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Q96DT0

- LEG12_HUMAN

UniProt

Q96DT0 - LEG12_HUMAN

Protein

Galectin-12

Gene

LGALS12

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 111 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Binds lactose. May participate in the apoptosis of adipocytes.

    GO - Molecular functioni

    1. carbohydrate binding Source: InterPro
    2. lactose binding Source: MGI

    GO - Biological processi

    1. intrinsic apoptotic signaling pathway Source: MGI

    Keywords - Biological processi

    Apoptosis

    Keywords - Ligandi

    Lectin

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Galectin-12
    Short name:
    Gal-12
    Alternative name(s):
    Galectin-related inhibitor of proliferation
    Gene namesi
    Name:LGALS12
    Synonyms:GRIP1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:15788. LGALS12.

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrion Source: Ensembl
    2. nucleus Source: Ensembl

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30338.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 336336Galectin-12PRO_0000076949Add
    BLAST

    Proteomic databases

    MaxQBiQ96DT0.
    PaxDbiQ96DT0.
    PRIDEiQ96DT0.

    PTM databases

    PhosphoSiteiQ96DT0.

    Expressioni

    Tissue specificityi

    Not widely expressed. Predominantly expressed in adipose tissue.

    Gene expression databases

    ArrayExpressiQ96DT0.
    BgeeiQ96DT0.
    CleanExiHS_GRIP1.
    HS_LGALS12.
    GenevestigatoriQ96DT0.

    Organism-specific databases

    HPAiCAB012971.

    Interactioni

    Protein-protein interaction databases

    BioGridi124475. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96DT0.
    SMRiQ96DT0. Positions 38-336.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini49 – 183135Galectin 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini212 – 336125Galectin 2PROSITE-ProRule annotationAdd
    BLAST

    Domaini

    Contains two homologous but distinct carbohydrate-binding domains.

    Sequence similaritiesi

    Contains 2 galectin domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG245014.
    HOVERGENiHBG105732.
    InParanoidiQ96DT0.
    KOiK10095.
    OrthoDBiEOG73Z2TM.
    PhylomeDBiQ96DT0.

    Family and domain databases

    Gene3Di2.60.120.200. 2 hits.
    InterProiIPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR001079. Galectin_CRD.
    [Graphical view]
    PfamiPF00337. Gal-bind_lectin. 2 hits.
    [Graphical view]
    SMARTiSM00908. Gal-bind_lectin. 2 hits.
    SM00276. GLECT. 1 hit.
    [Graphical view]
    SUPFAMiSSF49899. SSF49899. 2 hits.
    PROSITEiPS51304. GALECTIN. 2 hits.
    [Graphical view]

    Sequences (7)i

    Sequence statusi: Complete.

    This entry describes 7 isoformsi produced by alternative splicing. Align

    Isoform A (identifier: Q96DT0-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSQPSGGRAP GTRIYSWSCP TVMSPGEKLD PIPDSFILQP PVFHPVVPYV    50
    TTIFGGLHAG KMVMLQGVVP LDAHRFQVDF QCGCSLCPRP DIAFHFNPRF 100
    HTTKPHVICN TLHGGRWQRE ARWPHLALRR GSSFLILFLF GNEEVKVSVN 150
    GQHFLHFRYR LPLSHVDTLG IFGDILVEAV GFLNINPFVE GSREYPAGHP 200
    FLLMSPRLEV PCSHALPQGL SPGQVIIVRG LVLQEPKHFT VSLRDQAAHA 250
    PVTLRASFAD RTLAWISRWG QKKLISAPFL FYPQRFFEVL LLFQEGGLKL 300
    ALNGQGLGAT SMNQQALEQL RELRISGSVQ LYCVHS 336
    Length:336
    Mass (Da):37,542
    Last modified:December 1, 2001 - v1
    Checksum:iF35D0A0CE509E795
    GO
    Isoform B (identifier: Q96DT0-2) [UniParc]FASTAAdd to Basket

    Also known as: GRIP1a

    The sequence of this isoform differs from the canonical sequence as follows:
         1-61: Missing.

    Show »
    Length:275
    Mass (Da):31,036
    Checksum:i425CD0F6A36D2CBB
    GO
    Isoform C (identifier: Q96DT0-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         200-208: Missing.

    Show »
    Length:327
    Mass (Da):36,486
    Checksum:iAE8E558D1C913ACF
    GO
    Isoform D (identifier: Q96DT0-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-61: Missing.
         200-208: Missing.

    Show »
    Length:266
    Mass (Da):29,981
    Checksum:iF4A7CA07F89D79D7
    GO
    Isoform E (identifier: Q96DT0-5) [UniParc]FASTAAdd to Basket

    Also known as: 1

    The sequence of this isoform differs from the canonical sequence as follows:
         1-22: Missing.

    Show »
    Length:314
    Mass (Da):35,221
    Checksum:i0171723B2C7B8780
    GO
    Isoform F (identifier: Q96DT0-6) [UniParc]FASTAAdd to Basket

    Also known as: 2

    The sequence of this isoform differs from the canonical sequence as follows:
         1-22: Missing.
         74-74: H → HS

    Show »
    Length:315
    Mass (Da):35,308
    Checksum:i27B1024D57C65938
    GO
    Isoform G (identifier: Q96DT0-7) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         74-74: H → HS

    Show »
    Length:337
    Mass (Da):37,629
    Checksum:i3B332E35600F2B58
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 6161Missing in isoform B and isoform D. 2 PublicationsVSP_003100Add
    BLAST
    Alternative sequencei1 – 2222Missing in isoform E and isoform F. 1 PublicationVSP_003099Add
    BLAST
    Alternative sequencei74 – 741H → HS in isoform F and isoform G. 2 PublicationsVSP_003101
    Alternative sequencei200 – 2089Missing in isoform C and isoform D. 1 PublicationVSP_003102

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF244974 mRNA. Translation: AAK77328.1.
    AF244975 mRNA. Translation: AAK77329.1.
    AF244976 mRNA. Translation: AAK77330.1.
    AF244977 mRNA. Translation: AAK77331.1.
    AF310686 mRNA. Translation: AAG40863.1.
    AF310687 mRNA. Translation: AAG40864.1.
    AK313851 mRNA. Translation: BAG36579.1.
    AF222695 mRNA. Translation: AAF34677.1.
    AP001591 Genomic DNA. No translation available.
    CH471076 Genomic DNA. Translation: EAW74151.1.
    CH471076 Genomic DNA. Translation: EAW74152.1.
    CH471076 Genomic DNA. Translation: EAW74155.1.
    BC028222 mRNA. Translation: AAH28222.1.
    CCDSiCCDS44634.1. [Q96DT0-2]
    CCDS44635.1. [Q96DT0-4]
    CCDS53648.1. [Q96DT0-3]
    CCDS8045.1. [Q96DT0-1]
    RefSeqiNP_001136007.1. NM_001142535.1.
    NP_001136008.1. NM_001142536.1. [Q96DT0-3]
    NP_001136009.1. NM_001142537.1. [Q96DT0-2]
    NP_001136010.1. NM_001142538.1. [Q96DT0-4]
    NP_149092.2. NM_033101.3. [Q96DT0-1]
    UniGeneiHs.502774.

    Genome annotation databases

    EnsembliENST00000255684; ENSP00000255684; ENSG00000133317. [Q96DT0-3]
    ENST00000340246; ENSP00000339374; ENSG00000133317. [Q96DT0-7]
    ENST00000394618; ENSP00000378116; ENSG00000133317. [Q96DT0-1]
    ENST00000415491; ENSP00000394659; ENSG00000133317. [Q96DT0-2]
    ENST00000425950; ENSP00000399093; ENSG00000133317. [Q96DT0-4]
    GeneIDi85329.
    KEGGihsa:85329.
    UCSCiuc001nxa.2. human. [Q96DT0-1]
    uc001nxb.2. human. [Q96DT0-3]
    uc001nxe.2. human. [Q96DT0-4]

    Polymorphism databases

    DMDMi20138669.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Web resourcesi

    Functional Glycomics Gateway - Glycan Binding

    Galectin-12

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF244974 mRNA. Translation: AAK77328.1 .
    AF244975 mRNA. Translation: AAK77329.1 .
    AF244976 mRNA. Translation: AAK77330.1 .
    AF244977 mRNA. Translation: AAK77331.1 .
    AF310686 mRNA. Translation: AAG40863.1 .
    AF310687 mRNA. Translation: AAG40864.1 .
    AK313851 mRNA. Translation: BAG36579.1 .
    AF222695 mRNA. Translation: AAF34677.1 .
    AP001591 Genomic DNA. No translation available.
    CH471076 Genomic DNA. Translation: EAW74151.1 .
    CH471076 Genomic DNA. Translation: EAW74152.1 .
    CH471076 Genomic DNA. Translation: EAW74155.1 .
    BC028222 mRNA. Translation: AAH28222.1 .
    CCDSi CCDS44634.1. [Q96DT0-2 ]
    CCDS44635.1. [Q96DT0-4 ]
    CCDS53648.1. [Q96DT0-3 ]
    CCDS8045.1. [Q96DT0-1 ]
    RefSeqi NP_001136007.1. NM_001142535.1.
    NP_001136008.1. NM_001142536.1. [Q96DT0-3 ]
    NP_001136009.1. NM_001142537.1. [Q96DT0-2 ]
    NP_001136010.1. NM_001142538.1. [Q96DT0-4 ]
    NP_149092.2. NM_033101.3. [Q96DT0-1 ]
    UniGenei Hs.502774.

    3D structure databases

    ProteinModelPortali Q96DT0.
    SMRi Q96DT0. Positions 38-336.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 124475. 1 interaction.

    PTM databases

    PhosphoSitei Q96DT0.

    Polymorphism databases

    DMDMi 20138669.

    Proteomic databases

    MaxQBi Q96DT0.
    PaxDbi Q96DT0.
    PRIDEi Q96DT0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000255684 ; ENSP00000255684 ; ENSG00000133317 . [Q96DT0-3 ]
    ENST00000340246 ; ENSP00000339374 ; ENSG00000133317 . [Q96DT0-7 ]
    ENST00000394618 ; ENSP00000378116 ; ENSG00000133317 . [Q96DT0-1 ]
    ENST00000415491 ; ENSP00000394659 ; ENSG00000133317 . [Q96DT0-2 ]
    ENST00000425950 ; ENSP00000399093 ; ENSG00000133317 . [Q96DT0-4 ]
    GeneIDi 85329.
    KEGGi hsa:85329.
    UCSCi uc001nxa.2. human. [Q96DT0-1 ]
    uc001nxb.2. human. [Q96DT0-3 ]
    uc001nxe.2. human. [Q96DT0-4 ]

    Organism-specific databases

    CTDi 85329.
    GeneCardsi GC11P063273.
    HGNCi HGNC:15788. LGALS12.
    HPAi CAB012971.
    MIMi 606096. gene.
    neXtProti NX_Q96DT0.
    PharmGKBi PA30338.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG245014.
    HOVERGENi HBG105732.
    InParanoidi Q96DT0.
    KOi K10095.
    OrthoDBi EOG73Z2TM.
    PhylomeDBi Q96DT0.

    Miscellaneous databases

    GenomeRNAii 85329.
    NextBioi 75839.
    PROi Q96DT0.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q96DT0.
    Bgeei Q96DT0.
    CleanExi HS_GRIP1.
    HS_LGALS12.
    Genevestigatori Q96DT0.

    Family and domain databases

    Gene3Di 2.60.120.200. 2 hits.
    InterProi IPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR001079. Galectin_CRD.
    [Graphical view ]
    Pfami PF00337. Gal-bind_lectin. 2 hits.
    [Graphical view ]
    SMARTi SM00908. Gal-bind_lectin. 2 hits.
    SM00276. GLECT. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49899. SSF49899. 2 hits.
    PROSITEi PS51304. GALECTIN. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A; B; C; D AND G), CHARACTERIZATION.
      Tissue: Adipose tissue.
    2. "Cell cycle regulation by galectin-12, a new member of the galectin superfamily."
      Yang R.-Y., Hsu D.K., Yu L., Ni J., Liu F.-T.
      J. Biol. Chem. 276:20252-20260(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS B; E AND F).
      Tissue: Retina.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A).
      Tissue: Rectum.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A).
      Tissue: Blood.

    Entry informationi

    Entry nameiLEG12_HUMAN
    AccessioniPrimary (citable) accession number: Q96DT0
    Secondary accession number(s): B2R9N2
    , G5E970, Q96DS9, Q96PR9, Q9H258, Q9H259, Q9NZ02
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 3, 2002
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 111 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3