Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q96DR7

- ARHGQ_HUMAN

UniProt

Q96DR7 - ARHGQ_HUMAN

Protein

Rho guanine nucleotide exchange factor 26

Gene

ARHGEF26

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 4 (11 Jan 2011)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Activates RhoG GTPase by promoting the exchange of GDP by GTP. Required for the formation of membrane ruffles during macropinocytosis. Required for the formation of cup-like structures during trans-endothelial migration of leukocytes. In case of Salmonella enterica infection, activated by SopB, which induces cytoskeleton rearrangements and promotes bacterial entry.3 Publications

    GO - Molecular functioni

    1. Rho guanyl-nucleotide exchange factor activity Source: InterPro

    Keywords - Molecular functioni

    Guanine-nucleotide releasing factor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Rho guanine nucleotide exchange factor 26
    Alternative name(s):
    SH3 domain-containing guanine exchange factor
    Gene namesi
    Name:ARHGEF26
    Synonyms:SGEF
    ORF Names:HMFN1864
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:24490. ARHGEF26.

    Subcellular locationi

    Cell projectionruffle 2 Publications

    GO - Cellular componenti

    1. ruffle Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell projection

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi826 – 8261W → R: Fails to localize at sites of membrane ruffling. 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 871871Rho guanine nucleotide exchange factor 26PRO_0000322568Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei22 – 221Phosphoserine1 Publication
    Modified residuei392 – 3921Phosphoserine2 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ96DR7.
    PaxDbiQ96DR7.
    PRIDEiQ96DR7.

    PTM databases

    PhosphoSiteiQ96DR7.

    Expressioni

    Tissue specificityi

    Isoform 1 is broadly expressed, with highest levels in liver (at protein level). Certain mRNA species appear to be specifically expressed in prostate and liver.2 Publications

    Inductioni

    Certain mRNA species appear to be up-regulated by androgens in prostate cancer cells.1 Publication

    Gene expression databases

    BgeeiQ96DR7.
    GenevestigatoriQ96DR7.

    Organism-specific databases

    HPAiHPA017722.

    Interactioni

    Subunit structurei

    Interacts with ICAM1 and RHOG.2 Publications

    Structurei

    3D structure databases

    ProteinModelPortaliQ96DR7.
    SMRiQ96DR7. Positions 433-849.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini439 – 623185DHPROSITE-ProRule annotationAdd
    BLAST
    Domaini655 – 782128PHPROSITE-ProRule annotationAdd
    BLAST
    Domaini789 – 85062SH3PROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi106 – 17368Pro-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 DH (DBL-homology) domain.PROSITE-ProRule annotation
    Contains 1 PH domain.PROSITE-ProRule annotation
    Contains 1 SH3 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    SH3 domain

    Phylogenomic databases

    eggNOGiCOG5422.
    HOVERGENiHBG059167.
    InParanoidiQ96DR7.
    KOiK13744.
    OMAiNSITPLW.
    OrthoDBiEOG73NG2P.
    PhylomeDBiQ96DR7.
    TreeFamiTF316357.

    Family and domain databases

    Gene3Di1.20.900.10. 1 hit.
    2.30.29.30. 1 hit.
    InterProiIPR000219. DH-domain.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    IPR001452. SH3_domain.
    [Graphical view]
    PfamiPF00169. PH. 1 hit.
    PF00621. RhoGEF. 1 hit.
    PF00018. SH3_1. 1 hit.
    [Graphical view]
    SMARTiSM00233. PH. 1 hit.
    SM00325. RhoGEF. 1 hit.
    SM00326. SH3. 1 hit.
    [Graphical view]
    SUPFAMiSSF48065. SSF48065. 1 hit.
    SSF50044. SSF50044. 1 hit.
    PROSITEiPS50010. DH_2. 1 hit.
    PS50003. PH_DOMAIN. 1 hit.
    PS50002. SH3. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q96DR7-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MDGESEVDFS SNSITPLWRR RSIPQPHQVL GRSKPRPQSY QSPNGLLITD    50
    FPVEDGGTLL AAQIPAQVPT ASDSRTVHRS PLLLGAQRRA VANGGTASPE 100
    YRAASPRLRR PKSPKLPKAV PGGSPKSPAN GAVTLPAPPP PPVLRPPRTP 150
    NAPAPCTPEE DLTGLTASPV PSPTANGLAA NNDSPGSGSQ SGRKAKDPER 200
    GLFPGPQKSS SEQKLPLQRL PSQENELLEN PSVVLSTNSP AALKVGKQQI 250
    IPKSLASEIK ISKSNNQNVE PHKRLLKVRS MVEGLGGPLG HAGEESEVDN 300
    DVDSPGSLRR GLRSTSYRRA VVSGFDFDSP TSSKKKNRMS QPVLKVVMED 350
    KEKFSSLGRI KKKMLKGQGT FDGEENAVLY QNYKEKALDI DSDEESEPKE 400
    QKSDEKIVIH HKPLRSTWSQ LSAVKRKGLS QTVSQEERKR QEAIFEVISS 450
    EHSYLLSLEI LIRMFKNSKE LSDTMTKTER HHLFSNITDV CEASKKFFIE 500
    LEARHQNNIF IDDISDIVEK HTASTFDPYV KYCTNEVYQQ RTLQKLLATN 550
    PSFKEVLSRI ESHEDCRNLP MISFLILPMQ RVTRLPLLMD TICQKTPKDS 600
    PKYEVCKRAL KEVSKLVRLC NEGARKMERT EMMYTINSQL EFKIKPFPLV 650
    SSSRWLVKRG ELTAYVEDTV LFSRRTSKQQ VYFFLFNDVL IITKKKSEES 700
    YNVNDYSLRD QLLVESCDNE ELNSSPGKNS STMLYSRQSS ASHLFTLTVL 750
    SNHANEKVEM LLGAETQSER ARWITALGHS SGKPPADRTS LTQVEIVRSF 800
    TAKQPDELSL QVADVVLIYQ RVSDGWYEGE RLRDGERGWF PMECAKEITC 850
    QATIDKNVER MGRLLGLETN V 871
    Length:871
    Mass (Da):97,346
    Last modified:January 11, 2011 - v4
    Checksum:iE6EB57BAE7DD224B
    GO
    Isoform 2 (identifier: Q96DR7-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         428-446: GLSQTVSQEERKRQEAIFE → VILIVGFMEMKDGRLRGGK
         447-871: Missing.

    Show »
    Length:446
    Mass (Da):48,168
    Checksum:i4D112FF2EDBD3C26
    GO
    Isoform 3 (identifier: Q96DR7-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         790-871: SLTQVEIVRS...GRLLGLETNV → CG

    Note: No experimental confirmation available.

    Show »
    Length:791
    Mass (Da):88,134
    Checksum:i3722051098F4B67B
    GO

    Sequence cautioni

    The sequence AAL27002.1 differs from that shown. Reason: Intron retention.
    The sequence AAH16628.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence BAB14159.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence BAB14292.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti60 – 601L → S in AAL27001. (PubMed:12697679)Curated
    Sequence conflicti60 – 601L → S in AAS59842. (PubMed:15133129)Curated
    Sequence conflicti60 – 601L → S in BAG53860. (PubMed:14702039)Curated
    Sequence conflicti60 – 601L → S in AAH78655. (PubMed:15489334)Curated
    Sequence conflicti687 – 6871N → K in AAH16628. (PubMed:15489334)Curated
    Sequence conflicti707 – 7071S → T in AAH78655. (PubMed:15489334)Curated
    Sequence conflicti781 – 7811S → R in AAL27001. (PubMed:12697679)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti29 – 291V → L.6 Publications
    Corresponds to variant rs12493885 [ dbSNP | Ensembl ].
    VAR_039425
    Natural varianti60 – 601L → P.1 Publication
    Corresponds to variant rs12497267 [ dbSNP | Ensembl ].
    VAR_058205
    Natural varianti203 – 2031F → S.1 Publication
    Corresponds to variant rs13096373 [ dbSNP | Ensembl ].
    VAR_039426

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei428 – 44619GLSQT…EAIFE → VILIVGFMEMKDGRLRGGK in isoform 2. 1 PublicationVSP_031934Add
    BLAST
    Alternative sequencei447 – 871425Missing in isoform 2. 1 PublicationVSP_031935Add
    BLAST
    Alternative sequencei790 – 87182SLTQV…LETNV → CG in isoform 3. 1 PublicationVSP_045570Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF415175 mRNA. Translation: AAL27001.1.
    AF415176 mRNA. Translation: AAL27002.1. Sequence problems.
    AY552599 mRNA. Translation: AAS59842.1.
    AK022655 mRNA. Translation: BAB14159.1. Different initiation.
    AK022884 mRNA. Translation: BAB14292.1. Different initiation.
    AK123040 mRNA. Translation: BAG53860.1.
    AB073386 mRNA. Translation: BAD38637.1.
    AC018452 Genomic DNA. No translation available.
    FJ695204 Genomic DNA. No translation available.
    BC016628 mRNA. Translation: AAH16628.1. Different initiation.
    BC078655 mRNA. Translation: AAH78655.1.
    AL117429 mRNA. Translation: CAB55918.1.
    CCDSiCCDS46938.1. [Q96DR7-1]
    CCDS58858.1. [Q96DR7-4]
    PIRiT17228.
    RefSeqiNP_001238891.1. NM_001251962.1. [Q96DR7-1]
    NP_001238892.1. NM_001251963.1. [Q96DR7-4]
    NP_056410.3. NM_015595.3. [Q96DR7-1]
    UniGeneiHs.240845.

    Genome annotation databases

    EnsembliENST00000356448; ENSP00000348828; ENSG00000114790. [Q96DR7-1]
    ENST00000465093; ENSP00000423418; ENSG00000114790. [Q96DR7-1]
    ENST00000465817; ENSP00000423295; ENSG00000114790. [Q96DR7-3]
    ENST00000496710; ENSP00000424446; ENSG00000114790. [Q96DR7-4]
    GeneIDi26084.
    KEGGihsa:26084.
    UCSCiuc011bog.1. human. [Q96DR7-1]

    Polymorphism databases

    DMDMi317373555.

    Keywords - Coding sequence diversityi

    Alternative promoter usage, Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF415175 mRNA. Translation: AAL27001.1 .
    AF415176 mRNA. Translation: AAL27002.1 . Sequence problems.
    AY552599 mRNA. Translation: AAS59842.1 .
    AK022655 mRNA. Translation: BAB14159.1 . Different initiation.
    AK022884 mRNA. Translation: BAB14292.1 . Different initiation.
    AK123040 mRNA. Translation: BAG53860.1 .
    AB073386 mRNA. Translation: BAD38637.1 .
    AC018452 Genomic DNA. No translation available.
    FJ695204 Genomic DNA. No translation available.
    BC016628 mRNA. Translation: AAH16628.1 . Different initiation.
    BC078655 mRNA. Translation: AAH78655.1 .
    AL117429 mRNA. Translation: CAB55918.1 .
    CCDSi CCDS46938.1. [Q96DR7-1 ]
    CCDS58858.1. [Q96DR7-4 ]
    PIRi T17228.
    RefSeqi NP_001238891.1. NM_001251962.1. [Q96DR7-1 ]
    NP_001238892.1. NM_001251963.1. [Q96DR7-4 ]
    NP_056410.3. NM_015595.3. [Q96DR7-1 ]
    UniGenei Hs.240845.

    3D structure databases

    ProteinModelPortali Q96DR7.
    SMRi Q96DR7. Positions 433-849.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q96DR7.

    Polymorphism databases

    DMDMi 317373555.

    Proteomic databases

    MaxQBi Q96DR7.
    PaxDbi Q96DR7.
    PRIDEi Q96DR7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000356448 ; ENSP00000348828 ; ENSG00000114790 . [Q96DR7-1 ]
    ENST00000465093 ; ENSP00000423418 ; ENSG00000114790 . [Q96DR7-1 ]
    ENST00000465817 ; ENSP00000423295 ; ENSG00000114790 . [Q96DR7-3 ]
    ENST00000496710 ; ENSP00000424446 ; ENSG00000114790 . [Q96DR7-4 ]
    GeneIDi 26084.
    KEGGi hsa:26084.
    UCSCi uc011bog.1. human. [Q96DR7-1 ]

    Organism-specific databases

    CTDi 26084.
    GeneCardsi GC03P153839.
    H-InvDB HIX0003789.
    HGNCi HGNC:24490. ARHGEF26.
    HPAi HPA017722.
    neXtProti NX_Q96DR7.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5422.
    HOVERGENi HBG059167.
    InParanoidi Q96DR7.
    KOi K13744.
    OMAi NSITPLW.
    OrthoDBi EOG73NG2P.
    PhylomeDBi Q96DR7.
    TreeFami TF316357.

    Miscellaneous databases

    GenomeRNAii 26084.
    NextBioi 48000.
    PROi Q96DR7.

    Gene expression databases

    Bgeei Q96DR7.
    Genevestigatori Q96DR7.

    Family and domain databases

    Gene3Di 1.20.900.10. 1 hit.
    2.30.29.30. 1 hit.
    InterProi IPR000219. DH-domain.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    IPR001452. SH3_domain.
    [Graphical view ]
    Pfami PF00169. PH. 1 hit.
    PF00621. RhoGEF. 1 hit.
    PF00018. SH3_1. 1 hit.
    [Graphical view ]
    SMARTi SM00233. PH. 1 hit.
    SM00325. RhoGEF. 1 hit.
    SM00326. SH3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48065. SSF48065. 1 hit.
    SSF50044. SSF50044. 1 hit.
    PROSITEi PS50010. DH_2. 1 hit.
    PS50003. PH_DOMAIN. 1 hit.
    PS50002. SH3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation of the novel human guanine nucleotide exchange factor Src homology 3 domain-containing guanine nucleotide exchange factor (SGEF) and of C-terminal SGEF, an N-terminally truncated form of SGEF, the expression of which is regulated by androgen in prostate cancer cells."
      Qi H., Fournier A., Grenier J., Fillion C., Labrie Y., Labrie C.
      Endocrinology 144:1742-1752(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, INDUCTION, VARIANT LEU-29.
      Tissue: Prostatic carcinoma.
    2. "SGEF, a RhoG guanine nucleotide exchange factor that stimulates macropinocytosis."
      Ellerbroek S.M., Wennerberg K., Arthur W.T., Dunty J.M., Bowman D.R., DeMali K.A., Der C., Burridge K.
      Mol. Biol. Cell 15:3309-3319(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, INTERACTION WITH RHOG, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, MUTAGENESIS OF TRP-826, VARIANT LEU-29.
      Tissue: Brain.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 402-871 (ISOFORM 1), VARIANT LEU-29.
    4. "Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas."
      Yamada S., Ohira M., Horie H., Ando K., Takayasu H., Suzuki Y., Sugano S., Hirata T., Goto T., Matsunaga T., Hiyama E., Hayashi Y., Ando H., Suita S., Kaneko M., Sasaki F., Hashizume K., Ohnuma N., Nakagawara A.
      Oncogene 23:5901-5911(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANTS LEU-29; PRO-60 AND SER-203.
      Tissue: Liver.
    5. "The DNA sequence, annotation and analysis of human chromosome 3."
      Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
      , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
      Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT LEU-29.
      Tissue: Prostate and Testis.
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 661-871 (ISOFORM 1).
      Tissue: Testis.
    8. "Differential activation and function of Rho GTPases during Salmonella-host cell interactions."
      Patel J.C., Galan J.E.
      J. Cell Biol. 175:453-463(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    9. "RhoG regulates endothelial apical cup assembly downstream from ICAM1 engagement and is involved in leukocyte trans-endothelial migration."
      van Buul J.D., Allingham M.J., Samson T., Meller J., Boulter E., Garcia-Mata R., Burridge K.
      J. Cell Biol. 178:1279-1293(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH ICAM1, SUBCELLULAR LOCATION.
    10. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-392, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    11. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-22 AND SER-392, VARIANT [LARGE SCALE ANALYSIS] LEU-29, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiARHGQ_HUMAN
    AccessioniPrimary (citable) accession number: Q96DR7
    Secondary accession number(s): B3KVP8
    , E9PBD0, Q68CL1, Q6AZ96, Q6Q8Q8, Q96AW8, Q96DR6, Q9H9D7, Q9H9R2, Q9UFW5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 26, 2008
    Last sequence update: January 11, 2011
    Last modified: October 1, 2014
    This is version 94 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3