Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q96DR7

- ARHGQ_HUMAN

UniProt

Q96DR7 - ARHGQ_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Rho guanine nucleotide exchange factor 26

Gene

ARHGEF26

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Activates RhoG GTPase by promoting the exchange of GDP by GTP. Required for the formation of membrane ruffles during macropinocytosis. Required for the formation of cup-like structures during trans-endothelial migration of leukocytes. In case of Salmonella enterica infection, activated by SopB, which induces cytoskeleton rearrangements and promotes bacterial entry.3 Publications

GO - Molecular functioni

  1. Rho guanyl-nucleotide exchange factor activity Source: InterPro

GO - Biological processi

  1. endothelial cell morphogenesis Source: Ensembl
  2. ruffle assembly Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Guanine-nucleotide releasing factor

Names & Taxonomyi

Protein namesi
Recommended name:
Rho guanine nucleotide exchange factor 26
Alternative name(s):
SH3 domain-containing guanine exchange factor
Gene namesi
Name:ARHGEF26
Synonyms:SGEF
ORF Names:HMFN1864
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:24490. ARHGEF26.

Subcellular locationi

Cell projectionruffle 2 Publications

GO - Cellular componenti

  1. cell projection Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell projection

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi826 – 8261W → R: Fails to localize at sites of membrane ruffling. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 871871Rho guanine nucleotide exchange factor 26PRO_0000322568Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei22 – 221Phosphoserine1 Publication
Modified residuei392 – 3921Phosphoserine2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ96DR7.
PaxDbiQ96DR7.
PRIDEiQ96DR7.

PTM databases

PhosphoSiteiQ96DR7.

Expressioni

Tissue specificityi

Isoform 1 is broadly expressed, with highest levels in liver (at protein level). Certain mRNA species appear to be specifically expressed in prostate and liver.2 Publications

Inductioni

Certain mRNA species appear to be up-regulated by androgens in prostate cancer cells.1 Publication

Gene expression databases

BgeeiQ96DR7.
GenevestigatoriQ96DR7.

Organism-specific databases

HPAiHPA017722.

Interactioni

Subunit structurei

Interacts with ICAM1 and RHOG.2 Publications

Protein-protein interaction databases

BioGridi117537. 9 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ96DR7.
SMRiQ96DR7. Positions 433-849.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini439 – 623185DHPROSITE-ProRule annotationAdd
BLAST
Domaini655 – 782128PHPROSITE-ProRule annotationAdd
BLAST
Domaini789 – 85062SH3PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi106 – 17368Pro-richAdd
BLAST

Sequence similaritiesi

Contains 1 DH (DBL-homology) domain.PROSITE-ProRule annotation
Contains 1 PH domain.PROSITE-ProRule annotation
Contains 1 SH3 domain.PROSITE-ProRule annotation

Keywords - Domaini

SH3 domain

Phylogenomic databases

eggNOGiCOG5422.
GeneTreeiENSGT00550000074493.
HOVERGENiHBG059167.
InParanoidiQ96DR7.
KOiK13744.
OMAiNSITPLW.
OrthoDBiEOG73NG2P.
PhylomeDBiQ96DR7.
TreeFamiTF316357.

Family and domain databases

Gene3Di1.20.900.10. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR000219. DH-domain.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00169. PH. 1 hit.
PF00621. RhoGEF. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
SM00325. RhoGEF. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF48065. SSF48065. 1 hit.
SSF50044. SSF50044. 1 hit.
PROSITEiPS50010. DH_2. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q96DR7-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDGESEVDFS SNSITPLWRR RSIPQPHQVL GRSKPRPQSY QSPNGLLITD
60 70 80 90 100
FPVEDGGTLL AAQIPAQVPT ASDSRTVHRS PLLLGAQRRA VANGGTASPE
110 120 130 140 150
YRAASPRLRR PKSPKLPKAV PGGSPKSPAN GAVTLPAPPP PPVLRPPRTP
160 170 180 190 200
NAPAPCTPEE DLTGLTASPV PSPTANGLAA NNDSPGSGSQ SGRKAKDPER
210 220 230 240 250
GLFPGPQKSS SEQKLPLQRL PSQENELLEN PSVVLSTNSP AALKVGKQQI
260 270 280 290 300
IPKSLASEIK ISKSNNQNVE PHKRLLKVRS MVEGLGGPLG HAGEESEVDN
310 320 330 340 350
DVDSPGSLRR GLRSTSYRRA VVSGFDFDSP TSSKKKNRMS QPVLKVVMED
360 370 380 390 400
KEKFSSLGRI KKKMLKGQGT FDGEENAVLY QNYKEKALDI DSDEESEPKE
410 420 430 440 450
QKSDEKIVIH HKPLRSTWSQ LSAVKRKGLS QTVSQEERKR QEAIFEVISS
460 470 480 490 500
EHSYLLSLEI LIRMFKNSKE LSDTMTKTER HHLFSNITDV CEASKKFFIE
510 520 530 540 550
LEARHQNNIF IDDISDIVEK HTASTFDPYV KYCTNEVYQQ RTLQKLLATN
560 570 580 590 600
PSFKEVLSRI ESHEDCRNLP MISFLILPMQ RVTRLPLLMD TICQKTPKDS
610 620 630 640 650
PKYEVCKRAL KEVSKLVRLC NEGARKMERT EMMYTINSQL EFKIKPFPLV
660 670 680 690 700
SSSRWLVKRG ELTAYVEDTV LFSRRTSKQQ VYFFLFNDVL IITKKKSEES
710 720 730 740 750
YNVNDYSLRD QLLVESCDNE ELNSSPGKNS STMLYSRQSS ASHLFTLTVL
760 770 780 790 800
SNHANEKVEM LLGAETQSER ARWITALGHS SGKPPADRTS LTQVEIVRSF
810 820 830 840 850
TAKQPDELSL QVADVVLIYQ RVSDGWYEGE RLRDGERGWF PMECAKEITC
860 870
QATIDKNVER MGRLLGLETN V
Length:871
Mass (Da):97,346
Last modified:January 11, 2011 - v4
Checksum:iE6EB57BAE7DD224B
GO
Isoform 2 (identifier: Q96DR7-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     428-446: GLSQTVSQEERKRQEAIFE → VILIVGFMEMKDGRLRGGK
     447-871: Missing.

Show »
Length:446
Mass (Da):48,168
Checksum:i4D112FF2EDBD3C26
GO
Isoform 3 (identifier: Q96DR7-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     790-871: SLTQVEIVRS...GRLLGLETNV → CG

Note: No experimental confirmation available.

Show »
Length:791
Mass (Da):88,134
Checksum:i3722051098F4B67B
GO

Sequence cautioni

The sequence AAL27002.1 differs from that shown. Reason: Intron retention.
The sequence AAH16628.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence BAB14159.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence BAB14292.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti60 – 601L → S in AAL27001. (PubMed:12697679)Curated
Sequence conflicti60 – 601L → S in AAS59842. (PubMed:15133129)Curated
Sequence conflicti60 – 601L → S in BAG53860. (PubMed:14702039)Curated
Sequence conflicti60 – 601L → S in AAH78655. (PubMed:15489334)Curated
Sequence conflicti687 – 6871N → K in AAH16628. (PubMed:15489334)Curated
Sequence conflicti707 – 7071S → T in AAH78655. (PubMed:15489334)Curated
Sequence conflicti781 – 7811S → R in AAL27001. (PubMed:12697679)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti29 – 291V → L.6 Publications
Corresponds to variant rs12493885 [ dbSNP | Ensembl ].
VAR_039425
Natural varianti60 – 601L → P.1 Publication
Corresponds to variant rs12497267 [ dbSNP | Ensembl ].
VAR_058205
Natural varianti203 – 2031F → S.1 Publication
Corresponds to variant rs13096373 [ dbSNP | Ensembl ].
VAR_039426

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei428 – 44619GLSQT…EAIFE → VILIVGFMEMKDGRLRGGK in isoform 2. 1 PublicationVSP_031934Add
BLAST
Alternative sequencei447 – 871425Missing in isoform 2. 1 PublicationVSP_031935Add
BLAST
Alternative sequencei790 – 87182SLTQV…LETNV → CG in isoform 3. 1 PublicationVSP_045570Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF415175 mRNA. Translation: AAL27001.1.
AF415176 mRNA. Translation: AAL27002.1. Sequence problems.
AY552599 mRNA. Translation: AAS59842.1.
AK022655 mRNA. Translation: BAB14159.1. Different initiation.
AK022884 mRNA. Translation: BAB14292.1. Different initiation.
AK123040 mRNA. Translation: BAG53860.1.
AB073386 mRNA. Translation: BAD38637.1.
AC018452 Genomic DNA. No translation available.
FJ695204 Genomic DNA. No translation available.
BC016628 mRNA. Translation: AAH16628.1. Different initiation.
BC078655 mRNA. Translation: AAH78655.1.
AL117429 mRNA. Translation: CAB55918.1.
CCDSiCCDS46938.1. [Q96DR7-1]
CCDS58858.1. [Q96DR7-4]
PIRiT17228.
RefSeqiNP_001238891.1. NM_001251962.1. [Q96DR7-1]
NP_001238892.1. NM_001251963.1. [Q96DR7-4]
NP_056410.3. NM_015595.3. [Q96DR7-1]
UniGeneiHs.240845.

Genome annotation databases

EnsembliENST00000356448; ENSP00000348828; ENSG00000114790. [Q96DR7-1]
ENST00000465093; ENSP00000423418; ENSG00000114790. [Q96DR7-1]
ENST00000465817; ENSP00000423295; ENSG00000114790. [Q96DR7-3]
ENST00000496710; ENSP00000424446; ENSG00000114790. [Q96DR7-4]
GeneIDi26084.
KEGGihsa:26084.
UCSCiuc011bog.1. human. [Q96DR7-1]

Polymorphism databases

DMDMi317373555.

Keywords - Coding sequence diversityi

Alternative promoter usage, Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF415175 mRNA. Translation: AAL27001.1 .
AF415176 mRNA. Translation: AAL27002.1 . Sequence problems.
AY552599 mRNA. Translation: AAS59842.1 .
AK022655 mRNA. Translation: BAB14159.1 . Different initiation.
AK022884 mRNA. Translation: BAB14292.1 . Different initiation.
AK123040 mRNA. Translation: BAG53860.1 .
AB073386 mRNA. Translation: BAD38637.1 .
AC018452 Genomic DNA. No translation available.
FJ695204 Genomic DNA. No translation available.
BC016628 mRNA. Translation: AAH16628.1 . Different initiation.
BC078655 mRNA. Translation: AAH78655.1 .
AL117429 mRNA. Translation: CAB55918.1 .
CCDSi CCDS46938.1. [Q96DR7-1 ]
CCDS58858.1. [Q96DR7-4 ]
PIRi T17228.
RefSeqi NP_001238891.1. NM_001251962.1. [Q96DR7-1 ]
NP_001238892.1. NM_001251963.1. [Q96DR7-4 ]
NP_056410.3. NM_015595.3. [Q96DR7-1 ]
UniGenei Hs.240845.

3D structure databases

ProteinModelPortali Q96DR7.
SMRi Q96DR7. Positions 433-849.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 117537. 9 interactions.

PTM databases

PhosphoSitei Q96DR7.

Polymorphism databases

DMDMi 317373555.

Proteomic databases

MaxQBi Q96DR7.
PaxDbi Q96DR7.
PRIDEi Q96DR7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000356448 ; ENSP00000348828 ; ENSG00000114790 . [Q96DR7-1 ]
ENST00000465093 ; ENSP00000423418 ; ENSG00000114790 . [Q96DR7-1 ]
ENST00000465817 ; ENSP00000423295 ; ENSG00000114790 . [Q96DR7-3 ]
ENST00000496710 ; ENSP00000424446 ; ENSG00000114790 . [Q96DR7-4 ]
GeneIDi 26084.
KEGGi hsa:26084.
UCSCi uc011bog.1. human. [Q96DR7-1 ]

Organism-specific databases

CTDi 26084.
GeneCardsi GC03P153839.
H-InvDB HIX0003789.
HGNCi HGNC:24490. ARHGEF26.
HPAi HPA017722.
neXtProti NX_Q96DR7.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5422.
GeneTreei ENSGT00550000074493.
HOVERGENi HBG059167.
InParanoidi Q96DR7.
KOi K13744.
OMAi NSITPLW.
OrthoDBi EOG73NG2P.
PhylomeDBi Q96DR7.
TreeFami TF316357.

Miscellaneous databases

GenomeRNAii 26084.
NextBioi 48000.
PROi Q96DR7.

Gene expression databases

Bgeei Q96DR7.
Genevestigatori Q96DR7.

Family and domain databases

Gene3Di 1.20.900.10. 1 hit.
2.30.29.30. 1 hit.
InterProi IPR000219. DH-domain.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR001452. SH3_domain.
[Graphical view ]
Pfami PF00169. PH. 1 hit.
PF00621. RhoGEF. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view ]
SMARTi SM00233. PH. 1 hit.
SM00325. RhoGEF. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view ]
SUPFAMi SSF48065. SSF48065. 1 hit.
SSF50044. SSF50044. 1 hit.
PROSITEi PS50010. DH_2. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation of the novel human guanine nucleotide exchange factor Src homology 3 domain-containing guanine nucleotide exchange factor (SGEF) and of C-terminal SGEF, an N-terminally truncated form of SGEF, the expression of which is regulated by androgen in prostate cancer cells."
    Qi H., Fournier A., Grenier J., Fillion C., Labrie Y., Labrie C.
    Endocrinology 144:1742-1752(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, INDUCTION, VARIANT LEU-29.
    Tissue: Prostatic carcinoma.
  2. "SGEF, a RhoG guanine nucleotide exchange factor that stimulates macropinocytosis."
    Ellerbroek S.M., Wennerberg K., Arthur W.T., Dunty J.M., Bowman D.R., DeMali K.A., Der C., Burridge K.
    Mol. Biol. Cell 15:3309-3319(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, INTERACTION WITH RHOG, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, MUTAGENESIS OF TRP-826, VARIANT LEU-29.
    Tissue: Brain.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 402-871 (ISOFORM 1), VARIANT LEU-29.
  4. "Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas."
    Yamada S., Ohira M., Horie H., Ando K., Takayasu H., Suzuki Y., Sugano S., Hirata T., Goto T., Matsunaga T., Hiyama E., Hayashi Y., Ando H., Suita S., Kaneko M., Sasaki F., Hashizume K., Ohnuma N., Nakagawara A.
    Oncogene 23:5901-5911(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANTS LEU-29; PRO-60 AND SER-203.
    Tissue: Liver.
  5. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT LEU-29.
    Tissue: Prostate and Testis.
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 661-871 (ISOFORM 1).
    Tissue: Testis.
  8. "Differential activation and function of Rho GTPases during Salmonella-host cell interactions."
    Patel J.C., Galan J.E.
    J. Cell Biol. 175:453-463(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  9. "RhoG regulates endothelial apical cup assembly downstream from ICAM1 engagement and is involved in leukocyte trans-endothelial migration."
    van Buul J.D., Allingham M.J., Samson T., Meller J., Boulter E., Garcia-Mata R., Burridge K.
    J. Cell Biol. 178:1279-1293(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH ICAM1, SUBCELLULAR LOCATION.
  10. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-392, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  11. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-22 AND SER-392, VARIANT [LARGE SCALE ANALYSIS] LEU-29, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiARHGQ_HUMAN
AccessioniPrimary (citable) accession number: Q96DR7
Secondary accession number(s): B3KVP8
, E9PBD0, Q68CL1, Q6AZ96, Q6Q8Q8, Q96AW8, Q96DR6, Q9H9D7, Q9H9R2, Q9UFW5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: January 11, 2011
Last modified: October 29, 2014
This is version 95 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3