Q96DT0 (LEG12_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Galectin-12
Short name=Gal-12

Alternative name(s):
Galectin-related inhibitor of proliferation

Gene names

Name:	LGALS12
Synonyms:	GRIP1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	336 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Binds lactose. May participate in the apoptosis of adipocytes.
Subcellular location	Nucleus.
Tissue specificity	Not widely expressed. Predominantly expressed in adipose tissue.
Domain	Contains two homologous but distinct carbohydrate-binding domains.
Sequence similarities	Contains 2 galectin domains.

Ontologies

Keywords
Biological process	Apoptosis
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing
Domain	Repeat
Ligand	Lectin
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	intrinsic apoptotic signaling pathway Inferred from direct assay Ref.1. Source: MGI
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	lactose binding Inferred from direct assay Ref.1. Source: MGI
Complete GO annotation...

Alternative products

This entry describes 6 isoforms produced by alternative splicing. [Align] [Select]

Isoform A (identifier: Q96DT0-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform B (identifier: Q96DT0-2)

Also known as: GRIP1a;

The sequence of this isoform differs from the canonical sequence as follows:
     1-61: Missing.

Isoform C (identifier: Q96DT0-3)

The sequence of this isoform differs from the canonical sequence as follows:
     200-208: Missing.

Isoform D (identifier: Q96DT0-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-61: Missing.
     200-208: Missing.

Isoform E (identifier: Q96DT0-5)

Also known as: 1;

The sequence of this isoform differs from the canonical sequence as follows:
     1-22: Missing.

Isoform F (identifier: Q96DT0-6)

Also known as: 2;

The sequence of this isoform differs from the canonical sequence as follows:
     1-22: Missing.
     74-74: H → HS

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 336	336	Galectin-12		PRO_0000076949
Regions
	Domain	49 – 183	135	Galectin 1
	Domain	212 – 336	125	Galectin 2
Natural variations
	Alternative sequence	1 – 61	61	Missing in isoform B and isoform D.		VSP_003100
	Alternative sequence	1 – 22	22	Missing in isoform E and isoform F.		VSP_003099
	Alternative sequence	74	1	H → HS in isoform F.		VSP_003101
	Alternative sequence	200 – 208	9	Missing in isoform C and isoform D.		VSP_003102

Sequences

	Sequence		Length	Mass (Da)
	Isoform A [UniParc]. Last modified December 1, 2001. Version 1. Checksum: F35D0A0CE509E795	FASTA	336	37,542
	10 20 30 40 50 60 MSQPSGGRAP GTRIYSWSCP TVMSPGEKLD PIPDSFILQP PVFHPVVPYV TTIFGGLHAG 70 80 90 100 110 120 KMVMLQGVVP LDAHRFQVDF QCGCSLCPRP DIAFHFNPRF HTTKPHVICN TLHGGRWQRE 130 140 150 160 170 180 ARWPHLALRR GSSFLILFLF GNEEVKVSVN GQHFLHFRYR LPLSHVDTLG IFGDILVEAV 190 200 210 220 230 240 GFLNINPFVE GSREYPAGHP FLLMSPRLEV PCSHALPQGL SPGQVIIVRG LVLQEPKHFT 250 260 270 280 290 300 VSLRDQAAHA PVTLRASFAD RTLAWISRWG QKKLISAPFL FYPQRFFEVL LLFQEGGLKL 310 320 330 ALNGQGLGAT SMNQQALEQL RELRISGSVQ LYCVHS
	Isoform B (GRIP1a) [UniParc]. Checksum: 425CD0F6A36D2CBB	FASTA	275	31,036
	10 20 30 40 50 60 MVMLQGVVPL DAHRFQVDFQ CGCSLCPRPD IAFHFNPRFH TTKPHVICNT LHGGRWQREA 70 80 90 100 110 120 RWPHLALRRG SSFLILFLFG NEEVKVSVNG QHFLHFRYRL PLSHVDTLGI FGDILVEAVG 130 140 150 160 170 180 FLNINPFVEG SREYPAGHPF LLMSPRLEVP CSHALPQGLS PGQVIIVRGL VLQEPKHFTV 190 200 210 220 230 240 SLRDQAAHAP VTLRASFADR TLAWISRWGQ KKLISAPFLF YPQRFFEVLL LFQEGGLKLA 250 260 270 LNGQGLGATS MNQQALEQLR ELRISGSVQL YCVHS
	Isoform C [UniParc]. Checksum: AE8E558D1C913ACF	FASTA	327	36,486
	10 20 30 40 50 60 MSQPSGGRAP GTRIYSWSCP TVMSPGEKLD PIPDSFILQP PVFHPVVPYV TTIFGGLHAG 70 80 90 100 110 120 KMVMLQGVVP LDAHRFQVDF QCGCSLCPRP DIAFHFNPRF HTTKPHVICN TLHGGRWQRE 130 140 150 160 170 180 ARWPHLALRR GSSFLILFLF GNEEVKVSVN GQHFLHFRYR LPLSHVDTLG IFGDILVEAV 190 200 210 220 230 240 GFLNINPFVE GSREYPAGHE VPCSHALPQG LSPGQVIIVR GLVLQEPKHF TVSLRDQAAH 250 260 270 280 290 300 APVTLRASFA DRTLAWISRW GQKKLISAPF LFYPQRFFEV LLLFQEGGLK LALNGQGLGA 310 320 TSMNQQALEQ LRELRISGSV QLYCVHS
	Isoform D [UniParc]. Checksum: F4A7CA07F89D79D7	FASTA	266	29,981
	10 20 30 40 50 60 MVMLQGVVPL DAHRFQVDFQ CGCSLCPRPD IAFHFNPRFH TTKPHVICNT LHGGRWQREA 70 80 90 100 110 120 RWPHLALRRG SSFLILFLFG NEEVKVSVNG QHFLHFRYRL PLSHVDTLGI FGDILVEAVG 130 140 150 160 170 180 FLNINPFVEG SREYPAGHEV PCSHALPQGL SPGQVIIVRG LVLQEPKHFT VSLRDQAAHA 190 200 210 220 230 240 PVTLRASFAD RTLAWISRWG QKKLISAPFL FYPQRFFEVL LLFQEGGLKL ALNGQGLGAT 250 260 SMNQQALEQL RELRISGSVQ LYCVHS
	Isoform E (1) [UniParc]. Checksum: 0171723B2C7B8780	FASTA	314	35,221
	10 20 30 40 50 60 MSPGEKLDPI PDSFILQPPV FHPVVPYVTT IFGGLHAGKM VMLQGVVPLD AHRFQVDFQC 70 80 90 100 110 120 GCSLCPRPDI AFHFNPRFHT TKPHVICNTL HGGRWQREAR WPHLALRRGS SFLILFLFGN 130 140 150 160 170 180 EEVKVSVNGQ HFLHFRYRLP LSHVDTLGIF GDILVEAVGF LNINPFVEGS REYPAGHPFL 190 200 210 220 230 240 LMSPRLEVPC SHALPQGLSP GQVIIVRGLV LQEPKHFTVS LRDQAAHAPV TLRASFADRT 250 260 270 280 290 300 LAWISRWGQK KLISAPFLFY PQRFFEVLLL FQEGGLKLAL NGQGLGATSM NQQALEQLRE 310 LRISGSVQLY CVHS
	Isoform F (2) [UniParc]. Checksum: 27B1024D57C65938	FASTA	315	35,308
	10 20 30 40 50 60 MSPGEKLDPI PDSFILQPPV FHPVVPYVTT IFGGLHAGKM VMLQGVVPLD AHSRFQVDFQ 70 80 90 100 110 120 CGCSLCPRPD IAFHFNPRFH TTKPHVICNT LHGGRWQREA RWPHLALRRG SSFLILFLFG 130 140 150 160 170 180 NEEVKVSVNG QHFLHFRYRL PLSHVDTLGI FGDILVEAVG FLNINPFVEG SREYPAGHPF 190 200 210 220 230 240 LLMSPRLEVP CSHALPQGLS PGQVIIVRGL VLQEPKHFTV SLRDQAAHAP VTLRASFADR 250 260 270 280 290 300 TLAWISRWGQ KKLISAPFLF YPQRFFEVLL LFQEGGLKLA LNGQGLGATS MNQQALEQLR 310 ELRISGSVQL YCVHS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Galectin-12, an adipose-expressed galectin-like molecule possessing apoptosis-inducing activity." Hotta K., Funahashi T., Matsukawa Y., Takahashi M., Nishizawa H., Kishida K., Matsuda M., Kuriyama H., Kihara S., Nakamura T., Tochino Y., Bodkin N.L., Hansen B.C., Matsuzawa Y. J. Biol. Chem. 276:34089-34097(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A; B; C AND D), CHARACTERIZATION. Tissue: Adipose tissue.
[2]	"Cell cycle regulation by galectin-12, a new member of the galectin superfamily." Yang R.-Y., Hsu D.K., Yu L., Ni J., Liu F.-T. J. Biol. Chem. 276:20252-20260(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS B; E AND F). Tissue: Retina.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A). Tissue: Rectum.
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A). Tissue: Blood.
+	Additional computationally mapped references.

Web resources

Functional Glycomics Gateway - Glycan Binding

Galectin-12

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF244974 mRNA. Translation: AAK77328.1. AF244975 mRNA. Translation: AAK77329.1. AF244976 mRNA. Translation: AAK77330.1. AF244977 mRNA. Translation: AAK77331.1. AF310686 mRNA. Translation: AAG40863.1. AF310687 mRNA. Translation: AAG40864.1. AK313851 mRNA. Translation: BAG36579.1. AF222695 mRNA. Translation: AAF34677.1. CH471076 Genomic DNA. Translation: EAW74155.1. BC028222 mRNA. Translation: AAH28222.1.
IPI	IPI00220535. IPI00220536. IPI00220537. IPI00220538. IPI00220539. IPI00304389.
RefSeq	NP_001136007.1. NM_001142535.1. NP_001136008.1. NM_001142536.1. NP_001136009.1. NM_001142537.1. NP_001136010.1. NM_001142538.1. NP_149092.2. NM_033101.3.
UniGene	Hs.502774.
3D structure databases
ProteinModelPortal	Q96DT0.
ModBase	Search...
PTM databases
PhosphoSite	Q96DT0.
Polymorphism databases
DMDM	20138669.
Proteomic databases
PaxDb	Q96DT0.
PRIDE	Q96DT0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000255684; ENSP00000255684; ENSG00000133317. ENST00000394618; ENSP00000378116; ENSG00000133317. ENST00000415491; ENSP00000394659; ENSG00000133317. ENST00000425950; ENSP00000399093; ENSG00000133317.
GeneID	85329.
KEGG	hsa:85329.
UCSC	uc001nxa.2. human. uc001nxb.2. human. uc001nxc.2. human. uc001nxe.2. human.
Organism-specific databases
CTD	85329.
GeneCards	GC11P063273.
HGNC	HGNC:15788. LGALS12.
HPA	CAB012971.
MIM	606096. gene.
neXtProt	NX_Q96DT0.
PharmGKB	PA30338.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG245014.
HOVERGEN	HBG105732.
InParanoid	Q96DT0.
KO	K10095.
OrthoDB	EOG40ZQXV.
PhylomeDB	Q96DT0.
Gene expression databases
ArrayExpress	Q96DT0.
Bgee	Q96DT0.
CleanEx	HS_GRIP1. HS_LGALS12.
Genevestigator	Q96DT0.
GermOnline	ENSG00000133317. Homo sapiens.
Family and domain databases
Gene3D	2.60.120.200. 2 hits.
InterPro	IPR008985. ConA-like_lec_gl_sf. IPR013320. ConA-like_subgrp. IPR001079. Galectin_CRD. [Graphical view]
Pfam	PF00337. Gal-bind_lectin. 2 hits. [Graphical view]
SMART	SM00908. Gal-bind_lectin. 2 hits. SM00276. GLECT. 1 hit. [Graphical view]
SUPFAM	SSF49899. ConA_like_lec_gl. 2 hits.
PROSITE	PS51304. GALECTIN. 2 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	85329.
NextBio	75839.
SOURCE	Search...

Entry information

Entry name

LEG12_HUMAN

Accession

Primary (citable) accession number: Q96DT0
Secondary accession number(s): B2R9N2 , Q96DS9, Q96PR9, Q9H258, Q9H259, Q9NZ02

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 3, 2002
Last sequence update:	December 1, 2001
Last modified:	May 1, 2013
This is version 101 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.