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Q96DN2

- VWCE_HUMAN

UniProt

Q96DN2 - VWCE_HUMAN

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Protein
von Willebrand factor C and EGF domain-containing protein
Gene
VWCE, URG11
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

May be a regulatory element in the beta-catenin signaling pathway and a target for chemoprevention of hapatocellular carcinoma.1 Publication

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
von Willebrand factor C and EGF domain-containing protein
Alternative name(s):
HBV X protein up-regulated gene 11 protein
HBxAg up-regulated gene 11 protein
Gene namesi
Name:VWCE
Synonyms:URG11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:26487. VWCE.

Subcellular locationi

Secreted Reviewed prediction
Note: According to 1 Publication is localized in the cytoplasm.1 Publication

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA143485669.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121 Reviewed prediction
Add
BLAST
Chaini22 – 955934von Willebrand factor C and EGF domain-containing protein
PRO_0000318580Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi146 ↔ 155 By similarity
Disulfide bondi151 ↔ 164 By similarity
Disulfide bondi166 ↔ 179 By similarity
Disulfide bondi185 ↔ 194 By similarity
Disulfide bondi190 ↔ 203 By similarity
Disulfide bondi205 ↔ 218 By similarity
Disulfide bondi224 ↔ 237 By similarity
Disulfide bondi233 ↔ 246 By similarity
Disulfide bondi248 ↔ 261 By similarity
Glycosylationi462 – 4621N-linked (GlcNAc...) Reviewed prediction
Glycosylationi472 – 4721N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ96DN2.
PRIDEiQ96DN2.

PTM databases

PhosphoSiteiQ96DN2.

Expressioni

Tissue specificityi

Expressed in liver.1 Publication

Inductioni

By HBxAg.1 Publication

Gene expression databases

ArrayExpressiQ96DN2.
BgeeiQ96DN2.
CleanExiHS_VWCE.
GenevestigatoriQ96DN2.

Organism-specific databases

HPAiHPA040401.
HPA043921.

Interactioni

Protein-protein interaction databases

IntActiQ96DN2. 1 interaction.
STRINGi9606.ENSP00000334186.

Structurei

3D structure databases

ProteinModelPortaliQ96DN2.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini70 – 9829EGF-like 1
Add
BLAST
Domaini142 – 18039EGF-like 2; calcium-binding Reviewed prediction
Add
BLAST
Domaini181 – 21939EGF-like 3; calcium-binding Reviewed prediction
Add
BLAST
Domaini220 – 26243EGF-like 4; calcium-binding Reviewed prediction
Add
BLAST
Domaini384 – 44158VWFC 1
Add
BLAST
Domaini442 – 50261VWFC 2
Add
BLAST
Domaini503 – 56058VWFC 3
Add
BLAST
Domaini566 – 62661VWFC 4
Add
BLAST
Domaini627 – 68559VWFC 5
Add
BLAST
Domaini686 – 74358VWFC 6
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi285 – 2884Poly-Leu
Compositional biasi835 – 87238Pro-rich
Add
BLAST

Sequence similaritiesi

Contains 4 EGF-like domains.
Contains 6 VWFC domains.

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

eggNOGiNOG240200.
HOGENOMiHOG000168460.
HOVERGENiHBG067558.
InParanoidiQ96DN2.
OMAiCTCVPVR.
OrthoDBiEOG7D2FCX.
PhylomeDBiQ96DN2.
TreeFamiTF330819.

Family and domain databases

InterProiIPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_N_dom.
IPR001007. VWF_C.
[Graphical view]
PfamiPF07645. EGF_CA. 3 hits.
PF00093. VWC. 4 hits.
[Graphical view]
SMARTiSM00181. EGF. 1 hit.
SM00179. EGF_CA. 3 hits.
SM00214. VWC. 6 hits.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
PROSITEiPS00010. ASX_HYDROXYL. 3 hits.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 2 hits.
PS50026. EGF_3. 3 hits.
PS01187. EGF_CA. 3 hits.
PS01208. VWFC_1. 5 hits.
PS50184. VWFC_2. 5 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q96DN2-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MWAGLLLRAA CVALLLPGAP ARGYTGRKPP GHFAAERRRL GPHVCLSGFG    50
SGCCPGWAPS MGGGHCTLPL CSFGCGSGIC IAPNVCSCQD GEQGATCPET 100
HGPCGEYGCD LTCNHGGCQE VARVCPVGFS MTETAVGIRC TDIDECVTSS 150
CEGHCVNTEG GFVCECGPGM QLSADRHSCQ DTDECLGTPC QQRCKNSIGS 200
YKCSCRTGFH LHGNRHSCVD VNECRRPLER RVCHHSCHNT VGSFLCTCRP 250
GFRLRADRVS CEAFPKAVLA PSAILQPRQH PSKMLLLLPE AGRPALSPGH 300
SPPSGAPGPP AGVRTTRLPS PTPRLPTSSP SAPVWLLSTL LATPVPTASL 350
LGNLRPPSLL QGEVMGTPSS PRGPESPRLA AGPSPCWHLG AMHESRSRWT 400
EPGCSQCWCE DGKVTCEKVR CEAACSHPIP SRDGGCCPSC TGCFHSGVVR 450
AEGDVFSPPN ENCTVCVCLA GNVSCISPEC PSGPCQTPPQ TDCCTCVPVR 500
CYFHGRWYAD GAVFSGGGDE CTTCVCQNGE VECSFMPCPE LACPREEWRL 550
GPGQCCFTCQ EPTPSTGCSL DDNGVEFPIG QIWSPGDPCE LCICQADGSV 600
SCKRTDCVDS CPHPIRIPGQ CCPDCSAGCT YTGRIFYNNE TFPSVLDPCL 650
SCICLLGSVA CSPVDCPITC TYPFHPDGEC CPVCRDCNYE GRKVANGQVF 700
TLDDEPCTRC TCQLGEVSCE KVPCQRACAD PALLPGDCCS SCPDSLSPLE 750
EKQGLSPHGN VAFSKAGRSL HGDTEAPVNC SSCPGPPTAS PSRPVLHLLQ 800
LLLRTNLMKT QTLPTSPAGA HGPHSLALGL TATFPGEPGA SPRLSPGPST 850
PPGAPTLPLA SPGAPQPPPV TPERSFSASG AQIVSRWPPL PGTLLTEASA 900
LSMMDPSPSK TPITLLGPRV LSPTTSRLST ALAATTHPGP QQPPVGASRG 950
EESTM 955
Length:955
Mass (Da):99,915
Last modified:November 24, 2009 - v2
Checksum:iB745618AD37E712B
GO
Isoform 2 (identifier: Q96DN2-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     219-219: V → M
     220-955: Missing.

Note: No experimental confirmation available.

Show »
Length:219
Mass (Da):22,790
Checksum:iB018610FE43DAE45
GO

Sequence cautioni

The sequence AAO47606.1 differs from that shown. Reason: Frameshift at positions 210, 232, 745, 761, 769, 837 and 912.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti842 – 8421P → R.
Corresponds to variant rs3750982 [ dbSNP | Ensembl ].
VAR_038782

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei219 – 2191V → M in isoform 2.
VSP_031230
Alternative sequencei220 – 955736Missing in isoform 2.
VSP_031231Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti134 – 1341T → A in BAB71219. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK056571 mRNA. Translation: BAB71219.1.
BC052564 mRNA. No translation available.
BC077719 mRNA. No translation available.
BC142624 mRNA. Translation: AAI42625.1.
CH471076 Genomic DNA. Translation: EAW73932.1.
AY205235 mRNA. Translation: AAO47606.1. Frameshift.
CCDSiCCDS8002.1. [Q96DN2-1]
RefSeqiNP_689931.2. NM_152718.2. [Q96DN2-1]
UniGeneiHs.60640.

Genome annotation databases

EnsembliENST00000301770; ENSP00000301770; ENSG00000167992. [Q96DN2-2]
ENST00000335613; ENSP00000334186; ENSG00000167992. [Q96DN2-1]
GeneIDi220001.
KEGGihsa:220001.
UCSCiuc001nra.3. human. [Q96DN2-1]

Polymorphism databases

DMDMi269849477.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK056571 mRNA. Translation: BAB71219.1 .
BC052564 mRNA. No translation available.
BC077719 mRNA. No translation available.
BC142624 mRNA. Translation: AAI42625.1 .
CH471076 Genomic DNA. Translation: EAW73932.1 .
AY205235 mRNA. Translation: AAO47606.1 . Frameshift.
CCDSi CCDS8002.1. [Q96DN2-1 ]
RefSeqi NP_689931.2. NM_152718.2. [Q96DN2-1 ]
UniGenei Hs.60640.

3D structure databases

ProteinModelPortali Q96DN2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q96DN2. 1 interaction.
STRINGi 9606.ENSP00000334186.

PTM databases

PhosphoSitei Q96DN2.

Polymorphism databases

DMDMi 269849477.

Proteomic databases

PaxDbi Q96DN2.
PRIDEi Q96DN2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000301770 ; ENSP00000301770 ; ENSG00000167992 . [Q96DN2-2 ]
ENST00000335613 ; ENSP00000334186 ; ENSG00000167992 . [Q96DN2-1 ]
GeneIDi 220001.
KEGGi hsa:220001.
UCSCi uc001nra.3. human. [Q96DN2-1 ]

Organism-specific databases

CTDi 220001.
GeneCardsi GC11M061025.
H-InvDB HIX0009684.
HGNCi HGNC:26487. VWCE.
HPAi HPA040401.
HPA043921.
MIMi 611115. gene.
neXtProti NX_Q96DN2.
PharmGKBi PA143485669.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG240200.
HOGENOMi HOG000168460.
HOVERGENi HBG067558.
InParanoidi Q96DN2.
OMAi CTCVPVR.
OrthoDBi EOG7D2FCX.
PhylomeDBi Q96DN2.
TreeFami TF330819.

Miscellaneous databases

GenomeRNAii 220001.
NextBioi 90941.
PROi Q96DN2.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q96DN2.
Bgeei Q96DN2.
CleanExi HS_VWCE.
Genevestigatori Q96DN2.

Family and domain databases

InterProi IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_N_dom.
IPR001007. VWF_C.
[Graphical view ]
Pfami PF07645. EGF_CA. 3 hits.
PF00093. VWC. 4 hits.
[Graphical view ]
SMARTi SM00181. EGF. 1 hit.
SM00179. EGF_CA. 3 hits.
SM00214. VWC. 6 hits.
[Graphical view ]
SUPFAMi SSF57184. SSF57184. 1 hit.
PROSITEi PS00010. ASX_HYDROXYL. 3 hits.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 2 hits.
PS50026. EGF_3. 3 hits.
PS01187. EGF_CA. 3 hits.
PS01208. VWFC_1. 5 hits.
PS50184. VWFC_2. 5 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Teratocarcinoma.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Lymph.
  4. "Upregulated expression of a unique gene by hepatitis B x antigen promotes hepatocellular growth and tumorigenesis."
    Lian Z., Liu J., Li L., Li X., Tufan S.N.L., Clayton M., Wu M.-C., Wang H.-Y., Arbuthnot P., Kew M., Feitelson M.A.
    Neoplasia 5:229-244(2003)
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 73-955 (ISOFORM 1).
  5. "Enhanced cell survival of Hep3B cells by the hepatitis B x antigen effector, URG11, is associated with upregulation of beta-catenin."
    Lian Z., Liu J., Li L., Li X., Clayton M., Wu M.-C., Wang H.-Y., Arbuthnot P., Kew M., Fan D., Feitelson M.A.
    Hepatology 43:415-424(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, INDUCTION BY HBXAG, TISSUE SPECIFICITY.

Entry informationi

Entry nameiVWCE_HUMAN
AccessioniPrimary (citable) accession number: Q96DN2
Secondary accession number(s): A5PKV0, Q7Z7L6, Q86WK8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: November 24, 2009
Last modified: July 9, 2014
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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