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Protein

Endoplasmic reticulum resident protein 27

Gene

ERP27

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miscellaneous

Does not contain a CXXC active site motif indicating that it is a catalytically redox-inactive member of the protein disulfide isomerase family.

Enzyme and pathway databases

BRENDAi5.3.4.1 2681

Names & Taxonomyi

Protein namesi
Recommended name:
Endoplasmic reticulum resident protein 27
Short name:
ER protein 27
Short name:
ERp27
Gene namesi
Name:ERP27
Synonyms:C12orf46
ORF Names:UNQ781/PRO1575
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000139055.6
HGNCiHGNC:26495 ERP27
MIMi610642 gene
neXtProtiNX_Q96DN0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi168M → W: Decreases somatostatin-14 binding. 1 Publication1
Mutagenesisi196I → A, L or W: Decreases somatostatin-14 binding. 1 Publication1
Mutagenesisi196I → W: Conserved PDIA3 binding in vivo and in vitro. 1 Publication1
Mutagenesisi231E → K or A: Greatly reduces PDIA3 binding in vivo and in vitro. 1 Publication1
Mutagenesisi232W → A: Greatly reduces PDIA3 binding in vivo and in vitro. 1 Publication1
Mutagenesisi233D → G: Greatly reduces PDIA3 binding in vivo and in vitro. 1 Publication1

Organism-specific databases

OpenTargetsiENSG00000139055
PharmGKBiPA162385401

Polymorphism and mutation databases

BioMutaiERP27
DMDMi74731474

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000028111826 – 273Endoplasmic reticulum resident protein 27Add BLAST248

Proteomic databases

MaxQBiQ96DN0
PaxDbiQ96DN0
PeptideAtlasiQ96DN0
PRIDEiQ96DN0
ProteomicsDBi76296

Expressioni

Gene expression databases

BgeeiENSG00000139055
CleanExiHS_ERP27
ExpressionAtlasiQ96DN0 baseline and differential
GenevisibleiQ96DN0 HS

Organism-specific databases

HPAiHPA039636
HPA052851

Interactioni

Subunit structurei

Interacts with PDIA3. Binds somatostatin-14 via hydrophobic interactions.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi125733, 12 interactors
IntActiQ96DN0, 6 interactors
STRINGi9606.ENSP00000266397

Structurei

Secondary structure

1273
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi46 – 54Combined sources9
Beta strandi56 – 63Combined sources8
Helixi71 – 78Combined sources8
Turni79 – 81Combined sources3
Beta strandi85 – 90Combined sources6
Helixi93 – 98Combined sources6
Beta strandi103 – 110Combined sources8
Turni111 – 114Combined sources4
Beta strandi115 – 119Combined sources5
Helixi121 – 125Combined sources5
Helixi129 – 139Combined sources11
Beta strandi143 – 146Combined sources4
Helixi149 – 157Combined sources9
Beta strandi162 – 168Combined sources7
Helixi175 – 188Combined sources14
Turni189 – 192Combined sources4
Beta strandi194 – 199Combined sources6
Helixi203 – 205Combined sources3
Helixi206 – 211Combined sources6
Helixi216 – 218Combined sources3
Beta strandi220 – 229Combined sources10
Beta strandi232 – 235Combined sources4
Helixi242 – 253Combined sources12

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2L4CNMR-A26-141[»]
4F9ZX-ray2.20A/B/C/D/E30-256[»]
ProteinModelPortaliQ96DN0
SMRiQ96DN0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini39 – 152ThioredoxinAdd BLAST114

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni230 – 233PDIA3-binding site4

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi270 – 273Prevents secretion from ER4

Sequence similaritiesi

Belongs to the protein disulfide isomerase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG0191 Eukaryota
COG0526 LUCA
GeneTreeiENSGT00860000133691
HOGENOMiHOG000112391
HOVERGENiHBG081481
InParanoidiQ96DN0
KOiK20355
OMAiEHVQNFC
OrthoDBiEOG091G0CRI
PhylomeDBiQ96DN0
TreeFamiTF106381

Family and domain databases

InterProiView protein in InterPro
IPR036249 Thioredoxin-like_sf
SUPFAMiSSF52833 SSF52833, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q96DN0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEAAPSRFMF LLFLLTCELA AEVAAEVEKS SDGPGAAQEP TWLTDVPAAM
60 70 80 90 100
EFIAATEVAV IGFFQDLEIP AVPILHSMVQ KFPGVSFGIS TDSEVLTHYN
110 120 130 140 150
ITGNTICLFR LVDNEQLNLE DEDIESIDAT KLSRFIEINS LHMVTEYNPV
160 170 180 190 200
TVIGLFNSVI QIHLLLIMNK ASPEYEENMH RYQKAAKLFQ GKILFILVDS
210 220 230 240 250
GMKENGKVIS FFKLKESQLP ALAIYQTLDD EWDTLPTAEV SVEHVQNFCD
260 270
GFLSGKLLKE NRESEGKTPK VEL
Length:273
Mass (Da):30,480
Last modified:December 1, 2001 - v1
Checksum:iD47280F6F6FDE419
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05258252F → L. Corresponds to variant dbSNP:rs35030722Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358536 mRNA Translation: AAQ88900.1
AK056677 mRNA Translation: BAB71251.1
BC030218 mRNA Translation: AAH30218.1
CCDSiCCDS8670.1
RefSeqiNP_001287713.1, NM_001300784.1
NP_689534.1, NM_152321.3
UniGeneiHs.162143

Genome annotation databases

EnsembliENST00000266397; ENSP00000266397; ENSG00000139055
GeneIDi121506
KEGGihsa:121506
UCSCiuc001rco.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiERP27_HUMAN
AccessioniPrimary (citable) accession number: Q96DN0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: December 1, 2001
Last modified: June 20, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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