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Protein

Methyl-CpG-binding domain protein 6

Gene

MBD6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Binds to heterochromatin. Does not interact with either methylated or unmethylated DNA (in vitro).

GO - Molecular functioni

  • chromatin binding Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Methyl-CpG-binding domain protein 6
Alternative name(s):
Methyl-CpG-binding protein MBD6
Gene namesi
Name:MBD6
Synonyms:KIAA1887
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:20445. MBD6.

Subcellular locationi

GO - Cellular componenti

  • chromocenter Source: UniProtKB
  • nucleolus Source: HPA
  • nucleoplasm Source: HPA
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134866196.

Polymorphism and mutation databases

BioMutaiMBD6.
DMDMi29336893.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10031003Methyl-CpG-binding domain protein 6PRO_0000096267Add
BLAST

Proteomic databases

MaxQBiQ96DN6.
PaxDbiQ96DN6.
PeptideAtlasiQ96DN6.
PRIDEiQ96DN6.

PTM databases

iPTMnetiQ96DN6.
PhosphoSiteiQ96DN6.

Expressioni

Gene expression databases

BgeeiQ96DN6.
CleanExiHS_MBD6.
ExpressionAtlasiQ96DN6. baseline and differential.
GenevisibleiQ96DN6. HS.

Organism-specific databases

HPAiHPA038948.
HPA038949.

Interactioni

Protein-protein interaction databases

BioGridi125347. 5 interactions.
IntActiQ96DN6. 3 interactions.
MINTiMINT-1415249.
STRINGi9606.ENSP00000347896.

Structurei

3D structure databases

ProteinModelPortaliQ96DN6.
SMRiQ96DN6. Positions 21-61.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini11 – 8171MBDPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi140 – 846707Pro-richAdd
BLAST

Domaini

The MBD domain is necessary for chromocentric localization.

Sequence similaritiesi

Contains 1 MBD (methyl-CpG-binding) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IJ20. Eukaryota.
ENOG4111KTI. LUCA.
GeneTreeiENSGT00530000064137.
HOGENOMiHOG000113490.
HOVERGENiHBG039553.
InParanoidiQ96DN6.
OMAiYNPARNS.
OrthoDBiEOG7SN8DS.
PhylomeDBiQ96DN6.
TreeFamiTF338183.

Family and domain databases

InterProiIPR016177. DNA-bd_dom.
IPR001739. Methyl_CpG_DNA-bd.
[Graphical view]
SMARTiSM00391. MBD. 1 hit.
[Graphical view]
SUPFAMiSSF54171. SSF54171. 1 hit.
PROSITEiPS50982. MBD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96DN6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNGGNESSGA DRAGGPVATS VPIGWQRCVR EGAVLYISPS GTELSSLEQT
60 70 80 90 100
RSYLLSDGTC KCGLECPLNV PKVFNFDPLA PVTPGGAGVG PASEEDMTKL
110 120 130 140 150
CNHRRKAVAM ATLYRSMETT CSHSSPGEGA SPQMFHTVSP GPPSARPPCR
160 170 180 190 200
VPPTTPLNGG PGSLPPEPPS VSQAFPTLAG PGGLFPPRLA DPVPSGGSSS
210 220 230 240 250
PRFLPRGNAP SPAPPPPPAI SLNAPSYNWG AALRSSLVPS DLGSPPAPHA
260 270 280 290 300
SSSPPSDPPL FHCSDALTPP PLPPSNNLPA HPGPASQPPV SSATMHLPLV
310 320 330 340 350
LGPLGGAPTV EGPGAPPFLA SSLLSAAAKA QHPPLPPPST LQGRRPRAQA
360 370 380 390 400
PSASHSSSLR PSQRRPRRPP TVFRLLEGRG PQTPRRSRPR APAPVPQPFS
410 420 430 440 450
LPEPSQPILP SVLSLLGLPT PGPSHSDGSF NLLGSDAHLP PPPTLSSGSP
460 470 480 490 500
PQPRHPIQPS LPGTTSGSLS SVPGAPAPPA ASKAPVVPSP VLQSPSEGLG
510 520 530 540 550
MGAGPACPLP PLAGGEAFPF PSPEQGLALS GAGFPGMLGA LPLPLSLGQP
560 570 580 590 600
PPSPLLNHSL FGVLTGGGGQ PPPEPLLPPP GGPGPPLAPG EPEGPSLLVA
610 620 630 640 650
SLLPPPPSDL LPPPSAPPSN LLASFLPLLA LGPTAGDGEG SAEGAGGPSG
660 670 680 690 700
EPFSGLGDLS PLLFPPLSAP PTLIALNSAL LAATLDPPSG TPPQPCVLSA
710 720 730 740 750
PQPGPPTSSV TTATTDPGAS SLGKAPSNSG RPPQLLSPLL GASLLGDLSS
760 770 780 790 800
LTSSPGALPS LLQPPGPLLS GQLGLQLLPG GGAPPPLSEA SSPLACLLQS
810 820 830 840 850
LQIPPEQPEA PCLPPESPAS ALEPEPARPP LSALAPPHGS PDPPVPELLT
860 870 880 890 900
GRGSGKRGRR GGGGLRGING EARPARGRKP GSRREPGRLA LKWGTRGGFN
910 920 930 940 950
GQMERSPRRT HHWQHNGELA EGGAEPKDPP PPGPHSEDLK VPPGVVRKSR
960 970 980 990 1000
RGRRRKYNPT RNSNSSRQDI TLEPSPTARA AVPLPPRARP GRPAKNKRRK

LAP
Length:1,003
Mass (Da):101,201
Last modified:March 25, 2003 - v2
Checksum:i6C8E8693AA6A3BE6
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti637 – 6371D → G in BAB71176 (PubMed:14702039).Curated
Sequence conflicti802 – 8021Q → QQ in BAC04045 (PubMed:14702039).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056399 mRNA. Translation: BAB71176.1.
AK093078 mRNA. Translation: BAC04045.1.
AB067474 mRNA. Translation: BAB67780.1.
AL834230 mRNA. Translation: CAD38908.1.
AC022506 Genomic DNA. No translation available.
CCDSiCCDS8944.1.
RefSeqiNP_443129.3. NM_052897.3.
UniGeneiHs.524523.

Genome annotation databases

EnsembliENST00000355673; ENSP00000347896; ENSG00000166987.
GeneIDi114785.
KEGGihsa:114785.
UCSCiuc001soj.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056399 mRNA. Translation: BAB71176.1.
AK093078 mRNA. Translation: BAC04045.1.
AB067474 mRNA. Translation: BAB67780.1.
AL834230 mRNA. Translation: CAD38908.1.
AC022506 Genomic DNA. No translation available.
CCDSiCCDS8944.1.
RefSeqiNP_443129.3. NM_052897.3.
UniGeneiHs.524523.

3D structure databases

ProteinModelPortaliQ96DN6.
SMRiQ96DN6. Positions 21-61.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125347. 5 interactions.
IntActiQ96DN6. 3 interactions.
MINTiMINT-1415249.
STRINGi9606.ENSP00000347896.

PTM databases

iPTMnetiQ96DN6.
PhosphoSiteiQ96DN6.

Polymorphism and mutation databases

BioMutaiMBD6.
DMDMi29336893.

Proteomic databases

MaxQBiQ96DN6.
PaxDbiQ96DN6.
PeptideAtlasiQ96DN6.
PRIDEiQ96DN6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000355673; ENSP00000347896; ENSG00000166987.
GeneIDi114785.
KEGGihsa:114785.
UCSCiuc001soj.2. human.

Organism-specific databases

CTDi114785.
GeneCardsiMBD6.
H-InvDBHIX0010764.
HGNCiHGNC:20445. MBD6.
HPAiHPA038948.
HPA038949.
neXtProtiNX_Q96DN6.
PharmGKBiPA134866196.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJ20. Eukaryota.
ENOG4111KTI. LUCA.
GeneTreeiENSGT00530000064137.
HOGENOMiHOG000113490.
HOVERGENiHBG039553.
InParanoidiQ96DN6.
OMAiYNPARNS.
OrthoDBiEOG7SN8DS.
PhylomeDBiQ96DN6.
TreeFamiTF338183.

Miscellaneous databases

ChiTaRSiMBD6. human.
GenomeRNAii114785.
PROiQ96DN6.

Gene expression databases

BgeeiQ96DN6.
CleanExiHS_MBD6.
ExpressionAtlasiQ96DN6. baseline and differential.
GenevisibleiQ96DN6. HS.

Family and domain databases

InterProiIPR016177. DNA-bd_dom.
IPR001739. Methyl_CpG_DNA-bd.
[Graphical view]
SMARTiSM00391. MBD. 1 hit.
[Graphical view]
SUPFAMiSSF54171. SSF54171. 1 hit.
PROSITEiPS50982. MBD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  2. "Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins."
    Nagase T., Kikuno R., Ohara O.
    DNA Res. 8:179-187(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Amygdala.
  4. "The finished DNA sequence of human chromosome 12."
    Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
    , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
    Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The human proteins MBD5 and MBD6 associate with heterochromatin but they do not bind methylated DNA."
    Laget S., Joulie M., Le Masson F., Sasai N., Christians E., Pradhan S., Roberts R.J., Defossez P.A.
    PLoS ONE 5:E11982-E11982(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  6. "Toward a comprehensive characterization of a human cancer cell phosphoproteome."
    Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., Mohammed S.
    J. Proteome Res. 12:260-271(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma and Erythroleukemia.

Entry informationi

Entry nameiMBD6_HUMAN
AccessioniPrimary (citable) accession number: Q96DN6
Secondary accession number(s): Q8N3M0, Q8NA81, Q96Q00
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 25, 2003
Last sequence update: March 25, 2003
Last modified: July 6, 2016
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.