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Protein

BPI fold-containing family A member 2

Gene

BPIFA2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Has strong antibacterial activity against P. aeruginosa.1 Publication

GO - Molecular functioni

  • lipopolysaccharide binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionAntibiotic, Antimicrobial

Enzyme and pathway databases

ReactomeiR-HSA-6803157 Antimicrobial peptides

Names & Taxonomyi

Protein namesi
Recommended name:
BPI fold-containing family A member 2
Alternative name(s):
Parotid secretory protein
Short name:
PSP
Short palate, lung and nasal epithelium carcinoma-associated protein 2
Gene namesi
Name:BPIFA2
Synonyms:C20orf70, SPLUNC2
ORF Names:UNQ510/PRO1025
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000131050.10
HGNCiHGNC:16203 BPIFA2
neXtProtiNX_Q96DR5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi140683
OpenTargetsiENSG00000131050
PharmGKBiPA25781

Polymorphism and mutation databases

BioMutaiBPIFA2
DMDMi34395850

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000001718419 – 249BPI fold-containing family A member 2Add BLAST231

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi124N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi132N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi174 ↔ 217By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ96DR5
PeptideAtlasiQ96DR5
PRIDEiQ96DR5
ProteomicsDBi76306

PTM databases

iPTMnetiQ96DR5

Expressioni

Tissue specificityi

Detected in submandibular gland. Secreted into saliva.2 Publications

Gene expression databases

BgeeiENSG00000131050
CleanExiHS_C20orf70
GenevisibleiQ96DR5 HS

Organism-specific databases

HPAiHPA044006

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
AGTRAPQ6RW133EBI-10284754,EBI-741181

Protein-protein interaction databases

BioGridi126647, 11 interactors
IntActiQ96DR5, 1 interactor
STRINGi9606.ENSP00000253362

Structurei

3D structure databases

ProteinModelPortaliQ96DR5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the BPI/LBP/Plunc superfamily. Plunc family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IXQB Eukaryota
ENOG4111BIC LUCA
GeneTreeiENSGT00390000014788
HOGENOMiHOG000231511
HOVERGENiHBG004495
InParanoidiQ96DR5
OMAiMLQLWKL
OrthoDBiEOG091G0RXE
PhylomeDBiQ96DR5
TreeFamiTF337052

Family and domain databases

InterProiView protein in InterPro
IPR017943 Bactericidal_perm-incr_a/b_dom
IPR032942 BPI/LBP/Plunc
IPR017942 Lipid-bd_serum_glycop_N
PANTHERiPTHR10504 PTHR10504, 1 hit
PfamiView protein in Pfam
PF01273 LBP_BPI_CETP, 1 hit
SUPFAMiSSF55394 SSF55394, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q96DR5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLQLWKLVLL CGVLTGTSES LLDNLGNDLS NVVDKLEPVL HEGLETVDNT
60 70 80 90 100
LKGILEKLKV DLGVLQKSSA WQLAKQKAQE AEKLLNNVIS KLLPTNTDIF
110 120 130 140 150
GLKISNSLIL DVKAEPIDDG KGLNLSFPVT ANVTVAGPII GQIINLKASL
160 170 180 190 200
DLLTAVTIET DPQTHQPVAV LGECASDPTS ISLSLLDKHS QIINKFVNSV
210 220 230 240
INTLKSTVSS LLQKEICPLI RIFIHSLDVN VIQQVVDNPQ HKTQLQTLI
Length:249
Mass (Da):27,011
Last modified:August 29, 2003 - v2
Checksum:iE64E0794A1B4DB7D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti172G → R in AAL28113 (Ref. 1) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04975143G → R. Corresponds to variant dbSNP:rs6059139Ensembl.1
Natural variantiVAR_049752113K → E. Corresponds to variant dbSNP:rs17304572Ensembl.1
Natural variantiVAR_049753221R → C. Corresponds to variant dbSNP:rs6120140Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF432917 mRNA Translation: AAL28113.1
AY359055 mRNA Translation: AAQ89414.1
AL121901 Genomic DNA No translation available.
BC065726 mRNA Translation: AAH65726.1
CCDSiCCDS13214.1
RefSeqiNP_001306093.1, NM_001319164.1
NP_542141.1, NM_080574.3
UniGeneiHs.125960

Genome annotation databases

EnsembliENST00000253362; ENSP00000253362; ENSG00000131050
ENST00000354932; ENSP00000347012; ENSG00000131050
GeneIDi140683
KEGGihsa:140683
UCSCiuc002wyo.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiBPIA2_HUMAN
AccessioniPrimary (citable) accession number: Q96DR5
Secondary accession number(s): Q9BQQ0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: August 29, 2003
Last modified: June 20, 2018
This is version 128 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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