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Protein

Mucin-like protein 1

Gene

MUCL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role as marker for the diagnosis of metastatic breast cancer.3 Publications

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-5083625 Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC)
R-HSA-5083632 Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)
R-HSA-5083636 Defective GALNT12 causes colorectal cancer 1 (CRCS1)
R-HSA-5621480 Dectin-2 family
R-HSA-913709 O-linked glycosylation of mucins
R-HSA-977068 Termination of O-glycan biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Mucin-like protein 1
Alternative name(s):
Protein BS106
Small breast epithelial mucin
Gene namesi
Name:MUCL1
Synonyms:SBEM
ORF Names:UNQ590/PRO1160
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000172551.10
HGNCiHGNC:30588 MUCL1
MIMi610857 gene
neXtProtiNX_Q96DR8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi118430
OpenTargetsiENSG00000172551
PharmGKBiPA162396316

Polymorphism and mutation databases

BioMutaiMUCL1
DMDMi74731497

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 201 PublicationAdd BLAST20
ChainiPRO_000022815921 – 90Mucin-like protein 1Add BLAST70

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi23O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi24O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi30O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi34O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi46O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi47O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi51O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi52O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi54O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi55O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi59O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi60O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi62O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi63O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi66O-linked (GalNAc...) serineSequence analysis1
Glycosylationi67O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi68O-linked (GalNAc...) threonineSequence analysis1

Post-translational modificationi

O-glycosylated.1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ96DR8
PeptideAtlasiQ96DR8
PRIDEiQ96DR8

Expressioni

Tissue specificityi

Expressed in mammary, salivary glands and prostate. Also detected in lung. Mainly expressed in cancer cell lines of breast origin. Highly expressed in lymph node-positive compared with node-negative tumors. Detected in all lymph node containing metastatic cells.3 Publications

Gene expression databases

BgeeiENSG00000172551
CleanExiHS_MUCL1
ExpressionAtlasiQ96DR8 baseline and differential
GenevisibleiQ96DR8 HS

Organism-specific databases

HPAiHPA039093

Interactioni

Protein-protein interaction databases

BioGridi125603, 21 interactors
IntActiQ96DR8, 1 interactor
MINTiQ96DR8
STRINGi9606.ENSP00000311364

Structurei

3D structure databases

ProteinModelPortaliQ96DR8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati46 – 5318
Repeati54 – 6128
Repeati62 – 6938

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni46 – 693 X 8 AA tandem repeat of T-T-A-A-[APS]-T-T-AAdd BLAST24

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi23 – 68Thr-richAdd BLAST46

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410KCKM Eukaryota
ENOG4110NV7 LUCA
GeneTreeiENSGT00390000015427
HOGENOMiHOG000113694
InParanoidiQ96DR8
OMAiFLVSAQN
PhylomeDBiQ96DR8
TreeFamiTF341044

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q96DR8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFLAVLVLL GVSIFLVSAQ NPTTAAPADT YPATGPADDE APDAETTAAA
60 70 80 90
TTATTAAPTT ATTAASTTAR KDIPVLPKWV GDLPNGRVCP
Length:90
Mass (Da):9,039
Last modified:December 1, 2001 - v1
Checksum:iFEA58A2833B07262
GO

Polymorphismi

The number of repeats varies from 3 to 2 in one variant form which is equally present in breast cancer tumors.1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02570046 – 53Missing 1 Publication8

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF414087 mRNA Translation: AAL02119.1
AY651259 mRNA Translation: AAT72303.1
AY359062 mRNA Translation: AAQ89421.1
BC111421 mRNA Translation: AAI11422.1
CCDSiCCDS8885.1
RefSeqiNP_477521.1, NM_058173.2
UniGeneiHs.348419

Genome annotation databases

EnsembliENST00000308796; ENSP00000311364; ENSG00000172551
GeneIDi118430
KEGGihsa:118430
UCSCiuc001sgk.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiMUCL1_HUMAN
AccessioniPrimary (citable) accession number: Q96DR8
Secondary accession number(s): Q0VG95, Q32ZB5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: December 1, 2001
Last modified: February 28, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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