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Protein

von Willebrand factor C and EGF domain-containing protein

Gene

VWCE

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be a regulatory element in the beta-catenin signaling pathway and a target for chemoprevention of hapatocellular carcinoma.1 Publication

Caution

GO - Molecular functioni

GO - Biological processi

  • cellular response to virus Source: UniProtKB

Keywordsi

LigandCalcium

Names & Taxonomyi

Protein namesi
Recommended name:
von Willebrand factor C and EGF domain-containing protein
Alternative name(s):
HBV X protein up-regulated gene 11 protein
HBxAg up-regulated gene 11 protein
Gene namesi
Name:VWCE
Synonyms:URG11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000167992.12
HGNCiHGNC:26487 VWCE
MIMi611115 gene
neXtProtiNX_Q96DN2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi220001
OpenTargetsiENSG00000167992
PharmGKBiPA143485669

Polymorphism and mutation databases

BioMutaiVWCE
DMDMi269849477

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000031858022 – 955von Willebrand factor C and EGF domain-containing proteinAdd BLAST934

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi146 ↔ 155PROSITE-ProRule annotation
Disulfide bondi151 ↔ 164PROSITE-ProRule annotation
Disulfide bondi166 ↔ 179PROSITE-ProRule annotation
Disulfide bondi185 ↔ 194PROSITE-ProRule annotation
Disulfide bondi190 ↔ 203PROSITE-ProRule annotation
Disulfide bondi205 ↔ 218PROSITE-ProRule annotation
Disulfide bondi224 ↔ 237PROSITE-ProRule annotation
Disulfide bondi233 ↔ 246PROSITE-ProRule annotation
Disulfide bondi248 ↔ 261PROSITE-ProRule annotation
Glycosylationi462N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi472N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ96DN2
PeptideAtlasiQ96DN2
PRIDEiQ96DN2

PTM databases

iPTMnetiQ96DN2
PhosphoSitePlusiQ96DN2

Expressioni

Tissue specificityi

Expressed in liver.1 Publication

Inductioni

By HBxAg.1 Publication

Gene expression databases

BgeeiENSG00000167992
CleanExiHS_VWCE
ExpressionAtlasiQ96DN2 baseline and differential
GenevisibleiQ96DN2 HS

Organism-specific databases

HPAiHPA040401
HPA043921

Interactioni

Protein-protein interaction databases

BioGridi12861663 interactors.
IntActiQ96DN2 4 interactors.
MINTiQ96DN2
STRINGi9606.ENSP00000334186

Structurei

3D structure databases

ProteinModelPortaliQ96DN2
SMRiQ96DN2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini70 – 98EGF-like 1PROSITE-ProRule annotationAdd BLAST29
Domaini142 – 180EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd BLAST39
Domaini181 – 219EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd BLAST39
Domaini220 – 262EGF-like 4; calcium-bindingPROSITE-ProRule annotationAdd BLAST43
Domaini384 – 441VWFC 1PROSITE-ProRule annotationAdd BLAST58
Domaini442 – 502VWFC 2PROSITE-ProRule annotationAdd BLAST61
Domaini503 – 560VWFC 3PROSITE-ProRule annotationAdd BLAST58
Domaini566 – 626VWFC 4PROSITE-ProRule annotationAdd BLAST61
Domaini627 – 685VWFC 5PROSITE-ProRule annotationAdd BLAST59
Domaini686 – 743VWFC 6PROSITE-ProRule annotationAdd BLAST58

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi285 – 288Poly-Leu4
Compositional biasi835 – 872Pro-richAdd BLAST38

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

eggNOGiKOG1216 Eukaryota
KOG1217 Eukaryota
ENOG4110VWF LUCA
GeneTreeiENSGT00810000125382
HOGENOMiHOG000168460
HOVERGENiHBG067558
InParanoidiQ96DN2
OMAiWLGPGQC
OrthoDBiEOG091G01PY
PhylomeDBiQ96DN2
TreeFamiTF330819

Family and domain databases

InterProiView protein in InterPro
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR009030 Growth_fac_rcpt_cys_sf
IPR037578 Von_Willebrand_factor
IPR001007 VWF_dom
PANTHERiPTHR11339:SF361 PTHR11339:SF361, 7 hits
PfamiView protein in Pfam
PF07645 EGF_CA, 3 hits
PF00093 VWC, 4 hits
SMARTiView protein in SMART
SM00181 EGF, 4 hits
SM00179 EGF_CA, 3 hits
SM00214 VWC, 6 hits
SM00215 VWC_out, 3 hits
SUPFAMiSSF57184 SSF57184, 1 hit
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 3 hits
PS00022 EGF_1, 1 hit
PS01186 EGF_2, 2 hits
PS50026 EGF_3, 3 hits
PS01187 EGF_CA, 3 hits
PS01208 VWFC_1, 5 hits
PS50184 VWFC_2, 5 hits

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96DN2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MWAGLLLRAA CVALLLPGAP ARGYTGRKPP GHFAAERRRL GPHVCLSGFG
60 70 80 90 100
SGCCPGWAPS MGGGHCTLPL CSFGCGSGIC IAPNVCSCQD GEQGATCPET
110 120 130 140 150
HGPCGEYGCD LTCNHGGCQE VARVCPVGFS MTETAVGIRC TDIDECVTSS
160 170 180 190 200
CEGHCVNTEG GFVCECGPGM QLSADRHSCQ DTDECLGTPC QQRCKNSIGS
210 220 230 240 250
YKCSCRTGFH LHGNRHSCVD VNECRRPLER RVCHHSCHNT VGSFLCTCRP
260 270 280 290 300
GFRLRADRVS CEAFPKAVLA PSAILQPRQH PSKMLLLLPE AGRPALSPGH
310 320 330 340 350
SPPSGAPGPP AGVRTTRLPS PTPRLPTSSP SAPVWLLSTL LATPVPTASL
360 370 380 390 400
LGNLRPPSLL QGEVMGTPSS PRGPESPRLA AGPSPCWHLG AMHESRSRWT
410 420 430 440 450
EPGCSQCWCE DGKVTCEKVR CEAACSHPIP SRDGGCCPSC TGCFHSGVVR
460 470 480 490 500
AEGDVFSPPN ENCTVCVCLA GNVSCISPEC PSGPCQTPPQ TDCCTCVPVR
510 520 530 540 550
CYFHGRWYAD GAVFSGGGDE CTTCVCQNGE VECSFMPCPE LACPREEWRL
560 570 580 590 600
GPGQCCFTCQ EPTPSTGCSL DDNGVEFPIG QIWSPGDPCE LCICQADGSV
610 620 630 640 650
SCKRTDCVDS CPHPIRIPGQ CCPDCSAGCT YTGRIFYNNE TFPSVLDPCL
660 670 680 690 700
SCICLLGSVA CSPVDCPITC TYPFHPDGEC CPVCRDCNYE GRKVANGQVF
710 720 730 740 750
TLDDEPCTRC TCQLGEVSCE KVPCQRACAD PALLPGDCCS SCPDSLSPLE
760 770 780 790 800
EKQGLSPHGN VAFSKAGRSL HGDTEAPVNC SSCPGPPTAS PSRPVLHLLQ
810 820 830 840 850
LLLRTNLMKT QTLPTSPAGA HGPHSLALGL TATFPGEPGA SPRLSPGPST
860 870 880 890 900
PPGAPTLPLA SPGAPQPPPV TPERSFSASG AQIVSRWPPL PGTLLTEASA
910 920 930 940 950
LSMMDPSPSK TPITLLGPRV LSPTTSRLST ALAATTHPGP QQPPVGASRG

EESTM
Length:955
Mass (Da):99,915
Last modified:November 24, 2009 - v2
Checksum:iB745618AD37E712B
GO
Isoform 2 (identifier: Q96DN2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     219-219: V → M
     220-955: Missing.

Note: No experimental confirmation available.
Show »
Length:219
Mass (Da):22,790
Checksum:iB018610FE43DAE45
GO

Sequence cautioni

The sequence AAO47606 differs from that shown. Reason: Frameshift at positions 210, 232, 745, 761, 769, 837 and 912.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti134T → A in BAB71219 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_038782842P → R. Corresponds to variant dbSNP:rs3750982Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_031230219V → M in isoform 2. 1 Publication1
Alternative sequenceiVSP_031231220 – 955Missing in isoform 2. 1 PublicationAdd BLAST736

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056571 mRNA Translation: BAB71219.1
BC052564 mRNA No translation available.
BC077719 mRNA No translation available.
BC142624 mRNA Translation: AAI42625.1
CH471076 Genomic DNA Translation: EAW73932.1
AY205235 mRNA Translation: AAO47606.1 Frameshift.
CCDSiCCDS8002.1 [Q96DN2-1]
RefSeqiNP_689931.2, NM_152718.2 [Q96DN2-1]
UniGeneiHs.60640

Genome annotation databases

EnsembliENST00000301770; ENSP00000301770; ENSG00000167992 [Q96DN2-2]
ENST00000335613; ENSP00000334186; ENSG00000167992 [Q96DN2-1]
GeneIDi220001
KEGGihsa:220001
UCSCiuc001nra.4 human [Q96DN2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiVWCE_HUMAN
AccessioniPrimary (citable) accession number: Q96DN2
Secondary accession number(s): A5PKV0, Q7Z7L6, Q86WK8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: November 24, 2009
Last modified: February 28, 2018
This is version 125 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome