPGQVIIVRG LVLQEPKHFT VSLRDQAAHA
260 270 280 290 300
PVTLRASFAD RTLAWISRWG QKKLISAPFL FYPQRFFEVL LLFQEGGLKL
310 320 330
ALNGQGLGAT SMNQQALEQL RELRISGSVQ LYCVHS
Length:336
Mass (Da):37,542
Last modified:December 1, 2001 - v1
Checksum:iF35D0A0CE509E795
GO
Isoform B (identifier: Q96DT0-2) [UniParc]FASTAAdd to Basket

Also known as: GRIP1a

The sequence of this isoform differs from the canonical sequence as follows:
     1-61: Missing.

Show »
Length:275
Mass (Da):31,036
Checksum:i425CD0F6A36D2CBB
GO
Isoform C (identifier: Q96DT0-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     200-208: Missing.

Show »
Length:327
Mass (Da):36,486
Checksum:iAE8E558D1C913ACF
GO
Isoform D (identifier: Q96DT0-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-61: Missing.
     200-208: Missing.

Show »
Length:266
Mass (Da):29,981
Checksum:iF4A7CA07F89D79D7
GO
Isoform E (identifier: Q96DT0-5) [UniParc]FASTAAdd to Basket

Also known as: 1

The sequence of this isoform differs from the canonical sequence as follows:
     1-22: Missing.

Show »
Length:314
Mass (Da):35,221
Checksum:i0171723B2C7B8780
GO
Isoform F (identifier: Q96DT0-6) [UniParc]FASTAAdd to Basket

Also known as: 2

The sequence of this isoform differs from the canonical sequence as follows:
     1-22: Missing.
     74-74: H → HS

Show »
Length:315
Mass (Da):35,308
Checksum:i27B1024D57C65938
GO
Isoform G (identifier: Q96DT0-7) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     74-74: H → HS

Show »
Length:337
Mass (Da):37,629
Checksum:i3B332E35600F2B58
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 6161Missing in isoform B and isoform D. 2 PublicationsVSP_003100Add
BLAST
Alternative sequencei1 – 2222Missing in isoform E and isoform F. 1 PublicationVSP_003099Add
BLAST
Alternative sequencei74 – 741H → HS in isoform F and isoform G. 2 PublicationsVSP_003101
Alternative sequencei200 – 2089Missing in isoform C and isoform D. 1 PublicationVSP_003102

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF244974 mRNA. Translation: AAK77328.1.
AF244975 mRNA. Translation: AAK77329.1.
AF244976 mRNA. Translation: AAK77330.1.
AF244977 mRNA. Translation: AAK77331.1.
AF310686 mRNA. Translation: AAG40863.1.
AF310687 mRNA. Translation: AAG40864.1.
AK313851 mRNA. Translation: BAG36579.1.
AF222695 mRNA. Translation: AAF34677.1.
AP001591 Genomic DNA. No translation available.
CH471076 Genomic DNA. Translation: EAW74151.1.
CH471076 Genomic DNA. Translation: EAW74152.1.
CH471076 Genomic DNA. Translation: EAW74155.1.
BC028222 mRNA. Translation: AAH28222.1.
CCDSiCCDS44633.1. [Q96DT0-7]
CCDS44634.1. [Q96DT0-2]
CCDS44635.1. [Q96DT0-4]
CCDS53648.1. [Q96DT0-3]
CCDS8045.1. [Q96DT0-1]
RefSeqiNP_001136007.1. NM_001142535.1. [Q96DT0-7]
NP_001136008.1. NM_001142536.1. [Q96DT0-3]
NP_001136009.1. NM_001142537.1. [Q96DT0-2]
NP_001136010.1. NM_001142538.1. [Q96DT0-4]
NP_149092.2. NM_033101.3. [Q96DT0-1]
UniGeneiHs.502774.

Genome annotation databases

EnsembliENST00000255684; ENSP00000255684; ENSG00000133317. [Q96DT0-3]
ENST00000340246; ENSP00000339374; ENSG00000133317. [Q96DT0-7]
ENST00000394618; ENSP00000378116; ENSG00000133317. [Q96DT0-1]
ENST00000415491; ENSP00000394659; ENSG00000133317. [Q96DT0-2]
ENST00000425950; ENSP00000399093; ENSG00000133317. [Q96DT0-4]
GeneIDi85329.
KEGGihsa:85329.
UCSCiuc001nxa.2. human. [Q96DT0-1]
uc001nxb.2. human. [Q96DT0-3]
uc001nxe.2. human. [Q96DT0-4]

Polymorphism databases

DMDMi20138669.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - Glycan Binding

Galectin-12

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF244974 mRNA. Translation: AAK77328.1.
AF244975 mRNA. Translation: AAK77329.1.
AF244976 mRNA. Translation: AAK77330.1.
AF244977 mRNA. Translation: AAK77331.1.
AF310686 mRNA. Translation: AAG40863.1.
AF310687 mRNA. Translation: AAG40864.1.
AK313851 mRNA. Translation: BAG36579.1.
AF222695 mRNA. Translation: AAF34677.1.
AP001591 Genomic DNA. No translation available.
CH471076 Genomic DNA. Translation: EAW74151.1.
CH471076 Genomic DNA. Translation: EAW74152.1.
CH471076 Genomic DNA. Translation: EAW74155.1.
BC028222 mRNA. Translation: AAH28222.1.
CCDSiCCDS44633.1. [Q96DT0-7]
CCDS44634.1. [Q96DT0-2]
CCDS44635.1. [Q96DT0-4]
CCDS53648.1. [Q96DT0-3]
CCDS8045.1. [Q96DT0-1]
RefSeqiNP_001136007.1. NM_001142535.1. [Q96DT0-7]
NP_001136008.1. NM_001142536.1. [Q96DT0-3]
NP_001136009.1. NM_001142537.1. [Q96DT0-2]
NP_001136010.1. NM_001142538.1. [Q96DT0-4]
NP_149092.2. NM_033101.3. [Q96DT0-1]
UniGeneiHs.502774.

3D structure databases

ProteinModelPortaliQ96DT0.
SMRiQ96DT0. Positions 29-336.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124475. 4 interactions.

PTM databases

PhosphoSiteiQ96DT0.

Polymorphism databases

DMDMi20138669.

Proteomic databases

MaxQBiQ96DT0.
PaxDbiQ96DT0.
PRIDEiQ96DT0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000255684; ENSP00000255684; ENSG00000133317. [Q96DT0-3]
ENST00000340246; ENSP00000339374; ENSG00000133317. [Q96DT0-7]
ENST00000394618; ENSP00000378116; ENSG00000133317. [Q96DT0-1]
ENST00000415491; ENSP00000394659; ENSG00000133317. [Q96DT0-2]
ENST00000425950; ENSP00000399093; ENSG00000133317. [Q96DT0-4]
GeneIDi85329.
KEGGihsa:85329.
UCSCiuc001nxa.2. human. [Q96DT0-1]
uc001nxb.2. human. [Q96DT0-3]
uc001nxe.2. human. [Q96DT0-4]

Organism-specific databases

CTDi85329.
GeneCardsiGC11P063273.
HGNCiHGNC:15788. LGALS12.
HPAiCAB012971.
MIMi606096. gene.
neXtProtiNX_Q96DT0.
PharmGKBiPA30338.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG245014.
GeneTreeiENSGT00760000119105.
HOVERGENiHBG105732.
InParanoidiQ96DT0.
KOiK10095.
OMAiHFLHYRY.
OrthoDBiEOG73Z2TM.
PhylomeDBiQ96DT0.

Miscellaneous databases

GenomeRNAii85329.
NextBioi75839.
PROiQ96DT0.
SOURCEiSearch...

Gene expression databases

BgeeiQ96DT0.
CleanExiHS_GRIP1.
HS_LGALS12.
ExpressionAtlasiQ96DT0. baseline and differential.
GenevestigatoriQ96DT0.

Family and domain databases

Gene3Di2.60.120.200. 2 hits.
InterProiIPR013320. ConA-like_dom.
IPR001079. Galectin_CRD.
[Graphical view]
PfamiPF00337. Gal-bind_lectin. 2 hits.
[Graphical view]
SMARTiSM00908. Gal-bind_lectin. 2 hits.
SM00276. GLECT. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 2 hits.
PROSITEiPS51304. GALECTIN. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A; B; C; D AND G), CHARACTERIZATION.
    Tissue: Adipose tissue.
  2. "Cell cycle regulation by galectin-12, a new member of the galectin superfamily."
    Yang R.-Y., Hsu D.K., Yu L., Ni J., Liu F.-T.
    J. Biol. Chem. 276:20252-20260(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS B; E AND F).
    Tissue: Retina.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A).
    Tissue: Rectum.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A).
    Tissue: Blood.

Entry informationi

Entry nameiLEG12_HUMAN
AccessioniPrimary (citable) accession number: Q96DT0
Secondary accession number(s): B2R9N2
, G5E970, Q96DS9, Q96PR9, Q9H258, Q9H259, Q9NZ02
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2002
Last sequence update: December 1, 2001
Last modified: January 7, 2015
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.