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Q96DR7

- ARHGQ_HUMAN

UniProt

Q96DR7 - ARHGQ_HUMAN

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Protein

Rho guanine nucleotide exchange factor 26

Gene
ARHGEF26, SGEF, HMFN1864
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Activates RhoG GTPase by promoting the exchange of GDP by GTP. Required for the formation of membrane ruffles during macropinocytosis. Required for the formation of cup-like structures during trans-endothelial migration of leukocytes. In case of Salmonella enterica infection, activated by SopB, which induces cytoskeleton rearrangements and promotes bacterial entry.3 Publications

GO - Molecular functioni

  1. Rho guanyl-nucleotide exchange factor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Guanine-nucleotide releasing factor

Names & Taxonomyi

Protein namesi
Recommended name:
Rho guanine nucleotide exchange factor 26
Alternative name(s):
SH3 domain-containing guanine exchange factor
Gene namesi
Synonyms:SGEF
ORF Names:HMFN1864
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:24490. ARHGEF26.

Subcellular locationi

Cell projectionruffle 2 Publications

GO - Cellular componenti

  1. ruffle Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell projection

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi826 – 8261W → R: Fails to localize at sites of membrane ruffling. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 871871Rho guanine nucleotide exchange factor 26PRO_0000322568Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei22 – 221Phosphoserine1 Publication
Modified residuei392 – 3921Phosphoserine2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ96DR7.
PaxDbiQ96DR7.
PRIDEiQ96DR7.

PTM databases

PhosphoSiteiQ96DR7.

Expressioni

Tissue specificityi

Isoform 1 is broadly expressed, with highest levels in liver (at protein level). Certain mRNA species appear to be specifically expressed in prostate and liver.2 Publications

Inductioni

Certain mRNA species appear to be up-regulated by androgens in prostate cancer cells.1 Publication

Gene expression databases

BgeeiQ96DR7.
GenevestigatoriQ96DR7.

Organism-specific databases

HPAiHPA017722.

Interactioni

Subunit structurei

Interacts with ICAM1 and RHOG.2 Publications

Structurei

3D structure databases

ProteinModelPortaliQ96DR7.
SMRiQ96DR7. Positions 433-849.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini439 – 623185DHAdd
BLAST
Domaini655 – 782128PHAdd
BLAST
Domaini789 – 85062SH3Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi106 – 17368Pro-richAdd
BLAST

Sequence similaritiesi

Contains 1 PH domain.
Contains 1 SH3 domain.

Keywords - Domaini

SH3 domain

Phylogenomic databases

eggNOGiCOG5422.
HOVERGENiHBG059167.
InParanoidiQ96DR7.
KOiK13744.
OMAiNSITPLW.
OrthoDBiEOG73NG2P.
PhylomeDBiQ96DR7.
TreeFamiTF316357.

Family and domain databases

Gene3Di1.20.900.10. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR000219. DH-domain.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00169. PH. 1 hit.
PF00621. RhoGEF. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
SM00325. RhoGEF. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF48065. SSF48065. 1 hit.
SSF50044. SSF50044. 1 hit.
PROSITEiPS50010. DH_2. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q96DR7-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MDGESEVDFS SNSITPLWRR RSIPQPHQVL GRSKPRPQSY QSPNGLLITD    50
FPVEDGGTLL AAQIPAQVPT ASDSRTVHRS PLLLGAQRRA VANGGTASPE 100
YRAASPRLRR PKSPKLPKAV PGGSPKSPAN GAVTLPAPPP PPVLRPPRTP 150
NAPAPCTPEE DLTGLTASPV PSPTANGLAA NNDSPGSGSQ SGRKAKDPER 200
GLFPGPQKSS SEQKLPLQRL PSQENELLEN PSVVLSTNSP AALKVGKQQI 250
IPKSLASEIK ISKSNNQNVE PHKRLLKVRS MVEGLGGPLG HAGEESEVDN 300
DVDSPGSLRR GLRSTSYRRA VVSGFDFDSP TSSKKKNRMS QPVLKVVMED 350
KEKFSSLGRI KKKMLKGQGT FDGEENAVLY QNYKEKALDI DSDEESEPKE 400
QKSDEKIVIH HKPLRSTWSQ LSAVKRKGLS QTVSQEERKR QEAIFEVISS 450
EHSYLLSLEI LIRMFKNSKE LSDTMTKTER HHLFSNITDV CEASKKFFIE 500
LEARHQNNIF IDDISDIVEK HTASTFDPYV KYCTNEVYQQ RTLQKLLATN 550
PSFKEVLSRI ESHEDCRNLP MISFLILPMQ RVTRLPLLMD TICQKTPKDS 600
PKYEVCKRAL KEVSKLVRLC NEGARKMERT EMMYTINSQL EFKIKPFPLV 650
SSSRWLVKRG ELTAYVEDTV LFSRRTSKQQ VYFFLFNDVL IITKKKSEES 700
YNVNDYSLRD QLLVESCDNE ELNSSPGKNS STMLYSRQSS ASHLFTLTVL 750
SNHANEKVEM LLGAETQSER ARWITALGHS SGKPPADRTS LTQVEIVRSF 800
TAKQPDELSL QVADVVLIYQ RVSDGWYEGE RLRDGERGWF PMECAKEITC 850
QATIDKNVER MGRLLGLETN V 871
Length:871
Mass (Da):97,346
Last modified:January 11, 2011 - v4
Checksum:iE6EB57BAE7DD224B
GO
Isoform 2 (identifier: Q96DR7-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     428-446: GLSQTVSQEERKRQEAIFE → VILIVGFMEMKDGRLRGGK
     447-871: Missing.

Show »
Length:446
Mass (Da):48,168
Checksum:i4D112FF2EDBD3C26
GO
Isoform 3 (identifier: Q96DR7-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     790-871: SLTQVEIVRS...GRLLGLETNV → CG

Note: No experimental confirmation available.

Show »
Length:791
Mass (Da):88,134
Checksum:i3722051098F4B67B
GO

Sequence cautioni

The sequence AAL27002.1 differs from that shown. Reason: Intron retention.
The sequence AAH16628.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence BAB14159.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence BAB14292.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti29 – 291V → L.6 Publications
Corresponds to variant rs12493885 [ dbSNP | Ensembl ].
VAR_039425
Natural varianti60 – 601L → P.1 Publication
Corresponds to variant rs12497267 [ dbSNP | Ensembl ].
VAR_058205
Natural varianti203 – 2031F → S.1 Publication
Corresponds to variant rs13096373 [ dbSNP | Ensembl ].
VAR_039426

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei428 – 44619GLSQT…EAIFE → VILIVGFMEMKDGRLRGGK in isoform 2. VSP_031934Add
BLAST
Alternative sequencei447 – 871425Missing in isoform 2. VSP_031935Add
BLAST
Alternative sequencei790 – 87182SLTQV…LETNV → CG in isoform 3. VSP_045570Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti60 – 601L → S in AAL27001. 1 Publication
Sequence conflicti60 – 601L → S in AAS59842. 1 Publication
Sequence conflicti60 – 601L → S in BAG53860. 1 Publication
Sequence conflicti60 – 601L → S in AAH78655. 1 Publication
Sequence conflicti687 – 6871N → K in AAH16628. 1 Publication
Sequence conflicti707 – 7071S → T in AAH78655. 1 Publication
Sequence conflicti781 – 7811S → R in AAL27001. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF415175 mRNA. Translation: AAL27001.1.
AF415176 mRNA. Translation: AAL27002.1. Sequence problems.
AY552599 mRNA. Translation: AAS59842.1.
AK022655 mRNA. Translation: BAB14159.1. Different initiation.
AK022884 mRNA. Translation: BAB14292.1. Different initiation.
AK123040 mRNA. Translation: BAG53860.1.
AB073386 mRNA. Translation: BAD38637.1.
AC018452 Genomic DNA. No translation available.
FJ695204 Genomic DNA. No translation available.
BC016628 mRNA. Translation: AAH16628.1. Different initiation.
BC078655 mRNA. Translation: AAH78655.1.
AL117429 mRNA. Translation: CAB55918.1.
CCDSiCCDS46938.1. [Q96DR7-1]
CCDS58858.1. [Q96DR7-4]
PIRiT17228.
RefSeqiNP_001238891.1. NM_001251962.1. [Q96DR7-1]
NP_001238892.1. NM_001251963.1. [Q96DR7-4]
NP_056410.3. NM_015595.3. [Q96DR7-1]
UniGeneiHs.240845.

Genome annotation databases

EnsembliENST00000356448; ENSP00000348828; ENSG00000114790. [Q96DR7-1]
ENST00000465093; ENSP00000423418; ENSG00000114790. [Q96DR7-1]
ENST00000465817; ENSP00000423295; ENSG00000114790. [Q96DR7-3]
ENST00000496710; ENSP00000424446; ENSG00000114790. [Q96DR7-4]
GeneIDi26084.
KEGGihsa:26084.
UCSCiuc011bog.1. human. [Q96DR7-1]

Polymorphism databases

DMDMi317373555.

Keywords - Coding sequence diversityi

Alternative promoter usage, Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF415175 mRNA. Translation: AAL27001.1 .
AF415176 mRNA. Translation: AAL27002.1 . Sequence problems.
AY552599 mRNA. Translation: AAS59842.1 .
AK022655 mRNA. Translation: BAB14159.1 . Different initiation.
AK022884 mRNA. Translation: BAB14292.1 . Different initiation.
AK123040 mRNA. Translation: BAG53860.1 .
AB073386 mRNA. Translation: BAD38637.1 .
AC018452 Genomic DNA. No translation available.
FJ695204 Genomic DNA. No translation available.
BC016628 mRNA. Translation: AAH16628.1 . Different initiation.
BC078655 mRNA. Translation: AAH78655.1 .
AL117429 mRNA. Translation: CAB55918.1 .
CCDSi CCDS46938.1. [Q96DR7-1 ]
CCDS58858.1. [Q96DR7-4 ]
PIRi T17228.
RefSeqi NP_001238891.1. NM_001251962.1. [Q96DR7-1 ]
NP_001238892.1. NM_001251963.1. [Q96DR7-4 ]
NP_056410.3. NM_015595.3. [Q96DR7-1 ]
UniGenei Hs.240845.

3D structure databases

ProteinModelPortali Q96DR7.
SMRi Q96DR7. Positions 433-849.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q96DR7.

Polymorphism databases

DMDMi 317373555.

Proteomic databases

MaxQBi Q96DR7.
PaxDbi Q96DR7.
PRIDEi Q96DR7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000356448 ; ENSP00000348828 ; ENSG00000114790 . [Q96DR7-1 ]
ENST00000465093 ; ENSP00000423418 ; ENSG00000114790 . [Q96DR7-1 ]
ENST00000465817 ; ENSP00000423295 ; ENSG00000114790 . [Q96DR7-3 ]
ENST00000496710 ; ENSP00000424446 ; ENSG00000114790 . [Q96DR7-4 ]
GeneIDi 26084.
KEGGi hsa:26084.
UCSCi uc011bog.1. human. [Q96DR7-1 ]

Organism-specific databases

CTDi 26084.
GeneCardsi GC03P153839.
H-InvDB HIX0003789.
HGNCi HGNC:24490. ARHGEF26.
HPAi HPA017722.
neXtProti NX_Q96DR7.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5422.
HOVERGENi HBG059167.
InParanoidi Q96DR7.
KOi K13744.
OMAi NSITPLW.
OrthoDBi EOG73NG2P.
PhylomeDBi Q96DR7.
TreeFami TF316357.

Miscellaneous databases

GenomeRNAii 26084.
NextBioi 48000.
PROi Q96DR7.

Gene expression databases

Bgeei Q96DR7.
Genevestigatori Q96DR7.

Family and domain databases

Gene3Di 1.20.900.10. 1 hit.
2.30.29.30. 1 hit.
InterProi IPR000219. DH-domain.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR001452. SH3_domain.
[Graphical view ]
Pfami PF00169. PH. 1 hit.
PF00621. RhoGEF. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view ]
SMARTi SM00233. PH. 1 hit.
SM00325. RhoGEF. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view ]
SUPFAMi SSF48065. SSF48065. 1 hit.
SSF50044. SSF50044. 1 hit.
PROSITEi PS50010. DH_2. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation of the novel human guanine nucleotide exchange factor Src homology 3 domain-containing guanine nucleotide exchange factor (SGEF) and of C-terminal SGEF, an N-terminally truncated form of SGEF, the expression of which is regulated by androgen in prostate cancer cells."
    Qi H., Fournier A., Grenier J., Fillion C., Labrie Y., Labrie C.
    Endocrinology 144:1742-1752(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, INDUCTION, VARIANT LEU-29.
    Tissue: Prostatic carcinoma.
  2. "SGEF, a RhoG guanine nucleotide exchange factor that stimulates macropinocytosis."
    Ellerbroek S.M., Wennerberg K., Arthur W.T., Dunty J.M., Bowman D.R., DeMali K.A., Der C., Burridge K.
    Mol. Biol. Cell 15:3309-3319(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, INTERACTION WITH RHOG, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, MUTAGENESIS OF TRP-826, VARIANT LEU-29.
    Tissue: Brain.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 402-871 (ISOFORM 1), VARIANT LEU-29.
  4. "Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas."
    Yamada S., Ohira M., Horie H., Ando K., Takayasu H., Suzuki Y., Sugano S., Hirata T., Goto T., Matsunaga T., Hiyama E., Hayashi Y., Ando H., Suita S., Kaneko M., Sasaki F., Hashizume K., Ohnuma N., Nakagawara A.
    Oncogene 23:5901-5911(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANTS LEU-29; PRO-60 AND SER-203.
    Tissue: Liver.
  5. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT LEU-29.
    Tissue: Prostate and Testis.
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 661-871 (ISOFORM 1).
    Tissue: Testis.
  8. "Differential activation and function of Rho GTPases during Salmonella-host cell interactions."
    Patel J.C., Galan J.E.
    J. Cell Biol. 175:453-463(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  9. "RhoG regulates endothelial apical cup assembly downstream from ICAM1 engagement and is involved in leukocyte trans-endothelial migration."
    van Buul J.D., Allingham M.J., Samson T., Meller J., Boulter E., Garcia-Mata R., Burridge K.
    J. Cell Biol. 178:1279-1293(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH ICAM1, SUBCELLULAR LOCATION.
  10. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-392, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  11. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-22 AND SER-392, VARIANT [LARGE SCALE ANALYSIS] LEU-29, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiARHGQ_HUMAN
AccessioniPrimary (citable) accession number: Q96DR7
Secondary accession number(s): B3KVP8
, E9PBD0, Q68CL1, Q6AZ96, Q6Q8Q8, Q96AW8, Q96DR6, Q9H9D7, Q9H9R2, Q9UFW5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: January 11, 2011
Last modified: September 3, 2014
This is version 93 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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