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Q96DN0

- ERP27_HUMAN

UniProt

Q96DN0 - ERP27_HUMAN

Protein

Endoplasmic reticulum resident protein 27

Gene

ERP27

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Enzyme and pathway databases

    BRENDAi5.3.4.1. 2681.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Endoplasmic reticulum resident protein 27
    Short name:
    ER protein 27
    Short name:
    ERp27
    Gene namesi
    Name:ERP27
    Synonyms:C12orf46
    ORF Names:UNQ781/PRO1575
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:26495. ERP27.

    Subcellular locationi

    Endoplasmic reticulum lumen 1 Publication

    GO - Cellular componenti

    1. endoplasmic reticulum Source: RefGenome
    2. endoplasmic reticulum lumen Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi168 – 1681M → W: Decreases somatostatin-14 binding. 1 Publication
    Mutagenesisi196 – 1961I → A, L or W: Decreases somatostatin-14 binding. 1 Publication
    Mutagenesisi196 – 1961I → W: Conserved PDIA3 binding in vivo and in vitro. 1 Publication
    Mutagenesisi231 – 2311E → K or A: Greatly reduces PDIA3 binding in vivo and in vitro. 1 Publication
    Mutagenesisi232 – 2321W → A: Greatly reduces PDIA3 binding in vivo and in vitro. 1 Publication
    Mutagenesisi233 – 2331D → G: Greatly reduces PDIA3 binding in vivo and in vitro. 1 Publication

    Organism-specific databases

    PharmGKBiPA162385401.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2525Sequence AnalysisAdd
    BLAST
    Chaini26 – 273248Endoplasmic reticulum resident protein 27PRO_0000281118Add
    BLAST

    Proteomic databases

    MaxQBiQ96DN0.
    PaxDbiQ96DN0.
    PRIDEiQ96DN0.

    Expressioni

    Gene expression databases

    ArrayExpressiQ96DN0.
    BgeeiQ96DN0.
    CleanExiHS_ERP27.
    GenevestigatoriQ96DN0.

    Organism-specific databases

    HPAiHPA039636.

    Interactioni

    Subunit structurei

    Interacts with PDIA3. Binds somatostatin-14 via hydrophobic interactions.1 Publication

    Protein-protein interaction databases

    BioGridi125733. 1 interaction.
    IntActiQ96DN0. 1 interaction.
    MINTiMINT-2878436.
    STRINGi9606.ENSP00000266397.

    Structurei

    Secondary structure

    1
    273
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi46 – 549
    Beta strandi56 – 638
    Helixi71 – 788
    Turni79 – 813
    Beta strandi85 – 906
    Helixi93 – 986
    Beta strandi103 – 1108
    Turni111 – 1144
    Beta strandi115 – 1195
    Helixi121 – 1255
    Helixi129 – 13911
    Beta strandi143 – 1464
    Helixi149 – 1579
    Beta strandi162 – 1687
    Helixi175 – 18814
    Turni189 – 1924
    Beta strandi194 – 1996
    Helixi203 – 2053
    Helixi206 – 2116
    Helixi216 – 2183
    Beta strandi220 – 22910
    Beta strandi232 – 2354
    Helixi242 – 25312

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2L4CNMR-A26-141[»]
    4F9ZX-ray2.20A/B/C/D/E30-256[»]
    ProteinModelPortaliQ96DN0.
    SMRiQ96DN0. Positions 38-256.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini39 – 152114ThioredoxinAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni230 – 2334PDIA3-binding site

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi270 – 2734Prevents secretion from ER

    Sequence similaritiesi

    Belongs to the protein disulfide isomerase family.Curated
    Contains 1 thioredoxin domain.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG255456.
    HOGENOMiHOG000112391.
    HOVERGENiHBG081481.
    InParanoidiQ96DN0.
    OMAiEHVQNFC.
    OrthoDBiEOG7P2XT5.
    PhylomeDBiQ96DN0.
    TreeFamiTF106381.

    Family and domain databases

    Gene3Di3.40.30.10. 1 hit.
    InterProiIPR012336. Thioredoxin-like_fold.
    [Graphical view]
    SUPFAMiSSF52833. SSF52833. 2 hits.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q96DN0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEAAPSRFMF LLFLLTCELA AEVAAEVEKS SDGPGAAQEP TWLTDVPAAM    50
    EFIAATEVAV IGFFQDLEIP AVPILHSMVQ KFPGVSFGIS TDSEVLTHYN 100
    ITGNTICLFR LVDNEQLNLE DEDIESIDAT KLSRFIEINS LHMVTEYNPV 150
    TVIGLFNSVI QIHLLLIMNK ASPEYEENMH RYQKAAKLFQ GKILFILVDS 200
    GMKENGKVIS FFKLKESQLP ALAIYQTLDD EWDTLPTAEV SVEHVQNFCD 250
    GFLSGKLLKE NRESEGKTPK VEL 273
    Length:273
    Mass (Da):30,480
    Last modified:December 1, 2001 - v1
    Checksum:iD47280F6F6FDE419
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti52 – 521F → L.
    Corresponds to variant rs35030722 [ dbSNP | Ensembl ].
    VAR_052582

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY358536 mRNA. Translation: AAQ88900.1.
    AK056677 mRNA. Translation: BAB71251.1.
    BC030218 mRNA. Translation: AAH30218.1.
    CCDSiCCDS8670.1.
    RefSeqiNP_689534.1. NM_152321.2.
    UniGeneiHs.162143.

    Genome annotation databases

    EnsembliENST00000266397; ENSP00000266397; ENSG00000139055.
    GeneIDi121506.
    KEGGihsa:121506.
    UCSCiuc001rco.3. human.

    Polymorphism databases

    DMDMi74731474.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY358536 mRNA. Translation: AAQ88900.1 .
    AK056677 mRNA. Translation: BAB71251.1 .
    BC030218 mRNA. Translation: AAH30218.1 .
    CCDSi CCDS8670.1.
    RefSeqi NP_689534.1. NM_152321.2.
    UniGenei Hs.162143.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2L4C NMR - A 26-141 [» ]
    4F9Z X-ray 2.20 A/B/C/D/E 30-256 [» ]
    ProteinModelPortali Q96DN0.
    SMRi Q96DN0. Positions 38-256.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 125733. 1 interaction.
    IntActi Q96DN0. 1 interaction.
    MINTi MINT-2878436.
    STRINGi 9606.ENSP00000266397.

    Polymorphism databases

    DMDMi 74731474.

    Proteomic databases

    MaxQBi Q96DN0.
    PaxDbi Q96DN0.
    PRIDEi Q96DN0.

    Protocols and materials databases

    DNASUi 121506.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000266397 ; ENSP00000266397 ; ENSG00000139055 .
    GeneIDi 121506.
    KEGGi hsa:121506.
    UCSCi uc001rco.3. human.

    Organism-specific databases

    CTDi 121506.
    GeneCardsi GC12M015066.
    HGNCi HGNC:26495. ERP27.
    HPAi HPA039636.
    MIMi 610642. gene.
    neXtProti NX_Q96DN0.
    PharmGKBi PA162385401.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG255456.
    HOGENOMi HOG000112391.
    HOVERGENi HBG081481.
    InParanoidi Q96DN0.
    OMAi EHVQNFC.
    OrthoDBi EOG7P2XT5.
    PhylomeDBi Q96DN0.
    TreeFami TF106381.

    Enzyme and pathway databases

    BRENDAi 5.3.4.1. 2681.

    Miscellaneous databases

    ChiTaRSi ERP27. human.
    GenomeRNAii 121506.
    NextBioi 80755.
    PROi Q96DN0.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q96DN0.
    Bgeei Q96DN0.
    CleanExi HS_ERP27.
    Genevestigatori Q96DN0.

    Family and domain databases

    Gene3Di 3.40.30.10. 1 hit.
    InterProi IPR012336. Thioredoxin-like_fold.
    [Graphical view ]
    SUPFAMi SSF52833. SSF52833. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Pancreas.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung.
    4. "ERp27, a new non-catalytic endoplasmic reticulum-located human protein disulfide isomerase family member, interacts with ERp57."
      Alanen H.I., Williamson R.A., Howard M.J., Hatahet F.S., Salo K.E.H., Kauppila A., Kellokumpu S., Ruddock L.W.
      J. Biol. Chem. 281:33727-33738(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR, SUBCELLULAR LOCATION, INTERACTION WITH PDIA3, MUTAGENESIS OF MET-168; ILE-196; GLU-231; TRP-232 AND ASP-233.

    Entry informationi

    Entry nameiERP27_HUMAN
    AccessioniPrimary (citable) accession number: Q96DN0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 20, 2007
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 100 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Does not contain a CXXC active site motif indicating that it is a catalytically redox-inactive member of the protein disulfide isomerase family.

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3