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Protein

BPI fold-containing family A member 2

Gene

BPIFA2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Has strong antibacterial activity against P. aeruginosa.1 Publication

GO - Molecular functioni

  • lipopolysaccharide binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial

Enzyme and pathway databases

BioCyciZFISH:ENSG00000131050-MONOMER.
ReactomeiR-HSA-6803157. Antimicrobial peptides.

Names & Taxonomyi

Protein namesi
Recommended name:
BPI fold-containing family A member 2
Alternative name(s):
Parotid secretory protein
Short name:
PSP
Short palate, lung and nasal epithelium carcinoma-associated protein 2
Gene namesi
Name:BPIFA2
Synonyms:C20orf70, SPLUNC2
ORF Names:UNQ510/PRO1025
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:16203. BPIFA2.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • extracellular region Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi140683.
OpenTargetsiENSG00000131050.
PharmGKBiPA25781.

Polymorphism and mutation databases

BioMutaiBPIFA2.
DMDMi34395850.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000001718419 – 249BPI fold-containing family A member 2Add BLAST231

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi124N-linked (GlcNAc...)1 Publication1
Glycosylationi132N-linked (GlcNAc...)1 Publication1
Disulfide bondi174 ↔ 217By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ96DR5.
PeptideAtlasiQ96DR5.
PRIDEiQ96DR5.

Expressioni

Tissue specificityi

Detected in submandibular gland. Secreted into saliva.2 Publications

Gene expression databases

BgeeiENSG00000131050.
CleanExiHS_C20orf70.
GenevisibleiQ96DR5. HS.

Organism-specific databases

HPAiHPA044006.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
AGTRAPQ6RW133EBI-10284754,EBI-741181

Protein-protein interaction databases

BioGridi126647. 9 interactors.
IntActiQ96DR5. 1 interactor.
STRINGi9606.ENSP00000253362.

Structurei

3D structure databases

ProteinModelPortaliQ96DR5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the BPI/LBP/Plunc superfamily. Plunc family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IXQB. Eukaryota.
ENOG4111BIC. LUCA.
GeneTreeiENSGT00390000014788.
HOGENOMiHOG000231511.
HOVERGENiHBG004495.
InParanoidiQ96DR5.
OMAiMLQLWKL.
OrthoDBiEOG091G0RXE.
PhylomeDBiQ96DR5.
TreeFamiTF337052.

Family and domain databases

InterProiIPR017943. Bactericidal_perm-incr_a/b_dom.
IPR032942. BPI/LBP/Plunc.
IPR017942. Lipid-bd_serum_glycop_N.
[Graphical view]
PANTHERiPTHR10504. PTHR10504. 1 hit.
PfamiPF01273. LBP_BPI_CETP. 1 hit.
[Graphical view]
SUPFAMiSSF55394. SSF55394. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q96DR5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLQLWKLVLL CGVLTGTSES LLDNLGNDLS NVVDKLEPVL HEGLETVDNT
60 70 80 90 100
LKGILEKLKV DLGVLQKSSA WQLAKQKAQE AEKLLNNVIS KLLPTNTDIF
110 120 130 140 150
GLKISNSLIL DVKAEPIDDG KGLNLSFPVT ANVTVAGPII GQIINLKASL
160 170 180 190 200
DLLTAVTIET DPQTHQPVAV LGECASDPTS ISLSLLDKHS QIINKFVNSV
210 220 230 240
INTLKSTVSS LLQKEICPLI RIFIHSLDVN VIQQVVDNPQ HKTQLQTLI
Length:249
Mass (Da):27,011
Last modified:August 29, 2003 - v2
Checksum:iE64E0794A1B4DB7D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti172G → R in AAL28113 (Ref. 1) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04975143G → R.Corresponds to variant rs6059139dbSNPEnsembl.1
Natural variantiVAR_049752113K → E.Corresponds to variant rs17304572dbSNPEnsembl.1
Natural variantiVAR_049753221R → C.Corresponds to variant rs6120140dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF432917 mRNA. Translation: AAL28113.1.
AY359055 mRNA. Translation: AAQ89414.1.
AL121901 Genomic DNA. Translation: CAC03546.1.
BC065726 mRNA. Translation: AAH65726.1.
CCDSiCCDS13214.1.
RefSeqiNP_001306093.1. NM_001319164.1.
NP_542141.1. NM_080574.3.
UniGeneiHs.125960.

Genome annotation databases

EnsembliENST00000253362; ENSP00000253362; ENSG00000131050.
ENST00000354932; ENSP00000347012; ENSG00000131050.
GeneIDi140683.
KEGGihsa:140683.
UCSCiuc002wyo.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF432917 mRNA. Translation: AAL28113.1.
AY359055 mRNA. Translation: AAQ89414.1.
AL121901 Genomic DNA. Translation: CAC03546.1.
BC065726 mRNA. Translation: AAH65726.1.
CCDSiCCDS13214.1.
RefSeqiNP_001306093.1. NM_001319164.1.
NP_542141.1. NM_080574.3.
UniGeneiHs.125960.

3D structure databases

ProteinModelPortaliQ96DR5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126647. 9 interactors.
IntActiQ96DR5. 1 interactor.
STRINGi9606.ENSP00000253362.

Polymorphism and mutation databases

BioMutaiBPIFA2.
DMDMi34395850.

Proteomic databases

PaxDbiQ96DR5.
PeptideAtlasiQ96DR5.
PRIDEiQ96DR5.

Protocols and materials databases

DNASUi140683.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000253362; ENSP00000253362; ENSG00000131050.
ENST00000354932; ENSP00000347012; ENSG00000131050.
GeneIDi140683.
KEGGihsa:140683.
UCSCiuc002wyo.2. human.

Organism-specific databases

CTDi140683.
DisGeNETi140683.
GeneCardsiBPIFA2.
H-InvDBHIX0040667.
HGNCiHGNC:16203. BPIFA2.
HPAiHPA044006.
neXtProtiNX_Q96DR5.
OpenTargetsiENSG00000131050.
PharmGKBiPA25781.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IXQB. Eukaryota.
ENOG4111BIC. LUCA.
GeneTreeiENSGT00390000014788.
HOGENOMiHOG000231511.
HOVERGENiHBG004495.
InParanoidiQ96DR5.
OMAiMLQLWKL.
OrthoDBiEOG091G0RXE.
PhylomeDBiQ96DR5.
TreeFamiTF337052.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000131050-MONOMER.
ReactomeiR-HSA-6803157. Antimicrobial peptides.

Miscellaneous databases

ChiTaRSiBPIFA2. human.
GenomeRNAii140683.
PROiQ96DR5.

Gene expression databases

BgeeiENSG00000131050.
CleanExiHS_C20orf70.
GenevisibleiQ96DR5. HS.

Family and domain databases

InterProiIPR017943. Bactericidal_perm-incr_a/b_dom.
IPR032942. BPI/LBP/Plunc.
IPR017942. Lipid-bd_serum_glycop_N.
[Graphical view]
PANTHERiPTHR10504. PTHR10504. 1 hit.
PfamiPF01273. LBP_BPI_CETP. 1 hit.
[Graphical view]
SUPFAMiSSF55394. SSF55394. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiBPIA2_HUMAN
AccessioniPrimary (citable) accession number: Q96DR5
Secondary accession number(s): Q9BQQ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: August 29, 2003
Last modified: November 30, 2016
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.