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Q96DR5

- BPIA2_HUMAN

UniProt

Q96DR5 - BPIA2_HUMAN

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Protein

BPI fold-containing family A member 2

Gene

BPIFA2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. lipopolysaccharide binding Source: UniProt
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
BPI fold-containing family A member 2
Alternative name(s):
Parotid secretory protein
Short name:
PSP
Short palate, lung and nasal epithelium carcinoma-associated protein 2
Gene namesi
Name:BPIFA2
Synonyms:C20orf70, SPLUNC2
ORF Names:UNQ510/PRO1025
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 20

Organism-specific databases

HGNCiHGNC:16203. BPIFA2.

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProt
  2. extracellular vesicular exosome Source: UniProt
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25781.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence AnalysisAdd
BLAST
Chaini19 – 249231BPI fold-containing family A member 2PRO_0000017184Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi124 – 1241N-linked (GlcNAc...)1 Publication
Glycosylationi132 – 1321N-linked (GlcNAc...)1 Publication
Disulfide bondi174 ↔ 217By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ96DR5.
PeptideAtlasiQ96DR5.
PRIDEiQ96DR5.

Expressioni

Tissue specificityi

Detected in submandibular gland.1 Publication

Gene expression databases

BgeeiQ96DR5.
CleanExiHS_C20orf70.
GenevestigatoriQ96DR5.

Organism-specific databases

HPAiHPA044006.

Interactioni

Protein-protein interaction databases

BioGridi126647. 1 interaction.
STRINGi9606.ENSP00000253362.

Structurei

3D structure databases

ProteinModelPortaliQ96DR5.
SMRiQ96DR5. Positions 98-245.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the BPI/LBP/Plunc superfamily. Plunc family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG40022.
GeneTreeiENSGT00390000014788.
HOGENOMiHOG000231511.
HOVERGENiHBG004495.
InParanoidiQ96DR5.
OMAiMLQLWKL.
OrthoDBiEOG75TMCT.
PhylomeDBiQ96DR5.
TreeFamiTF337052.

Family and domain databases

InterProiIPR017943. Bactericidal_perm-incr_a/b_dom.
IPR017942. Lipid-bd_serum_glycop_N.
[Graphical view]
PfamiPF01273. LBP_BPI_CETP. 1 hit.
[Graphical view]
SUPFAMiSSF55394. SSF55394. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q96DR5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLQLWKLVLL CGVLTGTSES LLDNLGNDLS NVVDKLEPVL HEGLETVDNT
60 70 80 90 100
LKGILEKLKV DLGVLQKSSA WQLAKQKAQE AEKLLNNVIS KLLPTNTDIF
110 120 130 140 150
GLKISNSLIL DVKAEPIDDG KGLNLSFPVT ANVTVAGPII GQIINLKASL
160 170 180 190 200
DLLTAVTIET DPQTHQPVAV LGECASDPTS ISLSLLDKHS QIINKFVNSV
210 220 230 240
INTLKSTVSS LLQKEICPLI RIFIHSLDVN VIQQVVDNPQ HKTQLQTLI
Length:249
Mass (Da):27,011
Last modified:August 29, 2003 - v2
Checksum:iE64E0794A1B4DB7D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti172 – 1721G → R in AAL28113. 1 PublicationCurated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti43 – 431G → R.
Corresponds to variant rs6059139 [ dbSNP | Ensembl ].
VAR_049751
Natural varianti113 – 1131K → E.
Corresponds to variant rs17304572 [ dbSNP | Ensembl ].
VAR_049752
Natural varianti221 – 2211R → C.
Corresponds to variant rs6120140 [ dbSNP | Ensembl ].
VAR_049753

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF432917 mRNA. Translation: AAL28113.1.
AY359055 mRNA. Translation: AAQ89414.1.
AL121901 Genomic DNA. Translation: CAC03546.1.
BC065726 mRNA. Translation: AAH65726.1.
CCDSiCCDS13214.1.
RefSeqiNP_542141.1. NM_080574.2.
XP_005260338.1. XM_005260281.1.
UniGeneiHs.125960.

Genome annotation databases

EnsembliENST00000253362; ENSP00000253362; ENSG00000131050.
ENST00000354932; ENSP00000347012; ENSG00000131050.
GeneIDi140683.
KEGGihsa:140683.
UCSCiuc002wyo.1. human.

Polymorphism databases

DMDMi34395850.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF432917 mRNA. Translation: AAL28113.1 .
AY359055 mRNA. Translation: AAQ89414.1 .
AL121901 Genomic DNA. Translation: CAC03546.1 .
BC065726 mRNA. Translation: AAH65726.1 .
CCDSi CCDS13214.1.
RefSeqi NP_542141.1. NM_080574.2.
XP_005260338.1. XM_005260281.1.
UniGenei Hs.125960.

3D structure databases

ProteinModelPortali Q96DR5.
SMRi Q96DR5. Positions 98-245.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 126647. 1 interaction.
STRINGi 9606.ENSP00000253362.

Polymorphism databases

DMDMi 34395850.

Proteomic databases

PaxDbi Q96DR5.
PeptideAtlasi Q96DR5.
PRIDEi Q96DR5.

Protocols and materials databases

DNASUi 140683.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000253362 ; ENSP00000253362 ; ENSG00000131050 .
ENST00000354932 ; ENSP00000347012 ; ENSG00000131050 .
GeneIDi 140683.
KEGGi hsa:140683.
UCSCi uc002wyo.1. human.

Organism-specific databases

CTDi 140683.
GeneCardsi GC20P031750.
H-InvDB HIX0040667.
HGNCi HGNC:16203. BPIFA2.
HPAi HPA044006.
neXtProti NX_Q96DR5.
PharmGKBi PA25781.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG40022.
GeneTreei ENSGT00390000014788.
HOGENOMi HOG000231511.
HOVERGENi HBG004495.
InParanoidi Q96DR5.
OMAi MLQLWKL.
OrthoDBi EOG75TMCT.
PhylomeDBi Q96DR5.
TreeFami TF337052.

Miscellaneous databases

ChiTaRSi BPIFA2. human.
GenomeRNAii 140683.
NextBioi 84217.
PROi Q96DR5.

Gene expression databases

Bgeei Q96DR5.
CleanExi HS_C20orf70.
Genevestigatori Q96DR5.

Family and domain databases

InterProi IPR017943. Bactericidal_perm-incr_a/b_dom.
IPR017942. Lipid-bd_serum_glycop_N.
[Graphical view ]
Pfami PF01273. LBP_BPI_CETP. 1 hit.
[Graphical view ]
SUPFAMi SSF55394. SSF55394. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A member of the PSP/plunc family of BPI proteins is expressed in the human parotid gland."
    Venkatesh S.G., Geetha C., Gorr S.-U.
    Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Parotid gland.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Thyroid.
  5. "PLUNC: a novel family of candidate host defence proteins expressed in the upper airways and nasopharynx."
    Bingle C.D., Craven C.J.
    Hum. Mol. Genet. 11:937-943(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  6. "Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry."
    Ramachandran P., Boontheung P., Xie Y., Sondej M., Wong D.T., Loo J.A.
    J. Proteome Res. 5:1493-1503(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-124 AND ASN-132.
    Tissue: Saliva.

Entry informationi

Entry nameiBPIA2_HUMAN
AccessioniPrimary (citable) accession number: Q96DR5
Secondary accession number(s): Q9BQQ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: August 29, 2003
Last modified: October 29, 2014
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3