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Protein

Mucin-like protein 1

Gene

MUCL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a role as marker for the diagnosis of metastatic breast cancer.3 Publications

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-HSA-5083625. Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC).
R-HSA-5083632. Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS).
R-HSA-5083636. Defective GALNT12 causes colorectal cancer 1 (CRCS1).
R-HSA-913709. O-linked glycosylation of mucins.
R-HSA-977068. Termination of O-glycan biosynthesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Mucin-like protein 1
Alternative name(s):
Protein BS106
Small breast epithelial mucin
Gene namesi
Name:MUCL1
Synonyms:SBEM
ORF Names:UNQ590/PRO1160
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:30588. MUCL1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162396316.

Polymorphism and mutation databases

BioMutaiMUCL1.
DMDMi74731497.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 20201 PublicationAdd
BLAST
Chaini21 – 9070Mucin-like protein 1PRO_0000228159Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi23 – 231O-linked (GalNAc...)Sequence analysis
Glycosylationi24 – 241O-linked (GalNAc...)Sequence analysis
Glycosylationi30 – 301O-linked (GalNAc...)Sequence analysis
Glycosylationi34 – 341O-linked (GalNAc...)Sequence analysis
Glycosylationi46 – 461O-linked (GalNAc...)Sequence analysis
Glycosylationi47 – 471O-linked (GalNAc...)Sequence analysis
Glycosylationi51 – 511O-linked (GalNAc...)Sequence analysis
Glycosylationi52 – 521O-linked (GalNAc...)Sequence analysis
Glycosylationi54 – 541O-linked (GalNAc...)Sequence analysis
Glycosylationi55 – 551O-linked (GalNAc...)Sequence analysis
Glycosylationi59 – 591O-linked (GalNAc...)Sequence analysis
Glycosylationi60 – 601O-linked (GalNAc...)Sequence analysis
Glycosylationi62 – 621O-linked (GalNAc...)Sequence analysis
Glycosylationi63 – 631O-linked (GalNAc...)Sequence analysis
Glycosylationi66 – 661O-linked (GalNAc...)Sequence analysis
Glycosylationi67 – 671O-linked (GalNAc...)Sequence analysis
Glycosylationi68 – 681O-linked (GalNAc...)Sequence analysis

Post-translational modificationi

O-glycosylated.1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ96DR8.
PeptideAtlasiQ96DR8.
PRIDEiQ96DR8.

Expressioni

Tissue specificityi

Expressed in mammary, salivary glands and prostate. Also detected in lung. Mainly expressed in cancer cell lines of breast origin. Highly expressed in lymph node-positive compared with node-negative tumors. Detected in all lymph node containing metastatic cells.3 Publications

Gene expression databases

BgeeiENSG00000172551.
CleanExiHS_MUCL1.
ExpressionAtlasiQ96DR8. baseline and differential.
GenevisibleiQ96DR8. HS.

Organism-specific databases

HPAiHPA039093.

Interactioni

Protein-protein interaction databases

BioGridi125603. 15 interactions.
IntActiQ96DR8. 1 interaction.
STRINGi9606.ENSP00000311364.

Structurei

3D structure databases

ProteinModelPortaliQ96DR8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati46 – 5381
Repeati54 – 6182
Repeati62 – 6983

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni46 – 69243 X 8 AA tandem repeat of T-T-A-A-[APS]-T-T-AAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi23 – 6846Thr-richAdd
BLAST

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410KCKM. Eukaryota.
ENOG4110NV7. LUCA.
GeneTreeiENSGT00390000015427.
HOGENOMiHOG000113694.
InParanoidiQ96DR8.
OMAiFLVSAQN.
PhylomeDBiQ96DR8.
TreeFamiTF341044.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q96DR8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFLAVLVLL GVSIFLVSAQ NPTTAAPADT YPATGPADDE APDAETTAAA
60 70 80 90
TTATTAAPTT ATTAASTTAR KDIPVLPKWV GDLPNGRVCP
Length:90
Mass (Da):9,039
Last modified:December 1, 2001 - v1
Checksum:iFEA58A2833B07262
GO

Polymorphismi

The number of repeats varies from 3 to 2 in one variant form which is equally present in breast cancer tumors.1 Publication

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti46 – 538Missing .1 Publication
VAR_025700

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF414087 mRNA. Translation: AAL02119.1.
AY651259 mRNA. Translation: AAT72303.1.
AY359062 mRNA. Translation: AAQ89421.1.
BC111421 mRNA. Translation: AAI11422.1.
CCDSiCCDS8885.1.
RefSeqiNP_477521.1. NM_058173.2.
UniGeneiHs.348419.

Genome annotation databases

EnsembliENST00000308796; ENSP00000311364; ENSG00000172551.
GeneIDi118430.
KEGGihsa:118430.
UCSCiuc001sgk.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF414087 mRNA. Translation: AAL02119.1.
AY651259 mRNA. Translation: AAT72303.1.
AY359062 mRNA. Translation: AAQ89421.1.
BC111421 mRNA. Translation: AAI11422.1.
CCDSiCCDS8885.1.
RefSeqiNP_477521.1. NM_058173.2.
UniGeneiHs.348419.

3D structure databases

ProteinModelPortaliQ96DR8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125603. 15 interactions.
IntActiQ96DR8. 1 interaction.
STRINGi9606.ENSP00000311364.

Polymorphism and mutation databases

BioMutaiMUCL1.
DMDMi74731497.

Proteomic databases

PaxDbiQ96DR8.
PeptideAtlasiQ96DR8.
PRIDEiQ96DR8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000308796; ENSP00000311364; ENSG00000172551.
GeneIDi118430.
KEGGihsa:118430.
UCSCiuc001sgk.4. human.

Organism-specific databases

CTDi118430.
GeneCardsiMUCL1.
HGNCiHGNC:30588. MUCL1.
HPAiHPA039093.
MIMi610857. gene.
neXtProtiNX_Q96DR8.
PharmGKBiPA162396316.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410KCKM. Eukaryota.
ENOG4110NV7. LUCA.
GeneTreeiENSGT00390000015427.
HOGENOMiHOG000113694.
InParanoidiQ96DR8.
OMAiFLVSAQN.
PhylomeDBiQ96DR8.
TreeFamiTF341044.

Enzyme and pathway databases

ReactomeiR-HSA-5083625. Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC).
R-HSA-5083632. Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS).
R-HSA-5083636. Defective GALNT12 causes colorectal cancer 1 (CRCS1).
R-HSA-913709. O-linked glycosylation of mucins.
R-HSA-977068. Termination of O-glycan biosynthesis.

Miscellaneous databases

GeneWikiiMUCL1.
GenomeRNAii118430.
PROiQ96DR8.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000172551.
CleanExiHS_MUCL1.
ExpressionAtlasiQ96DR8. baseline and differential.
GenevisibleiQ96DR8. HS.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiMUCL1_HUMAN
AccessioniPrimary (citable) accession number: Q96DR8
Secondary accession number(s): Q0VG95, Q32ZB5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: December 1, 2001
Last modified: September 7, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.