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Protein

Endoplasmic reticulum resident protein 27

Gene

ERP27

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000139055-MONOMER.
BRENDAi5.3.4.1. 2681.

Names & Taxonomyi

Protein namesi
Recommended name:
Endoplasmic reticulum resident protein 27
Short name:
ER protein 27
Short name:
ERp27
Gene namesi
Name:ERP27
Synonyms:C12orf46
ORF Names:UNQ781/PRO1575
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:26495. ERP27.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi168M → W: Decreases somatostatin-14 binding. 1 Publication1
Mutagenesisi196I → A, L or W: Decreases somatostatin-14 binding. 1 Publication1
Mutagenesisi196I → W: Conserved PDIA3 binding in vivo and in vitro. 1 Publication1
Mutagenesisi231E → K or A: Greatly reduces PDIA3 binding in vivo and in vitro. 1 Publication1
Mutagenesisi232W → A: Greatly reduces PDIA3 binding in vivo and in vitro. 1 Publication1
Mutagenesisi233D → G: Greatly reduces PDIA3 binding in vivo and in vitro. 1 Publication1

Organism-specific databases

OpenTargetsiENSG00000139055.
PharmGKBiPA162385401.

Polymorphism and mutation databases

BioMutaiERP27.
DMDMi74731474.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000028111826 – 273Endoplasmic reticulum resident protein 27Add BLAST248

Proteomic databases

MaxQBiQ96DN0.
PaxDbiQ96DN0.
PeptideAtlasiQ96DN0.
PRIDEiQ96DN0.

Expressioni

Gene expression databases

BgeeiENSG00000139055.
CleanExiHS_ERP27.
ExpressionAtlasiQ96DN0. baseline and differential.
GenevisibleiQ96DN0. HS.

Organism-specific databases

HPAiHPA039636.
HPA052851.

Interactioni

Subunit structurei

Interacts with PDIA3. Binds somatostatin-14 via hydrophobic interactions.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
EEF1DP296923EBI-953772,EBI-358607
SGTAO437655EBI-953772,EBI-347996
UBQLN1Q9UMX03EBI-953772,EBI-741480
UBQLN1Q9UMX0-23EBI-953772,EBI-10173939

Protein-protein interaction databases

BioGridi125733. 4 interactors.
IntActiQ96DN0. 5 interactors.
MINTiMINT-2878436.
STRINGi9606.ENSP00000266397.

Structurei

Secondary structure

1273
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi46 – 54Combined sources9
Beta strandi56 – 63Combined sources8
Helixi71 – 78Combined sources8
Turni79 – 81Combined sources3
Beta strandi85 – 90Combined sources6
Helixi93 – 98Combined sources6
Beta strandi103 – 110Combined sources8
Turni111 – 114Combined sources4
Beta strandi115 – 119Combined sources5
Helixi121 – 125Combined sources5
Helixi129 – 139Combined sources11
Beta strandi143 – 146Combined sources4
Helixi149 – 157Combined sources9
Beta strandi162 – 168Combined sources7
Helixi175 – 188Combined sources14
Turni189 – 192Combined sources4
Beta strandi194 – 199Combined sources6
Helixi203 – 205Combined sources3
Helixi206 – 211Combined sources6
Helixi216 – 218Combined sources3
Beta strandi220 – 229Combined sources10
Beta strandi232 – 235Combined sources4
Helixi242 – 253Combined sources12

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2L4CNMR-A26-141[»]
4F9ZX-ray2.20A/B/C/D/E30-256[»]
ProteinModelPortaliQ96DN0.
SMRiQ96DN0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini39 – 152ThioredoxinAdd BLAST114

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni230 – 233PDIA3-binding site4

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi270 – 273Prevents secretion from ER4

Sequence similaritiesi

Belongs to the protein disulfide isomerase family.Curated
Contains 1 thioredoxin domain.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG0191. Eukaryota.
COG0526. LUCA.
GeneTreeiENSGT00860000133691.
HOGENOMiHOG000112391.
HOVERGENiHBG081481.
InParanoidiQ96DN0.
KOiK20355.
OMAiEHVQNFC.
OrthoDBiEOG091G0CRI.
PhylomeDBiQ96DN0.
TreeFamiTF106381.

Family and domain databases

Gene3Di3.40.30.10. 2 hits.
InterProiIPR012336. Thioredoxin-like_fold.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q96DN0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEAAPSRFMF LLFLLTCELA AEVAAEVEKS SDGPGAAQEP TWLTDVPAAM
60 70 80 90 100
EFIAATEVAV IGFFQDLEIP AVPILHSMVQ KFPGVSFGIS TDSEVLTHYN
110 120 130 140 150
ITGNTICLFR LVDNEQLNLE DEDIESIDAT KLSRFIEINS LHMVTEYNPV
160 170 180 190 200
TVIGLFNSVI QIHLLLIMNK ASPEYEENMH RYQKAAKLFQ GKILFILVDS
210 220 230 240 250
GMKENGKVIS FFKLKESQLP ALAIYQTLDD EWDTLPTAEV SVEHVQNFCD
260 270
GFLSGKLLKE NRESEGKTPK VEL
Length:273
Mass (Da):30,480
Last modified:December 1, 2001 - v1
Checksum:iD47280F6F6FDE419
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05258252F → L.Corresponds to variant rs35030722dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358536 mRNA. Translation: AAQ88900.1.
AK056677 mRNA. Translation: BAB71251.1.
BC030218 mRNA. Translation: AAH30218.1.
CCDSiCCDS8670.1.
RefSeqiNP_001287713.1. NM_001300784.1.
NP_689534.1. NM_152321.3.
UniGeneiHs.162143.

Genome annotation databases

EnsembliENST00000266397; ENSP00000266397; ENSG00000139055.
GeneIDi121506.
KEGGihsa:121506.
UCSCiuc001rco.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358536 mRNA. Translation: AAQ88900.1.
AK056677 mRNA. Translation: BAB71251.1.
BC030218 mRNA. Translation: AAH30218.1.
CCDSiCCDS8670.1.
RefSeqiNP_001287713.1. NM_001300784.1.
NP_689534.1. NM_152321.3.
UniGeneiHs.162143.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2L4CNMR-A26-141[»]
4F9ZX-ray2.20A/B/C/D/E30-256[»]
ProteinModelPortaliQ96DN0.
SMRiQ96DN0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125733. 4 interactors.
IntActiQ96DN0. 5 interactors.
MINTiMINT-2878436.
STRINGi9606.ENSP00000266397.

Polymorphism and mutation databases

BioMutaiERP27.
DMDMi74731474.

Proteomic databases

MaxQBiQ96DN0.
PaxDbiQ96DN0.
PeptideAtlasiQ96DN0.
PRIDEiQ96DN0.

Protocols and materials databases

DNASUi121506.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000266397; ENSP00000266397; ENSG00000139055.
GeneIDi121506.
KEGGihsa:121506.
UCSCiuc001rco.4. human.

Organism-specific databases

CTDi121506.
GeneCardsiERP27.
HGNCiHGNC:26495. ERP27.
HPAiHPA039636.
HPA052851.
MIMi610642. gene.
neXtProtiNX_Q96DN0.
OpenTargetsiENSG00000139055.
PharmGKBiPA162385401.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0191. Eukaryota.
COG0526. LUCA.
GeneTreeiENSGT00860000133691.
HOGENOMiHOG000112391.
HOVERGENiHBG081481.
InParanoidiQ96DN0.
KOiK20355.
OMAiEHVQNFC.
OrthoDBiEOG091G0CRI.
PhylomeDBiQ96DN0.
TreeFamiTF106381.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000139055-MONOMER.
BRENDAi5.3.4.1. 2681.

Miscellaneous databases

ChiTaRSiERP27. human.
GenomeRNAii121506.
PROiQ96DN0.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000139055.
CleanExiHS_ERP27.
ExpressionAtlasiQ96DN0. baseline and differential.
GenevisibleiQ96DN0. HS.

Family and domain databases

Gene3Di3.40.30.10. 2 hits.
InterProiIPR012336. Thioredoxin-like_fold.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiERP27_HUMAN
AccessioniPrimary (citable) accession number: Q96DN0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: December 1, 2001
Last modified: November 30, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Does not contain a CXXC active site motif indicating that it is a catalytically redox-inactive member of the protein disulfide isomerase family.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.