Q96DR5 (BPIA2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
BPI fold-containing family A member 2

Alternative name(s):
Parotid secretory protein
Short name=PSP
Short palate, lung and nasal epithelium carcinoma-associated protein 2

Gene names

Name:	BPIFA2
Synonyms:	C20orf70, SPLUNC2
ORF Names:	UNQ510/PRO1025

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	249 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Secreted By similarity.
Tissue specificity	Detected in submandibular gland. Ref.5
Sequence similarities	Belongs to the BPI/LBP/Plunc superfamily. Plunc family.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Polymorphism
Domain	Signal
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	lipid binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 18	18	Potential
	Chain	19 – 249	231	BPI fold-containing family A member 2		PRO_0000017184
Amino acid modifications
	Glycosylation	124	1	N-linked (GlcNAc...) Ref.6
	Glycosylation	132	1	N-linked (GlcNAc...) Ref.6
Natural variations
	Natural variant	43	1	G → R. Corresponds to variant rs6059139 [ dbSNP | Ensembl ].		VAR_049751
	Natural variant	113	1	K → E. Corresponds to variant rs17304572 [ dbSNP | Ensembl ].		VAR_049752
	Natural variant	221	1	R → C. Corresponds to variant rs6120140 [ dbSNP | Ensembl ].		VAR_049753
Experimental info
	Sequence conflict	172	1	G → R in AAL28113. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q96DR5 [UniParc]. Last modified August 29, 2003. Version 2. Checksum: E64E0794A1B4DB7D	FASTA	249	27,011
	10 20 30 40 50 60 MLQLWKLVLL CGVLTGTSES LLDNLGNDLS NVVDKLEPVL HEGLETVDNT LKGILEKLKV 70 80 90 100 110 120 DLGVLQKSSA WQLAKQKAQE AEKLLNNVIS KLLPTNTDIF GLKISNSLIL DVKAEPIDDG 130 140 150 160 170 180 KGLNLSFPVT ANVTVAGPII GQIINLKASL DLLTAVTIET DPQTHQPVAV LGECASDPTS 190 200 210 220 230 240 ISLSLLDKHS QIINKFVNSV INTLKSTVSS LLQKEICPLI RIFIHSLDVN VIQQVVDNPQ HKTQLQTLI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A member of the PSP/plunc family of BPI proteins is expressed in the human parotid gland." Venkatesh S.G., Geetha C., Gorr S.-U. Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Parotid gland.
[2]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	"The DNA sequence and comparative analysis of human chromosome 20." Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J. Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Thyroid.
[5]	"PLUNC: a novel family of candidate host defence proteins expressed in the upper airways and nasopharynx." Bingle C.D., Craven C.J. Hum. Mol. Genet. 11:937-943(2002) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY.
[6]	"Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry." Ramachandran P., Boontheung P., Xie Y., Sondej M., Wong D.T., Loo J.A. J. Proteome Res. 5:1493-1503(2006) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-124 AND ASN-132, MASS SPECTROMETRY. Tissue: Saliva.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF432917 mRNA. Translation: AAL28113.1. AY359055 mRNA. Translation: AAQ89414.1. AL121901 Genomic DNA. Translation: CAC03546.1. BC065726 mRNA. Translation: AAH65726.1.
IPI	IPI00304557.
RefSeq	NP_542141.1. NM_080574.2.
UniGene	Hs.125960.
3D structure databases
ProteinModelPortal	Q96DR5.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000253362.
Polymorphism databases
DMDM	34395850.
Proteomic databases
PaxDb	Q96DR5.
PeptideAtlas	Q96DR5.
PRIDE	Q96DR5.
Protocols and materials databases
DNASU	140683.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000253362; ENSP00000253362; ENSG00000131050. ENST00000354932; ENSP00000347012; ENSG00000131050.
GeneID	140683.
KEGG	hsa:140683.
UCSC	uc002wyo.1. human.
Organism-specific databases
CTD	140683.
GeneCards	GC20P031750.
H-InvDB	HIX0040667.
HGNC	HGNC:16203. BPIFA2.
HPA	HPA044006.
neXtProt	NX_Q96DR5.
PharmGKB	PA25781.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG40022.
HOGENOM	HOG000231511.
HOVERGEN	HBG004495.
InParanoid	Q96DR5.
OMA	LQLWKLV.
OrthoDB	EOG4G7C0N.
PhylomeDB	Q96DR5.
Gene expression databases
Bgee	Q96DR5.
CleanEx	HS_C20orf70.
Genevestigator	Q96DR5.
GermOnline	ENSG00000131050. Homo sapiens.
Family and domain databases
InterPro	IPR017943. Bactericidal_perm-incr_a/b_dom. IPR017942. Lipid-bd_serum_glycop_N. [Graphical view]
Pfam	PF01273. LBP_BPI_CETP. 1 hit. [Graphical view]
SUPFAM	SSF55394. Bactericidal_perm-incr_a/b_dom. 1 hit.
ProtoNet	Search...
Other
ChiTaRS	BPIFA2. human.
GenomeRNAi	140683.
NextBio	84217.

Entry information

Entry name

BPIA2_HUMAN

Accession

Primary (citable) accession number: Q96DR5
Secondary accession number(s): Q9BQQ0

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 29, 2003
Last sequence update:	August 29, 2003
Last modified:	April 3, 2013
This is version 91 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.