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Q96DR5 (BPIA2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
BPI fold-containing family A member 2
Alternative name(s):
Parotid secretory protein
Short name=PSP
Short palate, lung and nasal epithelium carcinoma-associated protein 2
Gene names
Name:BPIFA2
Synonyms:C20orf70, SPLUNC2
ORF Names:UNQ510/PRO1025
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length249 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Secreted By similarity.

Tissue specificity

Detected in submandibular gland. Ref.5

Sequence similarities

Belongs to the BPI/LBP/Plunc superfamily. Plunc family.

Ontologies

Keywords
   Cellular componentSecreted
   Coding sequence diversityPolymorphism
   DomainSignal
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentextracellular region

Inferred from direct assay PubMed 19499239PubMed 21833535. Source: UniProt

extracellular vesicular exosome

Inferred from direct assay PubMed 19199708. Source: UniProt

   Molecular_functionlipopolysaccharide binding

Inferred from direct assay PubMed 21833535. Source: UniProt

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818 Potential
Chain19 – 249231BPI fold-containing family A member 2
PRO_0000017184

Amino acid modifications

Glycosylation1241N-linked (GlcNAc...) Ref.6
Glycosylation1321N-linked (GlcNAc...) Ref.6
Disulfide bond174 ↔ 217 By similarity

Natural variations

Natural variant431G → R.
Corresponds to variant rs6059139 [ dbSNP | Ensembl ].
VAR_049751
Natural variant1131K → E.
Corresponds to variant rs17304572 [ dbSNP | Ensembl ].
VAR_049752
Natural variant2211R → C.
Corresponds to variant rs6120140 [ dbSNP | Ensembl ].
VAR_049753

Experimental info

Sequence conflict1721G → R in AAL28113. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q96DR5 [UniParc].

Last modified August 29, 2003. Version 2.
Checksum: E64E0794A1B4DB7D

FASTA24927,011
        10         20         30         40         50         60 
MLQLWKLVLL CGVLTGTSES LLDNLGNDLS NVVDKLEPVL HEGLETVDNT LKGILEKLKV 

        70         80         90        100        110        120 
DLGVLQKSSA WQLAKQKAQE AEKLLNNVIS KLLPTNTDIF GLKISNSLIL DVKAEPIDDG 

       130        140        150        160        170        180 
KGLNLSFPVT ANVTVAGPII GQIINLKASL DLLTAVTIET DPQTHQPVAV LGECASDPTS 

       190        200        210        220        230        240 
ISLSLLDKHS QIINKFVNSV INTLKSTVSS LLQKEICPLI RIFIHSLDVN VIQQVVDNPQ 


HKTQLQTLI 

« Hide

References

« Hide 'large scale' references
[1]"A member of the PSP/plunc family of BPI proteins is expressed in the human parotid gland."
Venkatesh S.G., Geetha C., Gorr S.-U.
Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Parotid gland.
[2]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]"The DNA sequence and comparative analysis of human chromosome 20."
Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. expand/collapse author list , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Thyroid.
[5]"PLUNC: a novel family of candidate host defence proteins expressed in the upper airways and nasopharynx."
Bingle C.D., Craven C.J.
Hum. Mol. Genet. 11:937-943(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
[6]"Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry."
Ramachandran P., Boontheung P., Xie Y., Sondej M., Wong D.T., Loo J.A.
J. Proteome Res. 5:1493-1503(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-124 AND ASN-132.
Tissue: Saliva.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF432917 mRNA. Translation: AAL28113.1.
AY359055 mRNA. Translation: AAQ89414.1.
AL121901 Genomic DNA. Translation: CAC03546.1.
BC065726 mRNA. Translation: AAH65726.1.
CCDSCCDS13214.1.
RefSeqNP_542141.1. NM_080574.2.
XP_005260338.1. XM_005260281.1.
UniGeneHs.125960.

3D structure databases

ProteinModelPortalQ96DR5.
SMRQ96DR5. Positions 98-245.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000253362.

Polymorphism databases

DMDM34395850.

Proteomic databases

PaxDbQ96DR5.
PeptideAtlasQ96DR5.
PRIDEQ96DR5.

Protocols and materials databases

DNASU140683.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000253362; ENSP00000253362; ENSG00000131050.
ENST00000354932; ENSP00000347012; ENSG00000131050.
GeneID140683.
KEGGhsa:140683.
UCSCuc002wyo.1. human.

Organism-specific databases

CTD140683.
GeneCardsGC20P031750.
H-InvDBHIX0040667.
HGNCHGNC:16203. BPIFA2.
HPAHPA044006.
neXtProtNX_Q96DR5.
PharmGKBPA25781.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG40022.
HOGENOMHOG000231511.
HOVERGENHBG004495.
InParanoidQ96DR5.
OMAMLQLWKL.
OrthoDBEOG75TMCT.
PhylomeDBQ96DR5.
TreeFamTF337052.

Gene expression databases

BgeeQ96DR5.
CleanExHS_C20orf70.
GenevestigatorQ96DR5.

Family and domain databases

InterProIPR017943. Bactericidal_perm-incr_a/b_dom.
IPR017942. Lipid-bd_serum_glycop_N.
[Graphical view]
PfamPF01273. LBP_BPI_CETP. 1 hit.
[Graphical view]
SUPFAMSSF55394. SSF55394. 1 hit.
ProtoNetSearch...

Other

ChiTaRSBPIFA2. human.
GenomeRNAi140683.
NextBio84217.
PROQ96DR5.

Entry information

Entry nameBPIA2_HUMAN
AccessionPrimary (citable) accession number: Q96DR5
Secondary accession number(s): Q9BQQ0
Entry history
Integrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: August 29, 2003
Last modified: July 9, 2014
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 20

Human chromosome 20: entries, gene names and cross-references to MIM