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Q96DN2

- VWCE_HUMAN

UniProt

Q96DN2 - VWCE_HUMAN

Protein

von Willebrand factor C and EGF domain-containing protein

Gene

VWCE

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 2 (24 Nov 2009)
      Previous versions | rss
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    Functioni

    May be a regulatory element in the beta-catenin signaling pathway and a target for chemoprevention of hapatocellular carcinoma.1 Publication

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro

    Keywords - Ligandi

    Calcium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    von Willebrand factor C and EGF domain-containing protein
    Alternative name(s):
    HBV X protein up-regulated gene 11 protein
    HBxAg up-regulated gene 11 protein
    Gene namesi
    Name:VWCE
    Synonyms:URG11
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:26487. VWCE.

    Subcellular locationi

    Secreted Curated
    Note: According to PubMed:16496348 is localized in the cytoplasm.1 Publication

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA143485669.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Chaini22 – 955934von Willebrand factor C and EGF domain-containing proteinPRO_0000318580Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi146 ↔ 155PROSITE-ProRule annotation
    Disulfide bondi151 ↔ 164PROSITE-ProRule annotation
    Disulfide bondi166 ↔ 179PROSITE-ProRule annotation
    Disulfide bondi185 ↔ 194PROSITE-ProRule annotation
    Disulfide bondi190 ↔ 203PROSITE-ProRule annotation
    Disulfide bondi205 ↔ 218PROSITE-ProRule annotation
    Disulfide bondi224 ↔ 237PROSITE-ProRule annotation
    Disulfide bondi233 ↔ 246PROSITE-ProRule annotation
    Disulfide bondi248 ↔ 261PROSITE-ProRule annotation
    Glycosylationi462 – 4621N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi472 – 4721N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ96DN2.
    PRIDEiQ96DN2.

    PTM databases

    PhosphoSiteiQ96DN2.

    Expressioni

    Tissue specificityi

    Expressed in liver.1 Publication

    Inductioni

    By HBxAg.1 Publication

    Gene expression databases

    ArrayExpressiQ96DN2.
    BgeeiQ96DN2.
    CleanExiHS_VWCE.
    GenevestigatoriQ96DN2.

    Organism-specific databases

    HPAiHPA040401.
    HPA043921.

    Interactioni

    Protein-protein interaction databases

    IntActiQ96DN2. 1 interaction.
    STRINGi9606.ENSP00000334186.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96DN2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini70 – 9829EGF-like 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini142 – 18039EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini181 – 21939EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini220 – 26243EGF-like 4; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini384 – 44158VWFC 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini442 – 50261VWFC 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini503 – 56058VWFC 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini566 – 62661VWFC 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini627 – 68559VWFC 5PROSITE-ProRule annotationAdd
    BLAST
    Domaini686 – 74358VWFC 6PROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi285 – 2884Poly-Leu
    Compositional biasi835 – 87238Pro-richAdd
    BLAST

    Sequence similaritiesi

    Contains 4 EGF-like domains.PROSITE-ProRule annotation
    Contains 6 VWFC domains.PROSITE-ProRule annotation

    Keywords - Domaini

    EGF-like domain, Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG240200.
    HOGENOMiHOG000168460.
    HOVERGENiHBG067558.
    InParanoidiQ96DN2.
    OMAiCTCVPVR.
    OrthoDBiEOG7D2FCX.
    PhylomeDBiQ96DN2.
    TreeFamiTF330819.

    Family and domain databases

    InterProiIPR000742. EG-like_dom.
    IPR001881. EGF-like_Ca-bd_dom.
    IPR013032. EGF-like_CS.
    IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
    IPR018097. EGF_Ca-bd_CS.
    IPR009030. Growth_fac_rcpt_N_dom.
    IPR001007. VWF_C.
    [Graphical view]
    PfamiPF07645. EGF_CA. 3 hits.
    PF00093. VWC. 4 hits.
    [Graphical view]
    SMARTiSM00181. EGF. 1 hit.
    SM00179. EGF_CA. 3 hits.
    SM00214. VWC. 6 hits.
    [Graphical view]
    SUPFAMiSSF57184. SSF57184. 1 hit.
    PROSITEiPS00010. ASX_HYDROXYL. 3 hits.
    PS00022. EGF_1. 1 hit.
    PS01186. EGF_2. 2 hits.
    PS50026. EGF_3. 3 hits.
    PS01187. EGF_CA. 3 hits.
    PS01208. VWFC_1. 5 hits.
    PS50184. VWFC_2. 5 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q96DN2-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MWAGLLLRAA CVALLLPGAP ARGYTGRKPP GHFAAERRRL GPHVCLSGFG    50
    SGCCPGWAPS MGGGHCTLPL CSFGCGSGIC IAPNVCSCQD GEQGATCPET 100
    HGPCGEYGCD LTCNHGGCQE VARVCPVGFS MTETAVGIRC TDIDECVTSS 150
    CEGHCVNTEG GFVCECGPGM QLSADRHSCQ DTDECLGTPC QQRCKNSIGS 200
    YKCSCRTGFH LHGNRHSCVD VNECRRPLER RVCHHSCHNT VGSFLCTCRP 250
    GFRLRADRVS CEAFPKAVLA PSAILQPRQH PSKMLLLLPE AGRPALSPGH 300
    SPPSGAPGPP AGVRTTRLPS PTPRLPTSSP SAPVWLLSTL LATPVPTASL 350
    LGNLRPPSLL QGEVMGTPSS PRGPESPRLA AGPSPCWHLG AMHESRSRWT 400
    EPGCSQCWCE DGKVTCEKVR CEAACSHPIP SRDGGCCPSC TGCFHSGVVR 450
    AEGDVFSPPN ENCTVCVCLA GNVSCISPEC PSGPCQTPPQ TDCCTCVPVR 500
    CYFHGRWYAD GAVFSGGGDE CTTCVCQNGE VECSFMPCPE LACPREEWRL 550
    GPGQCCFTCQ EPTPSTGCSL DDNGVEFPIG QIWSPGDPCE LCICQADGSV 600
    SCKRTDCVDS CPHPIRIPGQ CCPDCSAGCT YTGRIFYNNE TFPSVLDPCL 650
    SCICLLGSVA CSPVDCPITC TYPFHPDGEC CPVCRDCNYE GRKVANGQVF 700
    TLDDEPCTRC TCQLGEVSCE KVPCQRACAD PALLPGDCCS SCPDSLSPLE 750
    EKQGLSPHGN VAFSKAGRSL HGDTEAPVNC SSCPGPPTAS PSRPVLHLLQ 800
    LLLRTNLMKT QTLPTSPAGA HGPHSLALGL TATFPGEPGA SPRLSPGPST 850
    PPGAPTLPLA SPGAPQPPPV TPERSFSASG AQIVSRWPPL PGTLLTEASA 900
    LSMMDPSPSK TPITLLGPRV LSPTTSRLST ALAATTHPGP QQPPVGASRG 950
    EESTM 955
    Length:955
    Mass (Da):99,915
    Last modified:November 24, 2009 - v2
    Checksum:iB745618AD37E712B
    GO
    Isoform 2 (identifier: Q96DN2-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         219-219: V → M
         220-955: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:219
    Mass (Da):22,790
    Checksum:iB018610FE43DAE45
    GO

    Sequence cautioni

    The sequence AAO47606.1 differs from that shown. Reason: Frameshift at positions 210, 232, 745, 761, 769, 837 and 912.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti134 – 1341T → A in BAB71219. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti842 – 8421P → R.
    Corresponds to variant rs3750982 [ dbSNP | Ensembl ].
    VAR_038782

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei219 – 2191V → M in isoform 2. 1 PublicationVSP_031230
    Alternative sequencei220 – 955736Missing in isoform 2. 1 PublicationVSP_031231Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK056571 mRNA. Translation: BAB71219.1.
    BC052564 mRNA. No translation available.
    BC077719 mRNA. No translation available.
    BC142624 mRNA. Translation: AAI42625.1.
    CH471076 Genomic DNA. Translation: EAW73932.1.
    AY205235 mRNA. Translation: AAO47606.1. Frameshift.
    CCDSiCCDS8002.1. [Q96DN2-1]
    RefSeqiNP_689931.2. NM_152718.2. [Q96DN2-1]
    UniGeneiHs.60640.

    Genome annotation databases

    EnsembliENST00000301770; ENSP00000301770; ENSG00000167992. [Q96DN2-2]
    ENST00000335613; ENSP00000334186; ENSG00000167992. [Q96DN2-1]
    GeneIDi220001.
    KEGGihsa:220001.
    UCSCiuc001nra.3. human. [Q96DN2-1]

    Polymorphism databases

    DMDMi269849477.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK056571 mRNA. Translation: BAB71219.1 .
    BC052564 mRNA. No translation available.
    BC077719 mRNA. No translation available.
    BC142624 mRNA. Translation: AAI42625.1 .
    CH471076 Genomic DNA. Translation: EAW73932.1 .
    AY205235 mRNA. Translation: AAO47606.1 . Frameshift.
    CCDSi CCDS8002.1. [Q96DN2-1 ]
    RefSeqi NP_689931.2. NM_152718.2. [Q96DN2-1 ]
    UniGenei Hs.60640.

    3D structure databases

    ProteinModelPortali Q96DN2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q96DN2. 1 interaction.
    STRINGi 9606.ENSP00000334186.

    PTM databases

    PhosphoSitei Q96DN2.

    Polymorphism databases

    DMDMi 269849477.

    Proteomic databases

    PaxDbi Q96DN2.
    PRIDEi Q96DN2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000301770 ; ENSP00000301770 ; ENSG00000167992 . [Q96DN2-2 ]
    ENST00000335613 ; ENSP00000334186 ; ENSG00000167992 . [Q96DN2-1 ]
    GeneIDi 220001.
    KEGGi hsa:220001.
    UCSCi uc001nra.3. human. [Q96DN2-1 ]

    Organism-specific databases

    CTDi 220001.
    GeneCardsi GC11M061025.
    H-InvDB HIX0009684.
    HGNCi HGNC:26487. VWCE.
    HPAi HPA040401.
    HPA043921.
    MIMi 611115. gene.
    neXtProti NX_Q96DN2.
    PharmGKBi PA143485669.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG240200.
    HOGENOMi HOG000168460.
    HOVERGENi HBG067558.
    InParanoidi Q96DN2.
    OMAi CTCVPVR.
    OrthoDBi EOG7D2FCX.
    PhylomeDBi Q96DN2.
    TreeFami TF330819.

    Miscellaneous databases

    GenomeRNAii 220001.
    NextBioi 90941.
    PROi Q96DN2.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q96DN2.
    Bgeei Q96DN2.
    CleanExi HS_VWCE.
    Genevestigatori Q96DN2.

    Family and domain databases

    InterProi IPR000742. EG-like_dom.
    IPR001881. EGF-like_Ca-bd_dom.
    IPR013032. EGF-like_CS.
    IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
    IPR018097. EGF_Ca-bd_CS.
    IPR009030. Growth_fac_rcpt_N_dom.
    IPR001007. VWF_C.
    [Graphical view ]
    Pfami PF07645. EGF_CA. 3 hits.
    PF00093. VWC. 4 hits.
    [Graphical view ]
    SMARTi SM00181. EGF. 1 hit.
    SM00179. EGF_CA. 3 hits.
    SM00214. VWC. 6 hits.
    [Graphical view ]
    SUPFAMi SSF57184. SSF57184. 1 hit.
    PROSITEi PS00010. ASX_HYDROXYL. 3 hits.
    PS00022. EGF_1. 1 hit.
    PS01186. EGF_2. 2 hits.
    PS50026. EGF_3. 3 hits.
    PS01187. EGF_CA. 3 hits.
    PS01208. VWFC_1. 5 hits.
    PS50184. VWFC_2. 5 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Teratocarcinoma.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Lymph.
    4. "Upregulated expression of a unique gene by hepatitis B x antigen promotes hepatocellular growth and tumorigenesis."
      Lian Z., Liu J., Li L., Li X., Tufan S.N.L., Clayton M., Wu M.-C., Wang H.-Y., Arbuthnot P., Kew M., Feitelson M.A.
      Neoplasia 5:229-244(2003)
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 73-955 (ISOFORM 1).
    5. "Enhanced cell survival of Hep3B cells by the hepatitis B x antigen effector, URG11, is associated with upregulation of beta-catenin."
      Lian Z., Liu J., Li L., Li X., Clayton M., Wu M.-C., Wang H.-Y., Arbuthnot P., Kew M., Fan D., Feitelson M.A.
      Hepatology 43:415-424(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, INDUCTION BY HBXAG, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiVWCE_HUMAN
    AccessioniPrimary (citable) accession number: Q96DN2
    Secondary accession number(s): A5PKV0, Q7Z7L6, Q86WK8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: November 24, 2009
    Last modified: October 1, 2014
    This is version 93 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3