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Protein

StAR-related lipid transfer protein 4

Gene

STARD4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in the intracellular transport of sterols or other lipids. May bind cholesterol or other sterols (By similarity).By similarity

GO - Molecular functioni

  • cholesterol binding Source: BHF-UCL
  • cholesterol transporter activity Source: BHF-UCL

GO - Biological processi

  • cholesterol import Source: BHF-UCL
  • cholesterol transport involved in cholesterol storage Source: BHF-UCL
  • intracellular cholesterol transport Source: BHF-UCL
  • positive regulation of bile acid biosynthetic process Source: BHF-UCL
  • positive regulation of cholesterol esterification Source: BHF-UCL
Complete GO annotation...

Keywords - Biological processi

Lipid transport, Transport

Keywords - Ligandi

Lipid-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000164211-MONOMER.
ReactomeiR-HSA-196108. Pregnenolone biosynthesis.

Chemistry databases

SwissLipidsiSLP:000000718.
SLP:000000719.

Names & Taxonomyi

Protein namesi
Recommended name:
StAR-related lipid transfer protein 4
Alternative name(s):
START domain-containing protein 4
Short name:
StARD4
Gene namesi
Name:STARD4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:18058. STARD4.

Subcellular locationi

GO - Cellular componenti

  • cytoplasmic, membrane-bounded vesicle Source: CACAO
  • mitochondrion Source: GO_Central
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi134429.
OpenTargetsiENSG00000164211.
PharmGKBiPA38284.

Polymorphism and mutation databases

BioMutaiSTARD4.
DMDMi25091316.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002206671 – 205StAR-related lipid transfer protein 4Add BLAST205

Proteomic databases

EPDiQ96DR4.
MaxQBiQ96DR4.
PaxDbiQ96DR4.
PeptideAtlasiQ96DR4.
PRIDEiQ96DR4.

PTM databases

iPTMnetiQ96DR4.
PhosphoSitePlusiQ96DR4.

Expressioni

Gene expression databases

BgeeiENSG00000164211.
CleanExiHS_STARD4.
ExpressionAtlasiQ96DR4. baseline and differential.
GenevisibleiQ96DR4. HS.

Organism-specific databases

HPAiHPA046177.
HPA048081.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000296632.

Structurei

3D structure databases

ProteinModelPortaliQ96DR4.
SMRiQ96DR4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 205STARTPROSITE-ProRule annotationAdd BLAST205

Sequence similaritiesi

Contains 1 START domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IPNZ. Eukaryota.
ENOG4111F97. LUCA.
GeneTreeiENSGT00530000063294.
HOGENOMiHOG000137345.
HOVERGENiHBG106946.
InParanoidiQ96DR4.
OMAiINFYGDL.
OrthoDBiEOG091G0INO.
PhylomeDBiQ96DR4.

Family and domain databases

Gene3Di3.30.530.20. 1 hit.
InterProiIPR023393. START-like_dom.
IPR002913. START_lipid-bd_dom.
[Graphical view]
PfamiPF01852. START. 1 hit.
[Graphical view]
SMARTiSM00234. START. 1 hit.
[Graphical view]
PROSITEiPS50848. START. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96DR4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEGLSDVASF ATKLKNTLIQ YHSIEEDKWR VAKKTKDVTV WRKPSEEFNG
60 70 80 90 100
YLYKAQGVID DLVYSIIDHI RPGPCRLDWD SLMTSLDILE NFEENCCVMR
110 120 130 140 150
YTTAGQLWNI ISPREFVDFS YTVGYKEGLL SCGISLDWDE KRPEFVRGYN
160 170 180 190 200
HPCGWFCVPL KDNPNQSLLT GYIQTDLRGM IPQSAVDTAM ASTLTNFYGD

LRKAL
Length:205
Mass (Da):23,517
Last modified:December 1, 2001 - v1
Checksum:i59A8D4B95BFAE27F
GO
Isoform 2 (identifier: Q96DR4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     134-204: ISLDWDEKRP...TNFYGDLRKA → NNLNMLCFFSVWFKYLCFLGWMSLS

Note: No experimental confirmation available.
Show »
Length:159
Mass (Da):18,517
Checksum:i046606FDD2230F62
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_057170134 – 204ISLDW…DLRKA → NNLNMLCFFSVWFKYLCFLG WMSLS in isoform 2. 1 PublicationAdd BLAST71

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF480299 mRNA. Translation: AAL87129.1.
AK054566 mRNA. Translation: BAB70759.1.
AC011422 Genomic DNA. No translation available.
CH471086 Genomic DNA. Translation: EAW49029.1.
BC042956 mRNA. Translation: AAH42956.1.
CCDSiCCDS4104.1. [Q96DR4-1]
CCDS78046.1. [Q96DR4-2]
RefSeqiNP_001294985.1. NM_001308056.1. [Q96DR4-1]
NP_001294986.1. NM_001308057.1. [Q96DR4-2]
NP_001294987.1. NM_001308058.1. [Q96DR4-2]
NP_001294988.1. NM_001308059.1.
NP_001294989.1. NM_001308060.1.
NP_001294990.1. NM_001308061.1.
NP_631903.1. NM_139164.2. [Q96DR4-1]
UniGeneiHs.732430.
Hs.93842.

Genome annotation databases

EnsembliENST00000296632; ENSP00000296632; ENSG00000164211. [Q96DR4-1]
ENST00000502322; ENSP00000427639; ENSG00000164211. [Q96DR4-2]
ENST00000505803; ENSP00000427478; ENSG00000164211. [Q96DR4-1]
GeneIDi134429.
KEGGihsa:134429.
UCSCiuc003kph.2. human. [Q96DR4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF480299 mRNA. Translation: AAL87129.1.
AK054566 mRNA. Translation: BAB70759.1.
AC011422 Genomic DNA. No translation available.
CH471086 Genomic DNA. Translation: EAW49029.1.
BC042956 mRNA. Translation: AAH42956.1.
CCDSiCCDS4104.1. [Q96DR4-1]
CCDS78046.1. [Q96DR4-2]
RefSeqiNP_001294985.1. NM_001308056.1. [Q96DR4-1]
NP_001294986.1. NM_001308057.1. [Q96DR4-2]
NP_001294987.1. NM_001308058.1. [Q96DR4-2]
NP_001294988.1. NM_001308059.1.
NP_001294989.1. NM_001308060.1.
NP_001294990.1. NM_001308061.1.
NP_631903.1. NM_139164.2. [Q96DR4-1]
UniGeneiHs.732430.
Hs.93842.

3D structure databases

ProteinModelPortaliQ96DR4.
SMRiQ96DR4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000296632.

Chemistry databases

SwissLipidsiSLP:000000718.
SLP:000000719.

PTM databases

iPTMnetiQ96DR4.
PhosphoSitePlusiQ96DR4.

Polymorphism and mutation databases

BioMutaiSTARD4.
DMDMi25091316.

Proteomic databases

EPDiQ96DR4.
MaxQBiQ96DR4.
PaxDbiQ96DR4.
PeptideAtlasiQ96DR4.
PRIDEiQ96DR4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000296632; ENSP00000296632; ENSG00000164211. [Q96DR4-1]
ENST00000502322; ENSP00000427639; ENSG00000164211. [Q96DR4-2]
ENST00000505803; ENSP00000427478; ENSG00000164211. [Q96DR4-1]
GeneIDi134429.
KEGGihsa:134429.
UCSCiuc003kph.2. human. [Q96DR4-1]

Organism-specific databases

CTDi134429.
DisGeNETi134429.
GeneCardsiSTARD4.
HGNCiHGNC:18058. STARD4.
HPAiHPA046177.
HPA048081.
MIMi607049. gene.
neXtProtiNX_Q96DR4.
OpenTargetsiENSG00000164211.
PharmGKBiPA38284.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IPNZ. Eukaryota.
ENOG4111F97. LUCA.
GeneTreeiENSGT00530000063294.
HOGENOMiHOG000137345.
HOVERGENiHBG106946.
InParanoidiQ96DR4.
OMAiINFYGDL.
OrthoDBiEOG091G0INO.
PhylomeDBiQ96DR4.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000164211-MONOMER.
ReactomeiR-HSA-196108. Pregnenolone biosynthesis.

Miscellaneous databases

GeneWikiiSTARD4.
GenomeRNAii134429.
PROiQ96DR4.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000164211.
CleanExiHS_STARD4.
ExpressionAtlasiQ96DR4. baseline and differential.
GenevisibleiQ96DR4. HS.

Family and domain databases

Gene3Di3.30.530.20. 1 hit.
InterProiIPR023393. START-like_dom.
IPR002913. START_lipid-bd_dom.
[Graphical view]
PfamiPF01852. START. 1 hit.
[Graphical view]
SMARTiSM00234. START. 1 hit.
[Graphical view]
PROSITEiPS50848. START. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSTAR4_HUMAN
AccessioniPrimary (citable) accession number: Q96DR4
Secondary accession number(s): Q86TN9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: December 1, 2001
Last modified: November 2, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.