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Protein
Submitted name:

MDM2 variant FB26

Gene

MDM2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
MDM2 variant FB26Imported
Gene namesi
Name:MDM2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

PaxDbiQ96DS4.
PRIDEiQ96DS4.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000417281.

Chemistry

BindingDBiQ96DS4.

Structurei

3D structure databases

ProteinModelPortaliQ96DS4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini29 – 9567SWIBInterPro annotationAdd
BLAST

Phylogenomic databases

eggNOGiENOG410IGXG. Eukaryota.
ENOG41125MP. LUCA.
HOGENOMiHOG000293341.
HOVERGENiHBG093712.

Family and domain databases

Gene3Di1.10.245.10. 1 hit.
InterProiIPR015459. MDM2_E3_ligase.
IPR016495. p53_neg-reg_MDM_2/4.
IPR003121. SWIB_MDM2_domain.
[Graphical view]
PANTHERiPTHR13844:SF15. PTHR13844:SF15. 1 hit.
PfamiPF02201. SWIB. 1 hit.
[Graphical view]
PIRSFiPIRSF006748. p53_MDM_2/4. 1 hit.
SUPFAMiSSF47592. SSF47592. 1 hit.

Sequencei

Sequence statusi: Complete.

Q96DS4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCNTNMSVPT DGAVTTSQIP ASEQETLVRP KPLLLKLLKS VGAQKDTYTM
60 70 80 90 100
KEVLFYLGQY IMTKRLYDEK QQHIVYCSND LLGDLFGVPS FSVKEHRKIY
110 120 130 140 150
TMIYRNLVVV NQQESSDSGT SVSENRCHLE GGSDQKDLVQ ELQEEKPSSS
160 170 180 190
HLVSRPSTSS RRRAISETEE NSDELSGERQ RKRHKSDSKE AKEKE
Length:195
Mass (Da):22,161
Last modified:December 1, 2001 - v1
Checksum:i4987AE567DB12D5D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF385323 mRNA. Translation: AAL13243.1.
UniGeneiHs.484551.
Hs.733536.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF385323 mRNA. Translation: AAL13243.1.
UniGeneiHs.484551.
Hs.733536.

3D structure databases

ProteinModelPortaliQ96DS4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000417281.

Chemistry

BindingDBiQ96DS4.

Proteomic databases

PaxDbiQ96DS4.
PRIDEiQ96DS4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG410IGXG. Eukaryota.
ENOG41125MP. LUCA.
HOGENOMiHOG000293341.
HOVERGENiHBG093712.

Miscellaneous databases

ChiTaRSiMDM2. human.

Family and domain databases

Gene3Di1.10.245.10. 1 hit.
InterProiIPR015459. MDM2_E3_ligase.
IPR016495. p53_neg-reg_MDM_2/4.
IPR003121. SWIB_MDM2_domain.
[Graphical view]
PANTHERiPTHR13844:SF15. PTHR13844:SF15. 1 hit.
PfamiPF02201. SWIB. 1 hit.
[Graphical view]
PIRSFiPIRSF006748. p53_MDM_2/4. 1 hit.
SUPFAMiSSF47592. SSF47592. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Novel mdm2 splice variants identified in pediatric rhabdomyosarcoma tumors and cell lines."
    Bartel F., Taylor A.C., Taubert H., Harris L.C.
    Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Rhabdomyosarcoma tumorImported.

Entry informationi

Entry nameiQ96DS4_HUMAN
AccessioniPrimary (citable) accession number: Q96DS4
Entry historyi
Integrated into UniProtKB/TrEMBL: December 1, 2001
Last sequence update: December 1, 2001
Last modified: March 16, 2016
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.