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Q96DR5

- BPIA2_HUMAN

UniProt

Q96DR5 - BPIA2_HUMAN

Protein

BPI fold-containing family A member 2

Gene

BPIFA2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 2 (29 Aug 2003)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. lipopolysaccharide binding Source: UniProt

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    BPI fold-containing family A member 2
    Alternative name(s):
    Parotid secretory protein
    Short name:
    PSP
    Short palate, lung and nasal epithelium carcinoma-associated protein 2
    Gene namesi
    Name:BPIFA2
    Synonyms:C20orf70, SPLUNC2
    ORF Names:UNQ510/PRO1025
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 20

    Organism-specific databases

    HGNCiHGNC:16203. BPIFA2.

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular region Source: UniProt
    2. extracellular vesicular exosome Source: UniProt

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA25781.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818Sequence AnalysisAdd
    BLAST
    Chaini19 – 249231BPI fold-containing family A member 2PRO_0000017184Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi124 – 1241N-linked (GlcNAc...)1 Publication
    Glycosylationi132 – 1321N-linked (GlcNAc...)1 Publication
    Disulfide bondi174 ↔ 217By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ96DR5.
    PeptideAtlasiQ96DR5.
    PRIDEiQ96DR5.

    Expressioni

    Tissue specificityi

    Detected in submandibular gland.1 Publication

    Gene expression databases

    BgeeiQ96DR5.
    CleanExiHS_C20orf70.
    GenevestigatoriQ96DR5.

    Organism-specific databases

    HPAiHPA044006.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000253362.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96DR5.
    SMRiQ96DR5. Positions 98-245.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the BPI/LBP/Plunc superfamily. Plunc family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG40022.
    HOGENOMiHOG000231511.
    HOVERGENiHBG004495.
    InParanoidiQ96DR5.
    OMAiMLQLWKL.
    OrthoDBiEOG75TMCT.
    PhylomeDBiQ96DR5.
    TreeFamiTF337052.

    Family and domain databases

    InterProiIPR017943. Bactericidal_perm-incr_a/b_dom.
    IPR017942. Lipid-bd_serum_glycop_N.
    [Graphical view]
    PfamiPF01273. LBP_BPI_CETP. 1 hit.
    [Graphical view]
    SUPFAMiSSF55394. SSF55394. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q96DR5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLQLWKLVLL CGVLTGTSES LLDNLGNDLS NVVDKLEPVL HEGLETVDNT    50
    LKGILEKLKV DLGVLQKSSA WQLAKQKAQE AEKLLNNVIS KLLPTNTDIF 100
    GLKISNSLIL DVKAEPIDDG KGLNLSFPVT ANVTVAGPII GQIINLKASL 150
    DLLTAVTIET DPQTHQPVAV LGECASDPTS ISLSLLDKHS QIINKFVNSV 200
    INTLKSTVSS LLQKEICPLI RIFIHSLDVN VIQQVVDNPQ HKTQLQTLI 249
    Length:249
    Mass (Da):27,011
    Last modified:August 29, 2003 - v2
    Checksum:iE64E0794A1B4DB7D
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti172 – 1721G → R in AAL28113. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti43 – 431G → R.
    Corresponds to variant rs6059139 [ dbSNP | Ensembl ].
    VAR_049751
    Natural varianti113 – 1131K → E.
    Corresponds to variant rs17304572 [ dbSNP | Ensembl ].
    VAR_049752
    Natural varianti221 – 2211R → C.
    Corresponds to variant rs6120140 [ dbSNP | Ensembl ].
    VAR_049753

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF432917 mRNA. Translation: AAL28113.1.
    AY359055 mRNA. Translation: AAQ89414.1.
    AL121901 Genomic DNA. Translation: CAC03546.1.
    BC065726 mRNA. Translation: AAH65726.1.
    CCDSiCCDS13214.1.
    RefSeqiNP_542141.1. NM_080574.2.
    XP_005260338.1. XM_005260281.1.
    UniGeneiHs.125960.

    Genome annotation databases

    EnsembliENST00000253362; ENSP00000253362; ENSG00000131050.
    ENST00000354932; ENSP00000347012; ENSG00000131050.
    GeneIDi140683.
    KEGGihsa:140683.
    UCSCiuc002wyo.1. human.

    Polymorphism databases

    DMDMi34395850.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF432917 mRNA. Translation: AAL28113.1 .
    AY359055 mRNA. Translation: AAQ89414.1 .
    AL121901 Genomic DNA. Translation: CAC03546.1 .
    BC065726 mRNA. Translation: AAH65726.1 .
    CCDSi CCDS13214.1.
    RefSeqi NP_542141.1. NM_080574.2.
    XP_005260338.1. XM_005260281.1.
    UniGenei Hs.125960.

    3D structure databases

    ProteinModelPortali Q96DR5.
    SMRi Q96DR5. Positions 98-245.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000253362.

    Polymorphism databases

    DMDMi 34395850.

    Proteomic databases

    PaxDbi Q96DR5.
    PeptideAtlasi Q96DR5.
    PRIDEi Q96DR5.

    Protocols and materials databases

    DNASUi 140683.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000253362 ; ENSP00000253362 ; ENSG00000131050 .
    ENST00000354932 ; ENSP00000347012 ; ENSG00000131050 .
    GeneIDi 140683.
    KEGGi hsa:140683.
    UCSCi uc002wyo.1. human.

    Organism-specific databases

    CTDi 140683.
    GeneCardsi GC20P031750.
    H-InvDB HIX0040667.
    HGNCi HGNC:16203. BPIFA2.
    HPAi HPA044006.
    neXtProti NX_Q96DR5.
    PharmGKBi PA25781.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG40022.
    HOGENOMi HOG000231511.
    HOVERGENi HBG004495.
    InParanoidi Q96DR5.
    OMAi MLQLWKL.
    OrthoDBi EOG75TMCT.
    PhylomeDBi Q96DR5.
    TreeFami TF337052.

    Miscellaneous databases

    ChiTaRSi BPIFA2. human.
    GenomeRNAii 140683.
    NextBioi 84217.
    PROi Q96DR5.

    Gene expression databases

    Bgeei Q96DR5.
    CleanExi HS_C20orf70.
    Genevestigatori Q96DR5.

    Family and domain databases

    InterProi IPR017943. Bactericidal_perm-incr_a/b_dom.
    IPR017942. Lipid-bd_serum_glycop_N.
    [Graphical view ]
    Pfami PF01273. LBP_BPI_CETP. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55394. SSF55394. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "A member of the PSP/plunc family of BPI proteins is expressed in the human parotid gland."
      Venkatesh S.G., Geetha C., Gorr S.-U.
      Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Parotid gland.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "The DNA sequence and comparative analysis of human chromosome 20."
      Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
      , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
      Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Thyroid.
    5. "PLUNC: a novel family of candidate host defence proteins expressed in the upper airways and nasopharynx."
      Bingle C.D., Craven C.J.
      Hum. Mol. Genet. 11:937-943(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    6. "Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry."
      Ramachandran P., Boontheung P., Xie Y., Sondej M., Wong D.T., Loo J.A.
      J. Proteome Res. 5:1493-1503(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-124 AND ASN-132.
      Tissue: Saliva.

    Entry informationi

    Entry nameiBPIA2_HUMAN
    AccessioniPrimary (citable) accession number: Q96DR5
    Secondary accession number(s): Q9BQQ0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 29, 2003
    Last sequence update: August 29, 2003
    Last modified: October 1, 2014
    This is version 101 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 20
      Human chromosome 20: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3